We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog

DNA secondary structures, such as hairpins, cruciforms, triplexes, G-quadruplexes and iMotifs, are common, dynamic features that replication forks rou…

In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.

Telomerase counteracts telomere shortening by repeatedly adding DNA repeats to chromosome ends. We identified the replication protein A (RPA) heterotrimer as a telomerase processivity factor critical ...

DNA replication is molecularly asymmetric, due to distinct mechanisms for lagging and leading strand DNA synthesis. Whether chromatin assembly on newly replicated strands is also asymmetric remains un...

Nature Communications - Determining how replication forks move across the human genome is critical for the effective use of agents that target replication stress. Here, the authors present...

Nature Communications - The mediator protein Rad52 promotes Rad51 binding onto RPA-coated DNA to initiate homologous recombination. Here, the authors show that Rad52 sorts Rad51 into monomers and...

A tight coordination between transcription and DNA replication is essential to maintain genome stability. Both excessive transcription and upregulated…

Abstract. Disassembly of the replication machinery (replisome) from chromatin is an active process driven by two ubiquitin ligases Cul2LRR1 and TRAIP, whic

A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early even...

Hi! I work as an Assistant professor in HIllman Cancer Center, my research lab studies how cancer cells react to DNA damage (llike cancer drugs) and how they double their DNA to grow. As you probably ...

The 24th Annual Midwest DNA Repair Symposium will be held at the University of Michigan in the Kahn Auditorium of the Biomedical Science Research Building (BSRB) on May 17–18, 2025. The event will sta...

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DNA G-quadruplexes (G4s) are non–B-form DNA secondary structures that threaten genome stability by impeding DNA replication. To elucidate how G4s induce replication fork arrest, we characterized fork ...

In the Multicellularity Long Term Evolution Experiment, diploid yeast evolve to be tetraploid under selection for larger multicellular size, revealing how whole-genome duplication can arise due to its...

Pittsburgh's economy once relied heavily on the steel industry, which lined Second Avenue with miles of mills. When that industry collapsed, medicine and education filled the economic void.

DNA replication is essential to life and ensures the accurate transmission of genetic information, which is significantly disturbed during cancer development and chemotherapy. While DNA replication is...

DNA double-strand breaks induce local genome maintenance and inhibition of replication initiation at nearby topologically associating domains without affecting global DNA synthesis.

A spokesperson for the University told WESA Friday that the school has "temporarily paused additional Ph.D. offers of admission," while Pitt works to understand how proposed federal funding cuts could...

Losing parental histones during DNA replication fork passage challenges differentiation competence and cell viability.