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Ishier Raote

@ishier.bsky.social
1.1K followers 564 following 352 posts

Institut Jacques Monod, Paris @ijmonod.bsky.social www.ijm.fr/raote-lab Collagen secretion, membrane trafficking Formerly @crg.eu

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Reposted by Ishier Raote
Journal of Cell Biology @jcb.org · 7h
Abir Elfarkouchi, Arthur Vitard, @francoizochsenbein.bsky.social, @pconduit.bsky.social et al. reveal the first structural model for γ-TuRC CM1 domain autoinhibition, which prevents ectopic binding and activation of #microtubule-nucleating γ-tubulin ring complexes. rupress.org/jcb/article/...
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Mathilda Lennartz @mathilda95.bsky.social · 16h
UPDATE!: I am absolutely stoked that the second paper of my PhD is now out in @natcellbio.nature.com :D. We combined lipid imaging, STED microscopy, and mathematical modelling in a super cool team effort to quantify lipid partitioning inside clathrin-coated pits. www.nature.com/articles/s41....
nature.com
Quantification of lipid sorting during clathrin-mediated endocytosis - Nature Cell Biology
Lennartz et al. evaluate lipid enrichment in clathrin-coated pits and observe that the differential lipid partitioning into clathrin-coated pits is largely driven by the lipid asymmetry of the plasma ...
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Albert Pol Lab @albertpol.bsky.social · 24/09/2026
Curious how lipid droplets support innate immunity in our cells? Check out our lipidomics by Bosch et al @cp-cellreports.bsky.social! Critical role of LD phospholipids and lipases in supplying defensive w6 arachidonic acid for inflammation and bacterial phagocytosis. www.cell.com/cell-reports...
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Giovanni D’Angelo @giodang.bsky.social · 23/09/2026
#lipidtime: It's a lipid universe. Today in Nature we publish the Lipid Brain Atlas, the first map of membrane lipid composition across the entire mouse brain, a layer of organisation that cell-type and transcript maps had left out. #lipidomics #neuroscience #BrainAtlas
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Valeria Venturini @valeriaventurini.bsky.social · 22/09/2026
In @pcusachs.bsky.social’s lab at @ibecbarcelona.eu we have a fully founded open PhD position! It’s a very nice working environment & can promise cool mechanobiology🔬🧫 Here all the info ibecbarcelona.eu/predoctoral-...
ibecbarcelona.eu
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Endless Screaming @infinitescream.bsky.social · 17/09/2026
AAAAAAAAAAAAAAAAAAAAHHHHHHHHHH
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Fran Bottanelli @franbottanelli.bsky.social · 14/09/2026
#membranetrafficking seminars are back for the fall session! This Thursday two exciting talks from Roger Pons Lanau from @felixmendu.bsky.social lab and @veijosalo.bsky.social #ER #lipiddroplets and lots of wonderful imaging! From single molecules to cryo EM! Please repost
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Veijo Salo @veijosalo.bsky.social · 11/09/2026
Really excited to talk about our recent work next week Thursday in Membrane Trafficking Virtual Community Seminar Series!
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Reposted by Ishier Raote
Journal of Cell Biology @jcb.org · 10/09/2026
Stretching the secretory pathway: mechanical control of #Golgi export. Angelika Hausser @angelikahausser.bsky.social highlights new work by Bhaskar Naidu, Vera Lillo, Manneville, Miserey, @felixmendu.bsky.social et al. (rupress.org/jcb/article/...) in Spotlight: rupress.org/jcb/article/...
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Institut Jacques Monod @ijmonod.bsky.social · 10/09/2026
📢 Institut Jacques Monod Seminar 📅 September 18th 📍Institut Jacques Monod Next week, Prof. Omaya Dudin ( @dudinlab.bsky.social ) will present an Institut Jacques Monod seminar on the theme "Exploring multicellular developmental programs at the root of animals and beyond" ➡️ buff.ly/mY66omK
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Ishier Raote @ishier.bsky.social · 09/09/2026
If AI can solve the Navier–Stokes equations and predict protein structures, do you really expect me to believe it can’t find the accursed bicycles or traffic lights?
