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Boris Sieber

@borissieber.bsky.social
1.5K followers 1.6K following 24 posts

Postdoc @SophieMartinLab.bsky.social studying #MAPK signalling in fission yeast and emerging multicellular model organisms. Alumnus of @mjafreeman.bsky.social and @jordanraff.bsky.social Latest paper: www.nature.com/articles/s41467-026-…

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Reposted by Boris Sieber
Snezhka Oliferenko @alebenoit.bsky.social · 02/10/2026
Guys! @jbahler.bsky.social and I are recruiting a PhD student in this round - if you know great undergrads or Masters students please tell them about us! And Crick in general, of course ;) Thank you!!
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Bryan Roth @zenbrainest.bsky.social · 01/10/2026
Cool!! Systematic identification of p11 as a signaling modulator across the GPCRome | Science Advances www.science.org/doi/10.1126/...
science.org
Systematic identification of p11 as a signaling modulator across the GPCRome
The microprotein p11 (S100A10) is a ubiquitously expressed molecular scaffold that is known to be required for behavioral responses to certain antidepressants, presumably through its effect on G prote...
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Reposted by Boris Sieber
Philipp Radler @radler92.bsky.social · 01/10/2026
The first paper of my PostDoc in Christa Schlepers group (@archaea-vienna.bsky.social) on the dynamics of Asgard archaea is now out in Nature! www.nature.com/articles/s41... This was a great team effort and I am looking forward to uncover the complex behavior of these cells further!
nature.com
Dynamic protrusions mediate crawling motility in Asgard archaea - Nature
Anoxic live-cell imaging shows actin-dependent crawling motility and dynamic protrusions in Asgard archaea, providing insights into cellular innovations that may have contributed to eukaryotic evoluti...
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Matthew Freeman @mjafreeman.bsky.social · 30/09/2026
Yet another opportunity @dunnschool.bsky.social! We are looking for an Associate Professor If you have exciting research plans, @dunnschool.bsky.social is a great place: excellent science (and lovely people, obvs) www.path.ox.ac.uk/vacancy/asso...
path.ox.ac.uk
Associate Professorship of Cancer Biology - Sir William Dunn School of Pathology in association with the Queen’s College. - Dunn School
We are seeking to appoint an Associate Professor working in the area of the cellular and/or molecular biology of cancer, to be based in Oxford University’s Sir William Dunn School of Pathology. The ro...
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Mathilda Lennartz @mathilda95.bsky.social · 30/09/2026
UPDATE!: I am absolutely stoked that the second paper of my PhD is now out in @natcellbio.nature.com :D. We combined lipid imaging, STED microscopy, and mathematical modelling in a super cool team effort to quantify lipid partitioning inside clathrin-coated pits. www.nature.com/articles/s41....
nature.com
Quantification of lipid sorting during clathrin-mediated endocytosis - Nature Cell Biology
Lennartz et al. evaluate lipid enrichment in clathrin-coated pits and observe that the differential lipid partitioning into clathrin-coated pits is largely driven by the lipid asymmetry of the plasma ...
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Michael Way @drmichaelway.bsky.social · 28/09/2026
very cool science as always!
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Iñaki Ruiz-Trillo @multicellgenome.bsky.social · 28/09/2026
We have a new branch in the family tree of animals: Atreyea- a previously unrecognized lineage among the closest unicell relatives of animals. Led by @konsmitsi.bsky.social & @freejakoba.bsky.social together with a fantastic team of collaborators. 🔗 papers.ssrn.com/sol3/papers.... #protistsOnSky
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Kinga Kamieniarz-Gdula @stoplab.bsky.social · 26/09/2026
A thoughtful essay on AI use in science. Found it a good read.
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Michael Way @drmichaelway.bsky.social · 26/09/2026
Arp2/3 iso-complexes strike again! Axonal actin ring assembly and maintenance involves different iso-complexes that change expression during neuronal maturation 🎉 Great collaboration with Ana Rita Costa & Monica Sousa @ i3S in Porto www.i3s.up.pt/research-gro... www.science.org/doi/10.1126/...
science.org
Distinct Arp2/3 isocomplexes drive axonal actin ring assembly and integrity
The actin-related protein 2/3 (Arp2/3) complex is a central nucleator of branched actin filaments, essential for numerous cellular processes. Using superresolution imaging, we demonstrate that Arp2/3 ...
