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Anja Groth

@groth-anja.bsky.social
1.2K followers 511 following 14 posts

Group leader at the Danish Cancer Institute and Professor at University of Copenhagen #NNFCPR. Interested in epigenetics, genome maintenance, aging & cancer, creativity & innovation, society in general. Opinions are my own.

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Reposted by Anja Groth
Scaffidi Lab @scaffidilab.bsky.social · 13/05/2026
Registration open. Top-notch lineup of speakers from Europe, the US and beyond, covering chromatin biology, genome maintenance, cancer plasticity and evolution, and metabolism www.atoutcom.com/cancer-epige...
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EMBO @embo.org · 04/05/2026
Learn about the #DNAdamage response in #CellPhysiology and diseases in the eponymous EMBO Workshop in #Sounio, #Greece, 12–16 October 2026. Deadline: 17 May 2026 meetings.embo.org/event/26-dna-dama… #EMBODNADamageResponse #genesky #LifeSciences #research #meeting #EMBOevents 🧪
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Oded Rechavi @odedrechavi.bsky.social · 16/04/2026
This is really bad. The ERC is the lifeline of many labs. The letter from the ERC says “the only way is to reduce applications” No! It's the wrong direction. Use AI to assist review. It’s not perfect, but it allows more proposals to be evaluated, and it should support, not replace, human reviewers.
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Anja Groth @groth-anja.bsky.social · 23/04/2026
Join us for the 3rd EMBO:EMBL Symposium on 'DNA replication and Genome Maintenance - from basic biology to human health' @embl.org Heidelberg, Oct 20-23 2026. Fantastic speaker lineup 🤩 on chromosome replication, stability and organization 👉 abstract by July 28: s.embl.org/ees26-13-li
s.embl.org
DNA replication and genome maintenance: from basic biology to human health
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Elphege Nora Lab at UCSF @elphegenoralab.bsky.social · 23/04/2026
📖 The final version of our paper is out in press Cohesin cofactor dosage sets the rate of loop extrusion, rendering genome folding tunable yet vulnerable to genetic disruption authors.elsevier.com/a/1m%7EU03vV... or www.cell.com/molecular-ce...
cell.com
Cohesin cofactor dosage sets the rate of loop extrusion, rendering genome folding tunable yet vulnerable to genetic disruption
Shah, Tortora, et al. show that cells can dial the rate of cohesin loop extrusion by balancing the relative dosage of NIPBL and PDS5. Their models provide a quantitative mechanistic basis for the gene...
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The Groth lab @grothlab.bsky.social · 25/02/2026
DNA replication globally disrupts the epigenome. But does this create a chromatin-access opportunity for TF binding to facilitate cell identity change? Now 𝐫𝐞𝐩𝐥𝐢-𝐀𝐓𝐀𝐂-𝐬𝐞𝐪 shows 𝘥𝘦 𝘯𝘰𝘷𝘰 chromatin opening & TF binding occurs specifically post-replication, in cellular differentiation & reprogramming!
cell.com
Post-replicative chromatin accessibility predicts cell fate change
Knudsen and colleagues use repli-ATAC-seq to compare replicated and unreplicated chromatin in two models of cell identity change. They find that lineage-specific elements are accessible earlier in rep...
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Anja Groth @groth-anja.bsky.social · 12/11/2025
Chromatin fatigue: DNA repair alters the chromatin environment and introduces heritable variation in gene expression in a larger region around the lesion! Amazing achievement by @sbantele.bsky.social and Jiri Lukas published in @science.org 🙌 Happy we could contribute. See 👇
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Max Planck Institute for Molecular Genetics @molgen.mpg.de · 29/10/2025
📢 Don't miss @groth-anja.bsky.social from the Danish Cancer Institute, who will present her research at the #Embryo2026 🧬 "How cells copy their epigenome" Register until Oct 31! 👇 www.molgen.mpg.de/embryo2026 Supported by the Weizmann Institute of Science
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Robert Hänsel-Hertsch @epistrucstab.bsky.social · 28/07/2025
🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town. Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag. 🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41... 🧵Let’s break down what makes DynaTag so powerful (1/7)
Image credit: @gloglita.bsky.social‬ @lifescienceeditors.bsky.social‬ captured DynaTag in action: a pA-Tn5 probe (multicoloured) binds an antibody (white), which binds p53 DNA-binding domain (green) on DNA (blue) within 2 nucleosomes
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Journal of Cell Biology @jcb.org · 16/07/2025
Yadav, Jadhav, @hanasedlackova.bsky.social et al present a novel cell-permeable biotin-HaloTag ligand. The reported ligand expands the HaloTag toolbox by enabling in vivo labeling & providing capabilities for efficient affinity capture of protein variants from live cells rupress.org/jcb/article/...
