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MwahahahahahadScientist

@mads100tist.bsky.social
10K followers 3.4K following 13K posts

Neuro and Developmental biologist. PostDoc at day. Supervillain at night. He/him #BlackLivesMatter #TransRightsAreHumanRights @mads100tist@mastodon.social

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MwahahahahahadScientist @mads100tist.bsky.social · 29/08/2026
Do you work with microscopy images and segment to quantify or track? Do you study cell biology? development? Gather round! Let me tell you about FOCUS-3D, a segmentation algorithm that is fast, accurate and can be used on any model. We used it here to study zebrafish development. 🧪 (thread)
biorxiv.org
FOCUS‑3D: Robust, generalizable volumetric cell segmentation for three‑dimensional fluorescence microscopy
Understanding how cells establish spatial organization within tissues is a fundamental question in life sciences. While modern three-dimensional fluorescence microscopy captures large-volume tissue ar...
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MwahahahahahadScientist @mads100tist.bsky.social · 10h
static.klipy.com
Patrick Stewart's Mild Shock Reaction
Alt: Patrick Stewart's Mild Shock Reaction
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Sarah McAnulty, Ph.D. @sarahmackattack.bsky.social · 13h
It’s funny seeing my street art in a gallery space. This show’s theme is “All Art is Political”. The show includes everything from direct commentary on our fascist state to biodiversity pieces and a lot in between. Seems people are more likely to pull stuff on a street pole than in here though lol
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Bahl Lab @bahllab.bsky.social · 15h
New preprint from the lab! We built an atlas of functional ensembles across the zebrafish hindbrain, linking whole-hindbrain activity to behavior, structural organization, and molecular features. A few highlights below 🧵 www.biorxiv.org/content/10.6...
biorxiv.org
An atlas of functional ensembles in the zebrafish hindbrain links structural and molecular features to behavior
The vertebrate hindbrain sustains functions essential for survival and behavioral control, yet how it operates as a whole remains poorly understood. Here we map its functional organization in larval z...
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Mathieu M.J.E. Rebeaud @chercheurjuteux.com · 20h
Same same but different but still same.
Élections sud américaine 

Gabriela Rosa Sympatica : professeure des écoles bienveillante et appréciée de sa communauté, créditée de 49,9999 % des voix.

Diego Hitlerio de la Junta : le fils d'un ancien dictateur ayant des projets autoritaires, crédité de 50,0001 % des voix.
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MwahahahahahadScientist @mads100tist.bsky.social · 21h
Amazing statistic for a country of 9M people: "(there are) around 50,000 women in science in Cuba and (...) 38.4% of scientific leaders in Cuba are women" End the Cuba blockade. Let Cubans live free.
iuscientists.org
Cuban Science Under Siege: an Interview with Dr. Ernesto Estévez Rams
In an era when science is increasingly mobilized for militarism, surveillance, and corporate profit, the International Union of Scientists (IUS) seeks out voices that remind us what science can be whe...
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Vampi Moira Valentine @itsviviactually.bsky.social · 04/10/2026
I am Mad At The World today and you should buy trans books about it
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Nobel Prize @nobelprize.org · 04/10/2026
"We don't die when the body starts to end. Because what we leave is a message, which is left and this will survive us." - Rita Levi-Montalcini, awarded the Nobel Prize 40 years ago for her discovery of growth factors. She was the longest-living laureate, passing away at the age of 103 years.
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Zebrafish Rock! @zebrafishrock.bsky.social · 04/10/2026
In the spirit of #Inktober & #SpookySeason, we will be sharing some fin-raising #sciart this month during #ZebrafishZunday 👻🐟 First up, this wicked witch(fish) 🧙‍♀️ made by uber-talented science illustrator Priyanka Oberoi! #zebrafish #scicomm
Image of a zebrafish wearing a witches’ hat and riding a broom. Original artwork by Priyanka Oberoi.
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Lauren Flans @laurenflans.bsky.social · 10/03/2024
Oh; I concur that this is not my circus, but those ARE, in fact, my monkeys. And therein lies the problem, constable: this circus has obtained my monkeys by nefarious means.
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c0nc0rdance @c0nc0rdance.bsky.social · 03/10/2026
Let's talk about the HALLOWEEN GENES (really). 1979: It was a dark & stormy night⛈️& a scientist (Eric Wieschaus) is laboring over a microscope🔬, observing the dead remains of ... a fruitfly🪰. But not just ANY fruitfly. This was a TWISTED & MUTATED fruitfly with a GHOSTLY, transparent appearance.
static.klipy.com
Mad Scientist Working in a Laboratory
Alt: Mad Scientist Working in a Laboratory. A man in a lab coat works on a large cabinet sized device covered in proper dials and levers and blinky lights. We used to be researchers. PROPER researchers.
