Sign in

Matthias Trost

@mtrost.bsky.social
1.9K followers 1.9K following 165 posts

Professor of Proteomics. Currently at Newcastle University UK. he/him Here in personal capacity.

PostsRepliesMedia
Matthias Trost @mtrost.bsky.social · 6h
New paper from our lab. Driven by Ben Raymond, who now is a BBSRC fellow and builds his own line of research on this paper. Ben developed a method to define the proteome of macrophages after uptake of SILAC-labelled apoptotic cells. 1/2 www.nature.com/articles/s41...
nature.com
Efferocytosis triggered proteomic reprogramming of macrophages reveals CD97 as a novel apoptotic receptor - Cell Death & Differentiation
Cell Death & Differentiation - Efferocytosis triggered proteomic reprogramming of macrophages reveals CD97 as a novel apoptotic receptor
2111
Matthias Trost @mtrost.bsky.social · 27/07/2026
We have a 2-year postdoc position available for a bacterial infection biologist. We will use our exciting PhagoCyt method which uses flow cytometry to isolate pathogen-containing phagosomes & sensitive proteomics. Research Associate at The University of Manchester www.jobs.ac.uk/job/DSK144/r...
jobs.ac.uk
Research Associate at The University of Manchester
Explore an exciting academic career as a Research Associate. Don't miss out on other academic jobs. Click to apply and explore more opportunities.
010
Matthias Trost @mtrost.bsky.social · 06/07/2026
If FIFA was competent they would have scheduled the POR-SPA game really late at night and the MEX-ENG game earlier instead. 😃
010
Matthias Trost @mtrost.bsky.social · 05/07/2026
The referree in the Paraguay-France game is a disgrace.
110
Matthias Trost @mtrost.bsky.social · 23/06/2026
German Kicker asking if England can become World Champions with this Goalie.
000
Matthias Trost @mtrost.bsky.social · 05/06/2026
If you need another reason to use proteomics to quantify proteins rather than Western Blot:
1205
Matthias Trost @mtrost.bsky.social · 05/06/2026
A run down University building that is being demolished behind a sign stating "Modern University of the Year 2026"
010
Matthias Trost @mtrost.bsky.social · 02/05/2026
Bloody hell, Wu Yize is good. Such a snooker talent.
020
Matthias Trost @mtrost.bsky.social · 19/04/2026
I really hate journals asking me to review their paper on a Sunday evening. Get a life.
180
Reposted by Matthias Trost
Proteostasis UK @proteostasisuk.bsky.social · 18/03/2026
UK Proteostasis Meeting 2026 – Reminder: Register Today
 📅 20–21 July 2026 at The Francis Crick Institute, London 🗓 Abstract deadline: 1 May 2026
 💷 Fees: £45 (Student/Postdoc) | £75 (Group Leader) 🔗 Register: forms.gle/dWz2qztKgftB...
 🔗 Payment: www.eventbrite.co.uk/e/uk-proteos...
066
Matthias Trost @mtrost.bsky.social · 10/03/2026
Really enjoyed giving a BSPR lecture today at UCD. But the beer prices in Dublin are obscene.
160
Matthias Trost @mtrost.bsky.social · 26/02/2026
Trucks loaded up for the lab move. Next stop, Manchester! Quite amazing how much stuff is in a lab.
1131
Matthias Trost @mtrost.bsky.social · 26/02/2026
I am rather worried that this government not only will actively fail UK universities but also screw over one of the gems of UK economy - science and life science, particularly. Will UKRI's funding buckets shore up UK research? share.google/B92vQ7E6nEOK...
share.google
Will UKRI’s funding buckets shore up UK research’s sandcastle?
Academics’ concerns are mounting as news drips out of the research councils about cuts and freezes ahead of a major funding restructuring intended to promote interdisciplinarity and transparency. But ...
042
Matthias Trost @mtrost.bsky.social · 06/02/2026
A real pleasure to examine @emmottlab.bsky.social 's first PhD student. Well done, Stephen!
160
Reposted by Matthias Trost
Emmottlab @emmottlab.bsky.social · 06/02/2026
Congrats to Dr @stephenholmes.bsky.social on passing his PhD viva today! Thanks to examiners Al Darby and @mtrost.bsky.social!
063
Matthias Trost @mtrost.bsky.social · 02/02/2026
I have a 3-year postdoc position available at University of Manchester for a mass spec expert in proteomics. The person will be involved in exciting projects in single cell proteomics, drug discovery and innate immunity - on timsTOF Ultra AIP & HF & Astral Zoom. www.jobs.ac.uk/job/DQJ093/r...
trostlab.org
Home - Trost Lab
02628
Matthias Trost @mtrost.bsky.social · 23/01/2026
We have a 18 months Post-Doctoral Research Associate position available funded by the Kennedy Trust for a Mass Spectrometry/Proteomics expert at the @officialuom.bsky.social This is a collaborative position with the Rice lab @grainofscience.bsky.social www.jobs.manchester.ac.uk/Job/JobDetai...
jobs.manchester.ac.uk
Research Associate:Oxford Road
The successful candidate would be expected to be curious and rigorous, with demonstrable knowledge of cell biology relevant to the research focus of the laboratory and substantial hands-on experience with mass spectrometry platforms.
