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MRC Laboratory of Molecular Biology

@mrclmb.ac.uk
3.5K followers 756 following 415 posts

The MRC Laboratory of Molecular Biology aims to understand biological processes at the molecular level to help tackle human health problems and disease.

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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 2h
How does neurodegeneration spread across the brain? 🧠 @sjorsscheres.bsky.social, Michel Goedert & Masata Hasegawa’s groups have demonstrated that human misfolded tau filaments act as a molecular template for prion-like propagation in the mouse brain. mrclmb.ac.uk/news-events/... #LMBResearch 🧪
Alzheimer's and corticobasal degeneration tau filaments induce distinct pathologies in mouse brains, with corresponding cryo-EM images and structural models.
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 24/09/2026
Join us on Friday 16th October for our annual 'What Next For Your Career?’ event with Cambridge AWiSE. You'll hear about the different career paths pursued by our three excellent speakers: Carly Dix, @louisefets.bsky.social and Gisela Otten. More details: engagementhub.ukri.org/mrc-lmb-hr/9...
Event poster for 'What Next For Your Career?' on 16th October featuring speakers Louise Fets, Carly Dix, and Gisela Otten.
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 23/09/2026
How does the brain build its serotonin network? 🧠🧪 Jing Ren’s group (LMB Neurobiology Division) have built a 4D atlas, revealing how serotonin neuron subtypes are specified pre-birth and follow coordinated programmes to build brain-wide connections. More in @pnas.org: www.pnas.org/doi/10.1073/...
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Reposted by MRC Laboratory of Molecular Biology
HHMI @hhmi-science.bsky.social · 16/09/2026
(1/2) Serious science, unexpected fun. A fruit fly wiring diagram from our Janelia Research Campus & collaborators is being used to play Minecraft, parallel park (badly), & dance to '70s disco. That’s the joy of open science. More from @nytimes.com: bit.ly/4htsTm6.
The wiring diagram of the central nervous system of an adult male fruit fly will help researchers better understand how the brain enables complex action, from sensory perception to behavior. Credit: Data acquired and analyzed by the FlyEM Project Team at HHMI’s Janelia Research Campus, the Cambridge Connectomics Group, and Google Research. Image by Philip Hubbard/HHMI Janelia Research Campus
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 17/09/2026
📢 We're hiring an Assistant Divisional Administrator in our Neurobiology Division. Help support world-class science through HR, finance, events & administration. This is a rolling recruitment, apply early! fa-evzn-saasfaukgovprod1.fa.ocs.oraclecloud.com/hcmUI/Candid... #CambridgeJobs #AdminJobs
Photo of LMB atrium with people walking and sitting, overlaid with text stating: Now hiring: Assistant Divisional Administrator. First point of contact to a broad range of internal stakeholders and providing varied administrative support to the LMB Neurobiology Division. Rolling recruitment: Apply early.
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 16/09/2026
How do cells remove abnormal glycogen? Led by Matthew Yip, using mouse models, cell engineering & cryo-ET, Felix Randow's group found that RNF213 ubiquitylates aberrant glycogen to trigger autophagy. mrclmb.ac.uk/news-events/articles/h… #LMBResearch
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 11/09/2026
Ready to take the next step in your research career? The LMB is now accepting applications for PhD placements starting in October 2027. Deadline: 08 December 2026 (allow time for reference submission). Discover what we offer here: mrclmb.ac.uk/careers-and-people/phd…
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 08/09/2026
#ICYMI, @jefferis.bsky.social’s group, with @hhmijanelia.bsky.social & collaborators, published a collection of papers detailing the first complete connectome of the male fly CNS, enabling unprecedented male-female brain comparisons. Featured on the BBC: www.bbc.co.uk/news/article... #LMBintheNews
bbc.co.uk
How a fly brain may help explain the secrets of human behaviour
Comparing the brains of male and female flies may transform our understanding of how genes shape behaviour, including ours.
