Ubiquitin coordinates a complex network of cellular pathways through covalent modification of substrates. Specificity in substrate recognition and modification choice is largely conferred by ubiquitin...

The research group Ubiquitin Signaling Specificity (Dr. Sonja Lorenz) invites applications for the position as PhD student or Postdoc (f/m/d) – Understanding and manipulating ubiquitin ligase specifi...

Leishmaniasis, a neglected tropical disease caused by Leishmania parasites, poses an immense global health burden in desperate need of additional foun…

Recent reports by Orth, Pohl, et al. and Li, Garcia-Rivera et al. show that ubiquitin can mark drug-like molecules in cells. This non-canonical ubiqui…

Die Abteilung Gewebedynamik und Regeneration (Prof. Dr. Jochen Rink) sucht eine Technische Assistenz (w/m/d) - zur Unterstützung und Entwicklung von Next-Generation Sequencing Anwendungen -

Stringent control of ubiquitylation is a central requirement of signaling specificity in eukaryotes. Here, we discover a domain module integrating pro…

Editors' Highlights

Nature Communications - Ubiquitination is a versatile modification system in eukaryotic cells. Here, the authors unveil that the ubiquitin ligase HUWE1 can modify drug-like small-molecule...

Your role  As Policy Assistant, you will support the daily operations of the EMBO Policy Programme and contribute to projects on topics such as research assessment, research integrity, and science–pol...

Here, Arkinson et al. reconstitute NUB1-mediated FAT10 degradation by the human 26S proteasome and use biochemistry, cryo-EM and hydrogen–deuterium exchange to show that NUB1 acts as an ATP-independen...