SUMOylation is an essential eukaryotic ubiquitin-like post-translational modification that plays a central role in the regulation of various nuclear processes and stress responses. It canonically occu...

Science sleuth’s findings raise questions for researchers working to improve the reliability of commercial antibodies.

Planned acquisition of specialist PolyPeptide signals interest in peptides by drug outsourcing firms

Chemists make simple amides using only inexpensive lab chemicals

Affaiblissement financier et humain, montée des attaques idéologiques, émergence de l’intelligence artificielle… La communauté scientifique est confrontée à de nombreux défis, à l’image du CNRS, victi...

Mélanie Perrière-Chenon, 44 ans, était très appréciée. Ses obsèques auront lieu en fin de semaine à Neuvy-en-Sullias, où elle vivait.

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Thousands of ‘dark proteins’ have been reclassified as peptideins and added to databases as a new category.

Le patron du Centre national de la recherche scientifique, Antoine Petit, a déploré une situation budgétaire « extrêmement compliquée » devant la commission des affaires économiques du Sénat

Le gouvernement a informé le CNRS d'une nouvelle baisse de20 millions de budget pour 2026. Une annonce qui ne passe pas pour les chercheurs orléanais.

Nature Structural & Molecular Biology - Baretić and Missoury et al. identify vertebrate proteins FAM118B and FAM118A as sirtuins similar to bacterial antiphage enzymes and show that...

SUMOylation – a protein post-translational modification (PTM) related to ubiquitylation – involves the reversible covalent attachment of the small ubiquitin-like modifier (SUMO) to proteins. During th...

Covalent inhibitors are powerful entities in drug discovery. Now the amino acid selectivity and reactivity of a diverse electrophile library have been assessed proteome-wide using an unbiased workflow...

Nature Chemistry - In living systems, ATP provides an energetic driving force for protein synthesis and modification. Now, an engineered enzymatic tool has been developed for high-yield, ATP-driven...