Nature readers share their PhD time-management woes.

FUS, EWSR1 and TAF15 function in a variety of cellular processes by forming biomolecular condensates. Here the authors reveal that these proteins respond to replication stress to promote fork reversal...

Sarah Blackford reflects on how early-career scientists and professional football players share similar motivations, pressures and challenges.

The annual prize recognises individuals who have made outstanding contributions to organic chemistry

The DNA damage response (DDR) is a complex network of cellular pathways that ensures the faithful maintenance of our genomes upon a wide array of genomic insults. To elucidate the functional architect...

Break-induced replication (BIR) is mediated by DNA polymerase d (Pol d). Here, the authors identify a phospho-activated RPA-binding module in Pol d which promotes BIR efficiency, providing a paradigm ...

Apurinic/apyrimidinic (AP) sites, also known as abasic sites, are among the most frequent DNA lesions, arising spontaneously or as intermediates in base excision repair. Their structural impediment to...

DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-small cell lung cancer and the seeding patterns that underpin it.

The German artist lived through Nazism and communism – and his horrific, shaming works, including a masturbating Hitler, forced his country to face its past. Yet in later life, he beautifully captured human frailty, portraying himself and his wife nude

Failure is part and parcel of research, but discussing it sometimes seems to be taboo in science. It doesn’t need to be.

The human genome ‘maverick’ talks sequencing the ocean, setting up a health-screening company after checking his own genes — and why he has no plans to stop.

Competition winners receive a cash prize and will see their images featured in Nature.

Integrating replication-associated Micro-C and the reinforcement-learning-based computational framework Fun2, Zhangding et al. profile DNA-replication elongation driven by coupled replication forks at nucleosome resolution in mammalian cells and reveal that transcription has dual effects on replication elongation. Co-directional transcription facilitates fork progression, whereas head-on transcription blocks coupled forks.

Somatic human cells contain a diploid genome consisting of 23 pairs of chromosomes. The maintenance of this diploid state is essential across all layers of biological organization, ranging from the ph...

State-of-the-industry report finds that, despite the limitations of artificial-intelligence systems, researchers have embraced them.

Universität Wien bietet Stelle als Tenure-Track Professorship in Genome Biology in Wien - jetzt bewerben!

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Nature - DNA computers can use biological material to perform mathematical functions and store information, but their power sources have been fragile. Researchers now say they’ve developed a...

The primatologist challenged what it meant to be a scientist.