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Zebrafish Rock! @zebrafishrock.bsky.social · 03/10/2026
“These findings establish biological sex as a major regulator of zebrafish hematopoiesis and immunity, paralleling humans, and lay the groundwork necessary for future mechanistic studies on sexual dimorphism in hematologic health and disease.” New work from @dionnakasper.bsky.social et al. 🐟
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Jorge @bohemioe.bsky.social · 03/10/2026
www.theguardian.com/world/2026/o...
theguardian.com
Spanish right wing votes down housing crisis plans as protest movement grows
Opposition lawmakers join forces to defeat proposals made by Socialist-led coalition after eviction of 87-year-old
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Sarah McAnulty, Ph.D. @sarahmackattack.bsky.social · 02/10/2026
If you are part of an academic society or a professor of any kind, public statements that you do not condone Drexel cutting off the academy of natural sciences from the public of Philadelphia is very important right now. We need your voices. Urgently.
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Zebrafish Rock! @zebrafishrock.bsky.social · 03/10/2026
Cool new work from @bahllab.bsky.social 🐟🧠 #zebrafish
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Meredith Rose (from the grave) 👻 @mrose.ink · 02/10/2026
Honestly, I think a big part of this is conflating "AI" and "LLMs," which are two technologies that have overlapping but non-identical critiques and limitations.
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Hannah Shelley, MLIS (Maggots, Lycanthropes & Ice Skeletons) @hannahshelley.site · 02/10/2026
Please stop anthropomorphizing computers. They cannot "run" a program, because they don't have legs
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John Tuthill @tuthill.bsky.social · 01/10/2026
two new preprints from Wangchu Xiang (@darbly.bsky.social, Ginty labs) about connectomic reconstruction from electron microscopy of somatosensory afferents and projection neurons in the dorsal horn of the mouse spinal cord www.biorxiv.org/content/10.6... www.biorxiv.org/content/10.6...
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Martin Haesemeyer @haesemeyerlab.bsky.social · 01/10/2026
CLOK: Truly beautiful new #zebrafish tool for birthdating neurons from the Koyama and Del Bene labs doi.org/10.1038/s415...
doi.org
CLOK: a chemigenetic multicolor labeling system to visualize neuronal birthdate and circuit integration - Nature Neuroscience
Faini et al. develop CLOK, a method that labels neurons across a spectrum of colors according to when they were born, allowing successive generations of brain cells to be tracked as they take shape in...
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Zebrafish Rock! @zebrafishrock.bsky.social · 02/10/2026
Very cool tool, for those interested!
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MwahahahahahadScientist @mads100tist.bsky.social · 25/09/2026
As Gregor Samsa awoke one morning from uneasy dreams he found himself transformed in his bed into a senior postdoc
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Sarah McAnulty, Ph.D. @sarahmackattack.bsky.social · 02/10/2026
Do you think it's valuable to put biodiversity education smack in front of people integrated into their daily lives? Support @skypeascientist.bsky.social. Ideally monthly! I need to raise more $ before the end of '26 so we can afford to do projects like this in '27. givebutter.com/SupportSAS26
givebutter.com
Support Skype a Scientist!
By Skype a Scientist
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Sarah McAnulty, Ph.D. @sarahmackattack.bsky.social · 01/10/2026
Has your school connected with a scientist yet this year? Skype a Scientist offers free connections with scientists for virtual Q&As with classrooms, libraries, clubs, and more! Sign up for a match at www.skypeascientist.com/sign-up.html 🖼️ by @hanfranstudio.bsky.social
A goofy school of fish in a science class swim while dropping green liquid that says let’s talk science in school
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Michalis Averof @michalis-averof.bsky.social · 01/10/2026
A cost-effective method for finding cis-regulatory elements in a large genome (Parhyale, 3.6 Gb), combining info from chromatin accessibility (bulk & single-nucleus ATACseq) and cross-species sequence conservation (low coverage sequencing from 3 additional Parhyale species) Now published in eLife!
elifesciences.org
Genome-wide discovery of cis-regulatory elements in a large genome
Integrating genome-wide maps of chromatin accessibility and sequence conservation provides an accessible low-cost approach for identifying cis-regulatory elements in large genomes, validated in the em...
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Johannes Soltwedel @jo-soltwedel.bsky.social · 01/10/2026
Just released the napari-clusters-plotter 0.11.0 github.com/BiAPoL/napar..., a little passion-project of mine for interactive exploration of datasets and attached features in @napari.org Two cool things to take note of 👇
github.com
GitHub - BiAPoL/napari-clusters-plotter: A napari plugin for clustering objects according to their properties.
