iiinova — where your digital self keeps evolving

Caitie McCafferty @computingcaitie.bsky.social · 16/09/2026

Experience w proteomics data analysis? Come to the FMI!! #proteomics #massspec

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FMI science @fmiscience.bsky.social · 16/09/2026

We’re hiring! The FMI Computational Biology Facility is seeking a Computational Biologist with experience in proteomics data analysis. Join a collaborative team working with scientists across the FMI to turn complex datasets into biological insight. Apply by Oct 25: www.fmi.ch/education-ca...

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Baukje Hoogenberg @baukjeje.bsky.social · 11/09/2026

Do you want to label the nuclear envelope? Do you work on a non-model species? Try Concanavalin A! We tested ConA on various species across the eukaryotic tree and find it is a very useful ExM-compatible marker for the NE and ER. Read all about it in our preprint: www.biorxiv.org/content/10.6...

biorxiv.org

Concanavalin A as a pan-eukaryotic nuclear envelope marker for expansion microscopy

Across eukaryotes, the nuclear envelope exhibits distinct remodelling strategies during mitosis: complete breakdown (open mitosis), partial disruption (intermediate), or full retention (closed). Howev...

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Caitie McCafferty @computingcaitie.bsky.social · 09/09/2026

I am looking for a lab manager for my group that I will be starting at the @fmiscience.bsky.social in February! We will use in situ structural biology to investigate dynamic ciliary processes. More info here —> bsky.app/profile/comp... #cilia #teamtomo #proteomics #protistsky

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Janani Durairaj (Jay) @ninjani.bsky.social · 28/08/2026

Some exciting news: I'm joining the University of Lausanne @unil.bsky.social @dbc-unil.bsky.social as an Assistant Professor next month 🎉 My group will work on context-aware deep learning for protein structure, interaction & design. Postdoc and PhD openings coming soon - keep an eye out!

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Kirsty Wan @micromotility.bsky.social · 17/08/2026

What does a single-celled organism tell us about the origins of complex behaviour? Delighted to see the final version of our paper: Embodied behavioural complexity in a ciliated microorganism out in@natcomms.nature.com (Funded by @erc.europa.eu ERC) doi.org/10.1038/s414... #cilia #protistsonsky

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John Wallingford @jbwallingford.bsky.social · 04/08/2026

Cilia alert! Last year Juyeon Hong described a new domain in 9+2 cilia called the EDT, the extreme distal tip. Now, she's found a new protein required for its assembly, but only in non-mammalian vertebrates. A cool evo-cell / protein evolution story in @cellreports.bsky.social tinyurl.com/2xvdskx6

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Florent Waltz @florentwaltz.bsky.social · 27/07/2026

This story is now published in @natplants.nature.com ! 🎉🎩 Check out the final article here: nature.com/articles/s41477-026-02361-1 Very similar to the original bioRxiv preprint, with the addition of some cool polysome analysis (in the supplementals)! Thanks and congrats to everyone involved! 🙏

nature.com

Chloroplast-encoded small subunit extensions reshape the Chlamydomonas chlororibosome - Nature Plants

Using in situ cryo-electron tomography, researchers found a unique ‘arm’ domain on the small subunit of Chlamydomonas chlororibosomes. This discovery suggests that chlororibosome structure is more evo...

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sofie.rec @sofie-dot-rec.bsky.social · 27/07/2026

The artist formerly known as #thatmitoriboguy has now become #thatchlororiboguy Check out some cool tomo from @florentwaltz.bsky.social @phaips.vd.st

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Ben Engel @cellarchlab.com · 03/07/2026

Super excited to launch this search for a new endowed professor at the @biozentrum.unibas.ch! Join us to build a research cluster in Climate Biophysics! 🌍🌊🌾🔬🧪 This is a unique opportunity to create a community in Basel🇨🇭working together on this timely topic! ⏳🌡️ Questions? Please reach out! 👩‍🔬👨‍🔬

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Caitie McCafferty @computingcaitie.bsky.social · 22/06/2026

Happy to finally share that I will be starting my independent group at the @fmiscience.bsky.social in Feb 2027 in a vibrant new environment. We will use integrative in situ structural cell biology methods to investigate ciliary structure and dynamics in several model (and non-model 👀) systems!!