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Ishier Raote @ishier.bsky.social · 09/09/2026
LLMs starting to solve long-standing problems! ChatGPT: P = NP Me: I think you're wrong ChatGPT: That's correct. I'm sorry. Thanks for pointing it out. P ≠ NP QED.
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sandraduharcourt.bsky.social @sandraduharcourt.bsky.social · 08/09/2026
Very happy to see our Nature Reviews Genetics article on programmed DNA elimination across eukaryotes out! A fantastic collective effort with an amazing group of colleagues, born from inspiring discussions at the Fondation des Treilles. rdcu.be/tmvKgsPZNhBa @laurarossevo.bsky.social
rdcu.be
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Giovanni D’Angelo @giodang.bsky.social · 08/09/2026
Do not miss this fantastic symposium #lipidtime
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Ishier Raote @ishier.bsky.social · 08/09/2026
I'm willing - grudgingly - to accept that Lifeact is not a valid pangram in today's Spelling Bee, but what's wrong with felicitate?!
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Ishier Raote @ishier.bsky.social · 07/09/2026
Membrane Trafficking Seminar Series 2026 fall season is here! An exciting programme: membrane traffic, organelle biogenesis, lipid transport, endomembrane evolution, we have it all! Save the dates and join us for fun science and discussions. Details at felixcampelo.wixsite.com/membranetraf...
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Jim Hurley @jimhurley.bsky.social · 06/09/2026
The ULK1 complex triggers autophagy on membranes, but with no typical membrane binding domains, how does it get there? See the answer in a brilliant collective effort out now in Science Advances: www.science.org/doi/10.1126/....
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Nick Stroustrup @nstroustrup.bsky.social · 05/09/2026
Did you know that the cells of old animals contain much less mRNA than the cells of young ones? Let me share with you some results from an ongoing project in the lab, where we are finding that a progressive depletion of total mRNA abundance is a crucial part of aging 1/22
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Felix Campelo @felixmendu.bsky.social · 04/09/2026
Many thanks @jcb.org and @angelikahausser.bsky.social for highlighting our recent findings on how the Golgi responds to mechanical forces! As nicely pinpointed out, many (I think exciting and relevant) questions remain open, so I'm looking forward to seeing how this evolves in the next few years!
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Gerry Hammond @gerryhammond.bsky.social · 03/09/2026
I never get bored of watching my favorite lipid, PI(4,5)P2 - especially in real time! In this case imaged with a HaloTag-biosensor and 50 pM JF646.
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Development @dev-journal.bsky.social · 02/09/2026
Collagen remodeling supports Hydra vulgaris head regeneration and stem cell invasion Read this Research Article from our special issue #DevSIextracellular by Ben Cox, Celina E. Juliano and colleagues. journals.biologists.com/dev/article/...
Hydra vulgaris as a model for studying extracellular matrix function during regeneration. (A,B) Whole-mount image of a transgenic Hydra Tg(actin1:GFP)rs1-ec;(actin1:DsRed)rs1-en (also known as ‘Watermelon’) expressing GFP (green) in the ectodermal epithelium (A) and RFP (magenta) in the endodermal epithelium (B). The Hydra body plan consists of an oral end bearing the mouth and tentacles, an aboral end bearing the foot, and a body column connecting the two poles. The region outlined in A indicates the approximate location of the cryosection shown in D. Scale bar in A: 500 μm in A-C. (C) Image of the same Hydra stained with a monoclonal antibody raised against Collagen I (Sarras et al., 1993). Collagen I forms a continuous layer of fibrils along the entire body column. (D) Cryosection of a Watermelon strain Hydra stained with Collagen I antibody, demonstrating that Collagen I forms a distinct layer as part of the ECM that separates the two epithelial cell layers. Scale bar: 100 μm. (E)
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Julian Nüchel @jnuechel.bsky.social · 01/09/2026
Brandnew preprint from @marius-lemberg.bsky.social @bccologne.bsky.social and my lab ! Great to be Part of this collaboration!
