iiinova — where your digital self keeps evolving

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Anh Hoang Le, PhD 🏳️‍🌈🏴󠁧󠁢󠁳󠁣󠁴󠁿🇻🇳 @anhhle2702.bsky.social · 13h

Im still waiting to hear their response. Tomorrow will be the final day to respond based on their comment. Lets see after their (hopefully) extensive checking, there will be a verdict. If they fail to at least give us something tmr, nobody will take Nikon seriously anymore.

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Simon Cleary @simoncleary.bsky.social · 13h

It was good that Nature News did comment on the winner's unwillingness to show non-edited images. It is telling and was missed in the pieces from The Scientist and BBC News.

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Simon Cleary @simoncleary.bsky.social · 15h

This stood out in the Nature news coverage. I don't think that we will ever get to see the underlying data.

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Nikolai Slavov @slavov-n.bsky.social · 30/09/2026

bioRxiv has a dedicated section for negative results. Use it. Share negative results. Your colleagues will appreciate it.

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Gaspar Jekely @jekely.biologists.social.ap.brid.gy · 30/09/2026

If you are interested in serial sectioning for electron microscopy, we have now uploaded a revised version of our paper Shahidi et al: "Volume Electron Microscopy: Tips & Tricks on Micromanipulator-Assisted Serial Sectioning for Array Tomography" […] [Original post on biologists.social]

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Mathilda Lennartz @mathilda95.bsky.social · 30/09/2026

UPDATE!: I am absolutely stoked that the second paper of my PhD is now out in @natcellbio.nature.com :D. We combined lipid imaging, STED microscopy, and mathematical modelling in a super cool team effort to quantify lipid partitioning inside clathrin-coated pits. www.nature.com/articles/s41....

nature.com

Quantification of lipid sorting during clathrin-mediated endocytosis - Nature Cell Biology

Lennartz et al. evaluate lipid enrichment in clathrin-coated pits and observe that the differential lipid partitioning into clathrin-coated pits is largely driven by the lipid asymmetry of the plasma ...

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Ian Scott @icscott.bsky.social · 29/09/2026

Exciting opportunities at a world-class institute in Toronto! apply.interfolio.com/192324

apply.interfolio.com

Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio

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Needhi Bhalla 💅🏽 @needhibhalla.bsky.social · 29/09/2026

The wrong fucking people have imposter syndrome

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Mark Peifer (He, him) @peiferlabunc.bsky.social · 29/09/2026

For the last 34 years I have been on the faculty of the UNC-Chapel Hill Department of Biology and have never regretted that decision. This year we are hiring TWO new Assistant Professors in the broad area of Molecular, Cell, Developmental Biology 1/n bio.unc.edu

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Jez Carlton @jezcarlton.bsky.social · 28/09/2026

Hey! Submit your papers, and spread the word, this will be great! Thanks for inviting us @jcellsci.bsky.social and great to work with @pihanson.bsky.social on this issue!

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Aaron Rupar @atrupar.com · 28/09/2026

Trump on Canada: "They have been one of the worst countries in the entire world"

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Jaclyn A. Siegel, PhD @jacasiegel.bsky.social · 27/09/2026

There is not an endless supply of peer reviewers with an endless supply of hours. People's time, generosity, and willingness to participate in unpaid labor are finite resources for our field. The more manuscripts we pump into the peer review system, the work we create for reviewers.

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Zebrafish Rock! @zebrafishrock.bsky.social · 27/09/2026

Electrochemical response triggers organ growth, following tail injury in a #zebrafish embryo. Credit to @ritamateus.bsky.social, @nerlielisa.bsky.social, & @liujinghui.bsky.social. #ZebrafishZunday

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Valentin Dunsing-Eichenauer @dunsingvalentin.bsky.social · 26/09/2026

Thank you Pleasantine! Yes, sure. The movie was acquired on a Zeiss Lattice Light-sheet system. Cilia were stained with SiR-tubulin. Imaging was performed in a single 2D cross-section with very short camera exposure time (2ms). The sample is a 7w ALI culture from primary patient-derived lung cells.

