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Journal of Cell Science @jcellsci.bsky.social · 7h

Jin-Mo Gu, Andreas Nebenführ and colleagues discover that accelerated organelle movements can indirectly affect the motility of other organelles in plant cells. Highlight: journals.biologists.com/jcs/article/... Article: journals.biologists.com/jcs/article/...

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Journal of Cell Science @jcellsci.bsky.social · 29/09/2026

In their Review, Ishani Sharma and Partha Roy examine the cell-intrinsic, niche-specific and #immune controls that govern #cancer dormancy transitions, and the strategies aimed at blocking relapse. journals.biologists.com/jcs/article/...

Figure showing regulation of dormancy emergence of DTCs in the lung microenvironment. On arrival in the lung, DTCs lodge in the alveolar and perivascular niches. Dormancy is enforced by several converging cues. These include contact with AT1 lung epithelium (which promotes survival and restrains growth), anti-proliferative action of vascular endothelium-derived TSP-1, sequestration of tumor-derived ECM remodeling enzymes (e.g. LOXL2) by endothelial PEAR1, and activation of a NAS1-driven NR2F1-based dormancy transcriptional program by stromal cell-derived BMP. NR2F1 mediates suppression of ΔNp63, the pro-proliferative isoform of p63 (TP63). Reactivation (indicated by the proliferation marker Ki67) occurs when tumor cells interact with AT2 epithelium (which provides pro-proliferative signals). Additional reactivation cues include tumor-derived factors tenascin-C and Coco (which antagonizes BMP to release the dormancy brake via integrin-dependent FAK signaling; phosphorylated FAK is indicated as pFAK), sprouting angiogenesis (which supplies TGF-β1 and periostin), and activation of integrin-dependent ERK–MLCK signaling triggered by alterations in the ECM (e.g. fibrotic ECM and/or remodeling of laminin by NET-derived proteases like MMP9). Together, these opposing endothelial, epithelial, stromal and matrix inputs determine whether DTCs remain dormant or undergo metastatic outgrowth in the lung. Created in BioRender by Sharma, I., 2026. https://BioRender.com/j23rlwk. This figure was sublicensed under CC-BY 4.0 terms.

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Jez Carlton @jezcarlton.bsky.social · 28/09/2026

Hey! Submit your papers, and spread the word, this will be great! Thanks for inviting us @jcellsci.bsky.social and great to work with @pihanson.bsky.social on this issue!

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Journal of Cell Science @jcellsci.bsky.social · 28/09/2026

Our second special issue for 2027 will focus on the topic of membrane dynamics and repair. We invite you to submit your latest research to this issue, which will be coordinated by our Guest Editors @jezcarlton.bsky.social and @pihanson.bsky.social. journals.biologists.com/jcs/pages/me...

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Journal of Cell Science @jcellsci.bsky.social · 28/09/2026

Cutting corn-ers: @stephanieemartinez.bsky.social and @carolynplants.bsky.social discover that KATANIN p60 guides asymmetric division plane positioning in maize. Highlight: journals.biologists.com/jcs/article/... Article: journals.biologists.com/jcs/article/...

Figure showing that PPBs are incompletely formed in p60 mutants.

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Journal of Cell Science @jcellsci.bsky.social · 25/09/2026

Rui-Jie Ma, Shao-Chen Sun and colleagues discover that TRIM28 regulates the G2/M transition via histone modification and DNA damage repair during mouse oocyte meiosis. journals.biologists.com/jcs/article/...

Figure showing that TRIM28 regulate histone modifications in NSN-type mouse GV oocytes.

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Journal of Cell Science @jcellsci.bsky.social · 24/09/2026

Anne Ashford, Simon Cook @drsimoncook.bsky.social @babrahaminst.bsky.social and colleagues use phosphoproteomics to identify novel DYRK1B targets and establish DYRK1B as a regulator of processing body abundance. journals.biologists.com/jcs/article/... #OpenAccess #ReadandPublish

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Mélanie Laurin @melanielaurin.bsky.social · 23/09/2026

🎉 Excited to share our latest work led by Diana Hotea. Congratulations to Diana and the team for bringing this work across the finish line! 👏🔬🧫🎉 FGD1 restrains actomyosin contractility to promote suprabasal junction maturation in stratified keratinocytes journals.biologists.com/jcs/article/...

journals.biologists.com

FGD1 restrains actomyosin contractility to promote suprabasal junction maturation in stratified keratinocytes

Summary: We identify FGD1 as a regulator of suprabasal adherens junction remodeling that restrains actomyosin contractility to coordinate cytoskeletal organization and epithelial tissue mechanics.

