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Nature Reviews Molecular Cell Biology

@natrevmcb.nature.com
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A Reviews journal from SpringerNature. Timely Review articles, Comments and Highlights of the latest research in molecular cell biology. www.nature.com/nrm

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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 6h
New Online! Technological prominence alone does not justify leadership in SynCell governance
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Technological prominence alone does not justify leadership in SynCell governance
Nature Reviews Molecular Cell Biology, Published online: 30 September 2026; doi:10.1038/s41580-026-01034-3Technological prominence alone does not justify leadership in SynCell governance
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 28/09/2026
New Online! p53 keeps a transcription–replication balance that prevents chromothripsis
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p53 keeps a transcription–replication balance that prevents chromothripsis
Nature Reviews Molecular Cell Biology, Published online: 28 September 2026; doi:10.1038/s41580-026-01031-6p53 loss induces global increase of transcription that causes nucleotide shortage and replication stress, thereby driving formation of DNA double-strand breaks and chromothripsis.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 21/09/2026
ICYMI: New Online! Mechanisms and disease relevance of DNA break repair pathway choice
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Mechanisms and disease relevance of DNA break repair pathway choice
Nature Reviews Molecular Cell Biology, Published online: 18 September 2026; doi:10.1038/s41580-026-01026-3This Review focuses on the choice between homologous recombination and non-homologous end joining in DNA double-strand break repair. The antagonistic roles of 53BP1 and BRCA1–BARD1, the contribution of RNA–DNA hybrids and implications for targeting repair imbalance in cancer are discussed.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 18/09/2026
New Online! Mechanisms and disease relevance of DNA break repair pathway choice
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Mechanisms and disease relevance of DNA break repair pathway choice
Nature Reviews Molecular Cell Biology, Published online: 18 September 2026; doi:10.1038/s41580-026-01026-3This Review focuses on the choice between homologous recombination and non-homologous end joining in DNA double-strand break repair. The antagonistic roles of 53BP1 and BRCA1–BARD1, the contribution of RNA–DNA hybrids and implications for targeting repair imbalance in cancer are discussed.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 17/09/2026
ICYMI: New Online! A practical guide to studying genome function using single-molecule genomics
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A practical guide to studying genome function using single-molecule genomics
Nature Reviews Molecular Cell Biology, Published online: 14 September 2026; doi:10.1038/s41580-026-01017-4Single-molecule genomics methods are used to study the activity of regulatory factors on individual DNA molecules genome-wide, thereby enabling quantification of molecular heterogeneity and co-occurrence of regulatory events. This Expert Recommendation article provides a practical guide for adopting single-molecule genomics and outlines best practices.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 14/09/2026
New Online! A practical guide to studying genome function using single-molecule genomics
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A practical guide to studying genome function using single-molecule genomics
Nature Reviews Molecular Cell Biology, Published online: 14 September 2026; doi:10.1038/s41580-026-01017-4Single-molecule genomics methods are used to study the activity of regulatory factors on individual DNA molecules genome-wide, thereby enabling quantification of molecular heterogeneity and co-occurrence of regulatory events. This Expert Recommendation article provides a practical guide for adopting single-molecule genomics and outlines best practices.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 14/09/2026
ICYMI: New Online! PRC2–RNA interactions through the lens of bioinformatics pipeline choices
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PRC2–RNA interactions through the lens of bioinformatics pipeline choices
Nature Reviews Molecular Cell Biology, Published online: 11 September 2026; doi:10.1038/s41580-026-01028-1Four recent studies that have differently assessed PRC2–RNA interactions reveal key technical pitfalls underlying research in the field.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 11/09/2026
New Online! PRC2–RNA interactions through the lens of bioinformatics pipeline choices
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PRC2–RNA interactions through the lens of bioinformatics pipeline choices