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Michael Way @drmichaelway.bsky.social · 26/09/2026

Arp2/3 iso-complexes strike again! Axonal actin ring assembly and maintenance involves different iso-complexes that change expression during neuronal maturation 🎉 Great collaboration with Ana Rita Costa & Monica Sousa @ i3S in Porto www.i3s.up.pt/research-gro... www.science.org/doi/10.1126/...

science.org

Distinct Arp2/3 isocomplexes drive axonal actin ring assembly and integrity

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A/Prof Sam Stehbens PhD (She/Her) @samstehbens.bsky.social · 26/09/2026

#Nikon will address our concerns by next week. Hopefully the pre-processed movie & raw data will be part of that. #NikonSmallWorld

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Venkat Rao @venkyrao.bsky.social · 26/09/2026

Jumping on the bandwagon with a 3D view of Xenopus multiciliated cells: cilia (magenta) sprouting above the apical actin network (cyan) 🐸. Not live, but no #AISLOP

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Rebecca D. Burdine, PhD @rburdine1.bsky.social · 25/09/2026

@healthcare.nikon.com out of respect for the individuals dealing with PCD if nothing else, you need to retract this award. There is no way that is a AI enhanced representation of actual data. It's an AI created image that bears no reality to what biologist see when they look at multiciliated cells.

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Joachim Goedhart @joachimgoedhart.bsky.social · 25/09/2026

I think it is crucial for all of us to see how different the actual and published data are - it this point it is not even clear whether the original data was a timeseries or a single image.

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Mia Konjikusic, PhD @konjikusicmia.bsky.social · 25/09/2026

To add to all the lovely videos of non-AI processes multicilia beating: ctenophore multiciliated cells! They can reach up to 1mm long, causing a rainbow light refraction effect with the correct light positioning! Taken by myself at MBL in 2019 embryology. Realtime frame-rate!

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Anh Hoang Le, PhD 🏳️‍🌈🏴󠁧󠁢󠁳󠁣󠁴󠁿🇻🇳 @anhhle2702.bsky.social · 25/09/2026

Happy #FluorescenceFriday. The first time I imaged a 🐸 embryo, I didn't realise they had these ciliated cells on the outer surface. So you can imagine how surprised and curious I was! These cilia are similar to those found in the human airway. And yes, this is just a good old confocal + 🔥LUT!

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Valentin Dunsing-Eichenauer @dunsingvalentin.bsky.social · 25/09/2026

#FluorescenceFriday: Given the recently grown interest in ciliary beating, here is a movie of beating cilia in a human airway model that I captured last week with lattice light-sheet microscopy. No AI „processing“, this is the raw data! Frame rate is ca. 170fps, displayed here at 25fps.

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Christophe 🔬 Leterrier @christlet.bsky.social · 25/09/2026

Here's a balanced account of where the microscopy community stands on AI use by this year's Small World in Motion winner. My main issue is that no one seems to have seen the original data despite requests (no mention of it being reviewed by the organizers) www.the-scientist.com/allegations-...

the-scientist.com

Allegations of AI Use in Nikon Competition Spark Controversy | The Scientist

Microscopists raise concerns about inappropriate AI usage in Nikon's microscopy contest-winning video. Nikon stands their ground, citing no policy breach.

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Jorge Ferreira @jorgeferreira.bsky.social · 25/09/2026

Don´t know yet what you´ll be doing next April? Why not join us for a great meeting in Porto? Registration for Forces across scales is now open! meetings.embo.org/event/27-for...

meetings.embo.org

Forces across scales

This EMBO Workshop on Forces Across Scales will provide an integrative perspective on mechanobiology, a rapidly advancing field that examines how mechanical forces shape biological systems across mol…

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John Stott @jpsastro.bsky.social · 24/09/2026

Had a UKRI funded grant proposal rejected at the "AI triage stage". "This AI-based triage was used only to identify approximately 50% of the strongest proposals to take forward to full human review." 🧪 #academicsky

I am writing to let you know that, unfortunately, your application was not successful.