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Journal of Cell Science @jcellsci.bsky.social · 22/09/2026

Issue 17 is complete Explore our Toc: journals.biologists.com/jcs/issue/13... Our cover image shows a pupal Drosophila abdomen 14 h after pupariation labelled with E-Cadherin (green) with nuclei of pannier-GAL4 expressing cells in magenta. See Lyon et al. journals.biologists.com/jcs/article/...

JCS Cover: Dorsolateral view of a pupal Drosophila abdomen at 14 h after pupariation. Apical junctions are marked with E-Cadherin–GFP (green) whereas the nuclei of cells expressing pannier-GAL4 are labelled with His2A–RFP (red). At this time point, the abdomen is predominantly composed of large polyploid larval epidermal cells (LECs), which are destined to undergo apoptosis as development progresses. The small diploid histoblasts that eventually form the adult epithelium are visible in small nests along the lateral (right-hand) side of the abdomen, having just begun to proliferate at this early developmental stage. See article by K. Lyon et al. (jcs264798).

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The Company of Biologists @biologists.bsky.social · 21/09/2026

Applications are now open for early-career researchers to apply for a funded place at our Workshop on Membrane Function: Insights from Cellular Diversity and Evolution, organised by Snezhana Oliferenko @alebenoit.bsky.social & Cunqi Ye. Find out more and apply www.biologists.com/workshops/ju...

Membrane Function: Insights from Cellular Diversity and Evolution
Date: 13 – 16 June 2027

Location: Buxted Park, East Sussex, UK
Organisers: Snezhana Oliferenko and Cunqi Ye

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Journal of Cell Science @jcellsci.bsky.social · 18/09/2026

Did you know… JCS encourages the involvement of postdocs & other ECRs in the peer review process. Find out more in our reviewer guide: journals.biologists.com/jcs/pages/re... #PRW2026 #PeerReviewWeek We'd like to take this opportunity to thank all the researchers that have reviewed for us.

JCS Cover: Fluorescence micrograph of the female reproductive tract of Drosophila melanogaster. The image highlights the oviduct, spermathecae, seminal receptacle and associated reproductive organs involved in fertilisation and egg deposition, together with mature eggs poised for laying. Cell nuclei are shown in turquoise (DAPI), while enhanced fluorescence displayed in violet provides contrast for visualisation of additional structural features of the reproductive tract. See article by C. A. M. Costa et al. (jcs264328).

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Journal of Cell Science @jcellsci.bsky.social · 17/09/2026

We're now accepting submissions for our next special issue, which will focus on 'Proteostasis' and will be coordinated by two of our Academic Editors, Pedro Carvalho and Tamotsu Yoshimori. Submission deadline: 2 November Find out more: journals.biologists.com/jcs/pages/pr... #proteostasis

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Seema Grewal @seemagrewal.bsky.social · 16/09/2026

Working on #cellmigration? Join us online tomorrow for the second webinar in our series, hosted by @pjsaez.bsky.social and @valeriaventurini.bsky.social

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Journal of Cell Science @jcellsci.bsky.social · 17/09/2026

Kyle Lyon, Samuel Manning and Richard Burke find that the Hippo signalling pathway regulates the timing of epithelial cell replacement during #Drosophila abdominal #morphogenesis. journals.biologists.com/jcs/article/...

Figure showing that downregulating Hippo pathway-dependent transcription in LECs promotes their premature removal from the epithelium.

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Journal of Cell Science @jcellsci.bsky.social · 16/09/2026

Did you know… Through our publisher @biologists.bsky.social, we fund the restoration & preservation of ancient woodlands. These trees are dedicated to our peer reviewers. The trees are also represented in our virtual forest: forest.biologists.com/landscape/ #PRW2026 #PeerReviewWeek

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Journal of Cell Science @jcellsci.bsky.social · 16/09/2026

Goutham Kodakandla, Ying Fan, Darren Boehning and colleagues discover that the protein acyltransferase DHHC21 S-acylates STIM1 in vitro and in vivo to regulate Ca2+ homeostasis and immune cell function. journals.biologists.com/jcs/article/... #OpenAccess #ReadandPublish

Figure showing that DHHC21 KO cells have impaired SOCE.

