Lebrec et al. present a FRET-based cGAS reporter and show that cGAS activation by genotoxic stress is rare and uncoupled from micronuclei. The study implicates R-loop structures and subtypes of chroma...

We are looking for a Research Technician to support our research studies exploring how a ubiquitin ligase contributes to DNA replication stress and repair. The position is funded by an Academy of Medi...

Scientists from Lancaster University are appealing for volunteers to help a citizen science project helping the delivery of humanitarian aid in the wake of two earthquakes within less than one minute of each other in Venezuela.

PhD Project - Investigating chronic inflammation caused by asbestos-like fibres as a driver of mesothelioma at Lancaster University, listed on FindAPhD.com

Boards asked to recommend just three applications for funding, as BBSRC also suspends calls

UKRI Chief Executive outlines changes to UKRI investment approach, addressing concerns about research funding and the financial position of STFC.

Rizzotto et al. discuss the causes and consequences of deregulated mitosis that allow cells arrested in mitosis to escape to the next interphase, where they can initiate inflammatory signalling or und...

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Gamble et al. demonstrate that detection of stalled replication forks by the innate immune sensor IFI16 induces an early STING-dependent pro-inflammatory cytokine response independently of cGAS and DNA damage. Furthermore, IFI16 exhibits dual functionality during replication stress by protecting stalled, remodeled replication forks from nucleolytic degradation.

Replication stress is a key driver of DNA damage and genome instability. Here, we report that replication stress induces an inflammatory response in t…

Leukocytes accumulate in the skin during psoriatic-like inflammation upon cleavage of surface heparan sulfate.

ENDS Report's Power List spotlights the environmental professionals who have made the greatest impact in the past two years. Here, we meet those working in science, research and development who are co...

Nature Structural & Molecular Biology, Published online: 11 April 2025; doi:10.1038/s41594-025-01525-5DNA damage can be sensed as a danger signal by the innate immune system. Bournique et al. show that the transcription stress caused by DNA lesions can also initiate inflammation by causing the direct release of cytokine IL-1α, which then drives NF-κB activation in neighboring cells.

Nature Structural & Molecular Biology - DNA damage can be sensed as a danger signal by the innate immune system. Bournique et al. show that the transcription stress caused by DNA lesions can...

In this study, the authors show that DNA-damage-mediated transcriptional stress induces NF-κB through IRAK1, allowing damaged cells with impaired transcription to initiate an inflammatory response wit...