The motor protein MYO6 is spatially associated with RAMP3 and affects adrenomedullin signaling in lymphatic endothelial cells.

An approach to improve efficiency and establish a background expectation for ligand potency optimization is described.

An approach to improve efficiency and establish a background expectation for ligand potency optimization is described.

Recent studies have implicated dopaminergic signaling within the substantia nigra pars reticulata (SNr) in the emergence of Parkinsonian motor deficits. To better understand the mechanisms underlying ...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

New mouse models for psychedelic studies

Neuropsychopharmacology - Dopamine D1 agonists and cognition: a new frontier in neuropsychopharmacology

About the Opportunity Job Summary The Shansky Lab is seeking a full-time technician to conduct National Institutes of Health (NIH)-funded behavioral neuroscience research. The position includes lab ma...

Impaired insulin secretion represents a key feature of type 2 diabetes (T2D), a major global health burden. Insulin release from pancreatic β cells is regulated by G protein–coupled receptors linked t...

Novel analogs of the psychedelic lysergic acid diethylamide (LSD) have emerged on the gray market in recent years, typically containing substitutions to the ergoline scaffold on the indole (N1) nitrog...

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Molecular Psychiatry - Neurodegenerative-related gene rescue in anterior insula after early life maltreatment restores adult social interaction in male mice

Do nothing

Brighter electrochemical reaction powers superresolution imaging

China's first DREADDs human trials stun US scientists: 7 chemogenetic brain therapies for epilepsy, Parkinson's and trigeminal pain.

Chinese researchers are testing DREADDs, a gene therapy to turn down neuronal activity, in the clinic

Chair

NEW YORK CITY, NY / ACCESS Newswire / August 9, 2026 / Bronstein, Gewirtz & Grossman, LLC is investigating potential claims on behalf of purchasers of MapLight Therapeutics, Inc. ("MapLight" or "the C...

YouTube video by Nikolai Slavov

Many important biological functions arise not from single genes but from complex interactions encoded by entire genomes. We report the first generative design of complete bacteriophage genomes using g...

So to continue…by virtue of what I now recognize as a grand cosmic joke my lab was fortunate enough to obtain our FIRST NIH CONTRACT in 1998.

So to continue…by virtue of what I now recognize as a grand cosmic joke my lab was fortunate enough to obtain our FIRST NIH CONTRACT in 1998.

Chiu et al. have developed engineered HTR2A mouse lines enabling in vivo mapping, targeting and modulation of receptor-expressing neurons and validated their utility across biochemical, electrophysiol...

Chiu et al. have developed engineered HTR2A mouse lines enabling in vivo mapping, targeting and modulation of receptor-expressing neurons and validated their utility across biochemical, electrophysiol...

By selectively targeting peripheral 5-HT2AR without inducing psychedelic effects, a non-brain-penetrant agonist boosts antitumor CD8+ T cell immunity and improves immunotherapy responses in preclinica...

Inhibition of Gi-type G proteins expressed by gastrointestinal K cells promotes insulin release and lowers blood glucose levels.

Chemogenetic PV interneuron activation simultaneously rescues seizures and social deficits in polygenic absence epilepsy mice.

Posterior striatal circuits control sensory-guided actions and are disrupted in a rodent model of neurodevelopmental disorders.

Lower the National Debt by being more cost-effective!