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Journal of Cell Science @jcellsci.bsky.social · 15/09/2026

Did you know… JCS is one of the affiliate journals of @reviewcommons.org, a platform for high-quality, journal-independent peer review of manuscripts from the life sciences before submission to a journal. #PRW2026 #PeerReviewWeek Our collection: journals.biologists.com/collection/1...

JCS cover: Deconvolved confocal images showing a lateral view of the tail of the nematode Caenorhabditis elegans, highlighting the localisation of epidermal AGEF-1 (an orthologue of BIG2; gold, cyan and orange puncta in the top, middle and bottom images, respectively) and RAB-35 (cyan, green and yellow blobs and striated patterns in the top, middle and bottom images, respectively). AGEF-1 interacts with RAB-35 in the nematode epidermis to modulate the integrity of touch-sensing nerves embedded within the skin. See article by I. Bonacossa-Pereira et al. (jcs264565), a Review Commons transfer.

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Journal of Cell Science @jcellsci.bsky.social · 15/09/2026

Aleksandra Tempes, Agnieszka Brzozowska, Jacek Jaworski, Anna Malik and colleagues find that phosphorylation of adaptor protein AP2 coordinates clathrin-mediated endocytosis. Highlight: journals.biologists.com/jcs/article/... Article: journals.biologists.com/jcs/article/...

Figure showing that lack of S45 phosphorylation of AP2 μ2 mimics the effects of p70S6K inhibition on transferrin internalization.

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The Company of Biologists @biologists.bsky.social · 14/09/2026

We are pleased to welcome Dan Shanahan as our new CEO. Dan brings extensive publishing expertise and market knowledge to the role, with a strong background in Open Access publishing and non-profit organisations.Read more at www.biologists.com/stories/welc...

biologists.com

Welcome Dan Shanahan

The Company of Biologists is pleased to welcome Dan Shanahan as the new Chief Executive Officer, effective from 14 September 2026.

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Journal of Cell Science @jcellsci.bsky.social · 14/09/2026

Did you know… If you have a paper that's been reviewed elsewhere, we can consider your manuscript for a fast-track decision. Send us the paper, reviewer reports and decision letters, and we’ll use these to make a decision. #PRW2026 #PeerReviewWeek journals.biologists.com/jcs/pages/re...

JCS cover: Our cover image shows muscle fibre basement membranes and intramuscular nerves labelled for laminin (cyan), SV2 & neurofilament M (yellow) and nuclei (magenta).

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Journal of Cell Science @jcellsci.bsky.social · 14/09/2026

Sakshi Jain, Upendra Nongthomba and colleagues find that Beadex modulates haematopoiesis and innate immune defence against microbial infection in Drosophila melanogaster. journals.biologists.com/jcs/article/...

Figure showing that Beadex regulates phagocytosis and actin cytoskeleton dynamics in larval haemocytes. Confocal images and quantitative analysis of haemocytes isolated from wandering third instar larvae.

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Journal of Cell Science @jcellsci.bsky.social · 11/09/2026

Apocalypse? Nah! Part II – two roads diverge Mole considers how AI can/will/has changed how we interact with scientific literature journals.biologists.com/jcs/article/...

Original artwork by Pete Jeffs. Sketch of ‘Mole’ wearing a pointed hat looking at a crystal ball. Mole is saying “I look, I look, I see, I see...” The teapot, which is also wearing a pointed hat and sitting on a table responds, “…me thinks, me thinks, Mole has had too much tea!”

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Journal of Cell Science @jcellsci.bsky.social · 10/09/2026

Our latest interview is with Stephen Tait @mitosrus.bsky.social, winner of the 2026 @bscb-official.bsky.social Hooke Medal. We caught up with Stephen to discuss this award, his research and his career path. journals.biologists.com/jcs/article/...

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Seema Grewal @seemagrewal.bsky.social · 09/09/2026

Save the date! The next @jcellsci.bsky.social meeting will be on the topic of #metabolism and we’re excited to be teaming up with our sister journals, @dev-journal.bsky.social and @dmmjournal.bsky.social. Registration will open later in the year but you can register your interest now 👇

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Journal of Cell Science @jcellsci.bsky.social · 09/09/2026

Susanne Steigleder, Julian Nüchel @jnuechel.bsky.social, Marius Lemberg @marius-lemberg.bsky.social and colleagues identify a Golgi-bypass secretion mechanism for proTGFα involving TMED9 and GRASP65. journals.biologists.com/jcs/article/...