Review process

As part of the initial triage of the 179 proposals submitted to this call, each was assessed using an AI-based review. Every proposal was read independently by several different AI models against the same seven criteria used to shape this call (including cyber security relevance, research quality and novelty, importance of the problem addressed, feasibility of the project plan, likely outputs and impact, value for money, and responsible research practice), with each model asked to give a score and a written justification with supporting quotations from the text. To guard against any one model's idiosyncrasies, we also ran a second, independent process in which different AI models debated the merits and weaknesses of each proposal before reaching a judgement, again against the same criteria. Scores from both processes were combined to produce an overall ranking.

This AI-based triage was used only to identify approximately 50% of the strongest proposals to take forward to full human review. Projects selected for funding were drawn from those that progressed to the full human review stage. We recognise that AI-assisted assessment is a new and evolving part of the review process, and we are continuing to evaluate how well it aligns with the judgements of human reviewers on this call. We will soon produce a document detailing our method, so that others can build upon it and improve it.

Feedback on your application

Your application was not selected to progress beyond the AI triage stage. To provide transparency on the outcome of this assessment, we are sharing below the scores (out of 5) from each of the two AI review processes described above, together with the mean score across the two processes.

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Maria Barna @mbarnalab.bsky.social · 25/09/2026

Last chance to register for the ribosome heterogeneity and translation control meeting. Selected talks from abstracts and an excellent lineup of speakers! Please repost and register today!

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Hao Yin @haoyin.bsky.social · 25/09/2026

Cilia - AI champion show🏆 Credit: GPT6-Astra Inspired by @christlet.bsky.social

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Paul & Virginie - Centriole Lab @centriolelab.bsky.social · 24/09/2026

No response from Nikon so far… The member of the judging panel I contacted was also very concerned and reached out to Nikon directly. I don’t know whether he has received a response either.

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Christophe 🔬 Leterrier @christlet.bsky.social · 24/09/2026

I think I'm going to lose it being lectured on microscopy image presentation integrity by the winner of the Small Artificial World in Motion competition

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Eugene Katrukha 🇺🇦 @ekatrukha.bsky.social · 23/09/2026

Preparing my submission for the next year's "Nikon Small World in Motion". It should qualify, since I wrote it on a PC connected to a microscope. No AI, pure GLSL GPU code www.shadertoy.com/view/f333Dj

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Emma R Andersson @anderssonlab.bsky.social · 23/09/2026

🧬 Preprint! 🧵 Our goal is to genetically manipulate every embryonic germ layer to enable high throughput in vivo studies. We previously showed mouse ectoderm can be targeted by amniotic injection, enabling cell-specific manipulation, lineage tracing, and knockouts. But how to reach mesoderm?

Schematic of method developed and application. At embryonic day 7.5, a lentiviral library carrying unique 30-nucleotide barcodes and a fluorescent reporter is injected into the mouse exocoelomic cavity. An E8 embryo cross-section shows that this cavity is continuous with the intraembryonic coelomic cavity, allowing the virus to reach and barcode mesodermal progenitors, including lateral plate and paraxial mesoderm.

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Christophe 🔬 Leterrier @christlet.bsky.social · 23/09/2026

As they are not active here, I left a comment on the LinkedIn post from Nikon Small World about the concerns I think I share with many (first screenshot is their post, second screenshot is my comment) lnkd.in/p/ecdT6saZ

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Christophe 🔬 Leterrier @christlet.bsky.social · 19/09/2026

Here's a way to get a pure science shot on Bluesky: a custom feed that only shows the posts from people you follow that are linked to a DOI bsky.app/profile/pape...

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c0nc0rdance @c0nc0rdance.bsky.social · 06/02/2025

A Pirate Ribosome's first love is the C ... (GU). (🧑‍🎨: Science Fried Art)

Pirate ribosome: a brown ribosome cartoon wears a pirate hat with skull and crossbones and eyepatch, and a long string of ARG amino acids is on the nascent chain, while an mRNA consisting of CGU repeats is labeled from 5' to 3'.

