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Karla Feijs-Žaja

@kfeijszaja.bsky.social
489 followers 427 following 78 posts

First gen scientist studying protein & RNA ADP-ribosylation as part of a husband-and-wife team! Current location: Aachen Past: Zagreb, Oxford, Amsterdam, Maastricht Mum of 🧒👧

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Reposted by Karla Feijs-Žaja
Kurianlab @kurianlab.bsky.social · 07/09/2026
www.nature.com/articles/s41... Read it.
nature.com
How contemporary academic structures constrain scientific creativity and hold back early-career researchers - Nature Human Behaviour
In this Perspective, Haubrock et al. argue that today’s scientific structures constrain creativity and that strategic conformity is a rational response. They discuss how this holds back early-career r...
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Karla Feijs-Žaja @kfeijszaja.bsky.social · 03/08/2026
Reading about Humboldt on holidays. Intriguingly, the river Drava is at an all-time low, which allowed for some interesting finds. A 70kg WWII bomb was dismantled, we found many bones. Some look recent (lamb?), others much older… Any guesses at what they might be??
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Schlundt lab @lab-nmr.bsky.social · 07/07/2026
Interested in RNA and proteins? Perfect! 😀 We seek to fill a fully funded 3+ years PhD position for a project on pre-mRNA splicing regulation using structural biochemistry in combination with cell biology and bioinformatics. Find more information on our lab's homepage and get in contact via e-mail!
biochemie.uni-greifswald.de
Analytische Biochemie - Fakultät - Universität Greifswald
Universität Greifswald
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Karla Feijs-Žaja @kfeijszaja.bsky.social · 16/06/2026
The calm before the storm. In the next 4 weeks, ±300 1st year medicine and ±60 1st year dentistry students will try their hand at enzyme kinetics... We are ready!
Selfie in front of a class room with lab equipment.Empty class room with view on the screen "Enzymkinetik"
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Reposted by Karla Feijs-Žaja
GBM (Gesellschaft für Biochemie und Molekularbiologie) @gbmev.bsky.social · 11/06/2026
Ready to register for "GBM Compact - Focus on RNA Structure and Dynamics"? Early bird registration and abstract submission are open until June 30.
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Karla Feijs-Žaja @kfeijszaja.bsky.social · 28/05/2026
Next Wednesday, online seminar by Chris Carnie! Organised by the German Society for Biochemistry and Molecular Biology (GBM), everyone is welcome to join.
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Karla Feijs-Žaja @kfeijszaja.bsky.social · 26/05/2026
I woke up to a great spotted woodpecker in our garden. This is going to be a good day 😃 For context: we live in an urban area in the Netherlands, where even sparrows are becoming rare. Our garden is a rare fleck of green in a desert of stone, with most neighbours preferring gravel gardens 🤦‍♀️🤷‍♀️
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Reposted by Karla Feijs-Žaja
Jo-ho-ho @jobrodie.bsky.social · 24/05/2026
WATER SAFETY: Some people are seeing this as a paywalled article (I'm not). The original article was first published by Mario Vittone on gCaptain in 2010 and they republish it periodically. Try this one (it's also not paywalled for me but I can't tell if it is for others!) gcaptain.com/drowning/
gcaptain.com
Drowning Doesn't Look Like Drowning
Drowning is not the violent, splashing, call for help that most people expect. In this article, Mario explains what drowning really looks like and how to recognize it when its happening.
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Reposted by Karla Feijs-Žaja
Mark Peifer (He, him) @peiferlabunc.bsky.social · 23/05/2026
Someone in the news departments of @nature.com or @science.org needs to take a look at this--its a huge scandal from the scientific supplier that has become a monopoly
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Karla Feijs-Žaja @kfeijszaja.bsky.social · 21/05/2026
Introduce yourself with 10 acts you've seen live: Backstreet Boys (I'm a 90ies kid...) Ole Edvard Antonsen Cranberries Smashing Pumpkins Placebo Muse Green Day Foo Fighters Danny Elfman Neil Young
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Reposted by Karla Feijs-Žaja
Chris Lord and Andrew Tutt’s Lab Institute of Cancer Research @icrlordlab.bsky.social · 06/05/2026
If you are interested in PARP inhibitors and history, this might be of interest to you. www.nature.com/articles/s41.... An attempt to cover the work of thousands and their immense contributions to the development of a targeted approach to treating cancers.
nature.com
Two decades of PARP inhibitor synthetic lethality in cancer - Nature
The past two decades of PARP inhibitor synthetic lethality in cancer is explored.
