André Nadler @nadlerlab.bsky.social · 42mNot my field at all, but what a beautiful piece of work (in more than one sense)! Butterflies are amazing... 020
Reposted by André NadlerLevental Lab @leventallab.bsky.social · 1hCheck out below, a great opportunity for a funded trip to what looks like a very interesting Workshop in UK next summer 054
Reposted by André NadlerEllen Leffler @ellenleffler.bsky.social · 2hMy department at University of Utah is recruiting new faculty, with "Human" and "Genetics" broadly defined. It is a fantastic place to start a lab, with collaboration, creativity and conviviality encouraged. Applications due Oct 16. Please share and apply! utah.peopleadmin.com/postings/208... 01224
Reposted by André NadlerSusana Nunes @susananunes.bsky.social · 1hSuper excited to see this story out! Shout out to @mathilda95.bsky.social for her PhD work. I was lucky to have her and @sascha-kuhn.bsky.social as my bachelor's thesis supervisors.They helped me find and grow my excitement for science!Thanks to André @nadlerlab.bsky.social for having me in the lab! 161
Reposted by André NadlerAnthony Dornan @dornan.bsky.social · 7hSharing Matthew Broadhead's recent preprint outlining the discovery & characterisation of the novel Honeycomb Synapse - formed by postsynaptic scaffold proteins that form nanoclusters arranged into perfect rings of ~6, creating the eponymous hexagonal perforations. www.biorxiv.org/content/10.6... 185
Reposted by André Nadler@KayTrue (Sarah L. Keller) @kaytrue.bsky.social · 21hVery excited to share that my department at @uwchemistry.bsky.social will be hiring an Assistant Professor of Chemistry! Come be my colleague at the University of Washington in Seattle! It is a wonderful city filled with wonderful scientists. Details in the link: ap.washington.edu/ahr/academic...ap.washington.eduAcademic Jobs - Academic Personnel & FacultyFind current openings and apply for academic jobs at the University of Washington. 063
Reposted by André NadlerFilipe De Vadder @filipedevadder.bsky.social · 10h🚨PREPRINT ALERT How different are males and females? In physiology we mostly treat that as a fixed property of a species, something to control for. In mice, we found it is not fixed at all. It depends on what the animal ate while growing up.biorxiv.orgJuvenile protein restriction compresses sexual dimorphism in miceSexual dimorphism is canonically understood as a fixed adult trait, scaled by gonadal hormones at puberty, but whether its magnitude is shaped earlier in life by juvenile nutrition during the post-wea... 3137
Reposted by André NadlerDiz-Muñoz Lab @diz-lab.bsky.social · 10hMind the gap! Go check it out: www.nature.com/articles/s41... 062
Reposted by André Nadlerpaveltomancak.bsky.social @paveltomancak.bsky.social · 22hNo true scientist will outsource the fun of the creative process to a machine. We must focus on finding and eradicating the science operators who will stop at nothing to get more recognition & power. The impostors can be identified. We need to rely more on the good old human interactions. 45511
Reposted by André NadlerOmaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦ @dudinlab.bsky.social · 13hGuess who is the lucky lab hosting @mathilda95.bsky.social now ? Congrats on such an amazing work ! 1202
André Nadler @nadlerlab.bsky.social · 13hThis story in @natcellbio.nature.com by the amazing @mathilda95.bsky.social is the final flourish in a series of papers over the last year during which we reported a solution to the lipid imaging problem in biology. Stay tuned for the next chapters! 1338
Reposted by André NadlerCell Biology J-Club @cellclub.bsky.social · 29/09/2026Quantification of lipid sorting during clathrin-mediated endocytosis www.nature.com/articles/s41...nature.comQuantification of lipid sorting during clathrin-mediated endocytosis - Nature Cell BiologyLennartz et al. evaluate lipid enrichment in clathrin-coated pits and observe that the differential lipid partitioning into clathrin-coated pits is largely driven by the lipid asymmetry of the plasma ... 0209