Nature Reviews Molecular Cell Biology, Published online: 11 September 2026; doi:10.1038/s41580-026-01028-1Four recent studies that have differently assessed PRC2–RNA interactions reveal key technical pitfalls underlying research in the field.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 07/09/2026
ICYMI: New Online! Towards 3D-oid models that integrate molecular, morphological and spatial cellular features
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Towards 3D-oid models that integrate molecular, morphological and spatial cellular features
Nature Reviews Molecular Cell Biology, Published online: 04 September 2026; doi:10.1038/s41580-026-01025-4Combined analyses of cellular omics, morphology and spatial context in 3D-oids would advance tissue studies and organ engineering.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 06/09/2026
ICYMI: New Online! CDK1 links RNA methylation to mitosis progression
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CDK1 links RNA methylation to mitosis progression
Nature Reviews Molecular Cell Biology, Published online: 03 September 2026; doi:10.1038/s41580-026-01027-2During mitosis, the m6A methyltransferase METTL3 regulates transcription through functional interplay with the positive transcription elongation factor P-TEFb.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 04/09/2026
New Online! Towards 3D-oid models that integrate molecular, morphological and spatial cellular features
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Towards 3D-oid models that integrate molecular, morphological and spatial cellular features
Nature Reviews Molecular Cell Biology, Published online: 04 September 2026; doi:10.1038/s41580-026-01025-4Combined analyses of cellular omics, morphology and spatial context in 3D-oids would advance tissue studies and organ engineering.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 04/09/2026
New Online! The molecular basis of transcription initiation by RNA polymerase II
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The molecular basis of transcription initiation by RNA polymerase II
Nature Reviews Molecular Cell Biology, Published online: 04 September 2026; doi:10.1038/s41580-026-01019-2Recent technological breakthroughs have transformed our understanding of how transcription initiation in eukaryotes is regulated. This Review discusses the dynamics and roles of initiation-relevant protein complexes, and how chromatin states regulate the selection of transcription start sites and transcription directionality.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 03/09/2026
New Online! CDK1 links RNA methylation to mitosis progression
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CDK1 links RNA methylation to mitosis progression
Nature Reviews Molecular Cell Biology, Published online: 03 September 2026; doi:10.1038/s41580-026-01027-2During mitosis, the m6A methyltransferase METTL3 regulates transcription through functional interplay with the positive transcription elongation factor P-TEFb.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 31/08/2026
ICYMI: New Online! Charting meiotic recombination through the discovery of PRDM9
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Charting meiotic recombination through the discovery of PRDM9
Nature Reviews Molecular Cell Biology, Published online: 28 August 2026; doi:10.1038/s41580-026-01020-9A 2010 paper identified PRDM9 as the sequence-specific regulator of meiotic recombination hotspots, showing it co-evolves with its rapidly changing binding motifs.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 30/08/2026
ICYMI: New Online! Towards a systems-level view of the microtubule cytoskeleton and its functions in physiology and disease
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Towards a systems-level view of the microtubule cytoskeleton and its functions in physiology and disease
Nature Reviews Molecular Cell Biology, Published online: 27 August 2026; doi:10.1038/s41580-026-01011-wMicrotubules are essential components of the cytoskeleton, yet important links between their molecular properties and organismal functions remain unresolved. In this Roadmap, Janke et al. discuss key challenges, emerging opportunities and integrative approaches to connect microtubule regulation with physiology, ageing and disease.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 30/08/2026
ICYMI: New Online! Mechanisms and balanced regulation of plant immunity
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Mechanisms and balanced regulation of plant immunity
Nature Reviews Molecular Cell Biology, Published online: 27 August 2026; doi:10.1038/s41580-026-01009-4This Review discusses recent insights into the mechanisms of immune signalling in plants and their regulation to achieve effective defence against pathogens while preserving plant fitness. It also explores the interplay between the immune system and environmental stresses, and strategies for engineering optimal disease-resistant plants.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 29/08/2026
ICYMI: New Online! Not just for splicing — intronless mRNAs reveal role of nuclear speckles in nuclear export
