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Reposted by Yibo Xue

Daniel Durocher @durocher1.bsky.social · 25/08/2026

New work from the lab! We report that DDIAS is a downstream effector of CIP2A-TOPBP1 in mitosis that suppresses ssDNA to preserve genome integrity. From the great @yiboxue.bsky.social and many collaborators! Free link: authors.elsevier.com/a/1nfiF3vVUP... Pay link: www.cell.com/molecular-ce...

Model of DDIAS acting in mitosis to suppress ssDNA

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Andrew Blackford @andrewblackford.bsky.social · 10/09/2025

Excited to share our lab’s latest preprint! We identify DDIAS as a novel single-stranded DNA-binding component of the TOPBP1–CIP2A complex, which acts in a mitotic DNA damage response pathway to protect chromosome integrity. Short summary below, and read it here: www.biorxiv.org/content/10.1...

biorxiv.org

DDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosis

DNA double-strand breaks and unresolved DNA replication intermediates are particularly dangerous during mitosis. Paradoxically, cells inactivate canonical DNA repair mechanisms during chromosome segre...

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Lopes_Lab @lopeslab.bsky.social · 17/03/2025

Exciting seminar series from Genome integrity italian Network (GiiN), chaired by myself and Raffaella Di Micco! Short talks (2x30’), at convenient time for EU/USA attendees. Big shots and raising stars in an expanding field. See flyers + link to receive email alerts. Please repost to your network!👇

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The Tennessee Holler @thetnholler.bsky.social · 19/02/2025

European Parliament member 👇🏽

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Reposted by Yibo Xue

John Maciejowski @johnmaciejowski.bsky.social · 17/02/2025

Please check out our preprint where we find that mitotic transcription helps ensure ecDNA inheritance through chromosomal tethering: www.biorxiv.org/content/10.1...

biorxiv.org

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