Reposted by André NadlerMax Planck Institute of Molecular Cell Biology and Genetics @mpi-cbg.de · 29/09/2026Study today in @natcellbio.nature.com by @mathilda95.bsky.social @nadlerlab.bsky.social @mpi-cbg.de, Honigmann group @biotec-tud.bsky.social & @carldmodes.bsky.social reveals that clathrin-mediated endocytosis sorts proteins but not lipids. Lipids use different routes. www.mpi-cbg.de/news-outreac... 13311
Reposted by André NadlerMark Peifer (He, him) @peiferlabunc.bsky.social · 29/09/2026For the last 34 years I have been on the faculty of the UNC-Chapel Hill Department of Biology and have never regretted that decision. This year we are hiring TWO new Assistant Professors in the broad area of Molecular, Cell, Developmental Biology 1/n bio.unc.edu 3147134
Reposted by André NadlerKimberly Beatty @beattylab.bsky.social · 28/09/2026Please share: OHSU is hiring an Assistant Prof. in the Dept. of Chemical Physiology & Biochemistry. We are looking for a chemical biologist who will apply novel chemical tools in physiological systems. Apply online: www.ohsu.edu/human-resour... (Job # 2026-41667).ohsu.eduOHSU Faculty, Physician and Academic Jobs in OregonFind higher education faculty, physician and research jobs and build your academic health career at OHSU in Portland, Oregon. 04258
Reposted by André NadlerJames Saenz @jamessaenz.bsky.social · 25/09/2026We’ve finally installed the beautiful cell membrane wall art that Priyanka Oberoi made for the lab…now hanging in its new home @zmbh.uni-heidelberg.de in Heidelberg. The move is nearly complete! @anh-nhn.bsky.social @varvarakramkova.bsky.social 0203
Reposted by André NadlerSimon Hammann @simonhammann.bsky.social · 28/09/2026Ich hab ne Frage, weil ich verstehe es nicht mehr ganz. Dinge haben wieder Konsequenzen, ja? Aber nur völlige Nebenschauplätze, richtig? So richtig fieses, wichtiges, Bedeutsames ist immer noch egal, aber Kinderbetreuung und extravagante Sitzmöbel sind die roten Linien? Bitte um Aufklärung 191
Reposted by André NadlerWolfgang Huber @wkhuber.bsky.social · 28/09/2026I've been trying to respond with a personal email to every request for a PhD or Master thesis placement in my group. But with the flood of AI generated applications that's now coming in every day, this has become impossible. 7405
Reposted by André NadlerZebrafish Rock! @zebrafishrock.bsky.social · 27/09/2026Electrochemical response triggers organ growth, following tail injury in a #zebrafish embryo. Credit to @ritamateus.bsky.social, @nerlielisa.bsky.social, & @liujinghui.bsky.social. #ZebrafishZunday 18219
Reposted by André NadlerAbhishek Chatterjee @achemsynbio.bsky.social · 26/09/2026🚨🚨 A comprehensive review by Rahul Sarkar and Manas Joshi on genetically encoded bioorthogonal noncanonical amino acids, chemical reactions used for their chemoselective labeling, advantages and limitations of each approach, and the applications they unlock! onlinelibrary.wiley.com/doi/10.1002/...onlinelibrary.wiley.com 043
André Nadler @nadlerlab.bsky.social · 26/09/2026I am really curious how they're going to try and weasel out of that one. But I am sure it'll be entertaining. 041
Reposted by André NadlerRasmus Jensen @rasmusjensen.bsky.social · 25/09/2026🎉 Out today in Cell: the paper I've been looking forward to sharing for a long time 🎉 We used cryo-ET to find a molecular machine nobody knew existed on the surface of a minimal bacterium, and worked out what it does. 🧵(1/7) #TeamTomo #cryoET 1023190
Reposted by André NadlerValentin Dunsing-Eichenauer @dunsingvalentin.bsky.social · 25/09/2026#FluorescenceFriday: Given the recently grown interest in ciliary beating, here is a movie of beating cilia in a human airway model that I captured last week with lattice light-sheet microscopy. No AI „processing“, this is the raw data! Frame rate is ca. 170fps, displayed here at 25fps. 310728