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Naba Lab UIC @nabalabuic.bsky.social · 31/08/2026
1/5 📣 Hot off the press: Two papers, one story on the mechanisms of ECM assembly now out in @jcellsci.bsky.social! I am delighted to share two companion studies from our lab exploring the mechanisms of SNED1 fibrillar assembly into the #ECM and how SNED1 shapes ECM architecture and cell phenotype.
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Traffic @traffic-journal.bsky.social · 28/08/2026
Happy 50th anniversary, Clathrin! onlinelibrary.wiley.com/doi/full/10.... @effc.bsky.social
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Mary Munson @marymunson4.bsky.social · 26/08/2026
Structural biology postdoctoral position open in my lab--apply now! For more information about the lab, see www.umassmed.edu/munsonlab/. Interested candidates should apply through the University of Massachusetts Chan Medical School jobs portal (www.ummsjobs.com/job/11668/).
umassmed.edu
Munson Lab | Home | BMB | UMass Chan Medical School
The Munson Lab researches the mechanistic basis for the regulation of spatial and temporal specificity in membrane trafficking in the Biochemistry & Molecular Biotechnology Department at UMass Chan Me...
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Justin Taraska @taraska.bsky.social · 24/08/2026
The Biophysical Society Membrane Fusion, Fission, and Traffic Subgroup is hosting an exciting set of 4 virtual talks on Wednesday September 16th starting at 1 pm Eastern Time on clathrin structure and dynamics. Please join! www.biophysics.org/outreach/sub...
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Max Heiman @heiman.bsky.social · 16/08/2026
For the last year, aECM Club seminars have brought together researchers working on apical ECM in diverse species and tissues - yeast cell wall, C. elegans cuticle, Drosophila lens, mammalian inner ear and pancreatic lumen, and many others. Sign up for 2026-27: forms.gle/DDJUxGLkcSRb...
forms.gle
aECM Club 2026-27
Dear aECM researchers, Thank you for your interest in aECM Club! Feel free to forward this brief survey to any colleagues and trainees who may be interested.
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preLights @prelights.bsky.social · 19/08/2026
Cellularization as a mechanism to build cells. #CellBio #DevBio Supported by @girishkalephd.bsky.social, Anne Ruess highlights a #preprint of @margaridaaraujo.bsky.social et al. @hiralshah.bsky.social @gautamdey.bsky.social @dudinlab.bsky.social #preLight⬇️ prelights.biologists.com/highlights/m...
prelights.biologists.com
Microtubules sustain the fidelity of cellularization in a coenocytic relative of animals - preLights
Cellularization as a mechanism to build cells
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Club Exo Endo @clubexo-endo.bsky.social · 15/08/2026
exoendo.org/en/offre-dem...
exoendo.org
Regulation of organelle function by membrane contact sites
IGBMC, Strasbourg, France -C. Tomasetto
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Böke Lab @bokelab.bsky.social · 12/08/2026
What does an ovary actually look like as it ages—one oocyte at a time? We mapped >85,000 oocytes in >100 intact mouse ovaries, in 3D, across the reproductive lifespan. And the ovary turned out to be much more organized than we expected. 🧵 1/5 www.nature.com/articles/s43...
nature.com
Three-dimensional mapping of intact ovaries reveals the aging dynamics of the ovarian reserve - Nature Aging
The spatiotemporal dynamics of the depletion of the ovarian reserve remain incompletely understood. Combining whole-ovary imaging, AI and modeling, the authors mapped over 85,000 mouse oocytes and fou...
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Ishier Raote @ishier.bsky.social · 12/08/2026
What an amazing, visceral experience it is, to watch the sun quickly and inexorably eaten up by the moon.
