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Haselbach Lab

@haselbachlab.bsky.social
1.1K followers 413 following 82 posts

cryo EM enthusiasts with interest in molecular machines.

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Julius Brennecke @juliusbrennecke.bsky.social · 27/09/2026
Five years ago, on a walk with @mayavoichek.bsky.social through the third district around the @viennabiocenter.bsky.social we concluded that "every day we do not work on the mysterious Env-independent infectivity of MDG1 retrotransposons is a lost day ... " The birth of an entire research domain.
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Haselbach Lab @haselbachlab.bsky.social · 01/09/2026
We are hiring a new phd student.
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Haselbach Lab @haselbachlab.bsky.social · 31/08/2026
Last call: registration for the 9th Austrian Cryo-EM (ACE) Symposium closes tomorrow, 1 September. 24-25 Sept at the IMP, Vienna BioCenter. Eight invited speakers, selected talks, poster session. events.vbc.ac.at/imp_events/c... #cryoEM #cryoET
events.vbc.ac.at
Cryo-EM Symposium 2026
Register here for the Cryo-EM Symposium 2026, 24-25 September at the IMP, Campus-Vienna-Biocenter 1, 1030 Vienna.Please select the applicable registration fee and add it to the cart. Please click on t...
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Stella Hurtley @smhsci.bsky.social · 21/08/2026
Out now in @science.org Virome-wide ubiquitin ligase discovery reveals diverse mechanisms of immune evasion | Science www.science.org/doi/10.1126/...
science.org
Virome-wide ubiquitin ligase discovery reveals diverse mechanisms of immune evasion
Viruses are intracellular parasites that reprogram the host proteome to promote replication and evade immune recognition. We applied a virome-wide library of ~10,000 open reading frames to discover vi...
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Francis O'Reilly @fjoreilly.bsky.social · 14/08/2026
PhIX-MS is out in Molecular Cell! Rapid in situ photo-crosslinking traps transient proteasome interactions before purification; crosslinking MS, cryo-EM and AlphaFold tell us where they bind. Paper: doi.org/10.1016/j.mo... Preview: doi.org/10.1016/j.mo...
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Kashish Singh @kashishsingh.bsky.social · 13/08/2026
Very happy to see the final version of our work on the structure and composition of cytoplasmic lattices in mouse embryos, previously shared on bioRxiv, now published in The EMBO Journal! Many thanks to our editor, Ieva Gailite, and the reviewers for their constructive input.
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Juan Carlos De la Concepcion @delaconcepcionjc.bsky.social · 05/08/2026
PLEASE SHARE! New job openings in my lab @zmbp-tuebingen.bsky.social. We have a broad interest into the mechanistic basis of how molecular complexes are rewired during cellular development in plants and during invasion by pathogens. 🌱🍄🔬 See details below 👇 #PlantSciJobs
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Plaschka lab @plaschkalab.bsky.social · 03/08/2026
A friendly reminder that the 9th Austrian Cryo-EM (ACE) Symposium is taking place in Vienna, 24–25 September 2026. We'd love to see you there! Speakers: Chlanda, Costa, Demulder, Hurdiss, Su, Toropova, Weiss and Zhong. Abstract deadline 5 August; talks selected from submissions. shorturl.at/NGRZV
imp.ac.at
Cryo-EM Symposium | Vienna BioCenter | cryo-Electron Miscroscopy Conference
The annual Cryo-EM Symposium is a conference for structural biologists to discuss cutting-edge developments in cryo-Electron Miscroscopy. Held at the Vienna BioCenter.
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Haselbach Lab @haselbachlab.bsky.social · 01/07/2026
We're delighted to announce the 9th Austrian Cryo-EM (ACE) Symposium - Sept 24-25, 2026 at IMP, Vienna. Organized with @istaresearch.bsky.social 🎤 Abstract deadline: Aug 5, 2026 📅 Info & registration: imp.ac.at/research/cryo-em-symposium/
imp.ac.at
Cryo-EM Symposium | Vienna BioCenter | cryo-Electron Miscroscopy Conference
The annual Cryo-EM Symposium is a conference for structural biologists to discuss cutting-edge developments in cryo-Electron Miscroscopy. Held at the Vienna BioCenter.
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Haselbach Lab @haselbachlab.bsky.social · 11/06/2026
It was such a pleasure having @wulabharvard.bsky.social for the VBC seminar today in Vienna! Great structures and great presentation.
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Haselbach Lab @haselbachlab.bsky.social · 10/06/2026
okay I spend some time testing Claude Fable from @anthropic.com and it is utterly useless in life science what ever I tried it almost instantaneously switched model. Even when looking test editing an email to a colleague. No paper editing, no script improvement no hypothesis sparring
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IMP @impvienna.bsky.social · 13/05/2026
📣 Registration is open for the 20th Microsymposium on RNA Biology! Join in at the Vienna BioCenter for three days of cutting-edge science, discussion & networking. 📅 17-19 June 2026 🧬 Poster abstract deadline: 19 May Info & registration: www.oeaw.ac.at/imba/seminar...
