The lipid composition of the ER regulates the ability of Lst1/SEC24C to couple cargo to an autophagy receptor.

Nature Reviews Molecular Cell Biology, Published online: 30 June 2026; doi:10.1038/s41580-026-00997-7This study shows that neutral lipids regulate endoplasmic reticulum (ER) membrane curvature and bendability during ER-phagy, and finds that a COPII protein helps couple ER cargo to the autophagy receptor.

The small ubiquitin-like modifier UFM1 is known to regulate the ribosomal subunit RPL26, but whether other bona fide substrates exist remains debated. This Comment discusses criteria for the experimen...

During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...

Resident proteins of the Golgi recycle in vesicles and the protein GOLPH3 enables the COPI vesicle coat to accomplish this.

Cleavage by pathogen-derived proteases of an engineered chimeric protein activates its plant immune receptor component, enabling broad-spectrum resistance to pathogens in plants.

Transposable elements (TEs) comprise nearly half of the human genome. This Review discusses transcriptional and post-transcriptional mechanisms that repress TE activity, how TEs escape this suppressio...

The Japan Society for the Promotion of Science (JSPS) Research Fellowship supports you as a highly qualified postdoc from Germany in conducting your research in Japan – regardless of discipline.

Job Title: Associate or Senior Editor Nature Metabolism Location: New York, Beijing or Shanghai Application Deadline: June 10th, 2025 About Springer Nature Group Springer Nature opens the doors to dis...

Dr Caren Norden has been appointed Darwin Professor of Animal Embryology, joining the Department of Physiology, Development and Neuroscience in the School of Biological Sciences, from April 2026. Her ...

"I know that I am making the right decision because whenever I think about changing my gender role, I am flooded with feelings of relief."

For cells to polarize collectively along a tissue plane, asymmetrically localized planar cell polarity (PCP) complexes must form intercellular contacts between neighboring cells. Yet, it is unknown wh...

CRISPR–Cas-mediated genome, epigenome and transcriptome engineering in crops is crucial as the human population grows and climate deteriorates. This Review discusses new CRISPR–Cas tools for precise e...

Subunits of mitochondrial and cytosolic ribosomes need to be targeted to their correction cellular location. A study identified a mitochondrial avoidance segment in a eukaryotic cytosolic ribosome sub...

Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...

Nature Communications - The author presents an overview of the complex challenge of protein export from the Endoplasmic Reticulum, and discusses how cells may deploy novel pathways utilizing...