Proposed mechanism of TMED9- and GRASP65-induced unconventional proTGFα secretion.

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Journal of Cell Science @jcellsci.bsky.social · 08/09/2026

In these two studies, Leanna Leverton, Dharma Pally, Alexandra Naba nabalabuic.bsky.social & team dissect the role of SNED1 in ECM construction and remodelling. Highlight: journals.biologists.com/jcs/article/... 1: journals.biologists.com/jcs/article/... 2: journals.biologists.com/jcs/article/...

Figure showing that SNED1 colocalises with fibronectin and collagen I during ECM assembly.

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Journal of Cell Science @jcellsci.bsky.social · 07/09/2026

In this Review, James Conway @jrwconway.bsky.social discusses how integrin function is dynamically shaped by post-translational modifications. journals.biologists.com/jcs/article/...

Schematic of several PTMs investigated for their roles in regulating integrin functions. PTMs occurring on integrin β-subunits, including some of their known regulators and adaptors are shown. Integrins span the plasma membrane, with large extracellular domains that bind extracellular matrix (ECM) ligands, and short cytoplasmic tails that serve as platforms for intracellular signalling and mediate binding to the cell cytoskeleton. Glycosylation adds sugars to the extracellular domains via glycosyltransferases and glycosidases. Phosphorylation of conserved tyrosine (Y) or serine (S) and threonine (T) residues in the cytoplasmic tails can regulate the binding of different adaptor proteins and supports the dynamic roles of integrins during cell migration. Some of the known kinases and phosphatases that add or remove these modifications, respectively, are shown. Further PTMs can be made to other cytoplasmic residues, including ubiquitylation (i) or acetylation (ii) of lysine residues (K).

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Journal of Cell Science @jcellsci.bsky.social · 07/09/2026

Issue 16 is complete Explore our Toc: journals.biologists.com/jcs/issue/13... Our cover image shows muscle fibre basement membranes and intramuscular nerves. The image was acquired by @beccasimkin.bsky.social and was the winner of the @focalplane.bsky.social -ELMI2026 image competition.

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Jeremy Reiter @reitergroup.bsky.social · 05/09/2026

Check out the gorgeous expansion pix of diverse photoreceptors from Beltran et al @upenn.edu. The periciliary membrane of humans differs from that of dogs (and probably mouse). Could be why many mouse models of Usher syndrome don't show retinal degeneration? journals.biologists.com/jcs/article/...

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The Company of Biologists @biologists.bsky.social · 07/09/2026

Save the date - @dev-journal.bsky.social, @jcellsci.bsky.social and @dmmjournal.bsky.social are holding a meeting on #Metabolism 📅21 – 23 June 2027 📍St Mary’s Marylebone, London, UK Register your interest for #BiologistsMetabolism now www.biologists.com/meetings/met...

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Katie Pickup @katiepickup.bsky.social · 04/09/2026

Excited to attend @gensocuk.bsky.social RNA in physiology and disease in Newcastle next week! Please say hi if you want to know more about publishing in @jcellsci.bsky.social, @dmmjournal.bsky.social or @dev-journal.bsky.social, or about @biologists.bsky.social grants & sustainability initiatives

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Journal of Cell Science @jcellsci.bsky.social · 04/09/2026

Mario Pinar, Miguel Peñalva @miguelpenalva.bsky.social and team find that a subcomplex comprising TRAPPC11, TRAPPC12, TRAPPC13 and the fungal TRAPPC2L homolog, Tca17, targets Aspergillus TRAPPIII to autophagy. journals.biologists.com/jcs/article/... #OpenAccess #ReadandPublish

Figure showing that the localisation of Trs85 to PASs is impaired in cells lacking Trs33 or the Tca17 and TRAPPC11/12/13 subcomplex.

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Journal of Cell Science @jcellsci.bsky.social · 03/09/2026

Sibylle Schleich and Aurelio Teleman @telemanlab.bsky.social identify that stress- and mitosis-induced phosphorylation of NIFK at Ser247 by p38–MSK1 and Aurora B, respectively, primes mitotic hyperphosphorylation and promotes timely mitotic entry. journals.biologists.com/jcs/article/...

NIFK is phosphorylated on Ser247 by Aurora B during mitosis.

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Journal of Cell Science @jcellsci.bsky.social · 02/09/2026

Daniel Rioux, Samreen Manj and Derek Prosser find that Avl9 links recycling and secretion during vesicle trafficking. Highlight: journals.biologists.com/jcs/article/... Article: journals.biologists.com/jcs/article/...