Reposted by André NadlerChristophe 🔬 Leterrier @christlet.bsky.social · 25/09/2026The Small World in Motion winner is now officially a "rendition" 🙄 7548
Reposted by André Nadlerpaveltomancak.bsky.social @paveltomancak.bsky.social · 24/09/2026He is Groot. Sorry 😜 Apply 061
Reposted by André NadlerJoachim Goedhart @joachimgoedhart.bsky.social · 24/09/2026Thanks for sharing this version, to me the most stunning part is the region where the cilia seem to appear (out of nowhere?) 2164
Reposted by André NadlerChristophe 🔬 Leterrier @christlet.bsky.social · 24/09/2026I think I'm going to lose it being lectured on microscopy image presentation integrity by the winner of the Small Artificial World in Motion competition 1417733
Reposted by André NadlerStephen Royle @steveroyle.bsky.social · 23/09/2026I agree with this. TBH I find this pretty bleak. It might only be an imaging competition, not a Nature paper or a grant, but people who use AI to supercharge their way past honest scientists doing real work... and then collecting the spoils... and getting endorsed for doing so.... well, it sucks. 1254
Reposted by André NadlerMichael Hiller @hillermich.bsky.social · 23/09/2026Happy to share results of the @bat1kgenomes.bsky.social phase 1, providing reference genomes covering 21 bat families. New insights into bat phylogeny, ancestral genome reconstruction, European origin & ancestral echolocation. Great work by a team of 100+ colleagues www.nature.com/articles/s41...nature.comReference genomes and fossils revise bat family phylogeny and biogeography - NatureAn updated phylogeny of bats is presented, based on new genome assemblies and many ancient fossils and including all known bat families. 318379
André Nadler @nadlerlab.bsky.social · 23/09/2026This my friends, this is the big one. A long time coming. Lipid Cell Biology is coming of age and even for a hot field, this is a true game changer. This dataset will keep us all busy for years to come. Congrats to everybody on this amazing crew!!! Go party!! 13612
André Nadler @nadlerlab.bsky.social · 23/09/2026God that is so bad. Nuclei tend to be bigger... the freaking genome needs to fit in there. Post-processing... my a.. what a clusterf... If there isn't a course correction soon, the credibility of the competition is gone. And that would be a pity. 050
Reposted by André Nadlerpaveltomancak.bsky.social @paveltomancak.bsky.social · 21/09/2026Some 30 years ago, I went for it. ‘Twas a good decision. Do it! 02311
Reposted by André NadlerBuzz Baum @buzzbaum.bsky.social · 22/09/2026We are looking for a research assistant! Come join the team: www.jobs.ac.uk/job/DSZ826/r...jobs.ac.ukResearch Support Officer | Cell Biology | Dr Buzz Baum | LMB 2904 at MRC Laboratory of Molecular BiologyStart your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top... 02846
Reposted by André NadlerOmaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦ @dudinlab.bsky.social · 22/09/2026For two weeks, our entire lab is dropping everything to focus on one mission: deploying @embl.org's Advanced Mobile Laboratory to cultivate microbial eukaryotes from Alpine ecosystems. Our dream? Isolating new #Ichthyosporeans never cultured before. Let's see what we find. 🔬🏔️ 2399
Reposted by André NadlerJase Gehring @skyjase.bsky.social · 21/09/2026Also incredible that they used Claude and, surprise surprise, a major pharma company was already pursuing this target with a major drug program Think anyone at Merck has an Anthropic subscription? 251
Reposted by André Nadlerpaveltomancak.bsky.social @paveltomancak.bsky.social · 20/09/202621627 applications. Nothing to celebrate here. Impossible to evaluate fairly & safely. Neither the science (too diverse & possibly LLM generated) nor the soft criteria (likely LLM generated). Without an interview stage - a security risk! marie-sklodowska-curie-actions.ec.europa.eu/whats-new/ne...marie-sklodowska-curie-actions.ec.europa.euMSCA Postdoctoral Fellowships 2026 receives record number of applicationsThe 2026 call has attracted considerable interest from the research community with 21,627 applications submitted. 29843