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Not just for splicing — intronless mRNAs reveal role of nuclear speckles in nuclear export
Nature Reviews Molecular Cell Biology, Published online: 26 August 2026; doi:10.1038/s41580-026-01024-5The discovery that nuclear speckles support the nuclear export of intronless mRNAs expanded our understanding of their roles in gene regulation.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 28/08/2026
New Online! Charting meiotic recombination through the discovery of PRDM9
dlvr.it
Charting meiotic recombination through the discovery of PRDM9
Nature Reviews Molecular Cell Biology, Published online: 28 August 2026; doi:10.1038/s41580-026-01020-9A 2010 paper identified PRDM9 as the sequence-specific regulator of meiotic recombination hotspots, showing it co-evolves with its rapidly changing binding motifs.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 27/08/2026
New Online! Towards a systems-level view of the microtubule cytoskeleton and its functions in physiology and disease
dlvr.it
Towards a systems-level view of the microtubule cytoskeleton and its functions in physiology and disease
Nature Reviews Molecular Cell Biology, Published online: 27 August 2026; doi:10.1038/s41580-026-01011-wMicrotubules are essential components of the cytoskeleton, yet important links between their molecular properties and organismal functions remain unresolved. In this Roadmap, Janke et al. discuss key challenges, emerging opportunities and integrative approaches to connect microtubule regulation with physiology, ageing and disease.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 27/08/2026
ICYMI: New Online! The use of homology-directed repair in a complex landscape of genome editors
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The use of homology-directed repair in a complex landscape of genome editors
Nature Reviews Molecular Cell Biology, Published online: 24 August 2026; doi:10.1038/s41580-026-01018-3This Comment discusses the uses of Cas-induced homology-directed repair in the evolving landscape of highly specialized genome editing tools.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 27/08/2026
New Online! Mechanisms and balanced regulation of plant immunity
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Mechanisms and balanced regulation of plant immunity
Nature Reviews Molecular Cell Biology, Published online: 27 August 2026; doi:10.1038/s41580-026-01009-4This Review discusses recent insights into the mechanisms of immune signalling in plants and their regulation to achieve effective defence against pathogens while preserving plant fitness. It also explores the interplay between the immune system and environmental stresses, and strategies for engineering optimal disease-resistant plants.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 26/08/2026
New Online! Not just for splicing — intronless mRNAs reveal role of nuclear speckles in nuclear export
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Not just for splicing — intronless mRNAs reveal role of nuclear speckles in nuclear export
Nature Reviews Molecular Cell Biology, Published online: 26 August 2026; doi:10.1038/s41580-026-01024-5The discovery that nuclear speckles support the nuclear export of intronless mRNAs expanded our understanding of their roles in gene regulation.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 24/08/2026
New Online! The use of homology-directed repair in a complex landscape of genome editors
dlvr.it
The use of homology-directed repair in a complex landscape of genome editors
Nature Reviews Molecular Cell Biology, Published online: 24 August 2026; doi:10.1038/s41580-026-01018-3This Comment discusses the uses of Cas-induced homology-directed repair in the evolving landscape of highly specialized genome editing tools.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 17/08/2026
ICYMI: New Online! Spatial-EV-seq provides a tissue map of extracellular vesicles
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Spatial-EV-seq provides a tissue map of extracellular vesicles
Nature Reviews Molecular Cell Biology, Published online: 14 August 2026; doi:10.1038/s41580-026-01016-5In this Tools of the Trade article, Xu and Zhang (Yang lab) discuss the invention of Spatial-EV-seq, which allows researchers to spatially map extracellular vesicles in tissue slices.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 17/08/2026
ICYMI: New Online! Regulation and roles of mammalian mitophagy
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Regulation and roles of mammalian mitophagy
Nature Reviews Molecular Cell Biology, Published online: 14 August 2026; doi:10.1038/s41580-026-01012-9Mitophagy contributes to cellular homeostasis through the recycling of damaged mitochondria and precise control of mitochondrial numbers. In this Review, Martens and Ganley summarize the molecular mechanisms involved in mitophagy pathways, mitophagy regulation and roles in disease.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 16/08/2026