031
Matthias Trost @mtrost.bsky.social · 15/01/2026
How do you deal with missing values and "unique" proteins that were only identified in one condition in proteomics data? Mengchun Li, an amazing PhD student in my lab, developed this great Bayesian approach. Please try it and give feedback! www.biorxiv.org/content/10.6...
biorxiv.org
Empirical-Bayes and Bayesian Hierarchical Modelling for Missingness and Differential Expression in Proteomics
Mass spectrometry-based label-free proteomics data often suffer from missing values, especially for low-abundance proteins or when a protein is completely absent in one condition. This makes it challe...
2277
Matthias Trost @mtrost.bsky.social · 15/12/2025
I have a PhD position available with start date September 2026 at the University of Manchester. Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes Due to funding requirements, this position is for UK home students only. www.findaphd.com/phds/project...
findaphd.com
Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes at The University of Manchester on FindAPhD.com
PhD Project - Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes at The University of Manchester, listed on FindAPhD.com
11312
Reposted by Matthias Trost
Ishier Raote @ishier.bsky.social · 08/12/2025
Nice preprint from @derm-scientist.bsky.social! Ubiquitin system is key for tissue architecture in CYLD cutaneous syndrome (CCS) skin tumours. "Comparative ubiquitinomics of human skin reveals insulin receptor ubiquitination as a regulator of collagen secretion." www.biorxiv.org/content/10.6...
183
Matthias Trost @mtrost.bsky.social · 10/10/2025
Reposting this. If you are interested in applying for this fellowship in a research area of our lab's interest, let me know.
031
Matthias Trost @mtrost.bsky.social · 06/10/2025
Some news! We will move to the University of Manchester @manchester.ac.uk in January! We will keep some association with. Newcastle University for a while. Very excited!
5320
Matthias Trost @mtrost.bsky.social · 23/09/2025
Are you using DIA mass spectrometry in proteomics? We have just put this paper online: www.biorxiv.org/content/10.1... Here, we came up with some Recommendations for Quantitative Data-Independent Acquisition (DIA) Proteomics using Controlled Quantitative Experiments (CQEs) 1/4
eur03.safelinks.protection.outlook.com
Recommendations for Quantitative Data-Independent Acquisition (DIA) Proteomics using Controlled Quantitative Experiments (CQEs)
Advances in mass spectrometry and associated computational tools have resulted in the wide-spread adoption of Data-Independent Acquisition (DIA) for proteomics. Experiments using state-of-the-art inst...
2309
Matthias Trost @mtrost.bsky.social · 26/07/2025
Very happy that we have been awarded a £800k grant from the MRC for a novel mass spectrometer for the @newcastleuni.bsky.social NUPPA facility. Thanks to everyone involved!
1260
Matthias Trost @mtrost.bsky.social · 22/07/2025
Amazing podcast on the mitochondrial donation babies. Great work by wonderful colleagues@mitonewcastle.bsky.social at @newcastleuni.bsky.social and the @lilyfoundation.bsky.social www.theguardian.com/science/audi...
theguardian.com
The babies born with DNA from three parents – podcast
Doctors in the UK have announced the birth of eight healthy babies after performing a groundbreaking procedure that creates IVF embryos with DNA from three people. Ian Sample tells Madeleine Finlay ab...
074
Matthias Trost @mtrost.bsky.social · 27/06/2025
In life sciences there are two types of people in my experience: those that embrace and exploit omics and other large scale data technologies and those who work on one problem at the time. I had many collaborators from either side. 1/2
190
Matthias Trost @mtrost.bsky.social · 20/06/2025
The financial crisis of the HE sector in the UK now leads to increased numbers of grant and fellowship applications, pushing down the success rates. Since also overheads increased, in some cases we will see success rates halved. There is a BBSRC fellowship which will have a success rate of 5%.
365
Matthias Trost @mtrost.bsky.social · 19/06/2025
@drandyfrey.bsky.social having quite some interest at his poster at #EUPA2025 We have performed a controlled quantitative experiment with a three proteome mix and come up with recommendations using DIA. Biorxiv paper out soon (hopefully!)
1190
Matthias Trost @mtrost.bsky.social · 19/06/2025
The location and food will make it impossible for anyone else to ever make a better EUPA conference. Thank you for organising such an excellent event! #EUPA2025
181
Matthias Trost @mtrost.bsky.social · 17/06/2025
Good morning from St. Malo. #EUPA2025
0251
Matthias Trost @mtrost.bsky.social · 06/06/2025
Some of y'all can't handle 2 high agency males going at it and it really shows.
000
Matthias Trost @mtrost.bsky.social · 06/06/2025
Does anyone have an update on the number of ASMS attendees?