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 08/09/2026
🧠🦠 How can infection in the gut affect the brain? Menna Clatworthy’s group in the University of Cambridge’s Molecular Immunity Unit at the LMB have identified an immune link between the gut & the brain that protects the brain from future infection. Read: mrclmb.ac.uk/news-events/... #LMBResearch
Fluorescent image of cells
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 04/09/2026
From scientist to Health & Safety Advisor: Shahana Ahmed shares her career journey, including completing the NEBOSH General Certificate and why robust safety practices help make groundbreaking science possible. Read more here: mrclmb.ac.uk/news-events/... #LMBNews #HealthAndSafety
Shahana Ahmed, smiling in a blue blouse leaning on a chair in a modern office with a computer screen displaying a colourful webpage behind her.
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 03/09/2026
The complete #connectome of the adult Drosophila male CNS has allowed researchers, inc @jefferis.bsky.social’s group, to compare male & female brains at synaptic-resolution for the first time. Read more here: mrclmb.ac.uk/news-events/... #LMBResearch 1/2
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 02/09/2026
50 years after Barbara Pearse’s seminal discovery of clathrin, Frances Brodskey and Scottie Robinson met Barbara to reflect on the lasting impact her work has made to the field of cell biology. Read the interview here: onlinelibrary.wiley.com/doi/10.1111/... #LMBAlumni @cellbiol-mrclmb.bsky.social
onlinelibrary.wiley.com
Interview With Barbara Pearse and the Clathrin Family Tree
The clathrin family tree. Timeline of research on clathrin leading to and generated by Barbara Pearse's discovery, with milestones mapped onto the clathrin triskelion.
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 01/09/2026
Using advanced microscopy @piotrkolata.bsky.social @a-dsantos.bsky.social @tomdendooven.bsky.social @matteoall.bsky.social have identified the molecular anatomy & organisation of proteasomes in the sperm nucleus. Read more about the study here: mrclmb.ac.uk/news-events/... #LMBResearch 🧪
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Cambridge Biomedical Campus @cambridgebiocampus.bsky.social · 28/08/2026
Join us at our quarterly Open Forum on Monday 21st September (5.30-7pm), inviting the public to hear the latest news in life science, innovation and research on the Cambridge Biomedical Campus (CBC). Book your place now: cambridge-biomedical.com/event/cbc-op...
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 27/08/2026
Congratulations to the former LMB Group Leaders awarded prizes from @royalsociety.org! KJ Patel has received the Buchanan Medal and Sarah Teichmann (@teichlab.bsky.social) has been awarded the Gabor Medal. Read more here: mrclmb.ac.uk/news-events/... Image: The Royal Society #LMBAlumni
Two gold medals
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 27/08/2026
Kelly Nguyen, Group Leader in the LMB’s Structural Studies Division, has been awarded the 2027 Francis Crick Medal and Lecture from @royalsociety.org. Read more about @kellythd-nguyen.bsky.social’s research on telomerase here: mrclmb.ac.uk/news-events/... #LMBNews
Kelly Nguyen, smiling with a blurred background
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 26/08/2026
📣 Just 2 weeks left to register for the tenth anniversary Next Generation Biophysics Symposium. Join us at the LMB on 16 September to hear a range of speakers cover how they're using new & emerging biophysical techniques. Register by 9 September ➡️ www3.mrc-lmb.cam.ac.uk/sites/nextge…
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 25/08/2026
Looking to solve complex, technical challenges across hardware, software and large-scale computing systems? Join our Scientific Computing team and use open-source software and custom-built systems to support the LMB's computing infrastructure. Closes 17 SEP Read more: www.jobs.ac.uk/job/DSR455/s...
MRC Laboratory of Molecular Biology hiring Scientific Computing Officer to support breakthrough discoveries with complex computing tasks.
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 18/08/2026
Exciting plans for a new national hub at @scicambridge.bsky.social to advance novel alternative methodologies for disease models. @lancasterlab.bsky.social will co-lead neuroscience models, including brain organoids. Read more: www.bbc.co.uk/news/article... #LMBintheNews @cellbiol-mrclmb.bsky.social
bbc.co.uk
Plans for £20m hub in Cambridge to develop new medicines using AI
The hub is funded by the Medical Research Council and based at Cambridge Biomedical Campus.
