Zha Lab @zhalab.bsky.social · 27/05/2026Are you ready for the Summer? Social DNAing is! Check out the 2026 Summer line-up! Please note one schedule change on June 4th, 2026. Please RT! Sign up at cancer.columbia.edu/research/pro... 01012
Zha Lab @zhalab.bsky.social · 05/04/2026Why do mammalian cells need PAR, PARP1/2, but yeast does NOT? While studying the impact of PARG inhibition, Isaac in the lab found that extra-PAR sequesters nuclear PAR-binding proteins (XRCC1 and its partners, etc.) into nuclear condensates. biorxiv.org/content/10.6... 185
Zha Lab @zhalab.bsky.social · 05/04/2026Drs. Zhu and Jiang in the Zha lab developed FISH probes for murine rDNA (on Addgene:240559), uncovered high somatic and germline heterogeneities in inbred mice, and unique roles of ATM/LIG4/BRCA1 at rDNA, and proposed a model for single-ended DSB at rDNA loci. academic.oup.com/nar/article/... 031
Zha Lab @zhalab.bsky.social · 05/04/2026Thank you, Dr. Zhang, for a great talk. Dr. Yi from UCLA will take us to examine the hidden rearrangements - SCE in cancer genomes and, surprisingly, in normal cells as well. Sign up www.cancer.columbia.edu/research/pro... 041
Zha Lab @zhalab.bsky.social · 05/04/2026Our new review on NHEJ just came out on G&D genesdev.cshlp.org/cgi/content/... Highlight the 5 phases, and importantly, the 5 protein bridges that bring the 2 DNA ends together for NHEJ. Thank Dr. Geunil Yi, for generating the illustration for all structural models. 0146
Zha Lab @zhalab.bsky.social · 18/03/2026Thank Ylli for a wonderful view on telomere. This week, we have another telomere expert visit - Dr. Lottersberger will discuss the role of DNA-PKcs at telomere. Sign up at www.cancer.columbia.edu/research/pro... 010
Zha Lab @zhalab.bsky.social · 11/03/2026This week Dr. Doksani will join Social DNAing to discuss telomere biology! Please note the US is now in summer saving time. Check you local time! www.cancer.columbia.edu/research/pro... 052
Zha Lab @zhalab.bsky.social · 12/02/2026Unfortunately, due to unforeseen reasons, Social DNAing will be canceled today! 000
Zha Lab @zhalab.bsky.social · 10/02/2026Thank Dr. Kunkle, for a really thorough talk on DNA replication polymerases. This week Dr. Olsen will help us understand RAD51. Sign up at www.cancer.columbia.edu/research/pro... 100
Zha Lab @zhalab.bsky.social · 03/02/2026Dr. Thomas Kunkel will visit Social DNAing this week. Sign up and tune in! www.cancer.columbia.edu/research/pro... 010
Zha Lab @zhalab.bsky.social · 21/01/2026Thank Dr. James Berger from JHU for a wonderful tour in Topo II biology. This week Social DNAing will welcome an old friend - Dr. Greg Ira. Please sign up at www.cancer.columbia.edu/research/pro... 020
Zha Lab @zhalab.bsky.social · 21/01/2026Registration deadline extended to January 31, 2026. Join us @nucleosomepolice.bsky.social @leunglab.bsky.social at CSHL for the PARP Meeting—connect with leaders and rising stars from academia and industry. Please kindly repost! .https://meetings.cshl.edu/meetings.aspx?meet=parpmeetings.cshl.eduThe PARP Family & ADP-ribosylationCold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics. 021
Zha Lab @zhalab.bsky.social · 15/01/2026Check out the GRC for DNA damage and Cancer! Join us in Summy California for a week of DNA repair and Cancer! www.grc.org/dna-damage-m...grc.org2026 DNA Damage, Mutation and Cancer Conference GRCThe 2026 Gordon Research Conference on DNA Damage, Mutation and Cancer will be held in Ventura, California. Apply today to reserve your spot. 087