130
Reposted by Matthias Trost
Ada Palmer @adapalmer.bsky.social · 03/06/2025
Wow, yes. An amazing glimpse of the LLM Lie Machine at work. Anyone whose students are bring tempted by LLMs, sharing this could be very helpful showing how it lies, and how it fails.
12269137
Matthias Trost @mtrost.bsky.social · 02/06/2025
Does anyone know how many delegates are at #ASMS2025 ? I would assume that immigration policy and the blocking of grants will affect the numbers...
360
Reposted by Matthias Trost
Ed Emmott @edemmott.bsky.social · 14/05/2025
Two days left for abstract submission and early bird registration for BSPR2025!
062
Reposted by Matthias Trost
Ed Emmott @edemmott.bsky.social · 11/05/2025
Less than one week to go until the deadline for abstract submission and early bird registration for the British Society for Proteome Research @ukbspr.bsky.social annual conference 2025 in Liverpool! Deadline is Friday May 16! For more details see here: www.bspr.org/annual-meeti...
bspr.org
Annual Meetings | BSPR
063
Matthias Trost @mtrost.bsky.social · 07/05/2025
Who would have thought that hard right nationalist governments do ethnic cleansing and start wars?
000
Matthias Trost @mtrost.bsky.social · 02/05/2025
Labour dropping Net Zero will lead to Reform voters still voting Reform and Labour voters voting for the Greens. God, show some spine and do what is right.
030
Matthias Trost @mtrost.bsky.social · 01/05/2025
Sigh. Want to go to two conferences in France and ideally take the train to reduce my CO2 output. To get to Paris I can either spend £500 to take the train or fly for £88. This is so fucked up.
050
Matthias Trost @mtrost.bsky.social · 29/04/2025
I would like to share our latest work: After years of optimisation, we have developed a flow cytometry-based method to isolate pathogen-containing phagosomes. Paired with sensitive proteomics, this provides exciting new insights into host-pathogen interactions! www.biorxiv.org/content/10.1...
biorxiv.org
Flow cytometry-based isolation combined with ultra-sensitive proteomics of Salmonella-containing phagosomes reveals novel insights into host-pathogen interactions
Macrophages engulf pathogens into dynamic phagosomes, which many bacteria manipulate for survival. However, isolating pure pathogen-containing phagosomes remains challenging. Here, we developed a nove...
0105
Reposted by Matthias Trost
The Lancet @thelancet.com · 25/04/2025
🆕 “Science and medicine in the USA are being violently dismembered while the world watches [...] bullies are only emboldened by acquiescence or indifference.” The Lancet’s latest Editorial: Supporting medical science in the USA www.thelancet.com/journals/lan...
The Editorial in full.
4199111
Matthias Trost @mtrost.bsky.social · 25/04/2025
Communication with an autistic teenage boy via text is 99% getting answers like "yes", "no" and "ok". But even that you never get without a prompt.
000
Reposted by Matthias Trost
Itai Yanai @itaiyanai.bsky.social · 17/04/2025
Journal editors are now receiving such letters from the US government. The entire scientific community must unite to support our journals in flatly resisting such illegal interventions.
17253101
Reposted by Matthias Trost
Taylor Lab @taylorlabncl.bsky.social · 15/04/2025
Such a great day and opportunity to work together as a UK mitochondrial research community going forward! @mitonewcastle.bsky.social @drperscitus.bsky.social @sarahjpickett.bsky.social @mtrost.bsky.social @jim-ca.bsky.social @newcastleuni.bsky.social @medicalsciencesncl.bsky.social
081
Matthias Trost @mtrost.bsky.social · 16/04/2025
Very happy to contribute to this amazing group of researchers.
020
Reposted by Matthias Trost
Outspoken™️ @out5p0ken.bsky.social · 10/04/2025
“He made 2.5 million today and he made $900 million. That’s not bad.” Sounds like market manipulation to me. That’s bad.
2230235438955
Reposted by Matthias Trost
Tracy Palmer @proftracypalmer.bsky.social · 09/04/2025
Two ERC-funded postdoc positions available in the team - one here and second to follow - please repost! jobs.ncl.ac.uk/job/Newcastl...
jobs.ncl.ac.uk
Research Associate Genetic and functional analysis of Gram positive secretion systems and substrates
Research Associate Genetic and functional analysis of Gram positive secretion systems and substrates
13169
Matthias Trost @mtrost.bsky.social · 08/04/2025
@chionwurah.bsky.social @cmckinnellmp.bsky.social
000
Matthias Trost @mtrost.bsky.social · 08/04/2025
It's hard to believe Trump has only been in power for two and a half months. His goals were: – Gaza conflict – Ukraine war – America's economy Everything's going great! And now Iran. 🧨
010
Matthias Trost @mtrost.bsky.social · 02/04/2025
Excited about Liberation day? ✔️American consumers will be liberated of their money. ✔️Stocks will be liberated from their gains. ✔️ the money gained through tariffs will be used to subsidise areas that lost out due to reciprocal tariffs.
000