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Tugce Aktas @aktast.bsky.social · 30/06/2025
We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease. www.nature.com/articles/s41...
nature.com
Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease - Nature Reviews Molecular Cell Biology
Transposable elements (TEs) comprise nearly half of the human genome. This Review discusses transcriptional and post-transcriptional mechanisms that repress TE activity, how TEs escape this suppressio...
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Janet Iwasa @jiwasa.bsky.social · 02/07/2025
Check out this new review (with animations, natch) of mechanisms of licensing origins of DNA replication - a wonderful (and continuing!) collaboration with Bruce Stillman @cshlnews.bsky.social and John Diffley @crick.ac.uk! www.nature.com/articles/s41...
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Mathew Kiang @mathewkiang.com · 25/06/2025
Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages. ki.se/en/about-ki/...
ki.se
Call for 20 Assistant Professor positions
Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...
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Alessandro Costa @costalaboratory.bsky.social · 20/06/2025
Postdoc positions open in my lab (Francis Crick Institute) to study 1. initiation of DNA replication. 2. chromatin replication/epigenetic inheritance. Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists. Deadline 3 August 2025. crick.wd3.myworkdayjobs.com/External/job...
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Cees Dekker @ceesdekker.bsky.social · 16/06/2025
Latest #CDlab paper online now: Cohesin supercoils DNA during loop extrusion www.cell.com/cell-reports... This extensive study was led by Jan Michael Peters at Vienna; our lab contributed mostly modeling of plasmid supercoiling (@romanbarth.bsky.social‬) and single-molecule data (Richard Janissen).
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Zha Lab @zhalab.bsky.social · 15/06/2025
Please join us celebrate the 5th year birthday of Social DNAing! Dr. Chapman will take the stage in the coming week. Sign up at cancer.columbia.edu/research/progr…
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ME Torres-Padilla @metorrespadilla.bsky.social · 12/06/2025
Are you @ the late stages of your postdoc ? Want to pursue a PI career ? Then this 👇👇 is for you ! Apply for a spot @ our Talent Forum www.helmholtz-munich.de/en/stem-cell... Peer-networking / Career orientation and more !!! Please distribute :) 🙂
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Anja Groth @groth-anja.bsky.social · 12/06/2025
Amazing accomplishment 👏👏 congrats Hiten and team 🎉
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Anja Groth @groth-anja.bsky.social · 06/06/2025
Excellent advice!!
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EMBO @embo.org · 05/06/2025
From theory to practice — explore #computational approaches and #AI developments at EMBO Practical Course "Integrative modelling of biomolecular interactions" in Izmir, Türkiye, 28 September–3 October 2025 Deadline: 15 June meetings.embo.org/event/25-bio... #EMBObiomolInteractions #EMBOevents 🧪
meetings.embo.org
Integrative modelling of biomolecular interactions
Experimental structural studies of interactions can be costly, low-throughput, and challenging. Therefore, computational methods aiming to model protein complexes are particularly valuable. The accur…
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Mark A. Hanson @hansonmark.bsky.social · 03/06/2025
URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯 Any lab using @flybase.bsky.social please donate using the link in post below. This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
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Fusion Conferences @fusionconf.bsky.social · 28/05/2025
⏰🚨FINAL DEADLINE APPROACHING #BGFP25 's extended reg deadline is closing on 02 June 2025. This is your last chance to register and confirm your place at this fantastic conference 🧬! Join us in sunny Portugal this July and register now: bit.ly/3AnsVZF
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Enhanced Genomics @enhancedgenomics.bsky.social · 28/05/2025
📢 Next speaker in our '3D Regulatory Genome' series: Dr. Alvaro Rada Iglesias (@radaiglesiaslab.bsky.social) presenting innovative enhancer research using transgenic mouse stem cells! Moderated by @stefanschoenfelder.bsky.social Register: us02web.zoom.us/webinar/regi... #Genomics #VirtualSeminar
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Lopes_Lab @lopeslab.bsky.social · 28/05/2025
One more appointment with great science in a few days, one click away 👇
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Nature Cell Biology @natcellbio.nature.com · 09/05/2025
💫NEW: @jzylicz.bsky.social & co show that dimethyl α-ketoglutarate enhances the production and functional maturation of human #trophectoderm - like cells from embryonic #StemCells by regulating histone acetyltransferase activity and the pluripotency network. bit.ly/3EGflmL
bit.ly
α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells - Nature Cell Biology
Van Nerum et al. show that dimethyl α-ketoglutarate enhances the production and functional maturation of human trophectoderm-like cells from embryonic stem cells by regulating histone acetyltransferas...