ICYMI: New Online! How the discovery of mammalian regeneration shapes translational efforts
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How the discovery of mammalian regeneration shapes translational efforts
Nature Reviews Molecular Cell Biology, Published online: 13 August 2026; doi:10.1038/s41580-026-01014-7This Journal Club highlights the landmark study that provided the first evidence of regeneration in mammals, demonstrating that neonatal mice can regenerate damaged hearts and influencing regenerative medicine until today.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 15/08/2026
ICYMI: New Online! Model-free multiparametric analysis of SHG images reveals collagen signatures in breast cancer
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Model-free multiparametric analysis of SHG images reveals collagen signatures in breast cancer
Nature Reviews Molecular Cell Biology, Published online: 12 August 2026; doi:10.1038/s41598-026-62801-yModel-free multiparametric analysis of SHG images reveals collagen signatures in breast cancer
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 15/08/2026
ICYMI: New Online! Development of samarium-153 oxide loaded polystyrene radiotracer particles for gamma scintigraphy of whole gastrointestinal transit study
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Development of samarium-153 oxide loaded polystyrene radiotracer particles for gamma scintigraphy of whole gastrointestinal transit study
Nature Reviews Molecular Cell Biology, Published online: 12 August 2026; doi:10.1038/s41598-026-66901-7Development of samarium-153 oxide loaded polystyrene radiotracer particles for gamma scintigraphy of whole gastrointestinal transit study
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 15/08/2026
ICYMI: New Online! AlzheiNN: a convolutional neural network-based model for Alzheimer’s disease classification
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AlzheiNN: a convolutional neural network-based model for Alzheimer’s disease classification
Nature Reviews Molecular Cell Biology, Published online: 12 August 2026; doi:10.1038/s41598-026-64954-2AlzheiNN: a convolutional neural network-based model for Alzheimer’s disease classification
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 15/08/2026
ICYMI: New Online! The impact of CEOs’ multidisciplinary backgrounds on corporate financing and investment maturity mismatch
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The impact of CEOs’ multidisciplinary backgrounds on corporate financing and investment maturity mismatch
Nature Reviews Molecular Cell Biology, Published online: 12 August 2026; doi:10.1057/s41599-026-08677-9The impact of CEOs’ multidisciplinary backgrounds on corporate financing and investment maturity mismatch
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 15/08/2026
ICYMI: New Online! Experiences of kinesiophobia in patients with chronic obstructive pulmonary disease: a qualitative phenomenological study
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Experiences of kinesiophobia in patients with chronic obstructive pulmonary disease: a qualitative phenomenological study
Nature Reviews Molecular Cell Biology, Published online: 12 August 2026; doi:10.1038/s41598-026-66659-yExperiences of kinesiophobia in patients with chronic obstructive pulmonary disease: a qualitative phenomenological study
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 15/08/2026
ICYMI: New Online! Shaping the anticipatory governance of synthetic cell research
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Shaping the anticipatory governance of synthetic cell research
Nature Reviews Molecular Cell Biology, Published online: 12 August 2026; doi:10.1038/s41580-026-01015-6Li Du advocates for stronger legal frameworks and an interdisciplinary, international approach to governing synthetic cell research.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 14/08/2026
ICYMI: New Online! An iron logic unites bacterial and cancer persister cells
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An iron logic unites bacterial and cancer persister cells
Nature Reviews Molecular Cell Biology, Published online: 11 August 2026; doi:10.1038/s41580-026-01010-xBacterial persisters and drug-tolerant persister cells in cancer both show reprogrammed iron homeostasis and a vulnerability to ferroptosis. Agostinis and Rodriguez propose that this iron logic is a conserved principle with implications for therapeutics development.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 14/08/2026
New Online! Spatial-EV-seq provides a tissue map of extracellular vesicles
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Spatial-EV-seq provides a tissue map of extracellular vesicles
Nature Reviews Molecular Cell Biology, Published online: 14 August 2026; doi:10.1038/s41580-026-01016-5In this Tools of the Trade article, Xu and Zhang (Yang lab) discuss the invention of Spatial-EV-seq, which allows researchers to spatially map extracellular vesicles in tissue slices.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 14/08/2026
New Online! Regulation and roles of mammalian mitophagy