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EuroCilia2027 @eurocilia.bsky.social · 04/06/2026

Big congratulations to our winners: Smilla-Maria Koy (1st), Chandrama Ghosh (2nd), and Anthony Rabaté (3rd)! Check out their breath-taking micrographs and the rest of the Top 15 entries in the stunning poster attached. The future of cilia research looks beautiful. 📸 #Cilia2027

micrographs depicting cilia in different forms

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Caitie McCafferty @computingcaitie.bsky.social · 24/05/2026

Great opportunity to work in an exciting environment and a wonderful group!!

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Ben Larson @blarson.bsky.social · 19/05/2026

And now it's out! Happy that PNAS selected for the cover this SEM image snapped by @samjlord.bsky.social, one of the most evocative visualizations of Euplotes that I have ever encountered. www.pnas.org/doi/10.1073/... Stay tuned for what is shaping up to be some fascinating follow-up in the lab...

Scanning electron microscopy image of the ciliate Euplotes gigatrox on the cover of the journal PNAS. Distinct punk rock vibes

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HHMI @hhmi-science.bsky.social · 10/05/2026

This mesmerizing timelapse captures the nonstop motion inside an animal cell. Red/orange streaks are the growing ends of microtubules, tiny “highways” that can rapidly assemble and disassemble to move proteins & other molecules within the cell. 📸: Andy Moore, HHMI’s Janelia Research Campus

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Ben Engel @cellarchlab.com · 14/04/2026

Across scales from cells🦠 to atoms⚛️ – We reveal how anaerobic #bacteria break down very stable aromatic compounds found e.g. in oil spills 🛢️ #Bioremediation #TeamTomo 🧪 🧶🧬 🔬 Awesome collab with Lena, Matthias, @schullerjm.bsky.social @rnfr2d2.bsky.social @tomaspascoa.bsky.social @tamb-o.bsky.social

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Caitie McCafferty @computingcaitie.bsky.social · 08/04/2026

I told you it was final 😉, now we celebrate 🎉

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Ben Engel @cellarchlab.com · 08/04/2026

This is why I’m not allowed in the wet lab anymore 🥼 🕺. My technique is too effective! 🤪 #PILife #TeamTomo 🧪

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Ricardo D. Righetto @lifeonthewedge.bsky.social · 08/04/2026

Now THIS one was quite the journey. I'm beyond happy to see this work out in the world 🥹 Huge congrats to @computingcaitie.bsky.social and also to @hugovdhoek.bsky.social and everyone else involved ♥️ with @centriolelab.bsky.social @stearnslab.bsky.social @cellarchlab.com #Cilia #CryoET #TeamTomo

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Ben Engel @cellarchlab.com · 08/04/2026

It’s done!! Molecular architecture of the ciliary base in mammalian multiciliated cells! A study 13 years in the making 👴, thanks to collab with @stearnslab.bsky.social + @centriolelab.bsky.social & visionary work by @computingcaitie.bsky.social, who integrated native #cryoET with #XLMS & #UExM 🧪🧶🧬🔬

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sofie.rec @sofie-dot-rec.bsky.social · 08/04/2026

Crazy things have been happening in cilia world, catch up on them in Caitie's new paper! 🪱

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Caitie McCafferty @computingcaitie.bsky.social · 08/04/2026

I am excited to share our most recent work collaborating with @centriolelab.bsky.social and @stearnslab.bsky.social to look at the ciliary base of mammalian multiciliated cells w/ cryo-ET, XL/MS, and U-ExM www.biorxiv.org/content/10.6...

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Spang Lab @spanglab.bsky.social · 30/03/2026

What if you could cut out sub cellular structures and measure the proteome? SPEx: Compartment-Resolved Proteomics via Expansion Microscopy–Guided Microdissection www.biorxiv.org/content/10.6... awesome work by Curdin Franziscus, @imcf-lex.bsky.social, @biehli.bsky.social, Alexander Schmidt!

biorxiv.org

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Caitie McCafferty @computingcaitie.bsky.social · 19/03/2026

New protein complex stoichiometry prediction tool from talent PhD student @daniil-litvinov.bsky.social, check out the thread below!