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niels-fischer.bsky.social @niels-fischer.bsky.social · 07/05/2026
How do mitochondrial ribosomes keep pace with membrane insertion? Now out in NSMB: We show that mitoribosomes slow down at defined positions linked to membrane insertion and protein topology: rdcu.be/fhqIT #Mitochondria #Ribosome #CryoEM
rdcu.be
Membrane insertion of mitochondrial-encoded proteins regulates ribosome decoding speed
Nature Structural & Molecular Biology - Schöndorf and Petrychenko et al. show that mitochondrial translation speed is coupled to OXA1L-mediated inner membrane insertion, with...
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Haselbach Lab @haselbachlab.bsky.social · 23/04/2026
A new paper in which we could contribute structural insights to the great biochemical work from our collaborators from UNC Chapel Hill. Sascha Amann from our lab was yet again able to solve several very challenging structures. This time of a SCF with Protac and target www.nature.com/articles/s41...
nature.com
Structural basis of NSD2 degradation via targeted recruitment of SCF-FBXO22 - Nature Communications
Compound-mediated targeted protein degradation through the recruitment of Ub ligases is an emerging field. Here, the authors determine key structural and biochemical principles for harnessing SCF-FBXO...
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Kashish Singh @kashishsingh.bsky.social · 24/03/2026
Happy to share my first adventure in #TeamTomo in collaboration with the talented @inaharasimov.bsky.social. It was a fun experience experience with a lot of learning along the way.
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Carter Lab @carter-lab.bsky.social · 24/03/2026
Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with @niakanlab.bsky.social and work led by @kashishsingh.bsky.social and @inaharasimov.bsky.social . It is now out on BioRxiv: www.biorxiv.org/content/10.6...
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dimitristypas.bsky.social @dimitristypas.bsky.social · 18/03/2026
The @natsmb.nature.com March issue is out! Though always interested in proteostasis, in 2026 we have published and will continue to do so relevant content. Our editorial www.nature.com/articles/s41... recaps why the processes and mechanisms of proteostasis continue to interest us.
nature.com
No stasis in proteostasis - Nature Structural & Molecular Biology
In this issue of Nature Structural & Molecular Biology, we focus on all things protein homeostasis, highlighting a variety of processes, from protein quality control in translation to autophagy.
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EMBL-EBI @ebi.embl.org · 16/03/2026
You asked, we listened. Millions of AI-predicted protein complex structures are now available in the #AlphaFold Database. This spans homodimers from 20 of the most studied species, including humans, as well as the World Health Organization’s priority pathogens list. www.ebi.ac.uk/about/news/t...
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Vienna BioCenter Scientific Training @vbcscitraining.bsky.social · 13/03/2026
Learn more about the collaboration possibilities offered at Vienna BioCenter as Victoria Deneke shares her insights as a Postdoc at the Research Institute of Molecular Pathology. The VIP³ PostDoc Program call is open – apply now! training.vbc.ac.at/post-docs/vi... #VBCPostDoc
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Vienna BioCenter Scientific Training @vbcscitraining.bsky.social · 11/03/2026
Our Spring call is now open with over 30+ fully funded positions in the life sciences. Want to know more? Join our Info Session on 26 March, 1600 (CET). Register now: www.vbcphd.at Institute of Molecular Biotechnology, Max Perutz Labs Vienna, IMP, Gregor Mendel Institute of Molecular Plant Biology
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Haselbach Lab @haselbachlab.bsky.social · 11/03/2026
Welcome to the vbc and the wonderful Vienna cryo EM community
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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 08/03/2026
Review from Fia B. Larsen in @rhp-lab.bsky.social with everything you always wanted to know about proteasomal control of transcription factors (but were afraid to ask about) Proteasomal control of transcription factors: mechanisms, regulation and dysregulation. doi.org/10.1007/s000...
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IMP @impvienna.bsky.social · 09/03/2026
A consortium of group leaders from IMP, IMBA (Vienna BioCenter) and ISTA has been awarded an FWF Emerging Fields grant to study how germ cells safeguard and pass on genetic information across generations.
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Max Planck Institute of Biochemistry @mpibiochem.bsky.social · 04/03/2026
#pictureofthemonth: March shows a “Cross-section” of the endoplasmic reticulum, a kind of membrane-labyrinth, using cryo-electron microscopy. More: www.biochem.mpg.de/plitzko March – Calendar of @mpiforbi.bsky.social and @mpibiochem.bsky.social 📸 Illustration by Jürgen Plitzko & Sven Klumpe
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 24/02/2026
Are you a structural biologist pushing the boundaries of molecular science with an ambitious research programme? Join our Structural Studies Division as a tenure-track Group Leader, with core funding, world-leading facilities & enthusiastic colleagues. Apply by 16 MAR www.nature.com/naturecareer...