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Ishier Raote @ishier.bsky.social · 12/08/2026
Interesting new preprint from Cecile Gauthier-Rouviere! Flotillins link endolysosomes to ERES, recruiting COPII and ATG8 to drive secretory autophagy and extracellular vesicle release. Anew role for COPII in unconventional secretion! www.researchsquare.com/article/rs-1...
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Cell Biology J-Club @cellclub.bsky.social · 03/08/2026
Cooperative definition of ER exit sites by Tango1, Sec16 and Sec12 journals.biologists.com/jcs/article/...
journals.biologists.com
Cooperative definition of ER exit sites by Tango1, Sec16 and Sec12
Endoplasmic reticulum (ER) exit sites (ERES) are dynamic ER subdomains where secretory cargos are concentrated and exported towards the Golgi apparatus. The conserved proteins Sec16 and Sec12 have lon...
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Reposted by Ishier Raote
Mukund Thattai @thattai.bsky.social · 01/08/2026
To protest the unending Bangalore roadworks, I created a game called Swalpa Adjust Maadi (Kannada for "please bear with the inconvenience"). You play the contractor digging up the roads, the residents are mute spectators who always lose! A new puzzle each day: mthattai.github.io/Swalpa-Adjus...
mthattai.github.io
Swalpa Adjust Maadi
A game where you dig up Bangalore's roads.
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Liz Miller @lizmillercu.bsky.social · 31/07/2026
Job alert! I'm recruiting a new post-doc to work on mechanisms of co-translational quality control in the ER. Looking for expertise in ribosome biology and yeast genetics/cell biology. Please reach out to me with any questions. www.dundee.ac.uk/work-for-us/...
dundee.ac.uk
Postdoctoral Research Assistant - UOD2336
Closing date: Thursday 27 August 2026, 23:59
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Felix Campelo @felixmendu.bsky.social · 29/07/2026
Very happy to see this #MechanoGolgi story out (and in full open access, thanks to @upf.edu). Thanks a lot to everyone who contributed and helped make this possible, and, hopefully, more to come! rupress.org/jcb/article/...
rupress.org
Mechanical forces stimulate Golgi export
Bhaskar Naidu and Vera Lillo et al. show that extracellular mechanical forces reciprocally regulate Golgi function. By linking cell adhesion and spreading,
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Julian Nüchel @jnuechel.bsky.social · 23/07/2026
1/10 New preprint alert!🚨 @bccologne.bsky.social @mpiage.bsky.social
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Club Exo Endo @clubexo-endo.bsky.social · 22/07/2026
Save the date! Club Exocytose-Endocytose half-day scientific meeting is planned 📅 1 Dec 2026, 2 pm 📍 Centre Broca Nouvelle-Aquitaine, Bordeaux Neurocampus 🎤 ~8 talks 💻 Hybrid: in person or online Registration & abstract submission open in September. Stay tuned !!
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Nicolas Minc @minclab.bsky.social · 21/07/2026
Latest work from the team driven by our fantastic post-doc Maribel Arjona. Using cytoplasm extract fractions and active rheology, we adress how endomembranes, that pack the cell interior, influence the mechanics of the cytoplasm! @ijmonod.bsky.social @cnrsbiologie.bsky.social
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Nicolas Guyon @nicolasguyon.bsky.social · 20/07/2026
Haven’t written science in French in years, but just published a short open-access commentary on my Nat Neuro work with @pierrelemerre.bsky.social. Hopefully useful for teaching in French-speaking contexts! You can find it here: doi.org/10.1051/meds... Original work: www.nature.com/articles/s41...
3 representations of the human brain illustrating the evolution of hypotheses and methods of brain mapping: from phrenology (drawing by Nirupa Rao) to modern atlases.
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Benoit Ladoux @bladoux.bsky.social · 08/07/2026
Thrilled to share our new paper on cell extrusion. A beautiful study with a tremendous amount of data, led by the fantastic @fanny-wodrascka.bsky.social ! www.biorxiv.org/content/10.6...