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Emmanuel Levy's lab @elevylab.bsky.social · 25/09/2026
It took a while, but here we are. Our micDROP paper is out in @natcomms.nature.com, led by @atargt.bsky.social. She asked whether the sequence of a disordered region can self-recognize specifically. She measured this for ten IDRs in living yeast cells. www.nature.com/articles/s41...
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Kate Baker @ksbakes.bsky.social · 25/09/2026
We have an open Assistant/Associate Professor position in Pathogen Biology at the Department of Genetics - come and join us! 🦠 🧫 🧬https://www.cam.ac.uk/jobs/assistantassociate-professor-in-pathogen-genetics-pc51175
cam.ac.uk
Assistant/Associate Professor in Pathogen Genetics
Applications are invited for an Assistant or Associate Professorship in Pathogen Genetics to be held in the Department of Genetics. We are searching for a talented individual with a track record of fu...
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David Drubin @drubin.bsky.social · 22/09/2026
In a new preprint we provide evidence that biophysical properties of protein condensates can explain the order of events in the endocytic pathway, and that these events are tuned by protein condensate phosphorylation. www.biorxiv.org/content/10.6...
biorxiv.org
Phosphoregulation of hierarchical protein condensate formation during clathrin-mediated endocytosis
The sequential assembly of over 50 proteins during clathrin-mediated endocytosis (CME) is well documented in yeast. However, the mechanisms governing this ordered recruitment remain poorly understood....
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André Nadler @nadlerlab.bsky.social · 23/09/2026
This my friends, this is the big one. A long time coming. Lipid Cell Biology is coming of age and even for a hot field, this is a true game changer. This dataset will keep us all busy for years to come. Congrats to everybody on this amazing crew!!! Go party!!
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H. B. Beryl Rappaport @hbrappap.bsky.social · 22/09/2026
Our description of fire amoeba, 𝘐𝘯𝘤𝘦𝘯𝘥𝘪𝘢𝘮𝘰𝘦𝘣𝘢 𝘤𝘢𝘴𝘤𝘢𝘥𝘦𝘯𝘴𝘪𝘴, is now online at Cell! Thanks @oliverio.bsky.social and amazing team for questioning the limits of eukaryotes! 🔥 www.cell.com/cell/fulltex...
cell.com
A geothermal amoeba sets a new upper temperature limit for eukaryotes
The amoeba Incendiamoeba cascadensis demonstrates that eukaryotic life can withstand temperatures beyond what was thought possible and sheds light on molecular strategies for survival in extreme heat.
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The Company of Biologists @biologists.bsky.social · 21/09/2026
Applications are now open for early-career researchers to apply for a funded place at our Workshop on Membrane Function: Insights from Cellular Diversity and Evolution, organised by Snezhana Oliferenko @alebenoit.bsky.social & Cunqi Ye. Find out more and apply www.biologists.com/workshops/ju...
Membrane Function: Insights from Cellular Diversity and Evolution
Date: 13 – 16 June 2027

Location: Buxted Park, East Sussex, UK
Organisers: Snezhana Oliferenko and Cunqi Ye
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Buzz Baum @buzzbaum.bsky.social · 22/09/2026
We are looking for a research assistant! Come join the team: www.jobs.ac.uk/job/DSZ826/r...
jobs.ac.uk
Research Support Officer | Cell Biology | Dr Buzz Baum | LMB 2904 at MRC Laboratory of Molecular Biology
Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...
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Martin Pacesa @martinpacesa.bsky.social · 21/09/2026
ʙɪɴᴅᴄʀᴀꜰᴛ2 is out, and we're not waiting for the paper. The full code drops today, free for academic and industry use. We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition. github.com/PacesaLab/Bi...
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Thomas Arnesen @natmachinery.bsky.social · 21/09/2026
Coenzyme A biosynthesis is regulated by two distinct Ubiquitin E3 ligase complexes | UBR4-KCMF1 and MKLN1-CTLH independently converge on a common N-terminal MK Arg/N-degron to promote PANK degradation and restrict CoA biosynthesis | @ispt-proteinterm.bsky.social www.biorxiv.org/content/10.6...
biorxiv.org
Parallel Arg/N-degron recognition systems regulate coenzyme A biosynthesis
Coenzyme A (CoA) is an essential metabolic cofactor whose biosynthesis is controlled by pantothenate kinases (PANKs), the rate-limiting enzymes in CoA synthesis. Although CoA production is extensively...