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Reposted by Karla Feijs-Žaja
Sorek Lab @soreklab.bsky.social · 23/04/2026
We found that TIR domains in animal immune proteins, including the human TLR4, are enzymes that cleave NAD+ to produce the signaling molecule cADPR Read our new preprint by talented Bohdana Hurieva: “Conserved catalytic activity of immune TIR domains in animals” www.biorxiv.org/content/10.6...
biorxiv.org
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Karla Feijs-Žaja @kfeijszaja.bsky.social · 16/04/2026
I am very excited about this seminar next week: no science this time, but a discussion on combining parenthood with a job in science. If you have specific questions --> let me know, and I'll make sure we discuss them! Not restricted to GBM members only, feel free to join!
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Karla Feijs-Žaja @kfeijszaja.bsky.social · 06/04/2026
Some words are hard to translate. The Dutch “uitbuiken” for example. Here’s our cat demonstrating what this looks like after spending Easter with the family (lots of food involved…)
Black and white cat sitting in a weird pose
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Reposted by Karla Feijs-Žaja
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 01/04/2026
Human PARPs modify RNA nucleobases in vitro and in cells www.biorxiv.org/content/10.64898/20…
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Reposted by Karla Feijs-Žaja
Stephen Moran. @moranstephen1000.bsky.social · 04/04/2026
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Reposted by Karla Feijs-Žaja
GBM (Gesellschaft für Biochemie und Molekularbiologie) @gbmev.bsky.social · 02/04/2026
I thought you should know that 😀
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Karla Feijs-Žaja @kfeijszaja.bsky.social · 01/04/2026
The next chapter in ADP-ribosylation biology: modification of uracil and guanine bases by PARP10 and PARP15 www.biorxiv.org/content/10.6...
biorxiv.org
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Addgene @addgene.bsky.social · 30/03/2026
New to Plasmidsaurus? They're offering the Addgene community their first three sequences free with code ADDGENE. twp.ai/4iwdRq
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Karla Feijs-Žaja @kfeijszaja.bsky.social · 25/03/2026
Not sure why, but I always have the urge to post travel updates on here... #cshlPARP, I'm on the way! Today's itinerary: Kerkrade - Aachen - Cologne - Frankfurt - NY JFK - Cold Spring Harbor!!
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Reposted by Karla Feijs-Žaja
Vicky Lioy @vslioy.bsky.social · 11/03/2026
Are you investigating the biology of prokaryotic or eukaryotic cells? Are you looking for an excellent scientific environment to establish and lead your own research team? The I2BC is your place and a new call for team leaders is now open. More info👇Deadline 22nd April @i2bcparissaclay.bsky.social
i2bc.paris-saclay.fr
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Reposted by Karla Feijs-Žaja
Rhineland RNA Club @rhinelandrna.bsky.social · 13/03/2026
Kathrin @katleppek.bsky.social and Ina @inahuppertz.bsky.social cordially invite all RNA enthusiasts based in the Rhineland to attend our series of inspiring in-person talks on RNA-related topics, delivered by local and invited speakers.
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Reposted by Karla Feijs-Žaja
The Matić Lab @maticlab.bsky.social · 09/02/2025
We’ve uploaded a bioRxiv preprint on new antibodies specific for poly-ADP-ribosylation (PARylation). These modular tools were developed and validated through novel applications of our Serine ADP-ribosylation-based technology. www.biorxiv.org/content/10.1...
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Reposted by Karla Feijs-Žaja
GDCh Division of Biochemistry @gdchbiochem.bsky.social · 26/01/2026
Are you interested in cutting edge #Biochemistry and #ChemBio? Check out our #Biochemistry2026 meeting in Würzburg from March 16th to 18th. Deadlines for reduced early bird registration fee and abstracts have been extended to January 28th. veranstaltungen.gdch.de/microsite/in...
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Reposted by Karla Feijs-Žaja
Mike Cohen @michaelnadbio.bsky.social · 21/01/2026
Did you miss the original abstract deadline? No worries, we’ve extended it to January 30th! Don’t miss your chance to be part of an exciting meeting highlighting the cutting edge of the field.
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Karla Feijs-Žaja @kfeijszaja.bsky.social · 15/01/2026
I must admit... Websites with timers like this make me slightly nervous. We've still got 4 hours left - why the red?? 😅
Screenshot from website stating that time remaining before the closing of the call is 4 hours and 6 minutes, in a red font
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Reposted by Karla Feijs-Žaja
Mike Cohen @michaelnadbio.bsky.social · 15/01/2026
Just two more days to submit abstracts for the "PARP Family and ADP-ribosylation CSHL meeting. We have an amazing lineup of speakers. The majority of speakers are selected from abstracts. Don't miss out! meetings.cshl.edu/meetings.asp...
meetings.cshl.edu
The PARP Family & ADP-ribosylation
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
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Reposted by Karla Feijs-Žaja
GfV - Gesellschaft für Virologie @gesvirologie.bsky.social · 06/01/2026
The YoungPI working group organised an online workshop to gain insight into the grant review process, using DFG grants as an example. The focus will be on improving our understanding from a reviewer's perspective. Our guest will be @friedemann.bsky.social Register now for the 2nd February at 4pm.