A napari plugin for clustering objects according to their properties. - BiAPoL/napari-clusters-plotter
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The Company of Biologists @biologists.bsky.social · 01/10/2026
ECRs - apply by 23 Oct for a funded place at our Workshop - Bridging Scales and Disciplines to Understand Robust Development, 18-21 April 2027, organised by Mauricio Rocha @rocha-lab.bsky.social and Giulia Paci @giuliapaci.bsky.social Find out more and apply at www.biologists.com/workshops/ap...
Workshop - Bridging Scales and Disciplines to Understand Robust Development, early-career researchers apply for funded places
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MwahahahahahadScientist @mads100tist.bsky.social · 01/10/2026
'tis time
A halloween version of my avatar. The avatar is usually Dexter from Dexter's laboratory, but I painted it to look like me. Now I have turned that into a green-looking zombie/frankenstein with red eyes
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Zebrafish Rock! @zebrafishrock.bsky.social · 01/10/2026
"Using molecular markers, tract tracing, and quantitative comparisons of cellular 12 distribution patterns, we report a detailed neuroanatomical atlas of the adult Danionella dracula (“Dracula fish”) telencephalon." New #Danionella work from Perelmuter & Bass at Cornell 🐟 @danionella.bsky.social
(A) Dorsal view of Dracula fish head. 
(B) Adult Dracula fish and zebrafish brains.
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MwahahahahahadScientist @mads100tist.bsky.social · 01/10/2026
I think we need to start explicitly making the real distinction of AI vs genAI when we talk about genAI. The problem with the whole thing is that the author admitted to using genAI to create parts of the video. That is completely different from using AI for post processing
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Arnaud Martin @evolvwing.bsky.social · 30/09/2026
Cell Press giving a rather biased, pro-eugenics platform to self-proclaimed "Biotech Barbie", former a Thiel Fellow who briefly married He Jiankui, and fails to properly frame the debate on germline editing. Partly bonkers, partly important, check out this thread 🤯
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MwahahahahahadScientist @mads100tist.bsky.social · 30/09/2026
Nobel to Michael Hall for mTor, and during the reasoning they say "only to Michael and not to the individual that rhymes with Panini"
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MwahahahahahadScientist @mads100tist.bsky.social · 30/09/2026
There's literally more human content out there than you can listen to, and you'd rather ask a machine to show you an statistical average? Loser behavior
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MwahahahahahadScientist @mads100tist.bsky.social · 30/09/2026
I had someone tell me this once, to which I reminded them that there are *hours* of any genre of music online and the best thing that can happen is stumbling upon the channel of a 20 year old from Warsaw who will show you a playlist that will melt your face. That cannot be simulated
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MwahahahahahadScientist @mads100tist.bsky.social · 30/09/2026
Zebrafish travels in time with TimeMachine! 🧪🐟 @zenlabpasteur.bsky.social
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MwahahahahahadScientist @mads100tist.bsky.social · 30/09/2026
When your proposal gets killed by an algorithm that has no capacity to understand science, what will you do? When your colleague's proposal gets killed by an algorithm that has no capacity to understand science and amplifies biases by default, what will you do? That's where we're at 🧪
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Iris van Rooij 💭 @irisvanrooij.bsky.social · 30/09/2026
Also, in light of all of the above considerations and resources, I again present my below advice to the @erc.europa.eu, in line with the principles of scientific integrity mu.social/profile/iris...
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Iris van Rooij 💭 @irisvanrooij.bsky.social · 29/09/2026
Dear @erc.europa.eu , we DO already have common standards & frameworks. 'AI' likes to pose itself as 'special' but we do not need to reinvent the wheel. We already have established codes of conduct for research integrity. We just need to apply them. See below + more resources in thread🧵
Protecting the Ecosystem of Human Knowledge: Five Principles
We must protect and cultivate the ecosystem of human knowledge. AI models can mimic
the appearance of scholarly work, but they are (by construction) unconcerned with truth
— the result is a torrential outpouring of unchecked but convincing-sounding “informa-
tion”. At best, such output is accidentally true, but generally citationless, divorced from
human reasoning and the web of scholarship that it steals from. At worst, it is confidently
wrong. Both outcomes are dangerous to the ecosystem.
Olivia Guest, Iris van Rooij, Marcela Suarez, et al. (2025, n.p.)