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EMBO @embo.org · 08/05/2025
Get to know Tuncay Baubec, former EMBO Young Investigator and EMBO Postdoctoral Fellow, who studied in #Austria, started his own group at University of Zurich and is now Professor at @utrechtuniversity.bsky.social: www.embo.org/people/the-f... 🧪 #LifeSciences #research #opportunities
embo.org
The freedom to choose your own research focus – People – EMBO
Meet Tuncay Baubec, Professor at Utrecht University | Former EMBO Young Investigator and EMBO Postdoctoral Fellow
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Lopes_Lab @lopeslab.bsky.social · 01/05/2025
Exciting science ahead! Hope to see many of you online on Tuesday 6th (just connect, no registration needed)
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Francesca Mattiroli @fmattiroli.bsky.social · 04/05/2025
Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, replication and damage repair. Thanks to Biochemistry for inviting us! doi.org/10.1021/acs....
doi.org
Always on the Move: Overview on Chromatin Dynamics within Nuclear Processes
Our genome is organized into chromatin, a dynamic and modular structure made of nucleosomes. Chromatin organization controls access to the DNA sequence, playing a fundamental role in cell identity and...
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The EMBO Journal @embojournal.org · 25/04/2025
Comprehensive mapping of protein-protein interactions in the Drosophila piRNA pathway reveals how adaptive evolution contributes to rapid diversification of this genome-defense mechanism Peter Andersen @germline.bsky.social and collaborators www.embopress.org/doi/full/10....
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EMBO @embo.org · 23/04/2025
Co-organized by EMBL, EMBO and EMBO Press, the EMBL Science and Society Conference "In science we trust?" will explore the importance of public trust in science and the role we all play in shaping its future. 🧪 Register by 5 May: www.embl.org/about/info/c... #LifeSciences @embl.org @embopress.org
embl.org
In science we trust?
EMBL Science and Society Conference
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Journal of Cell Science @jcellsci.bsky.social · 21/04/2025
Cell scientist to watch – Hana Polasek-Sedlackova @hanasedlackova.bsky.social In this interview, we learn about Hana’s career, her insights on collaborative research and her engineering hobby. journals.biologists.com/jcs/article/...
Hana Polasek-Sedlackova
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Vijay Ramani @vram142.bsky.social · 16/04/2025
To the top of the "to-read" list. Looks like a heroic amount of work from the Hahn lab (large-scale ChEC-seq compendium!) www.nature.com/articles/s41...
nature.com
Low overlap of transcription factor DNA binding and regulatory targets - Nature
A near-complete survey of transcription factor activities in Saccharomyces cerevisiae reveals that most transcription factors have both activator and repressor activities and limited overlap between t...
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Deegan Lab @deeganlab.bsky.social · 15/04/2025
3rd edition of the fantastic UK DNA replication meeting is happening next September in Edinburgh. Don't miss out 🧬🏴󠁧󠁢󠁳󠁣󠁴󠁿 www.biochemistry.org/events-and-t...
biochemistry.org
UK DNA Replication Meeting 2026
Research in the DNA replication field is progressing at a remarkable rate. Technological innovations in biochemical reconstitution, structural biology, proteomics and DNA sequencing are helping to rap...
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Farrukh @implausibleblog.bsky.social · 11/04/2025
Dr Peter Marks, "Vaccines have been studied very extensively for being potentially associated with autism" "That theory has been debunked" "One study in Denmark, over 600,000 children. It shows that if anything, children had a lower rate of autism than unvaccinated children"
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Sally Lowell @cellysally.bsky.social · 11/04/2025
This is really great. Congratulations to @guijacquemet.bsky.social and all authors. #PaperThemeTune can be anything from the atypical album Milijard by Circle, who are Finnish and also really great.