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Regulation and roles of mammalian mitophagy
Nature Reviews Molecular Cell Biology, Published online: 14 August 2026; doi:10.1038/s41580-026-01012-9Mitophagy contributes to cellular homeostasis through the recycling of damaged mitochondria and precise control of mitochondrial numbers. In this Review, Martens and Ganley summarize the molecular mechanisms involved in mitophagy pathways, mitophagy regulation and roles in disease.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 13/08/2026
ICYMI: New Online! Mechanisms of transcription termination across the coding and noncoding loci of the genome
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Mechanisms of transcription termination across the coding and noncoding loci of the genome
Nature Reviews Molecular Cell Biology, Published online: 10 August 2026; doi:10.1038/s41580-026-01005-8Transcription termination by RNA polymerase II is a tightly regulated process that involves RNA surveillance and the chromatin environment. This Review discusses the interactions between transcription termination, RNA processing, nuclear RNA decay and mRNP export, which together guide RNA fate.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 13/08/2026
ICYMI: New Online! A call for studying the impact of multiple stressors on biological systems
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A call for studying the impact of multiple stressors on biological systems
Nature Reviews Molecular Cell Biology, Published online: 10 August 2026; doi:10.1038/s41580-026-01013-8Biological systems are exposed to complex combinations of environmental stressors, yet research often studies single stress conditions in isolation. In this Comment, the authors argue that studying multifactorial stress combinations is essential for understanding biological responses and improving resilience in crops, ecosystems and human health.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 13/08/2026
New Online! How the discovery of mammalian regeneration shapes translational efforts
dlvr.it
How the discovery of mammalian regeneration shapes translational efforts
Nature Reviews Molecular Cell Biology, Published online: 13 August 2026; doi:10.1038/s41580-026-01014-7This Journal Club highlights the landmark study that provided the first evidence of regeneration in mammals, demonstrating that neonatal mice can regenerate damaged hearts and influencing regenerative medicine until today.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 12/08/2026
New Online! Shaping the anticipatory governance of synthetic cell research
dlvr.it
Shaping the anticipatory governance of synthetic cell research
Nature Reviews Molecular Cell Biology, Published online: 12 August 2026; doi:10.1038/s41580-026-01015-6Li Du advocates for stronger legal frameworks and an interdisciplinary, international approach to governing synthetic cell research.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 11/08/2026
New Online! An iron logic unites bacterial and cancer persister cells
dlvr.it
An iron logic unites bacterial and cancer persister cells
Nature Reviews Molecular Cell Biology, Published online: 11 August 2026; doi:10.1038/s41580-026-01010-xBacterial persisters and drug-tolerant persister cells in cancer both show reprogrammed iron homeostasis and a vulnerability to ferroptosis. Agostinis and Rodriguez propose that this iron logic is a conserved principle with implications for therapeutics development.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 10/08/2026
New Online! A call for studying the impact of multiple stressors on biological systems
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A call for studying the impact of multiple stressors on biological systems
Nature Reviews Molecular Cell Biology, Published online: 10 August 2026; doi:10.1038/s41580-026-01013-8Biological systems are exposed to complex combinations of environmental stressors, yet research often studies single stress conditions in isolation. In this Comment, the authors argue that studying multifactorial stress combinations is essential for understanding biological responses and improving resilience in crops, ecosystems and human health.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 10/08/2026
New Online! Mechanisms of transcription termination across the coding and noncoding loci of the genome
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Mechanisms of transcription termination across the coding and noncoding loci of the genome
Nature Reviews Molecular Cell Biology, Published online: 10 August 2026; doi:10.1038/s41580-026-01005-8Transcription termination by RNA polymerase II is a tightly regulated process that involves RNA surveillance and the chromatin environment. This Review discusses the interactions between transcription termination, RNA processing, nuclear RNA decay and mRNP export, which together guide RNA fate.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 06/08/2026
ICYMI: New Online! Structure and function of the centromere and inner kinetochore
