SUMOylation is an essential eukaryotic ubiquitin-like post-translational modification that plays a central role in the regulation of various nuclear processes and stress responses. It canonically occu...

Cohesin-mediated loop extrusion limits sister-fork coupling and tethers nearby replication forks under replication stress, promoting fork reversal and slowing fork progression to safeguard genome...

Xue et al. identify DDIAS as an effector of the CIP2A-TOPBP1 complex. DDIAS is a single-stranded DNA-binding protein that promotes the repair of single-stranded DNA lesions during cell division. This activity is essential in cells lacking the BRCA1 or BRCA2 tumor suppressors or in cells lacking DNA polymerase ζ.

Popular vendors’ catalogs feature more than 18,000 manipulated images

Join us for the annual in-person meeting of the UK Cilia & Centrosomal Network meeting, which for 2026 will be at the University of Leeds!

Ubiquitin coordinates a complex network of cellular pathways through covalent modification of substrates. Specificity in substrate recognition and modification choice is largely conferred by ubiquitin...

Mechanism of the myosin inhibitor mavacamten is revealed by cryo-EM and cross-linking studies.

A modular strategy combining genetic code expansion with a selective amide bond-forming reaction enables the site-specific installation of lysine acylations on folded proteins. Acylboronates react sel...

Wang et al. show that OXCT1 and HDAC11 regulate RAD51 K285 succinylation, thereby suppressing homologous recombination repair and enhancing chemosensitivity.

The 2026 Gordon Research Conference on DNA Damage, Mutation and Cancer will be held in Ventura, California. Apply today to reserve your spot.

Replication stress is a key driver of DNA damage and genome instability. Here, we report that replication stress induces an inflammatory response in t…

The Institute is proud to announce the winners of this year

Abstract. Disassembly of the replication machinery (replisome) from chromatin is an active process driven by two ubiquitin ligases Cul2LRR1 and TRAIP, whic

Alt: a cartoon drawing of a clock with a face and arms and legs

Among the ubiquitin-like superfamily, small ubiquitin-like modifiers (SUMOs) are the most well-understood. However, in comparison with the prototypical small modifier ubiquitin, our understanding of t...

PhD Project - Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes at The University of Manchester, listed on FindAPhD.com

Some of Leeds’ top biological researchers have received two new Wellcome Discovery Awards, confirming the university’s status as a centre of excellence in biological research.

Summary: Control of RNA:DNA hybrids by RNase H2 helps protect genome stability. Recent insights into RNase H2 molecular functions and alterations in cancer shed new light on mechanisms of human diseas...

DNA secondary structures, such as hairpins, cruciforms, triplexes, G-quadruplexes and iMotifs, are common, dynamic features that replication forks rou…

BBS Awards The BBS Kendrew Doctoral Thesis Prize was established in 2019 and will be awarded every two years for an outstanding PhD thesis in biophysics for which the principal work has been carried o...

Pathogenic BRCA2 truncating variants in heterozygosis drive distinct cancer-linked mechanisms. Here the authors show that one causes PARPi sensitivity and HR loss via haploinsufficiency, while another...

Nature Structural & Molecular Biology - Riechmann et al. uncover structural features governing ubiquitin transfer from ubiquitin-activating E1 enzymes UBA1 and UBA6 to specific E2...

SUMOylation, a protein post-translational modification (PTM) involving the covalent attachment of small ubiquitin-like modifier (SUMO), regulates a wide range of cellular processes. The key hallmark o...

Typos in the genome: Defining the molecular mechanism of replication slippage

PhD Project - Stopping GLI transcription factors in their tracks: identifying regulators of proteolysis as therapeutic targets. at University of Leeds, listed on FindAPhD.com

Universität Wien bietet Stelle als Tenure-Track Professorship in Genome Biology in Wien - jetzt bewerben!