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Van Andel Institute (VAI) @vai.org · 08/04/2025
The VAI Epigenomics Workshop is a great opportunity for #PhD students to learn the latest techniques from internationally recognized #epigenomics experts! 🗓️ July 29–31, 2025 📍 Van Andel Institute 👇 Learn more and apply
vai.org
2025 VAI Epigenomics Workshop
Join us for 2025 VAI Epigenomics Workshop at Van Andel Institute Stay informed about exciting upcoming events and activities.
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Joanna W Jachowicz @jjachowicz.bsky.social · 06/04/2025
Join our team as a postdoc and explore the exciting world of transposable elements and developmental biology with us! @imbavienna.bsky.social @vbcscitraining.bsky.social
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Itai Yanai @itaiyanai.bsky.social · 02/04/2025
🔥New Night Science paper!! Discovery happens when your initial plans fall apart but it requires you to have a particular mindset: it's not extraverted, orderly, neurotic or agreeable that's the most important – discovery requires an OPENNESS to new ideas and unexpected insights.
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Ewan Birney @ewanbirney.bsky.social · 01/04/2025
Calling Danish colleagues! Some advertising for talks I will be doing in Denmark after Easter - On Wednesday 23rd April I will be at Aarhus Denmark, Universitetsbyen 81, 1315. On Thursday 24th April I will be at Natural History Museum, Copenhagen, at 1400 (www.aicentre.dk/events/talk-...).
aicentre.dk
Talk by Ewan Birney | Event | Pioneer Centre for Artificial Intelligence
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Anja Groth @groth-anja.bsky.social · 28/03/2025
A few days left to apply for exciting PhD and Postdoc opportunities in wonderful Copenhagen and join our efforts in understanding Epigenetic Cell Memory.
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zhoujt.bsky.social @zhoujt.bsky.social · 25/03/2025
1/10 Excited to share our latest - the first whole-body map of both DNA methylation and 3D genome at single-cell resolution.
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Ellenberg Lab @ellenberglab.bsky.social · 24/03/2025
Our new findings on how chromosomes get ready for cell division are now published in @cellpress.bsky.social! Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩 www.sciencedirect.com/science/arti...
sciencedirect.com
Nanoscale DNA tracing reveals the self-organization mechanism of mitotic chromosomes
How genomic DNA is folded during cell division to form the characteristic rod-shaped mitotic chromosomes essential for faithful genome inheritance is …
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Itai Yanai @itaiyanai.bsky.social · 25/03/2025
David Baker talks about how the current uncertainty and instability hinder creativity because of the difficulty in thinking long-term. From this week’s Night Science Podcast nightscience.buzzsprout.com/1744020/epis... @nightsciencepod.bsky.social
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Björn Schumacher @bjornschumacher.bsky.social · 24/03/2025
FINAL DEADLINE ENDING: Only one day left to submit your abstract for the EMBO | EMBL Symposium The ageing genome: from mechanisms to disease www.embl.org/about/info/c...
embl.org
The ageing genome: from mechanisms to disease
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Peter Andersen @germline.bsky.social · 24/03/2025
⌛📝 One week left to apply to our latest call for faculty positions here at @molbiolau.bsky.social in Aarhus, Denmark 🇩🇰 Two (👀) positions are available w. open topic + rank (tenure-track assist or assoc professorship dep. on career stage). mbg.au.dk/en/news-and-...
mbg.au.dk
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Anja Groth @groth-anja.bsky.social · 23/03/2025
Arrived! The Groth lab moved to the Danish Cancer Institute. Beautiful new labs shared with @nilskrietenstein.bsky.social Thanks to everyone at DCI for a warm welcome. We are excited to be here and get experiments going 🧬
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Anja Groth @groth-anja.bsky.social · 23/03/2025
Cells control the supply of new histones to chromatin by blocking histone chaperone function - see here how Codanin-1 sequesters 4 ASF1 molecules.
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BrunetLab @brunetlab.bsky.social · 22/03/2025
Interested in aging? Super excited about this upcoming Keystone meeting!! 🧪🌲🌲 Aging: Immune Function and Organ Health -- Banff, Canada in 2026!!! ✨✨ Joint meeting with the Keystone Innate Immunity meeting! #aging #immunity @keystonesymposia.bsky.social www.keystonesymposia.org/conferences/...
keystonesymposia.org
Aging: Immune Function and Organ Health | Keystone Symposia
Join us at the Keystone Symposia on Aging: Immune Function and Organ Health, March 2026, in Banff, with field leaders!
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