Zha Lab @zhalab.bsky.social · 23/12/2025Happy Holiday! Less than 70 Days to the 2026 GRC in DNA Damage, mutation and Cancer. Less than 50 spots available. Hope to see you all in sunny California! Full program available grc.org/dna-damage-mut… 000
Zha Lab @zhalab.bsky.social · 22/12/2025Are you ready for 2026? Social DNAing is! See who is coming. Sign up at www.cancer.columbia.edu/research/pro... 074
Zha Lab @zhalab.bsky.social · 22/12/2025Happy Holiday! Less than 70 Days to the 2026 GRC in DNA Damage, mutation and Cancer. Less than 50 spots available. Hope to see you all in sunny California! Full program available www.grc.org/dna-damage-m... 010
Zha Lab @zhalab.bsky.social · 19/12/2025Happy holiday, everyone! 2026 Social DNAing Schedule is now online. Here is a sneak peek. Check it out and sign up at www.cancer.columbia.edu/research/pro... 0116
Zha Lab @zhalab.bsky.social · 08/10/2025Due to unforeseen reason, Tomorrow’s Social DNAing ( Oct.9 ) will be cancelled and we will see each other next week on Oct 16th. Thank you for your understanding. 010
Reposted by Zha LabKara Bernstein @karabernstein.bsky.social · 03/09/2025Co-organizing a one day FREE conference on Genome Instability- Discovery to Personalized Medicine 11/1/25. Please join us! Short talks available. https//noncredit.t... 087
Reposted by Zha LabArdem Patapoutian @ardemp.bskyverified.social · 19/06/2025I spoke with Jade Hindmon, host of @kpbssandiego.bsky.social Midday Edition, about the consequences of the current administration’s cuts to science funding. Please share to help spread the word and raise awareness. www.kpbs.org/podcasts/kpb...kpbs.orgNobel laureate on how Trump's cuts are hurting scienceNeuroscientist, biologist and 2021 Nobel Prize winner Ardem Patapoutian joined Midday Edition to talk about how the Trump administration's effort to cut back on science spending is impacting researche... 2185123
Zha Lab @zhalab.bsky.social · 15/06/2025Please join us celebrate the 5th year birthday of Social DNAing! Dr. Chapman will take the stage in the coming week. Sign up at cancer.columbia.edu/research/progr… 081
Zha Lab @zhalab.bsky.social · 20/05/2025Are you ready for the 2nd half of 2025? Social DNAing is ready. Check out the speaker list and schedule! Sign up at www.cancer.columbia.edu/research/pro... 01011
Zha Lab @zhalab.bsky.social · 17/05/2025Excited to share our new paper on Nature - how Ku accommodates Alu expansion in primates by binding to dsRNA, providing a clue for both the high levels of Ku and its essentiality in human cells. Thank @chaolinzhang @hchung03 @LenaSteckelberg More to come www.nature.com/articles/s41...nature.comKu limits RNA-induced innate immunity to allow Alu-expansion in primates - NatureNature - Ku limits RNA-induced innate immunity to allow Alu-expansion in primates 14925
Zha Lab @zhalab.bsky.social · 10/02/2025Exciting results! Using AID-Degron system, Dr. Yimeng Zhu in the lab found that Ku suppresses RNA-mediated innate immunity to accommodate Alu-expansion in primates - solving the misery of Ku essentiality in human cell and uncover 94r^2 for co evolution www.biorxiv.org/content/10.1...biorxiv.orgKu suppresses RNA-mediated innate immune responses in human cells to accommodate primate-specific Alu expansionKu70 and Ku80 form Ku, a ring-shaped protein that initiates the non-homologous end-joining (NHEJ) DNA repair pathway.[1][1] Specifically, Ku binds to double-stranded DNA (dsDNA) ends and recruits othe... 0195