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Gerry Hammond @gerryhammond.bsky.social · 28/08/2026

There is nothing as beautiful as cells... my favorite art (says the cell biologist!) cob.silverchair-cdn.com/cob/content_... From this week's @jcellsci.bsky.social cover, showing aortic endothelial cells from an article by M. M. Islam et al. (jcs264023).

A beautiful field of cells stained for their cytoskeleton with yellow and magenta colored fluorescent dyes

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Journal of Cell Science @jcellsci.bsky.social · 01/09/2026

Vitaly Zimyanin, Magdalena Magaj, Stefanie Redemann and team discover that KLP-19 regulates microtubule overlap and dynamics during anaphase in C. elegans. journals.biologists.com/jcs/article/...

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Naba Lab UIC @nabalabuic.bsky.social · 31/08/2026

1/5 📣 Hot off the press: Two papers, one story on the mechanisms of ECM assembly now out in @jcellsci.bsky.social! I am delighted to share two companion studies from our lab exploring the mechanisms of SNED1 fibrillar assembly into the #ECM and how SNED1 shapes ECM architecture and cell phenotype.

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Journal of Cell Science @jcellsci.bsky.social · 28/08/2026

Apocalypse? Nah! Part I – future tense Mole considers how AI can/will/has changed how we interact with scientific literature journals.biologists.com/jcs/article/...

Cartoon of an anthropomorphised mole sticking its head out of ‘Mole lab’ to talk to two headphone-wearing molelets. Mole says, “Ah-Gen-M!!! Listening to paper on their AI players…. They reply, “No way, Mole!” “…We’re mini-prepping to Kanda Bongo Man”
Original artwork by Pete Jeffs

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Journal of Cell Science @jcellsci.bsky.social · 27/08/2026

We invite you to submit your latest research to our upcoming special issue: Proteostasis. This issue will be coordinated by two of our Academic Editors: Pedro Carvalho and Tamotsu Yoshimori. journals.biologists.com/jcs/pages/pr...

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Journal of Cell Science @jcellsci.bsky.social · 27/08/2026

Iker Benavides-Puy, Jakob Nilsson and colleagues discover that regulation of the PP2A-B55 by the FAM122A depends on a bipartite binding mechanism and is regulated by phosphorylation of FAM122A. journals.biologists.com/jcs/article/...

Figure showing that FAM122A Ser158 is required for PP2A-B55 inhibition and efficient mitotic entry.

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Journal of Cell Science @jcellsci.bsky.social · 26/08/2026

Md Mydul Islam, Vignesharavind Subramanianbalachandar and Robert Steward, Jr interrogate endothelial cell biomechanical adaptation to altered connexin 43 expression under fluid shear stress. #OpenAccess #ReadandPublish journals.biologists.com/jcs/article/...

Figure showing impact of chalcone on tractions and intercellular stress.

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Journal of Cell Science @jcellsci.bsky.social · 25/08/2026

Hirokazu Suzuki, Norikazu Yabuta and colleagues find that ribosomal RNA transcription is regulated by sequestration of LATS2 and PHF6 to the nuclear speckles following DNA damage. journals.biologists.com/jcs/article/...

Figure showing that LATS2 promotes rRNA transcription.

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The Company of Biologists @biologists.bsky.social · 25/08/2026

@jcellsci.bsky.social is looking to recruit an enthusiastic & motivated Reviews Editor. This is an exciting opportunity for a talented scientific editor to make a significant contribution to an important journal in the field of cell biology. Apply by 3 September. www.biologists.com/about-us/wor...

biologists.com

Work for us

Explore career opportunities at The Company of Biologists. Join a team passionate about science, publishing and community support.

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Journal of Cell Science @jcellsci.bsky.social · 24/08/2026

K Aruna, Mitra Kulkarni and Samarjit Bhattacharyya uncover a novel role for dopamine in metabotropic glutamate receptor internalization and synaptic AMPA receptor endocytosis. journals.biologists.com/jcs/article/...

Figure showing dose response and time course of dopamine-mediated internalization of mGluR1.

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The Company of Biologists @biologists.bsky.social · 22/08/2026

We are gathering feedback from our readers, authors and reviewers about the use of AI tools in scholarly publishing. Have your say at: www.surveymonkey.com/r/ZBFC663

Community survey - The role of AI tools in scholarly publishing

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