Reposted by André NadlerNordenLab @nordenlab.bsky.social · 18/09/2026We also finally have a lab picture! Growth in progress … 😉 1322
Reposted by André NadlerJoachim Goedhart @joachimgoedhart.bsky.social · 18/09/2026Anything is possible with antibodies from Thermo Fisher... 3212
Reposted by André NadlerChristophe 🔬 Leterrier @christlet.bsky.social · 18/09/2026Can't see your comment - although the LinkedIn page led me to see that the author of the movie knows his ways around AI 181
Reposted by André NadlerChristophe 🔬 Leterrier @christlet.bsky.social · 18/09/2026Questions about the recently announced Small World in Motion winner @healthcare.nikon.com 02815
Reposted by André NadlerPrasad Jallepalli, MD, PhD @prasad.bsky.social · 18/09/2026just considering the beat frequency of airway cilia (10-20 Hz), any contrastive timelapse should run on the scale of seconds, in which case basal cell/tissue movement should be imperceptible (minutes to hours) 2154
André Nadler @nadlerlab.bsky.social · 18/09/2026Yeah, not great. But the colors are nice, I guess. 071
Reposted by André NadlerDaumann Lab @daumannl.bsky.social · 17/09/2026Come be our colleague at @hhu.de @chemiehhu.bsky.social ! We are currently looking for 2 Full Professors in Physical chemistry in our department! berufungsportal.hhu.de/VAADIN/dynam... berufungsportal.hhu.de/VAADIN/dynam... #chemsky #chemchat 🧪berufungsportal.hhu.de 159
Reposted by André NadlerThibaut Brunet @thibautbrunet.bsky.social · 17/09/2026It had been theoretically predicted that the expansion of the Nature family of journals would inevitably lead to oxymoronic titles in the long run if left unchecked. This prediction has just been experimentally confirmed 108516
André Nadler @nadlerlab.bsky.social · 17/09/2026This one is really important. In particular in the light of the lipotype hypothesis. (And it really helps a point that I am making in a grant application due very soon, so well done Erdinc!) 071
Reposted by André NadlerCaroline Bartman @cbartman.bsky.social · 16/09/2026Excited to share our second Bartman lab paper! MSTP student Amelia developed a sensitive LC-MS method to measure Coenzyme A level. We can also combine this method with tracing to measure CoA synthesis rate. Congratulations Amelia!! pubs.acs.org/doi/10.1021/...pubs.acs.orgA Liquid Chromatography-Mass Spectrometry Method to Quantify Total Coenzyme A Concentration and Isotopic LabelingAbstract. Coenzyme A is an essential cofactor synthesized from pantothenate, which carries activated acyl groups in cellular metabolic reactions. Coenzyme 1276
Reposted by André NadlerMaja Radulovic @majarad.bsky.social · 15/09/2026Our study on DFCP1 and lysosome membrane repair is live! We uncover a previously unrecognized role for omegasomes in the cellular response to lysosomal membrane damage, revealing another layer of regulation in how damaged lysosomes are repaired. www.nature.com/articles/s41...nature.comDFCP1-containing ER microdomains mediate lysosomal membrane repair - Nature Cell BiologyRadulovic et al. show that phosphatidylinositol 3-phosphate (PI3P), produced by the phosphatidylinositol 3-kinase PIK3C3, is formed on ER domains after lysosome damage. ER domain PI3P helps to recruit... 43318
Reposted by André NadlerSascha Pust @moerno.bsky.social · 15/09/2026Our new publication in Nature Cell Biology 🔬 How cells reseal damaged lysosomes: Ca²⁺ leak → VPS34 makes PI3P on the ER → recruits DFCP1 → clusters VPS13C lipid-transfer bridges at ER–lysosome contacts to patch the membrane. No DFCP1 = failed repair. www.nature.com/articles/s41...nature.comDFCP1-containing ER microdomains mediate lysosomal membrane repair - Nature Cell BiologyRadulovic et al. show that phosphatidylinositol 3-phosphate (PI3P), produced by the phosphatidylinositol 3-kinase PIK3C3, is formed on ER domains after lysosome damage. ER domain PI3P helps to recruit... 01811