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Reposted by Boris Sieber
Akos Nyerges @akosnyerges.bsky.social · 19/09/2026
Proud and excited to share our first preprint 🚀 in which we • create a high-fitness firewalled organism, • that stably colonizes the mouse gut for >100 days, • resists all tested phages in the gut, • and blocks horizontal gene transfer. + A new method: Chimera genomes to tailor existing synthetic
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The EMBO Journal @embojournal.org · 18/09/2026
What defines limits & regulation of epigenetic inheritance? Florian Steiner et al show altered genomic distribution of histone modification H3K27me3 can be transmitted across C. elegans generations through successive SET-32 & MES-4 action that alters its deposition link.springer.com/article/10.1...
link.springer.com
Transgenerational inheritance of altered H3K27me3 in wild-type Caenorhabditis elegans - The EMBO Journal
Epigenetic inheritance provides mutation-free mechanisms for phenotypic adaptation, including modifications to DNA or DNA-associated proteins that create patterns of heritable gene regulation. However...
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MwahahahahahadScientist @mads100tist.bsky.social · 17/09/2026
You know what's also interactive? Reading the paper. Talk to your colleagues about the paper you just read. Tell them why you loved it. Tell them why you hated it. And even better: invite the authors to talk about their paper 🧪
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Anna Bodzeta @annabodzeta.bsky.social · 17/09/2026
Here it is my 1st preprint about synapse and rhomboid intramembrane protease: www.biorxiv.org/content/10.6... Using imaging and biochemistry, together with @adamgrieve.bsky.social we identify RHBDL2 as a membrane-immersed regulator of synapses architecture. 1/2
biorxiv.org
The unhindered lateral mobility of a rhomboid intramembrane protease enables synapse remodelling
Synapses must maintain their stable molecular organisation while retaining the capacity to remodel in response to changing demands. In order to flexibly change synaptic strength, the abundance of tran...
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Felix Campelo @felixmendu.bsky.social · 16/09/2026
A great PhD opportunity with my former @icfo.eu colleague and friend Pamina Winkler, now starting her group at @cicbiomagune.bsky.social in beautiful San Sebastian! Biophysics, cell biology, protein interactions & advanced imaging 🔬, check it out: www.cicbiomagune.es/job-offer-de...
cicbiomagune.es
Job offer detail | CIC biomaGUNE
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Milot Mirdita @milot.bsky.social · 16/09/2026
ColabFold 1.6.3 is out! 2.5x faster, pip-installable, ipSAE+pDockQ2 scores. Thanks Choonghwan Lee, Marielle Russo, Gyuri Kim 🐍pip install colabfold[alphafold] CF2 Sneak Peak with AF3/Boltz/Protenix/ESMFold2… 🐍pip install "colabfold[alphafold3]@git+https://github.com/sokrypton/ColabFold@af3-preview"
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Sachin Kotak @spindlebehavior.bsky.social · 15/09/2026
Can light build centrosome-like activity? 💡🔬 Yes! We introduce LISA (Light-Induced Spindle Assembly), now in @emboreports.org. By clustering Aurora A with optogenetics, we build centrosome-like activity that nucleates microtubules and rescues spindle defects after centrosome loss. shorturl.at/9h3VQ
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Sjors Scheres @sjorsscheres.bsky.social · 15/09/2026
Michel Goedert and myself are looking for two postdocs to work on #cryoEM and #masspec of #alphasynuclein filaments from neurodegenerative disease. Come join our bubbly and friendly team at the @mrclmb.ac.uk in lovely Cambridge, UK. www.nature.com/naturecareer...
nature.com
Postdoctoral Scientist | Neurobiology | Dr Michel Goedert | LMB 2842 - Cambridgeshire job with MRC Laboratory of Molecular Biology | 12864505
Postdoctoral Scientist Salary £42,694 per annum Fixed term, 3 years MRC Laboratory of Molecular Biology, Cambridge, UK To work in the group of Dr M...
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Alex Ludwig @alexludwig.bsky.social · 14/09/2026
How do epithelial cells make a lumen as they polarize? We have some exciting new answers to this long standing question. Check out our new paper in which we show that lumen initiation is driven by large vacuoles that deliver a pre-assembled apical cortex to the AMIS: www.nature.com/articles/s41...
nature.com
Bulk delivery of a preassembled apical surface initiates epithelial lumen formation - Nature Communications
Epithelial lumen formation is fundamental to organ development, yet how apical surfaces first emerge remains unclear. Ghosh, Martin, and Chen et al., show that lumen initiation is driven via bulk deli...