Job opening for Research Group Leader in Structural Studies at MRC Laboratory of Molecular Biology, focusing on macromolecular structures.
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Vienna BioCenter @viennabiocenter.bsky.social · 19/02/2026
SAVE THE DATE: Ubiquitin & Friends Symposium 2026 on April 29-30 or even better, sign up now: lnkd.in/eEQmaCYT It takes place at Van Swieten Hall, 1090 Vienna & is organized by the SFB Targeted Protein Degradation (incl. numerous research groups at Vienna BioCenter) @sfb-tpd-vienna.bsky.social
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Kristina Stapornwongkul @kstapornwongkul.bsky.social · 17/02/2026
We‘re looking for a motivated Master student to join our team! Do you want to optogenetically control metabolic activity to see how metabolism affects patterning and morphogenesis? 💡🧫🧬🔬 Then please apply! #optogenetics #metabolism #devbio #hESCs Please RT. Thank you!🙏
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Sjors Scheres @sjorsscheres.bsky.social · 16/02/2026
Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳 mrc.tal.net/vx/mobile-0/...
mrc.tal.net
Research Group Leader Tenure Track - Structural Studies - LMB 2775 - Medical Research Council
Location: Cambridge. Vacancy: Research Group Leader Tenure Track - Structural Studies - LMB 2775. Closing Date: 16/03/2026, 23:55
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versteegga.bsky.social @versteegga.bsky.social · 17/02/2026
Our paper is out in @natcomms.nature.com! APOBEC3s drive mutagenesis in cancer. We uncover a novel pathway keeping them in check. The key is APOBEC3 binding of cellular RNAs, which simultaneously controls their nuclear localization and shields them from degradation. Read it here: rdcu.be/e4qaa
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Haselbach Lab @haselbachlab.bsky.social · 12/02/2026
This is a video summarizing our recent paper (www.nature.com/articles/s41...) youtu.be/eNY2CRlYTRo
nature.com
A multivalent adaptor mechanism drives the nuclear import of proteasomes - Nature Communications
Nuclear protein homeostasis relies on proteasome import into the nucleus. Here the authors identify how assembled human proteasomes are transported across the nuclear pore complex and reveal a mechani...
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Haselbach Lab @haselbachlab.bsky.social · 11/02/2026
And a new paper from the lab. A follow up to a previous study in which we elucidate the mechanism of the nuclear transport. Read the full story: www.nature.com/articles/s41...
nature.com
A multivalent adaptor mechanism drives the nuclear import of proteasomes - Nature Communications
Nuclear protein homeostasis relies on proteasome import into the nucleus. Here the authors identify how assembled human proteasomes are transported across the nuclear pore complex and reveal a mechani...
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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 07/02/2026
A near-complete map of human cytosolic degrons and their relevance for disease We measured degron potency of >200,000 30-residue tiles from >5,000 human proteins, and trained a model to predict degrons from sequence Led by @vvouts.bsky.social in @rhp-lab.bsky.social doi.org/10.1126/scia...
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Haselbach Lab @haselbachlab.bsky.social · 30/01/2026
Great story from our neighbours at the university of Vienna. We are that we could contribute to this.
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Juan Carlos De la Concepcion @delaconcepcionjc.bsky.social · 30/01/2026
Please share! My group at @zmbp-tuebingen.bsky.social is offering a post-doctoral position (4 years). We look for a structural biologist with experience in Cryo-EM/Cryo-ET to investigate the mechanisms of host invasion by pathogenic fungi. Deadline February 28th! uni-tuebingen.de/universitaet...
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Lorenz Grundmann @lgrundmann.bsky.social · 27/01/2026
Check out our new paper in @natcomms.nature.com .com where we used #cryoEM together with biochemical and mutational analyses investigated the cotranslational protein folding by Ssb in yeast. Publication: doi.org/10.1038/s41467-025-67685-6 Check below for the cryoEM centric feed. 👇
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Max Planck Institute of Biochemistry @mpibiochem.bsky.social · 28/01/2026
Formation & function of #MembranelessOrganelles! #CryoET structures of #proteasome storage granules inside cells! Read our paper @cp-cell.bsky.social! ❕Publication: doi.org/10.1016/j.ce... ❕Press Release: www.biochem.mpg.de/en/pressroom @uoftmedicine.bsky.social @erc.europa.eu #UPSmeetMet
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IMP @impvienna.bsky.social · 27/01/2026
New work from our Haselbach lab with collaborators captures ribosomes 𝘮𝘪𝘥-𝘣𝘶𝘪𝘭𝘥 and reveals a flexible, modular strategy behind their assembly, rather than a strict assembly line. Published in _Nucleic Acids Research _👉 doi.org/10.1093/nar/gkag036
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Michael Prattes @hexamergraphics.bsky.social · 25/01/2026
🔬 Ribosomes are hands down one of the most intricate molecular machines we know. Huge (for a cellular scale at least) complexes made of long RNAs (rRNAs) and proteins … a lot of different proteins. 1/6 (❗️Sound on!) @narjournal.bsky.social
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Haselbach Lab @haselbachlab.bsky.social · 22/01/2026
And the 4th paper in this week contribution from our lab tells about ribosome biogenesis in yeast. A follow-up story from our wonderful collaborators in Graz - the Bergler Lab. Structural work was again done by the amazing @lgrundmann.bsky.social: academic.oup.com/nar/article/...