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Caitie McCafferty @computingcaitie.bsky.social · 11/03/2026

Exciting opportunity to work in a lab that’s pushing the boundaries of environmental sampling and work with an amazing scientist!!! 👩‍🔬🔬

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Thibaut Brunet @thibautbrunet.bsky.social · 28/02/2026

Final version @nature.com of our paper describing unconventional multicellular development in a choanoflagellate inhabiting an extreme environment. A ton of new data since the first @biorxivpreprint.bsky.social preprint (which we've kept updating). A brief 🧵 (carried over from the old place)

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Caitie McCafferty @computingcaitie.bsky.social · 25/02/2026

Nice collab w my neighbor in Basel @abimoye.bsky.social on SAXO6 mol bio and genetics!!

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Abigail Moye @abimoye.bsky.social · 24/02/2026

Thrilled to share that our paper on a novel IRD gene has been published in The American Journal of Human Genetics (AJHG)! 🎉 This wouldn’t have been possible without the incredible group of colleagues and collaborators. Special thanks to @computingcaitie.bsky.social, Ditta Zobor, and ERDC members!

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IOB - Institute of Molecular and Clinical Ophthalmology Basel @iobswiss.bsky.social · 24/02/2026

📏🔬In collaboration with @computingcaitie.bsky.social and @cellarchlab.com, SAXO6 localization was mapped along ciliary microtubules with direct links to α-tubulin, linking this structural protein class to human retinal disease for the first time. 👉 @ajhgnews.bsky.social #Ophthalmology

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Florent Waltz @florentwaltz.bsky.social · 10/02/2026

Long in the making, but happy to present the Chlamydomonas chlororibosome! Cryo-ET🔬reveals a large new domain on the small subunit, built from multiple extensions in conserved ribosomal proteins. bioRxiv 📖: shorturl.at/q44tG This suggests greater chlororibosome diversity than expected! 1/n 🧵

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Helen Foster @helenfoster.bsky.social · 06/02/2026

Very happy to say that our work on how axonemes are generated is now available on bioRxiv: www.biorxiv.org/content/10.6... - if you’ve ever wondered how the incredibly beautiful, complex structures within motile #cilia are constructed then this is for you!

biorxiv.org

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German Society for Plant Sciences (DBG) @plantsciencedbg.bsky.social · 03/02/2026

For #ECR’s: DBG’s Hot Tpoic Workshop on Cryo-Electron Tomography + FIB-milling 13 – 15 April 2026 In @cellarchlab.com 's lab @biozentrum.unibas.ch Organised by @tamb-o.bsky.social, Karen Zinzius, @fannyleblanc.bsky.social Details: www.deutsche-botanische-gesellschaft.de/en/about-us/...

deutsche-botanische-gesellschaft.de

Hot Topic Conference

Support for an "Eduard Strasburger Hot Topic Conference" for DBG's members

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Philippe Van der Stappen @phaips.vd.st · 30/01/2026

You like #LLPS? #TeamTomo? #Rubisco? Check out our latest preprint! What a great collaboration this has been!

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Matt Lycas @lycasworks.bsky.social · 20/01/2026

🔬🚨New preprint alert! 🚨🔬 We developed quantitative expansion microscopy (qExM) - a method to accurately count proteins in situ by combining expansion microscopy's improved labeling with statistical estimators borrowed from ecology www.biorxiv.org/content/10.6... #SuperResolution #CellBiology

biorxiv.org

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Thibaut Brunet @thibautbrunet.bsky.social · 12/01/2026

Our research scientist Núria Ros-Rocher won the 1st prize @zeiss-microscopy.bsky.social microscopy contest with this beautiful choano colony www.zeiss.fr/microscopie/... 🥳 C. flexa might not yet be a genetic model, but it is now at least a calendar model, which counts for something. I think.

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Ricardo D. Righetto @lifeonthewedge.bsky.social · 09/01/2026

This one was quite the journey! The paper describing the #ChlamyDataset is finally out and on the cover of Mol Cell! This beautiful rendering made by co-author @jessheebner.bsky.social and Holly Peterson shows an instance of mitochondrial fission found in the dataset 😍 [Maybe long thread ahead]

cell.com

Toward community-driven visual proteomics with large-scale cryo-electron tomography of Chlamydomonas reinhardtii

Using the latest advances in instrumentation and computational workflows, Kelley et al. present a large-scale annotated cryo-electron tomography dataset of the model green alga, Chlamydomonas reinhard...