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Kirsty Wan @micromotility.bsky.social · 18/09/2026

The link states that the cilia were imaged with "diffractive super resolution microscopy" which is not a technique I have ever heard of... anyone?? Apparently based on this paper? (which at first glance does not seem as outrageous as the Nikon video) arxiv.org/abs/2512.13432

arxiv.org

Spatiotemporally decoupled super-oscillatory microscopy enables label-free reconstruction of human ciliary waveforms

Imaging native motile cilia requires label-free contrast, sub-diffraction spatial discrimination, and millisecond temporal sampling. We introduce Super-Oscillatory Label-free Inertia-free Scanning (SO...

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Simon Cleary @simoncleary.bsky.social · 18/09/2026

You can see the nice (label-free) images that this microscope modality produces in this preprint: doi.org/10.48550/arX... Not sure how you would get from this to the prize-winning image (with very long anenome-like cilia) without genAI shenanigans...

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Joachim Goedhart @joachimgoedhart.bsky.social · 18/09/2026

Anything is possible with antibodies from Thermo Fisher...

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László Tora @tlaszlo.bsky.social · 17/09/2026

Pierre Chambon was one of the driving architects of modern molecular biology, whose scientific vision transformed the understanding of gene regulation in eukaryotic cells. His passing in May 2026 represents the loss of an extraordinary scientist. www.nature.com/articles/s41...

nature.com

Pierre Chambon (1931–2026) - Nature Genetics

Nature Genetics - Pierre Chambon (1931–2026)

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The Company of Biologists @biologists.bsky.social · 14/09/2026

We are pleased to welcome Dan Shanahan as our new CEO. Dan brings extensive publishing expertise and market knowledge to the role, with a strong background in Open Access publishing and non-profit organisations.Read more at www.biologists.com/stories/welc...

biologists.com

Welcome Dan Shanahan

The Company of Biologists is pleased to welcome Dan Shanahan as the new Chief Executive Officer, effective from 14 September 2026.

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Alan Brown @alanbrownhms.bsky.social · 10/09/2026

Millions of beating cilia keep airways clean. At the base of each is the transition zone (TZ), a gate that controls which proteins enter and leave. In our paper out today in Science, we used cryo-FIB-ET to image the TZ inside human airway cells www.science.org/doi/10.1126/...

science.org

In situ structure of the human ciliary transition zone links linker defects to primary ciliary dyskinesia

The ciliary transition zone (TZ) regulates ciliary proteome composition, yet its molecular architecture, protein content, and contribution to motile ciliopathies remain poorly defined. We applied in situ cryo-electron tomography and subtomogram averaging ...

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Mihaly Badonyi @mbadonyi.bsky.social · 10/09/2026

AlphaFold can now predict protein complexes at unprecedented scale. But once we have a predicted complex, the core question of how much we should trust the interface remains. Existing confidence scores are useful, but their meaning is not always obvious. #alphafold

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Anh Hoang Le, PhD 🏳️‍🌈🏴󠁧󠁢󠁳󠁣󠁴󠁿🇻🇳 @anhhle2702.bsky.social · 07/09/2026

Very happy to share my postdoc paper is out now in @natcellbio.nature.com titled "Tissue flow acts as a guidance cue for immune cell polarization and directional migration". If you love imaging and immune cells, this is for you! #microscopymonday www.nature.com/articles/s41... A 🧵: 1/n

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Ishier Raote @ishier.bsky.social · 07/09/2026

Membrane Trafficking Seminar Series 2026 fall season is here! An exciting programme: membrane traffic, organelle biogenesis, lipid transport, endomembrane evolution, we have it all! Save the dates and join us for fun science and discussions. Details at felixcampelo.wixsite.com/membranetraf...

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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 27/08/2026

Kelly Nguyen, Group Leader in the LMB’s Structural Studies Division, has been awarded the 2027 Francis Crick Medal and Lecture from @royalsociety.org. Read more about @kellythd-nguyen.bsky.social’s research on telomerase here: mrclmb.ac.uk/news-events/... #LMBNews

Kelly Nguyen, smiling with a blurred background

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