academic.oup.com
A comprehensive view on r-protein binding and rRNA domain structuring during early eukaryotic ribosome formation
Abstract. Formation of the eukaryotic ribosomal subunits follows a strict regime to assemble ribosomal proteins (r-protein) with ribosomal RNAs (rRNA) whil
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Maximilian Madern @maxmadern.bsky.social · 20/01/2026
Excited to share our new paper! We developed a method to visualize proteasomal degradation at the single–molecule level in live cells, enabling us to dissect distinct modes of substrate engagement, probe co-factor dependence, and study proteasome–ribosome collisions. www.biorxiv.org/content/10.6...
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Haselbach Lab @haselbachlab.bsky.social · 21/01/2026
I am very happy that I could advice in this great story. Seeing single proteasomes degrade in cells is opens so many interesting possibilities. Check the preprint.
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Haselbach Lab @haselbachlab.bsky.social · 21/01/2026
And another paper with contribution from us. Here Sascha Amann solved the structure of the BORC complex. Due to its shape it is extremely challenging for cryo EM analysis but still he cracked it. Read the full story spearheaded by the Huber lab in Innsbruck: www.pnas.org/doi/10.1073/...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Gregor Weiss @weiss-lab.bsky.social · 19/01/2026
🔬 Postdoc position – Infection Biology & Cryo-ET (Zurich) 🇨🇭 We are looking for a motivated Postdoc to join our interdisciplinary team. 📩 Interested? Check out the job advert: www.imm.uzh.ch/dam/jcr:cb17... 👉 More info on the lab: www.weiss-laboratory.com Please share with interested colleagues!
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Haselbach Lab @haselbachlab.bsky.social · 19/01/2026
Have a look at our new structure of co translational folding in yeast. This is collaborative work initialized by the Rospert lab from the @uni-freiburg.de. Structural work has been done by the amazing @lgrundmann.bsky.social Stay tuned for the next ribosome paper from him, following very soon.
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Jakob Farnung @jakobfarnung.bsky.social · 06/01/2026
When RNA Degradation 🤝 meets 🤝 Protein Degradation! tinyurl.com/E3TDMD In a collaboration of @bartellab.bsky.social and Schulman lab, we show that, in target-directed microRNA degradation (TDMD), 2-RNA-factors recruit an E3 ligase and induce the degradation of not only a protein but also RNA (1/5).
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Haselbach Lab @haselbachlab.bsky.social · 16/12/2025
My this years Christmas chocolates ended up a little IMP branded ;)
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Kate Beckham @kshbeckham.bsky.social · 14/12/2025
www.nature.com/articles/s41...
nature.com
AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination - Nature Methods
An analysis of AlphaFold protein structure predictions shows that while in many cases the predictions are highly accurate, there are also many instances where the predicted structures or parts of pred...
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Karolin Luger @nucleosomepolice.bsky.social · 10/12/2025
so many grand gestures welcoming US researchers - neglecting the fact that funding in Canada, Australia, Europe and China is already fiercly competitive. This is not the solution. #standupforscience
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Yasin Dagdas @plantophagy.bsky.social · 10/12/2025
Please RT‼️ #TenureTrack position @zmbh.uni-heidelberg.de one of the best #proteostasis research centres in the world. www.nature.com/naturecareer...
nature.com
Tenure Track Professorship (W1 with Tenure Track to W3) in “Molecular Biology" (f/m/d) - Heidelberg job with Universität Heidelberg | 12850668
The Center for Molecular Biology of Heidelberg University (ZMBH) and the Faculty of Biosciences invite applications for a   Tenure Track Professors...
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Alicia Michael @aliciakmichael.bsky.social · 08/12/2025
One month later and still thinking about the great science and conversations from the 8th Austrian Cryo-EM Symposium 🧊🔬 Huge thanks to all who joined - let’s make next year even bigger! cryoem-symposium.pages.ist.ac.at/invited-spea...
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