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Peter Sarkies

@psarkies.bsky.social
835 followers 277 following 223 posts

Epigenetics and Evolution

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Reposted by Peter Sarkies
Emilia Dimitrova @edimitrova.bsky.social · 13h
Great session next week! Not to be missed! @paul-villain.bsky.social from our neighbouring lab has a fantastic story
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Peter Sarkies @psarkies.bsky.social · 28/09/2026
CpG islands are fascinating both from molecular mechanism point of view and in terms of evolutionary conservation in the context of elevated mutation rate of CpG dinucleotides in mammalian genomes. Lots of new insights from cool technical and theoretical advances from @robklose.bsky.social + lab.
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Reposted by Peter Sarkies
Julius Brennecke @juliusbrennecke.bsky.social · 27/09/2026
Five years ago, on a walk with @mayavoichek.bsky.social through the third district around the @viennabiocenter.bsky.social we concluded that "every day we do not work on the mysterious Env-independent infectivity of MDG1 retrotransposons is a lost day ... " The birth of an entire research domain.
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Peter Sarkies @psarkies.bsky.social · 26/09/2026
Interesting article on philosophy of biology. a quote: "despite such a capability to describe cells, we lack a fundamental account of how molecular interactions generate cellular identity and function." Sounds very grand... 1/4 elifesciences.org/articles/112...
elifesciences.org
Client Challenge
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René Ketting @reneketting.bsky.social · 03/09/2026
Happy to share PhD work of @shamithagovind.bsky.social She unraveled how GTSF1, a protein known from the Piwi field, regulates RdRP in nematodes. Thanks also to @psarkies.bsky.social @sebastianfalk.bsky.social Ralf Sommer, Falk Butter, @migueldvalmeida.bsky.social link.springer.com/article/10.1...
link.springer.com
An evolutionarily conserved N-terminal domain of RRF-3 governs GTSF-1 binding in nematodes - EMBO Reports
GTSF1 is an essential activating cofactor for PIWI proteins in many metazoans. In the nematode Caenorhabditis elegans, however, GTSF-1 does not bind PIWI, but is associated with the RNA-dependent RNA ...
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Peter Sarkies @psarkies.bsky.social · 02/09/2026
Interesting article, but I think the more fundamental issue is that science, including science writing, generally rewards conformity both to style and received wisdom. www.nature.com/articles/d41... www.nature.com/articles/d41...
nature.com
Bland new world: is AI making us all think the same?
Researchers worry that generative AI is homogenizing culture and cognition.
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Reposted by Peter Sarkies
Peter Andersen @germline.bsky.social · 29/08/2026
We watched piRNAs and transposons across development, saw them dance tightly and wrote a paper about it. It's so cool to see it online and we will make a thread about it all very soon. Stay tuned :-)
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Peter Sarkies @psarkies.bsky.social · 25/08/2026
Sad news re Dolly. Was hoping she would have survived to 95 at least
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Peter Sarkies @psarkies.bsky.social · 17/07/2026
Super interesting paper on the evolution of parasitism
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Peter Sarkies @psarkies.bsky.social · 17/07/2026
Odyssey: great film- cinematography, acting and storyline all superb. Until the credits: dreadful Travis Scott rap completely ruins the atmosphere. Very strange decision
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Peter Sarkies @psarkies.bsky.social · 16/07/2026
Two factor authentication needed for Biorender now??
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Peter Sarkies @psarkies.bsky.social · 13/07/2026
This is a very interesting discussion. Like many scientists I got inspired by many post hoc narratives of discovery eg Galileo, Darwin and the Beagle, that turn out to be much more complicated, and also falsely representing how science works. Perhaps the truer stories would be just as inspiring?
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Peter Sarkies @psarkies.bsky.social · 09/07/2026
So many hopes pinned to a Bin.
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Reposted by Peter Sarkies
The Fromm Lab @frommlab.bsky.social · 23/05/2026
0/ 💡💡💡Had one of those slightly weird moments reading something today. Two seemingly very different research traditions—starting from opposite directions—appear to be converging on almost the same conclusion about one of biology’s biggest questions: How do genomes generate phenotypes? 👇🧵
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Peter Sarkies @psarkies.bsky.social · 07/06/2026
Possibly the best novel by one of the greatest 20thC writers. And as this podcast episode explains it is a very realistic idea of a truly free society. Perhaps Le Guin drew on her anthropology knowledge (her father was a professor of anthropology I believe)
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Peter Sarkies @psarkies.bsky.social · 05/05/2026
A different kind of publication for me- a poem, published on Spillwords! Please read and comment here: spillwords.com/ammonite/
spillwords.com
Ammonite, a poem by Peter Sarkies at Spillwords.com
Spillwords.com presents: Ammonite, a poem written by Peter Sarkies, a Biochemist based at the University of Oxford, UK.