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 17/08/2026
How is AI changing biomedical research? 🤖🔬 In a new article, @jmrko.bsky.social & @neurofinch.bsky.social in the LMB’s Neurobiology Division explore how AI-assisted programming is transforming coding in biomedical research. Read more here: www.nature.com/articles/s41...
nature.com
Disruption of the research software landscape through AI software generation - Nature Methods
Specialized research software has historically been costly and time-consuming to create, but large language models (LLMs) have become capable enough at code generation to fundamentally change this. We...
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 14/08/2026
Congratulations to the @cambridgebiocampus.bsky.social cricket team, including players from the LMB, who have triumphed in the Cuppers cup! 🏆🏏 cambridge-biomedical.com/news/cbc-cri... #LMBintheNews
Group of cricketers, wearing cricket whites, grouped around two trophies.
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 07/08/2026
Magdalena Sutcliffe, @lancasterlab.bsky.social & @stefanschoenfelder.bsky.social demonstrate how epigenetic ‘memory’ shapes stem cell potential, but a chemical reset can restore differentiation ability. Read more: shorturl.at/PZ4tV #LMBResearch @cellbiol-mrclmb.bsky.social @babrahaminst.bsky.social🧪
Human pluripotent stem cells favour either anterior or posterior formation, but this can be mediated by chromatin restoration (CHR) treatment.Fluorescent micrograph of an organoid with intricate folds and patterns in blue and purple
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 30/07/2026
Congratulations to Chris Russo, Group Leader in the LMB’s Structural Studies Division, who has been awarded the 2026 K. H. Kuo Award for Distinguished Scientist in Biological Electron Microscopy. www.bsc.org.cn/KuoSymposium... #LMBintheNews
Chris Russo
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 24/07/2026
Thousands of possible receptor-peptide combinations. One AI-powered solution. Led by @lariferg.bsky.social, a study from @schaferlab.bsky.social & Isabel Beets has developed DeorphaNN, a neural network to identify peptide pairings for GPCRs. Read more: mrclmb.ac.uk/news-events/... #LMBResearch
Protein structure prediction confidence for a specific region is improved when an active-state template is used.
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 22/07/2026
In brain development, timing is everything. @sebastiancachero.bsky.social @erikadona.bsky.social & @jefferis.bsky.social have mapped 450,000+ cells from developing fly nervous systems to build an expansive atlas, revealing how neurons 'remember' when they were born. shorturl.at/tfI4s #LMBResearch🧪
Heatmap shows temporal expression of 17 transcription factors across neuron birth orders, with a UMAP plot visualising cell identity relationships.
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Simon Bullock @simonbullock11.bsky.social · 21/07/2026
The winners of our school microscopy competition for this year have been announced. Thank you to all the team, and especially Molly Magarotto for all her hard work coordinating the project! mrclmb.ac.uk/news-events/...
mrclmb.ac.uk
A catalyst for curiosity: the 2026 Microscopes 4 Schools Competition sparks students’ scientific intrigue | MRC Laboratory of Molecular Biology
Over 600 students across Cambridge, Peterborough and Bedfordshire took part in the 2026 Microscopes 4 Schools Competition, unlocking a new thirst for scient ...
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 20/07/2026
Looking for a people-focussed role? Join the LMB Reception team and help deliver a first-class visitor experience at our prestigious Cambridge institute. Apply by 02 AUG fa-evzn-saasfaukgovprod1.fa.ocs.ora… #CambridgeJobs
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 17/07/2026
🔧 We're hiring a Maintenance Engineer. Join the Estates & Facilities team at the LMB and help maintain our world-class research facilities. Electrical or mechanical backgrounds welcome. Apply by 03 AUG www.jobs.ac.uk/job/DSG140/maintenan… #EngineeringJobs #CambridgeJobs #Hiring
Industrial facility interior with pipes and ducts, announcing a Maintenance Engineer job opening at MRC Laboratory of Molecular Biology.