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Structure and function of the centromere and inner kinetochore
Nature Reviews Molecular Cell Biology, Published online: 03 August 2026; doi:10.1038/s41580-026-00989-7The kinetochore is a macromolecular complex that assembles on centromeric chromatin and connects spindle microtubules to the chromosome. This Review discusses recent advances in determining the organization of centromeric chromatin and the complete structure and function of the inner kinetochore, which are crucial for accurate chromosome segregation.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 06/08/2026
ICYMI: New Online! Structure and function of the outer kinetochore
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Structure and function of the outer kinetochore
Nature Reviews Molecular Cell Biology, Published online: 03 August 2026; doi:10.1038/s41580-026-00988-8The kinetochore orchestrates chromosome segregation. The KMN complex, which forms the core of the outer kinetochore binds to microtubules, recruits regulators and functions as a switch for the spindle assembly checkpoint. Recent integrative imaging, biochemical and structural studies have revealed how the KMN assemblies ensure accurate chromosome segregation.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 03/08/2026
New Online! Structure and function of the outer kinetochore
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Structure and function of the outer kinetochore
Nature Reviews Molecular Cell Biology, Published online: 03 August 2026; doi:10.1038/s41580-026-00988-8The kinetochore orchestrates chromosome segregation. The KMN complex, which forms the core of the outer kinetochore binds to microtubules, recruits regulators and functions as a switch for the spindle assembly checkpoint. Recent integrative imaging, biochemical and structural studies have revealed how the KMN assemblies ensure accurate chromosome segregation.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 03/08/2026
New Online! Structure and function of the centromere and inner kinetochore
dlvr.it
Structure and function of the centromere and inner kinetochore
Nature Reviews Molecular Cell Biology, Published online: 03 August 2026; doi:10.1038/s41580-026-00989-7The kinetochore is a macromolecular complex that assembles on centromeric chromatin and connects spindle microtubules to the chromosome. This Review discusses recent advances in determining the organization of centromeric chromatin and the complete structure and function of the inner kinetochore, which are crucial for accurate chromosome segregation.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 02/08/2026
ICYMI: New Online! Exchange dynamics and kinetic control of gene regulation complexes
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Exchange dynamics and kinetic control of gene regulation complexes
Nature Reviews Molecular Cell Biology, Published online: 30 July 2026; doi:10.1038/s41580-026-00991-zRecent evidence reveals how gene expression complexes form transient assemblies that continually exchange their subunits under kinetic control. This Perspective proposes that these dynamics form the basis of RNA processing and gene regulation.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 02/08/2026
ICYMI: New Online! At high noon, plants apply a condensate sunscreen
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At high noon, plants apply a condensate sunscreen
Nature Reviews Molecular Cell Biology, Published online: 30 July 2026; doi:10.1038/s41580-026-01008-5MBS1 condensates induced by high light conditions shield chloroplasts and prevent accumulation of singlet oxygen, thereby conferring tolerance without reduction in photosynthesis.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 02/08/2026
ICYMI: New Online! Regulation of RNA transcript elongation in metazoans and its relevance to disease
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Regulation of RNA transcript elongation in metazoans and its relevance to disease
Nature Reviews Molecular Cell Biology, Published online: 30 July 2026; doi:10.1038/s41580-026-01003-wThis Review discusses how transcript elongation by RNA polymerase II is regulated and how obstacles such as nucleosomes are overcome. Also discussed are the roles of transcription surveillance machineries, which ensure mRNA integrity and suppress spurious transcription, and how elongation defects contribute to diseases.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 01/08/2026
ICYMI: New Online! Modulating the degree of X-inactivation escape to establish causal links to sex-biased disease
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Modulating the degree of X-inactivation escape to establish causal links to sex-biased disease
Nature Reviews Molecular Cell Biology, Published online: 29 July 2026; doi:10.1038/s41580-026-01007-6Gene escape from X-chromosome inactivation can cause sex-biased diseases. A workflow is presented to help find escape genes and experimentally manipulate their expression.
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