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The EMBO Journal @embojournal.org · 29/08/2025
A general rather than site- & function-specific role for protein modification by ADP-ribosylation? @kfeijszaja.bsky.social , Roko Zaja and coworkers find that labeling by #PARP7 facilitates ubiquitin-dependent degradation of multiple targets upon proteotoxic stress www.embopress.org/doi/full/10....
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Karla Feijs-Žaja @kfeijszaja.bsky.social · 28/10/2025
Job alert! We are recruiting a postdoc to study a novel RNA modification: ADP-ribose. 🔬Do you have experience working with RNA? Are you eager to explore new frontiers in RNA biology? Join our team and help uncover the secrets of RNA ADP-ribosylation: adpribosylationlab.wordpress.com/2025/10/28/p...
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Reposted by Karla Feijs-Žaja
GBM (Gesellschaft für Biochemie und Molekularbiologie) @gbmev.bsky.social · 22/10/2025
🎯 𝐒𝐭𝐫𝐚𝐭𝐞𝐠𝐢𝐜 𝐏𝐥𝐚𝐧𝐧𝐢𝐧𝐠 𝐟𝐨𝐫 𝐘𝐨𝐮𝐫 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐂𝐚𝐫𝐞𝐞𝐫 – 𝐉𝐨𝐢𝐧 𝐔𝐬! 📅 Workshop Details (Limited to 8 participants) 𝐃𝐚𝐭𝐞: January 20, 2026 (online) 𝐀𝐩𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐃𝐞𝐚𝐝𝐥𝐢𝐧𝐞: November 1, 2025 Led by: Dr. Beate Scholz (Scholz CTC GmbH) Not a member of the GBM-YI? You can register here: gbm-online.de/de/young-inv...
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Karla Feijs-Žaja @kfeijszaja.bsky.social · 18/09/2025
Seeing how I always comment on train connections when traveling in Germany... My train is on time 🎉 Which means I'll be arriving an hour and a half early 😅 See you later at the @gbmev.bsky.social GBM Compact Meeting in Frankfurt!
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Karla Feijs-Žaja @kfeijszaja.bsky.social · 22/08/2025
I'm very excited to be able to share the latest work from our group with you: doi.org/10.1038/s443... We find that PARP7 is stabilised following proteotoxic stress and ADP-ribosylates proteins to enable their degradation. This occurs in a ubiquitin-dependent manner.
doi.org
PARP7 is a proteotoxic stress sensor that labels proteins for degradation | The EMBO Journal
imageimageADP-ribosylation is thought to occur on specific sites to affect specific characteristics of target proteins. Here, it is found to play a more promiscuous role, with PARP7 labelling proteins for efficient degradation during proteotoxic ...
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Karla Feijs-Žaja @kfeijszaja.bsky.social · 17/08/2025
The advantage of having a Croatian husband, is that you can find beautiful spots to spend some time away from everything 😏
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GBM (Gesellschaft für Biochemie und Molekularbiologie) @gbmev.bsky.social · 04/08/2025
Upcoming Event: "From Academia to Industry – Working at Novo Nordisk A/S" 📅 Date: August 21, 2025 🕟 Time: 4:30 p.m. 🎤 Speaker: Dr. Martin Peter 🔗 Register here: gbm-online.de/de/nachwuchs... Zoom link will be sent to registered participants. Please share with your postdoc colleagues!
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Reposted by Karla Feijs-Žaja
Biochemical Society @biochemsoc.bsky.social · 04/08/2025
Nominations are now open for the 2027 Awards! With 12 categories spanning all career stages, there's never been a better time to recognise the outstanding work of your colleagues. Visit our website to find out how to nominate #BiochemAwards buff.ly/FHTSGz8
The Biochemical Society 2027 Awards. Our 2027 Awards are now open for nominations! Deadline 3 November 2025
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Jonny Edwards @veritasgaston.bsky.social · 22/07/2025
An incomparable legend.
Ozzy Osbourne being Ozzy Osbourne.
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Trends in Genetics @cp-trendsgenetics.bsky.social · 08/07/2025
"m6A in the coding sequence: linking deposition, translation and decay" by Kathi Zarnack (@zarnack-group.bsky.social) & colleagues "This review explores [m6A in] mRNA decay, with a focus on the newly discovered CDS–m6A decay (CMD) pathway..." Read it here: authors.elsevier.com/sd/article/S...