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Peter Sarkies @psarkies.bsky.social · 02/05/2026
To me it is not to be celebrated that Trump respects an unelected monarch more than the UK government. It’s typical of his approach.
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Peter Sarkies @psarkies.bsky.social · 24/04/2026
now just waiting for the survey that says that 50% of men think they could win in a fight against this creature. www.science.org/doi/10.1126/...
science.org
Earliest octopuses were giant top predators in Cretaceous oceans
Top predators drive changes in ecosystem structure. For the last ~370 million years, large-sized vertebrates have dominated the apex of the marine food chain, while invertebrates have served as smalle...
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Peter Sarkies @psarkies.bsky.social · 16/04/2026
Orwell on Hitler is a real WTF moment
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Peter Sarkies @psarkies.bsky.social · 09/04/2026
This is a really great article and fun to read! Strongly recommend!
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Tobias Warnecke @tobiaswarnecke.bsky.social · 08/04/2026
I wrote an essay. It’s about gain-of-function mutations. And penguins. Also ion channels, chihuahuas, the film Alien, recycled cardboard, and the Apollonian mind. Oh, and muffins. Thanks to the editors of #GENETICS @genetics-gsa.bsky.social for letting me take some stylistic liberties. 1/2
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Peter Sarkies @psarkies.bsky.social · 01/04/2026
Thought the idea of neo conservativism derived from Trotsky was an April fool’s joke but seems not! Intriguing.
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Rob Klose @robklose.bsky.social · 13/03/2026
We are excited to be recruiting into 3 Associate Professorship's in @oxfordbiochemistry.bsky.social. Come join us as a colleague and benefit from our vibrant and multidisciplinary environment. Reach out to me if you have any questions. Please repost! (tinyurl.com/48deybuu) (tinyurl.com/4pdvjaft).
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Peter Sarkies @psarkies.bsky.social · 14/03/2026
Happy pi (RNA) day everyone! And what better way to enjoy than to revisit the unusual features of nematode piRNAs: www.cell.com/developmenta...
cell.com
Comparative Epigenomics Reveals that RNA Polymerase II Pausing and Chromatin Domain Organization Control Nematode piRNA Biogenesis
piRNAs are an important genome regulatory mechanism conserved across metazoans. In the nematode C. elegans, piRNA biogenesis evolved several differences from other metazoans. Beltran et al. study the ...
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League Against Cruel Sports @leagueacs.bsky.social · 11/03/2026
Another horse has died at this year’s Cheltenham Festival. HMS Seahorse’s death follows that of Hansard, bringing the total number of horses who have died at the festival since 2000 to 80*. This is unacceptable. If this happened in any other sport, there would be a huge outcry. *Animal Aid
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Matt Higgins @parasitematt.bsky.social · 03/03/2026
Introducing our new blood-stage malaria vaccine immunogen based on the essential invasion protein PfCyRPA. By understanding where on PfCyRPA the best antibodies bind, we used structure guided design to generate PfCyRPA-EM, which contains only the epitopes of the best antibodies.
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Peter Sarkies @psarkies.bsky.social · 24/01/2026
Most nematodes don't have piRNAs?!!
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Peter Sarkies @psarkies.bsky.social · 24/01/2026
This is really interesting. Tony Blair condemned Saddam Hussein's execution publicly. Was this genuine or was he perhaps happy with it behind the scenes? If he was genuinely opposed, what would he have preferred? UN trial might not have gone the way he would have wanted.
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Peter Sarkies @psarkies.bsky.social · 18/01/2026
the current Greenland thing shows that fawning to Trump like Starmer has been doing is totally pointless as well as degrading.
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Reposted by Peter Sarkies
Matt Higgins @parasitematt.bsky.social · 18/01/2026
Check out our latest study on the PfRIPR protein, essential for the malaria parasite to get inside our blood cells. We show how antibodies block the function of PfRIPR by preventing its flexible hinges from bending, or by stopping it from compacting as part of its mechanism.
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The EMBO Journal @embojournal.org · 16/01/2026
Epimutations: raw material for evolution? Nabeel Ganem & @psarkies.bsky.social explore how epimutations mediating transgenerational epigenetic inheritance compare to DNA sequence mutations w.r.t. influence on drift and natural selection link.springer.com/article/10.1...
link.springer.com
Epimutations: raw material for evolution? - The EMBO Journal
Epigenetics is fundamental to cell differentiation as it enables cells with identical genomes to adopt distinct fates. Some epigenetic information can also be transmitted between generations, in a pro...
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Peter Sarkies @psarkies.bsky.social · 08/01/2026
Incredibly cool- a must read!
