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hummerlab.bsky.social

@hummerlab.bsky.social

Reposted by @hummerlab.bsky.social

Jim Hurley @jimhurley.bsky.social · 06/02/2025

Therapeutic enhancement of autophagy may hold promise for Parkinson’s and other currently incurable neurodegenerative diseases. Targeting the VPS15 myristate could be an attractive path for therapeutic autophagy enhancement.

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Reposted by @hummerlab.bsky.social

Jim Hurley @jimhurley.bsky.social · 06/02/2025

Molecular dynamics by @hummerlab.bsky.social showed how the transition occurs and how the active state is aligned with the plane of the membrane to facilitate entry of the PI substrate lipid.

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Reposted by @hummerlab.bsky.social

Jim Hurley @jimhurley.bsky.social · 06/02/2025

The VPS15 pseudokinase binds to GTP, not ATP, thanks to an Arg residue at the gatekeeper position which is unique in the kinome. GTP binding controls the VPS34 conformation. @lazaroulab.bsky.social knocked out N-myristoylation and GTP binding, which dysregulates autophagy.

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Jim Hurley @jimhurley.bsky.social · 06/02/2025

Excited to see work led by @autophazeke.bsky.social, @minghaochen.bsky.social, Thanh Nguyen, and Ainara Claveras out in @science.org today, the culmination of a 15-year project to understand structurally how the synthesis of the critical lipid of autophagy, PI3P, is regulated. tinyurl.com/ywvjh8u4

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