iiinova — where your digital self keeps evolving

Kevin A. Scott, PhD @sculpturatus.bsky.social · 28/09/2026

man it's been a wild year so far. lots of approvals including many first in class.

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Kevin A. Scott, PhD @sculpturatus.bsky.social · 28/09/2026

Viral envelope proteins were co-opted to facilitate placental development.

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Kevin A. Scott, PhD @sculpturatus.bsky.social · 27/09/2026

i dont think ive ever posted on here ( #chemsky?) and gotten more than a handful of likes. 500 its a new high. nice work. i thought this place was dying.

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Kevin A. Scott, PhD @sculpturatus.bsky.social · 27/09/2026

TLC is my favorite analytical technique. i think you get more information per dollar than with any other.

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Kevin A. Scott, PhD @sculpturatus.bsky.social · 16/09/2026

nothing like a "feel good" reaction to start the day. sorry for the spill. #chemsky

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Kevin A. Scott, PhD @sculpturatus.bsky.social · 16/09/2026

fda approvals hit 40 on the year. it's going to be a good year. www.fda.gov/drugs/novel-...

fda.gov

Novel Drug Approvals for 2026

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Kevin A. Scott, PhD @sculpturatus.bsky.social · 16/09/2026

a couple billion years ago O2 levels started rising and oxidizing everything within biological systems. intracellular redox pathways evolved to maintain redox states inside the cell but outside was still perilous. this is why there are very few -SH cysteines on surface proteins.

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Kevin A. Scott, PhD @sculpturatus.bsky.social · 15/09/2026

The Red Queen hypothesis: life must constantly evolve just to stay in the same place, because everything around it is evolving too. (making lecture slides for my students).

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Kevin A. Scott, PhD @sculpturatus.bsky.social · 15/09/2026

i spend a lot of time discussing mild traumatic brain injury (mTBI) with my colleagues due to the nature of my work so i think it's funny that i get a lot of Myers-Briggs Type Indicator (MTBI) advertisements. myers briggs is complete nonsense btw.

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Kevin A. Scott, PhD @sculpturatus.bsky.social · 15/09/2026

in grad school we rescued a black widow from the elevator. we named her princess and kept her in an erlenmeyer with glass pipettes for years. we fed her crickets every week and sometimes the odd mosquito.

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Kevin A. Scott, PhD @sculpturatus.bsky.social · 14/09/2026

if you want to understand how natural products became medicines you have to understand the coevolutionary history of the secondary metabolites and the proteins that they target. this history is impossibly rich.

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Kevin A. Scott, PhD @sculpturatus.bsky.social · 14/09/2026

before coffee, there was nothing. even an empty void would be *something*.

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Kevin A. Scott, PhD @sculpturatus.bsky.social · 14/09/2026

Njardarson groups latest poster is out now (top 200 of 2024 by prescription). happy to see this tradition continue from my PhD lab bpb-us-e2.wpmucdn.com/sites.arizon...

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Kevin A. Scott, PhD @sculpturatus.bsky.social · 14/09/2026

by identifying covariation hotspots in GPCRs we can functionally couple residues that bind with the receptor ligand and intracellular functional loops (like g-protein or beta arrestin binding domains).

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Kevin A. Scott, PhD @sculpturatus.bsky.social · 11/09/2026

with evolution-guided pharmacology we can non-conserved contacts between gpcrs and their peptide hormone ligands, and identify functional covariation hotspots on the intracellular side of the membrane. this guides us to active site residues responsible for information transmission

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Kevin A. Scott, PhD @sculpturatus.bsky.social · 10/09/2026

help me settle a debate (urgent and important). what is the name of the piece of equipment shown below? a. flippy floppy; b. rotisserie. dont let me down.

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Kevin A. Scott, PhD @sculpturatus.bsky.social · 08/09/2026

it’s been almost 20 years since i set up my first chemical reaction. it's still magical to me that by understanding chemistry you can fundamentally change physical matter. rearrange the same atoms in the right way, and you change the practical and monetary value of a molecule.