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Hesso Farhan @hessofarhan.bsky.social · 07/07/2026
1/4 Thrilled to share our new paper on the role of ER-export in multiple myeloma (MM) published in @sigtrans-sttt.bsky.social www.nature.com/articles/s41... Thanks to editors and reviewers for a constructive process. Here is a thread to summarize the major findings #ER_literature #MultipleMyeloma
nature.com
Targeting endoplasmic reticulum export disrupts metabolic resilience in multiple myeloma - Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy - Targeting endoplasmic reticulum export disrupts metabolic resilience in multiple myeloma
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Institut Jacques Monod @ijmonod.bsky.social · 07/07/2026
#JobOffer Offre pour les agents du service public (fonctionnaires et CDI) 💼 Secrétaire Général(e) H/F 📍Institut Jacques Monod Candidatez sur le portail emploi CNRS avant le 23 juillet🔗 emploi.cnrs.fr/Offres/MOBIN...
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Florence Niedergang @florenceniedergang.bsky.social · 06/07/2026
🤩 Really happy our publication in mSphere showing how #HIV and #Chlamydia trachomatis join forces to survive inside #macrophages! lnkd.in/ejNj66PE Strong collaboration between our group @institutcochin.bsky.social Paris and Maria-Teresa Damiani's group @CONICET @UniversidadNacionaldeCuyo, Argentina
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Ishier Raote @ishier.bsky.social · 06/07/2026
Exciting preprint from @hessofarhan.bsky.social! Mechanical stress has a new sensor! IRE1 detects ER membrane tension and drives protein synthesis independently of its canonical UPR role, reshaping cell and organelle mechanobiology. www.researchsquare.com/article/rs-1...
researchsquare.com
Mechanosensing at the endoplasmic reticulum by IRE1
Sensing and integration of mechanical forces in eukaryotic cells have largely been attributed to the plasma membrane and the nucleus. Here, we identify the endoplasmic reticulum (ER) as an autonomous ...
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Ishier Raote @ishier.bsky.social · 06/07/2026
Interesting review from @pconduit.bsky.social on the Golgi as a microtubule organiser in neurons! onlinelibrary.wiley.com/share/SN4YJH...
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Germán Orizaola @gorizaola.bsky.social · 01/07/2026
Today marks one of the most important days in the history of Science. OTD in 1858, Charles Darwin and Alfred R. Wallace revealed the idea of evolution by natural selection @linneansociety.bsky.social meeting (although any of them was actually present) darwin-online.org.uk/content/fram...
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Institut Jacques Monod @ijmonod.bsky.social · 30/06/2026
📣 The Institut Jacques Monod ( @cnrs.fr | @upcite.bsky.social ) is proud to announce the election of Dr. Nicolas Minc ( @minclab.bsky.social ) as a new member of the EMBO community! Congratulations! #EMBOMembers2026 More informations 🔗 buff.ly/2HSXoSd @embo.org @cnrs-idf-villejuif.bsky.social
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Institut Jacques Monod @ijmonod.bsky.social · 25/06/2026
✍️ The @romet-jegou-lab.bsky.social Lab published a new article 📖 @cp-cellreports.bsky.social 📃 Rapid aging and disassembly of actin filaments from two evolutionary distant yeasts 🔗 www.cell.com/cell-reports...
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Yamuna Krishnan @krishnanyamuna.bsky.social · 22/06/2026
1/ Mitochondrial Na⁺ links metabolism, Ca2+ signaling and disease. We know how it gets in, how it gets out, and proteins that use it. But: we've never actually seen Na⁺ in single mitochondria in live cells. We started with an unusual observation, went down a rabbit hole & found some cool biology .
A mitochondrion showing Ca2+ entering through the MCU, exchanged for Na+ by NCLX, Complex I acting as a Na+/H+ exchanger, and various transporters that use Na+ to move their substrates in and out of the mitochondria
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