Figure 2. Overview of N6-methyladenosine (m6A) decay pathways. m6A acts as a destabilizing mark on mRNA.
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Karla Feijs-Žaja @kfeijszaja.bsky.social · 05/07/2025
Almost 80 but what an energy - Neil Young! I am so grateful to have seen him play with the Chrome Hearts yesterday 🤩 Rock 'n' roll will never die...
Neil young and the Chrome hearts on stage. Background text love earth
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The Company of Biologists @biologists.bsky.social · 19/06/2025
Enter our essay competition and win £250. Share with us your ideas on how to innovate event organisation to have a lower environmental impact. Entry deadline: Friday 20 June Enter now: www.biologists.com/stories/essa... #Innovation #Sustainability #Environment
Have your say...
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Stephen Graham's Lab @atomicvirology.bsky.social · 19/06/2025
Q for the hive-mind 🧠: What transfection reagents do people like for big constructs these days? (I am thinking #HSV encoding BACs, ~170 kb). We've recently had poor performance with Trans-IT LT1 and Lipofectamine 2000, our two go-tos. Target cells are U2OS. Suggestions or RTs greatly appreciated 🙏
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The EMBO Journal @embojournal.org · 12/06/2025
Autophagy-lysosome pathways are known targets of intracellular bacteria – Ivan Đikić @idikic.bsky.social et al find Legionella uses phosphoribosyl-ubiquitination via SidE to alter autophagic SNAREs & create a bacteria-containing vacuole unable to fuse with lysosomes www.embopress.org/doi/full/10....
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sigtrans.bsky.social @sigtrans.bsky.social · 26/05/2025
Registration is OPEN for the 28th Signal Transduction Society Meeting—first-ever #CellCommSummit! 🗓️ November 3–5, 2025, Leonardo Hotel, Weimar Join us for talks, poster sessions, and networking. Travel grants for young researchers available. 🔗 www.sigtrans.de #SignalTransduction #CellCommSummit
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Ted Pavlic (he/him/his) @tedpavlic.bsky.social · 08/06/2025
Reminder: Nobel-prize winning PCR (1983), used in basically all genetic tech today, was only possible because of extremophile bacterium discovered in 1964 in Yellowstone funded by a small ~$80k NSF grant with no obvious application at the time. #science 🧪 www.richmondscientific.com/how-a-discov...
richmondscientific.com
How a discovery in Yellowstone National Park led to the development of PCR - Richmond Scientific
A discovery in Yellowstone National Park led to the development of PCR, the gold-standard COVID-19 tests used to fight the global pandemic.
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Journal of Cell Biology @jcb.org · 05/06/2025
We're hiring! The Journal of Cell Biology (JCB) seeks Scientific Editor or Senior Scientific Editor, dependent on experience. Join our team in New York City! Apply here 👉 careers.rockefeller.edu/jobs?keyword... #STEMjobs #LifeScienceJobs #PublishingJobs #ScienceJobs
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Karla Feijs-Žaja @kfeijszaja.bsky.social · 05/06/2025
The newest addition to my board game collection just arrived 🤩 Need a game night soon then 😁 #publishorperish
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GBM (Gesellschaft für Biochemie und Molekularbiologie) @gbmev.bsky.social · 04/06/2025
🏆 𝐑𝐨𝐥𝐚𝐧𝐝 𝐒𝐜𝐡𝐚𝐮𝐞𝐫 𝐍𝐚𝐜𝐡𝐰𝐮𝐜𝐡𝐬𝐩𝐫𝐞𝐢𝐬: Deadline bis 30.06.2025 verlängert! 2.000 € für exzellente Forschung in #Glykobiologie. Bewerben können sich junge Wissenschaftler:innen. Infos & Bewerbung: awards@gbm-online.de und gbm-online.de/en/news-even... #Nachwuchsförderung #GBM
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Karla Feijs-Žaja @kfeijszaja.bsky.social · 28/05/2025
Interested in doing a postdoc in Germany, on a topic involving ADP-ribosylation of proteins or RNA? Or even the novel dual modification with ubiquitin attached to proteins via ADP-ribose?? If yes ➡️ do get in touch 😊
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Silvia Ramundo @sramundo.bsky.social · 19/05/2025
Calling all last-minute legends! The formal deadline to apply for the GMI GLs call is tomorrow—so there’s still time to make it look like you planned this all along 😉
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Mike Cohen @michaelnadbio.bsky.social · 17/05/2025
Another awesome collaboration with @jnpruneda.bsky.social and team providing deeper insight into the writers of MARUbylation. Check out thread 👇!
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