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Florent Waltz @florentwaltz.bsky.social · 19/12/2025

Final version is out! Our large-scale cryo-ET dataset 🔬 of Chlamydomonas reinhardtii 🦠 is now published in @cp-molcell.bsky.social Huge collaborative effort! So glad to see the community already using it to develop new resources & tools. Check it out here: shorturl.at/z4i4c #CryoEM #CryoET

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Ben Engel @cellarchlab.com · 10/12/2025

Happy to share our fun team-up with @centriolelab.bsky.social & @stearnslab.bsky.social to reveal the architecture of the mammalian centriole’s Distal Ring 🛟. Very cool multiscale integration of #UExM 📏🔬with #CryoET ❄️🔬. Congrats to @ebertiaux.bsky.social & @computingcaitie.bsky.social #TeamTomo 🧪

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Ben Engel @cellarchlab.com · 25/11/2025

Great talk (and work 🧪 ) by @computingcaitie.bsky.social from @biozentrum.unibas.ch about exploring multiciliated cells with a complementary trio of structural techniques! Looking forward to sharing the preprint. Thanks for the fab collab @centriolelab.bsky.social @stearnslab.bsky.social #TeamTomo

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FocalPlane @focalplane.bsky.social · 13/11/2025

While trying to steer clear of the ‘best organelle’ debate, we’re delighted to highlight #JCSciliaSI, guest edited by @cilialab.bsky.social & @lottepedersen.bsky.social. And, we hope that even the most ardent fans of other organelles can agree that cilia are certainly beautiful to image!

focalplane.biologists.com

JCS Special Issue - 'Cilia and Flagella: from Basic Biology to Disease' - FocalPlane

JCS Special Issue - 'Cilia and Flagella: from Basic Biology to Disease' - News

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Abigail Moye @abimoye.bsky.social · 31/10/2025

Super happy this work is out and included in the really interesting cilia and flagella focused issue!

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Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦ @dudinlab.bsky.social · 31/10/2025

🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny. #ProtistsOnSky #SciComm #SciSky www.cell.com/cell/fulltex...

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Journal of Cell Science @jcellsci.bsky.social · 27/10/2025

Our Special Issue on Cilia and Flagella: from Basic Biology to Disease, guest edited by @cilialab.bsky.social‬ and @lottepedersen.bsky.social, is building. We’ll be highlighting all the articles over the next couple of weeks. Follow along at #JCSciliaSI. journals.biologists.com/jcs/issue/13...

journals.biologists.com

Volume 138 Issue 20 | Journal of Cell Science | The Company of Biologists

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Ben Engel @cellarchlab.com · 26/10/2025

A class like no other!! From #AI structure hallucination 🤖 to #CryoEM structure reality 🔬 by @biozentrum.unibas.ch @unibas.ch undergraduate students👩‍🔬👩‍🎓 in just a few weeks! One of their creations is this beautiful flower-shaped tetrameric pore 🌼, a brand new member of the #ProteinCosmos 🧶🧬 🧪

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Caitie McCafferty @computingcaitie.bsky.social · 25/10/2025

That’s a wrap of the 2nd edition of our one of a kind structural biology block course at the @biozentrum.unibas.ch! In just 6 short weeks students designed protein oligomers; rotated in cryo-ET, cryo-EM SPA, AFM, and NMR labs; and expressed, purified, and structurally characterized their designs

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Caitie McCafferty @computingcaitie.bsky.social · 21/10/2025

Mark your calendars for some cilia science!!!

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Florent Waltz @florentwaltz.bsky.social · 19/10/2025

Last Friday (17th), we had an amazing first Young Swiss Tomo meeting in Bern, organized with Elda Bauda, Zanetta Kechagia, and @leonieanton.bsky.social! Over 70 people from 🇨🇭 gathered to talk about cryo-electron tomography 🔬. Huge thanks to the DCI for making the event possible! See you next year! 👋

Young Swiss Tomo Organizers
Elda, Zanetta, Leonie and Florent

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Thibaut Brunet @thibautbrunet.bsky.social · 05/10/2025

Latest from ours: www.cell.com/cell-reports... This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵

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