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Kevin A. Scott, PhD @sculpturatus.bsky.social · 08/09/2026

my dog fell asleep like this after an hour of brain training

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Kevin A. Scott, PhD @sculpturatus.bsky.social · 04/09/2026

ok but what does my sexual orientation have to do with submitting a paper to science

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Kevin A. Scott, PhD @sculpturatus.bsky.social · 02/09/2026

this is awful. we dont need accidents in order to remember that chemistry can be dangerous. that must have been some hydrofluoric acid exposure. www.chemistryworld.com/news/hokkaid...

chemistryworld.com

Hokkaido University graduate student dies after exposure to hydrofluoric acid

Two other students stable after receiving minor injuries during fatal accident

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Kevin A. Scott, PhD @sculpturatus.bsky.social · 29/08/2026

the fda has approved lisraya (brepocitinib), the first oral therapy specifically approved for adults with dermatomyositis. the once-daily jak1/tyk2 inhibitor showed improvements in muscle function, skin disease activity, and corticosteroid use in Ph. III www.fda.gov/news-events/...

fda.gov

FDA Approves First Oral Drug Indicated to Treat Dermatomyositis in Adults

The U.S. Food and Drug Administration has approved Lisraya (brepocitinib) tablets for the treatment of dermatomyositis in adults.

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Kevin A. Scott, PhD @sculpturatus.bsky.social · 29/08/2026

if youre not solving nmr spectra in traffic are you even grinding? #chemsky

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Kevin A. Scott, PhD @sculpturatus.bsky.social · 28/08/2026

choosing a drug target is the most important decision of a drug discovery campaign. of 704 proteins targeted by FDA-approved drugs, 95% predate mammals evolutionarily, 35% predate animals (eukaryotes or older) 5% are mammal specific or younger, and the mediate age of the gene is 680 million years

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Kevin A. Scott, PhD @sculpturatus.bsky.social · 26/08/2026

iconic smile that punctuated my childhood

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Kevin A. Scott, PhD @sculpturatus.bsky.social · 26/08/2026

#chemsky what is the current best source for high quality lab clamps and ring stands/scaffolding?

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Kevin A. Scott, PhD @sculpturatus.bsky.social · 26/08/2026

i think i figured out how to detoxify poison oak. the poison in poison oak (urishiol) gets absorbed by the skin and the quinone of urishiol is electrophilic and covalently modifies proteins. the modified peptide gets displayed on MHC and causes an immune response. that's how the poison works.

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Kevin A. Scott, PhD @sculpturatus.bsky.social · 25/08/2026

bro 80 grams of methanol heat to 333 K what world is this #chemsky

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Kevin A. Scott, PhD @sculpturatus.bsky.social · 24/08/2026

my dog (left) always laughs at my jokes

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Kevin A. Scott, PhD @sculpturatus.bsky.social · 17/08/2026

strongly agree #chemsky also meet the smallest NMR spectrometer at 1 MHz www.immaterialscience.org/2026/pocketnmr

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Reposted by Kevin A. Scott, PhD

Scott Bagley @bagphos.bsky.social · 16/08/2026

#chemsky 🧪⚗️ #chemchat boost: post a fun chemistry meme

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Kevin A. Scott, PhD @sculpturatus.bsky.social · 12/08/2026

half a decade later my legacy remains in my former lab and it warms my heart

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Kevin A. Scott, PhD @sculpturatus.bsky.social · 12/08/2026

derek lowe strikes again - we may not be as far along as hype seems to suggest, in terms of AI in drug discovery. www.science.org/content/blog...

science.org

So How Is AI Drug Discovery Doing, Really?

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Kevin A. Scott, PhD @sculpturatus.bsky.social · 11/08/2026

10 largest AI healthcare deals in Q2

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Kevin A. Scott, PhD @sculpturatus.bsky.social · 11/08/2026

the whitehouse just removed 7 vaccines from the childhood recommendation list. here's who manufactures them.

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Kevin A. Scott, PhD @sculpturatus.bsky.social · 11/08/2026

the back half of 2026 is stacked for FDA decisions 👀 a new mechanism for hypertension (lorundrostat), maybe the first BTK inhibitor for primary CNS lymphoma (tirabrutinib), and a sodium-current drug for rare pediatric epilepsies (relutrigine) i'm really pulling for. good time to be in this field

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