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Peter Sarkies @psarkies.bsky.social · 08/01/2026
don't miss this! will be very interesting
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Peter Sarkies @psarkies.bsky.social · 06/01/2026
Need a bit of escapism? Not exactly Lord of the Rings, but in similar vein: doi.org/10.1038/s443...
link.springer.com
Epimutations: raw material for evolution? - The EMBO Journal
Epigenetics is fundamental to cell differentiation as it enables cells with identical genomes to adopt distinct fates. Some epigenetic information can also be transmitted between generations, in a pro...
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Peter Sarkies @psarkies.bsky.social · 05/01/2026
Worth a read. In my opinion possibly the only thing worse than humans recklessly driving a species to extinction is for us to attempt to bring it back- likely to be a vanity project with huge potential for cruelty and harm. www.cell.com/trends/genet...
cell.com
If we could turn back time
De-extinction critiques focus on animal welfare, ecosystem disruption, threats to traditional conservation, and anxiety about human hubris. Respondents argue that humanity is obligated to reverse dama...
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Reposted by Peter Sarkies
Zack Polanski @zackpolanski.bsky.social · 05/01/2026
On BBC News today: striking that it’s the two old establishment parties - Labour and the Conservatives - refusing to condemn the US breaking international law and doing what it wants. Feels like politics stuck in the past, while the public has clearly moved on.
Green party leader branded the strikes a breach of international law. The conservatives party said it was important to understand the full facts before rushing to judgment.
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Zack Polanski @zackpolanski.bsky.social · 03/01/2026
Starmer and Farage both drape themselves in flags but once again it's really clear where their loyalty really is. It's Trump first. They will always be on the side of the super rich and powerful - no matter how heinous the crime. This is not patriotism. It's subservience.
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George Monbiot @georgemonbiot.bsky.social · 03/01/2026
Whatever you might think of Maduro, the seizure and kidnapping of a head of state takes us to a very dark place. Vast, arbitrary, extra-legal power, which could be exercised almost anywhere, regardless of the character of the target government.
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Peter Sarkies @psarkies.bsky.social · 04/01/2026
Great to contribute in a small way to this study on the evolution of piRNA biogenesis in nematodes from @reneketting.bsky.social lab. GTSF-1 is preserved in many nematodes despite absence of piRNAs- it has evolved an alternative function in RNAi through RdRP interaction.
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Peter Sarkies @psarkies.bsky.social · 03/01/2026
RIP international law.
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Peter Sarkies @psarkies.bsky.social · 02/01/2026
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Peter Sarkies @psarkies.bsky.social · 20/12/2025
Nibbler or Trimmer? www.bbc.co.uk/news/article...
bbc.co.uk
Wigan pie-eating champion polishes off pie in 64 seconds
Tom O'Neil is crowned pie-eating champion after the annual contest in Wigan, Greater Manchester.
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Peter Sarkies @psarkies.bsky.social · 19/12/2025
Very exciting to see this published- opens lots of real interesting possibilities about how memory works!
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Peter Sarkies @psarkies.bsky.social · 12/12/2025
Truly a great meeting with so many highlights- thanks to @embo.org and all organisers for inspiring science program!
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Elliott Lab @elliottlab.bsky.social · 09/12/2025
Excited to share our work into ubiquitin E1-E2 specificity mechanisms. CryoEM visualising #ubiquitin transfer,biochemistry,evolution @labhofmann.bsky.social & tissue expression analyses @psarkies.bsky.social Big thanks to the team,reviewers & handling editor @dimitristypas.bsky.social rdcu.be/eTRdR
rdcu.be
UBA6 specificity for ubiquitin E2 conjugating enzymes reveals a priority mechanism of BIRC6
Nature Structural & Molecular Biology - Riechmann et al. uncover structural features governing ubiquitin transfer from ubiquitin-activating E1 enzymes UBA1 and UBA6 to specific E2...
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Peter Sarkies @psarkies.bsky.social · 07/12/2025
I had heard of the trial of Lady Chatterley's Lover but had no idea of the details. The whole case is so strange it's amazing it took place during my parents' lifetime- today DH Lawrence would not be considered even edgy let alone obscene. Fascinating episode.
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Peter Sarkies @psarkies.bsky.social · 29/11/2025
RIP Tom Stoppard. Forever with Rosencrantz and Guildenstern now.
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Peter Sarkies @psarkies.bsky.social · 28/11/2025
Great seminar in @oxfordbiochemistry.bsky.social today from Laura Landweber on the awesome world of ciliate DNA elimination- so many different gene regulation/repair pathways come together to achieve this remarkable feat
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Peter Sarkies @psarkies.bsky.social · 27/11/2025
baffled that Black Friday deals seem to have spread to companies selling PCR reagents.
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Peter Sarkies @psarkies.bsky.social · 25/11/2025
I’m fairly sure we don’t have to go back to Farage’s schooldays to find evidence of racism.
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