iiinova — where your digital self keeps evolving

Dr Jaime Pitts @jaimedoesxlms.bsky.social · 29/04/2026

Phenomenally proud that this work is out in the wild now - excellent feeling having my qXL-MS of myosin conformational dynamics paired with @snmcmillan.bsky.social incredible cryo-EM work and analysis. A real team effort from @scarfflab.bsky.social www.science.org/doi/10.1126/...

science.org

Mavacamten inhibits myosin activity by stabilizing the myosin interacting-heads motif and stalling motor force generation

Mechanism of the myosin inhibitor mavacamten is revealed by cryo-EM and cross-linking studies.

0112

Reposted by Dr Jaime Pitts

Charlie Scarff @scarfflab.bsky.social · 16/06/2025

3.5 yr funded PhD studentship available in my lab October start. Exploring cardiac myosin modulators with cryoEM and mass spec. Get in touch if interested. Apply before 28th July. www.findaphd.com/phds/project...

findaphd.com

Unravelling the mechanisms of action of cardiac myosin modulators in health and heart disease at University of Leeds on FindAPhD.com

PhD Project - Unravelling the mechanisms of action of cardiac myosin modulators in health and heart disease at University of Leeds, listed on FindAPhD.com

037

Dr Jaime Pitts @jaimedoesxlms.bsky.social · 18/02/2025

Really proud of the qXL-MS work developed to build this story with the beautiful Cryo-EM structures from @snmcmillan.bsky.social

070

Dr Jaime Pitts @jaimedoesxlms.bsky.social · 02/01/2025

Starting the year off right with a very pretty spectrum from an experiment showing no interaction between two proteins that should be interacting.

An MS/MS spectrum of a crosslinked dipeptide

020

Dr Jaime Pitts @jaimedoesxlms.bsky.social · 10/06/2024

My gaming laptop was bought six years ago to mostly play CS:GO now its fragging of a different kind. 9 hours to searching....

Screenshot of an MSfragger output window showing the search took 563.5 minutes.

010

Dr Jaime Pitts @jaimedoesxlms.bsky.social · 12/04/2024

Thank you to the angels who updated MSFragger and Skyline so analysis of MeroX data is somewhat practical just in time for my birthday! I’m just a women standing in front of buckets of qXL-MS needing to be analysed and not wanting to use xlinkx….

000

Dr Jaime Pitts @jaimedoesxlms.bsky.social · 20/11/2023

Last week the Scarff group hosted the Don of adenovirus myosin expression, this week I have to decipher my notes I took. Very excited to crack on with it!

000

Dr Jaime Pitts @jaimedoesxlms.bsky.social · 16/11/2023

UoLeeds are looking for a facility manager to join our team. If you want to be responsible for the day-to-day running of our mass spectrometry research service and facility equipment have a look at ad! Happy to answer queries! jobs.leeds.ac.uk/vacancy.aspx...

jobs.leeds.ac.uk

Job Opportunity at University of Leeds: Mass Spectrometry Facility Manager

010

Dr Jaime Pitts @jaimedoesxlms.bsky.social · 07/11/2023

Boy, would I love to chat to someone who’s got #skyline working for quantitative crosslinking ms! Please! Anyone! Because it looks like Wednesday is going to be watching YouTube videos about skyline with a lot of coffee.

020

Dr Jaime Pitts @jaimedoesxlms.bsky.social · 26/10/2023

Rip the bird app; hello it’s replacement. I’m Jaime, I adore roller derby and Mass Spectrometry.

A photo of the jam line from the roller derby tournament GYSD

020