Knowledge production is supposed to be safeguarded by (inter)national codes of conduct for research
integrity (ALLEA 2023; KNAW et al. 2018). Such codes forbid, for instance, fabrication of data,
falsification of results, plagiarism, and, generally, distortion of the scientific record. Many argue that
new rules are required to regulate academic AI use, but pre-existing guidelines fit the bill (cf. Tafani
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MwahahahahahadScientist @mads100tist.bsky.social · 29/09/2026
This is the critical part of the thread, I think 🧪
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✧𝔰𝔭𝔬𝔬𝔨𝔶 𝔪𝔲𝔡 𝔰𝔠𝔞𝔪𝔭✧ @altaudge.bsky.social · 29/09/2026
fish are friends
Stop using anti-fish language
Instead of: this seems fishy
Try saying:
this seems like a situation in which we should consult the wisdom and grace of the European seabass, a species with which i would entrust my entire life and personal safety
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MwahahahahahadScientist @mads100tist.bsky.social · 29/09/2026
Well, there it is. The EU is also going to use slop algorithms to put an artificial number on proposals. This is how we lose. This is a disaster 🧪
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BrainFacts @brainfacts.org · 29/09/2026
Print out 3D-printed models of different animal brains for the classroom, lab — or just for fun. vist.ly/5kc8x
brainfacts.org
3D-Printed Animal Brain Models
Print out 3D-printed models of different animal brains for the classroom, lab — or just for fun.
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MwahahahahahadScientist @mads100tist.bsky.social · 29/09/2026
I love me a whole-organ imaging in zebrafish 🧪 "An adult (zebrafish) liver contains approximately 1.27 million hepatocytes." In this economy!
journals.plos.org
Whole-organ single-cell mapping defines growth dynamics and clonal organization in developing and adult zebrafish livers
Vertebrate organs undergo massive growth during the post-embryonic period, but it remains unclear how organs are organised at single-cell resolution. This study develops whole adult-organ expansion mi...
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Development @dev-journal.bsky.social · 29/09/2026
Pathway to Independence – an interview with Evan Healy In this interview, we learn about @evhealy.bsky.social's career path, what he hopes to gain from the Pathway to Independence programme, and what questions he hopes to tackle with his own group. doi.org/10.1242/dev....
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feeb | yuritober!! @magicmooshka.bsky.social · 09/01/2026
it’s come to my attention that my tumblr post has been crossposted to bluesky, so I’m posting it on my account here #AntiAI #GenAI
recently my friend's comics professor told her that it's acceptable to use gen AI for script-writing but not for art, since a machine can't generate meaningful artistic work. meanwhile, my sister's screenwriting professor said that they can use gen AI for concept art and visualization, but that it won't be able to generate a script that's any good. and at my job, it seems like each department says that AI can be useful in every field except the one that they know best.

It's only ever the jobs we're unfamiliar with that we assume can be replaced with automation. The more attuned we are with certain processes, crafts, and occupations, the more we realize that gen AI will never be able to provide a suitable replacement. The case for its existence relies on our ignorance of the work and skill required to do everything we don't.
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Mathieu M.J.E. Rebeaud @chercheurjuteux.com · 29/09/2026
Allegations of AI Use in Nikon Competition Spark Controversy AI hallucinating things. Again. We talked about that with @christlet.bsky.social and @mads100tist.bsky.social here on Bluesky among lots of colleagues. www.the-scientist.com/allegations-...
the-scientist.com
Allegations of AI Use in Nikon Competition Spark Controversy | The Scientist
Microscopists raise concerns about inappropriate AI usage in Nikon's microscopy contest-winning video. Nikon stands their ground, citing no policy breach.
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c0nc0rdance @c0nc0rdance.bsky.social · 27/09/2026
The obvious conclusion (to me): if you have proprietary research & you upload it into the Plagiarism Nexus, it's not YOUR proprietary research anymore. Behave accordingly.
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c0nc0rdance @c0nc0rdance.bsky.social · 27/09/2026
I'll save you the click-through: A lab at University of Copenhagen had been feeding draft manuscripts & data into "Claude Science" & then Anthropic announces a discovery that this lab made a year ago but hasn't published yet. It's plausible that Claude found the same signatures independently...
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Development @dev-journal.bsky.social · 28/09/2026
Pathway to Independence – an interview with Margherita Zamboni In this interview, @margheritazamboni.bsky.social talks about her journey into science and her career path, what she hopes to get out of the programme and the questions she wants to ask in her own group. doi.org/10.1242/dev....
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samuel mehr @mehr.nz · 28/09/2026
senior postdocs on the academic job market:
screenshots from the latest season of British Bake Off of a chef named Mo, he's a tan skinned young man. He's got dark hair falling over his forehead and a beard. He's saying, "I come with a lot of baggage, but it's, like, the good baggage." 
Mo continued, "Like Louis Vuitton baggage."
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Brooke Fitzwater, PhD (she/her) 🐟🪱🏳️‍🌈♾️ @oceanfilly.bsky.social · 27/09/2026
I will be attending #SICB2027 this year! I am also actively looking for a postdoc position and would love to connect with PIs looking for postdocs! I have interest/expertise in behavior, mate choice/sexual selection, host-parasite interactions, and disability/neurodivergent advocacy in biology.
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