Li et al. obtain high-resolution, native structures revealing that cytoplasmic lattices in mammalian eggs organize and store degradative and cytoskeletal complexes for early embryonic development.

Hippo signalling is an evolutionarily conserved pathway that regulates tissue growth. The FERM domain protein Expanded (Ex) integrates polarity cues to activate the Hippo pathway. Previous work has sh...

Leading biomedical research institute says it will “go full in on green and gold”

Scientific societies and scholarly publishing organizations launch the Trust Seal, a new community-led initiative designed to strengthen confidence in science by supporting trustworthy publishing prac...

Mammals share a laminar cerebral cortex, with excitatory neuron subtypes organized in distinct layers. Although this framework is conserved, subtype balance varies markedly between species due to larg...

Transgenic mouse models expressing predefined T-cell receptors (TCRs) have been instrumental in advancing our understanding of T-cell biology. However, these traditional models rely on random genomic ...

The research group Ubiquitin Signaling Specificity (Dr. Sonja Lorenz) invites applications for the position as PhD student or Postdoc (f/m/d) – Understanding and manipulating ubiquitin ligase specifi...

To define and systematically characterize the human E3 ubiquitin ligase (E3) landscape, we generated the E3-ome, a compendium of E3s encoded by the hu…

Target-directed microRNA degradation is driven by the atypical ZSWIM8–CUL3 E3 ubiquitin ligase that uses a two-RNA-factor authentication mechanism to specifically recognize AGO–miRNA–trigger...

Applicant-led calls to reopen on 7 April, as research council overhauls grant review structure

Employers describe claim as “extremely challenging” in current financial climate

Exclusive: Scale of redundancies revealed by RPN branded a “disaster” for UK research capacity

Exclusive: Scale of redundancies revealed branded a “disaster” for UK research capacity

Knudsen and colleagues use repli-ATAC-seq to compare replicated and unreplicated chromatin in two models of cell identity change. They find that lineage-specific elements are accessible earlier in rep...

The company behind the test said there were positive signs that some of the most aggressive cancers could be prevented.

CASERTA – Sono stata particolarmente colpita dalla notizia che un mio compagno di scuola, il dott. Vincenzo D’Angiolella, allievo del Liceo Classico “Domenico Cirillo” di Aversa (CE), sia diventato ti...

Temporary block on grant applications by MRC, BBSRC and EPSRC heightens concerns over funding cuts

Nature - PCNA–PAF15 has a key role in determining replisome dynamics during genome replication and protecting against genome instability.

Academic publishing system often allows scientific errors to persist because it prioritises profit and prestige over timely correction.

Some of Leeds’ top biological researchers have received two new Wellcome Discovery Awards, confirming the university’s status as a centre of excellence in biological research.

PhD Project - Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes at The University of Manchester, listed on FindAPhD.com

Among the ubiquitin-like superfamily, small ubiquitin-like modifiers (SUMOs) are the most well-understood. However, in comparison with the prototypical small modifier ubiquitin, our understanding of t...

CASERTA – Sono stata particolarmente colpita dalla notizia che un mio compagno di scuola, il dott. Vincenzo D’Angiolella, allievo del Liceo Classico “Domenico Cirillo” di Aversa (CE), sia diventato ti...