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Ylva Ivarsson @ivarssonlab.bsky.social · 11/09/2026
Do you want to be my colleague? We are recruiting a tenured #Associate #Professor in #Biochemistry to the Department of Chemistry for Life Sciences at #Uppsala University. Deadline for application November 20. www.uu.se/en/about-uu/...
uu.se
Associate Professor in Biochemistry - Uppsala University
Associate Professor in Biochemistry, Department of Chemistry for life sciences, Uppsala University
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Andres Bendesky @bendeskylab.com · 11/09/2026
We have a tenure-track faculty position in Evolutionary Biology in Columbia's E3B Department. Application deadline is October 15. Come be our colleague. Please RT! apply.interfolio.com/193016
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
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Buzz Baum @buzzbaum.bsky.social · 11/09/2026
If you thought you understood how one cell becomes two (and imagined studying the problem using an organism that lives in deep sea volcanic vents was impossible), read Florian’s paper and think again!
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Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦ @dudinlab.bsky.social · 11/09/2026
Very proud of the team, led by @baukjeje.bsky.social & @fmikus.bsky.social To all of you doing #Expansion #Microscopy #UExM Try Concanavalin A. Its cheap, easy to use & labels the #nuclear #Envelope @moorefound.bsky.social @embl.org @sciencesunige.bsky.social @erc.europa.eu @snsf.ch
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Saravanan Palani @syncellbiolab.bsky.social · 10/09/2026
🚨 Our new @elife.bsky.social study dissects how a dividing cell keeps its septin scaffold and its contractile ring in step. 👉 elifesciences.org/articles/106... Spearheaded by @bindubhojappa.bsky.social #cellbiology #celldivision #septins #yeast #kinases
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David Maddison @bembidion.bsky.social · 08/09/2026
The Tree of Life Web Project is back online! tolweb.org Thanks to Travis Wheeler (@wheelerlab.org), Danny Mandel, and Andrew Lenards, the original programmers for ToLWeb, for retooling the code to work on a modern OS! It is hard for me to believe it lives again.
tolweb.org
Tree of Life Web Project
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Caitie McCafferty @computingcaitie.bsky.social · 09/09/2026
I am looking for a lab manager for my group that I will be starting at the @fmiscience.bsky.social in February! We will use in situ structural biology to investigate dynamic ciliary processes. More info here —> bsky.app/profile/comp... #cilia #teamtomo #proteomics #protistsky
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Janet Iwasa @jiwasa.bsky.social · 09/09/2026
Interested in molecular animation? Give ProteinBlender a try! It's free and open source. animation-lab.github.io/ProteinBlend... The latest tools include a DNA builder (shown in the tutorial video below). We'd love to hear what you think! We have short tutorials that cover all the features!
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Matthew Freeman @mjafreeman.bsky.social · 08/09/2026
Feels like an interesting one... oh, wait...!
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André Nadler @nadlerlab.bsky.social · 09/09/2026
This is an amzing opportunity. If you want to do cutting-edge, high risk science, that's what you go for.
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Seychelle Vos @voslab.org · 08/09/2026
⚡Preprint alert⚡ So proud of @amohamed98.bsky.social! Abdallah determined the cryo-EM structure of BRD4 bound to the kinase P-TEFb, defining the molecular basis of this key transcription interaction — and revealing that BRD4 and AFF4 binding are mutually exclusive to P-TEFb. Lots more inside 👇
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Ishier Raote @ishier.bsky.social · 07/09/2026
Membrane Trafficking Seminar Series 2026 fall season is here! An exciting programme: membrane traffic, organelle biogenesis, lipid transport, endomembrane evolution, we have it all! Save the dates and join us for fun science and discussions. Details at felixcampelo.wixsite.com/membranetraf...
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Anh Hoang Le, PhD 🏳️‍🌈🏴󠁧󠁢󠁳󠁣󠁴󠁿🇻🇳 @anhhle2702.bsky.social · 07/09/2026
Very happy to share my postdoc paper is out now in @natcellbio.nature.com titled "Tissue flow acts as a guidance cue for immune cell polarization and directional migration". If you love imaging and immune cells, this is for you! #microscopymonday www.nature.com/articles/s41... A 🧵: 1/n
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Magnus Bauer @kinasekid.bsky.social · 06/09/2026
AlphaFold Server’s ligand menu just got a lot bigger and I almost missed it! You can now add any ligand from the wwPDB Chemical Component Dictionary. Just enter its CCD code 🥳
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Florian Wollweber @florianwollweber.bsky.social · 05/09/2026
Exciting news! Our @erc.europa.eu StG project ARCHAEAOLOGY got funded 🎉 We’ll combine cryoET/EM, ExM & spatial omics to explore the subcellular organization of Asgard archaea. Job ads coming soon! 🦠 ❄️ 🔬 #TeamTomo #ArchaeaSky #MicroSky
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Guillaume Jacquemet @guijacquemet.bsky.social · 04/09/2026
🚨New preprint alert 🚨 "Pancreatic cancer cells breach endothelial barriers through protrusion-driven invasion or endothelial retraction" www.biorxiv.org/content/10.6...
