New preprint: in the last bit of my graduate work in the @voslab.org, we describe the mechanism for how BRD4 engages with P-TEFb in the context of regulating early RNA Pol II elongation. Read more here: www.biorxiv.org/content/10.6...
biorxiv.org
Structural basis for P-TEFb association with BRD4
Cyclin-dependent kinases (CDK) dynamically regulate RNA Polymerase (Pol) II during each stage of transcription. Phosphorylation of RNA Pol II and associated transcription factors by CDKs enables stage...