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Stephen Royle @steveroyle.bsky.social · 04/09/2026
NEWS: @anne.mechanochemistry.org and I are the new Joint Directors of the Centre for Mechanochemical Cell Biology (CMCB) at Warwick @mechanochemistry.org We thank @rob.mechanochemistry.org who has been at the helm of CMCB since its inception. Looking forward to more exciting science in the future.
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mareikejordan.bsky.social @mareikejordan.bsky.social · 04/09/2026
Check out our preprint on the structural mechanisms of how LEM2 and ESCRTs seal the nuclear envelope. Awesome collaboration with @karenpalacior.bsky.social who brought my structures to life 💃🔬❄️🌀 @hummerlab.bsky.social www.biorxiv.org/content/10.6...
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FocalPlane @focalplane.bsky.social · 03/09/2026
We are excited to invite you to the second webinar in our cell migration series. In this webinar, we focus on new models for studying cell migration with talks from @ankita13jha.bsky.social, @raphclement.bsky.social & @katrinavelle.bsky.social. More info⤵️: focalplane.biologists.com/2026/09/03/f...
FocalPlane features... emergent models and quantitative analysis of cell migration
Thursday 17 September, 15:00-16:30 BST (UTC+1) 
Organised by Organised by Pablo J. Sáez and Valeria Venturini
FocalPlane logo
Picture of Ankita Jha (National Institutes of Health, USA)
Decoding bleb driven signaling in cancer disease progression
Picture of Raphaël Clément (L’Institut de Biologie du Développement de Marseille (IBDM), France)
Navigating without neurons or muscles: Locomotion in Trichoplax
Picture of Katrina Velle (University of Massachusetts Dartmouth, USA)
Naegleria amoebae seek confinement and crawl persistently through narrow spaces
#FocalPlaneFeatures
focalplane.biologists.com
Image of Naegleria.
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Thibaut Brunet @thibautbrunet.bsky.social · 02/09/2026
🚨 New preprint alert! 🚨 Choanoflagellates reorganize their global cytoskeletal architecture within seconds to explore confined microspaces. This is the main PhD work of the amazing @maitefreired.bsky.social www.biorxiv.org/content/10.6... A tread 🧵⬇️
biorxiv.org
Rapid repurposing of microvillar content drives a flagellate-to-amoeboid switch in the closest relative of animals
Animal cells extensively remodel their cytoskeleton during differentiation and can notably switch between two major motility modes: flagellum-based swimming and actin-based crawling. We previously sho...
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Chloe Girard, PhD @chloegirard.bsky.social · 02/09/2026
I support Wikipedia, where information is still human-created, fact-checked, and 100% free. Join me! donate.wikimedia.org
donate.wikimedia.org
Make your donation now - Wikimedia Foundation
Donate to the Wikimedia Foundation, the nonprofit that hosts Wikipedia and other crucial free knowledge projects. Each year, the generosity of the 2% of readers who donate allows us to expand the reac...
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Protein Structure Evolution (ProSE) Seminar @proteinstructure.bsky.social · 01/09/2026
Join us next Tuesday, 5PM CET for our first ProSE after the summer! Betül Kaçar @kacarlab.bsky.social will talk about the origin and early evolution of ancient proteins! 📜🧬 tinyurl.com/prose-seminar2
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Will Ratcliff @wcratcliff.bsky.social · 01/09/2026
Four billion years ago, Earth was a sterile rock. Today it is teeming with life, from simple microbes to extraordinarily complex societies that span the globe. How does that happen? I'm writing a book about the answer: Life Unbounded, from Quanta Books. www.quantabooks.org/books/life-u...
quantabooks.org
Life Unbounded
In LIFE UNBOUNDED, pioneering evolutionary biologist William C. Ratcliff reveals that every great leap in life’s complexity, from the first cells to human culture, was driven by the same underlying pr...
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