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 17/07/2026
More than 600 students from across Cambridge, Peterborough & Bedfordshire took part in this year's Microscopes 4 Schools Competition submitting images of bugs, flowers & more! 🔬 📸 2026 Winners Read more about this year’s competition here: mrclmb.ac.uk/news-events/... #LMBNews #PublicEngagement
Tarantula skin microscopyGreen flower microscopyDead fly microscopy
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 10/07/2026
The LMB is proud to be part of the National Research Organisations @nro-group.bsky.social, a collective voice for around 40 of the UK’s science and research organisations, which celebrated it's launch in London yesterday with Minister Patrick Vallance. 📷 ©UK Atomic Energy Authority #LMBintheNews
Minister Patrick Vallance, speaking at the NRO launch event in front of a screen full of logos of NRO members.LMB Director Jan Löwe speaking at the NRO launch event
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 10/07/2026
We're hiring! Join the LMB as an HR Advisor (Training Coordinator) in Cambridge. Help shape recruitment, learning & development and HR support at a world-leading research institute. Apply by 02 Aug shorturl.at/TROAu #HRJobs #CambridgeJobs #Hiring
Bright, spacious workplace scene with staff interacting, highlighting a vacancy for an HR Advisor to support employee training and development.
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 09/07/2026
Following the Home Office’s report issuing the 2025 animal research statistics, we’ve shared our annual statistics on the use of animals in research. See our #AnimalStats here: mrclmb.ac.uk/science/animal-researc… #ConcordatOpenness Understanding Animal Research
Small white mouse gently held in hands wearing purple gloves against a green background.
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 08/07/2026
Curious about how drugs are designed? Check out this seminar for non-scientists by Chris Tate, Group Leader in the LMB’s Structural Studies Division. He covers how drugs work and how researchers are working to design drugs better, faster and with fewer side effects. youtu.be/fOzwbmiKNKI
youtu.be
Drugs! How they work and how to design them. Seminar for non-scientists by Chris Tate
YouTube video by MRC Laboratory of Molecular Biology
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 08/07/2026
Opportunity for a #postdoc to join Sven Truckenbrodt's group in the LMB’s Neurobiology Division, developing expansion microscopy technology & imaging tools for optical #connectomics! www.nature.com/naturecareers/job/12… Apply by 21 JUL #PostdocJobs #ScienceJobs
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 07/07/2026
UPDATE: Unfortunately this lecture has been cancelled. As and when it is rearranged, details will be available on our Seminars & Events webpage: mrclmb.ac.uk/news-events/...
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 07/07/2026
In June, LMB scientists teamed up with @bioclocksuk.bsky.social for a chronobiology outreach exhibit at #TheBigBangFair, engaging 3000 teachers and students over 3 days. Read more about their exhibit here: mrclmb.ac.uk/news-events/... #LMBNews #PublicEngagement @nsmyllie.bsky.social
LMB scientistsExhibit with brain models and worksheets
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 06/07/2026
The LMB warmly welcomes Reinhard Lührmann to deliver the Max Perutz Lecture at 11am (BST) on Monday 13 July titled ‘Structural insights into the cascade of snRNP remodelling steps leading to the formation of a catalytically activated spliceosome’ Read more here: mrclmb.ac.uk/news-events/... #LMBNews
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 03/07/2026
LMB spinout company @trimtechtx.bsky.social has now raised $47M in seed funding. Building on research by Leo James and @w-mcewan.bsky.social, TRIMTECH Therapeutics will utilise targeted protein degradation to develop novel neurodegeneration treatments. Read more here: shorturl.at/LeTaZ #LMBintheNews
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Reposted by MRC Laboratory of Molecular Biology
Stephen McLaughlin @lmbbiophysics.bsky.social · 29/06/2026
It will be our 10th Next Generation Biophysics Symposium @mrclmb.ac.uk on 16th September. Please join us in person or online and celebrate all things #biophysics www3.mrc-lmb.cam.ac.uk/sites/nextge...
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 02/07/2026
🚆 It’s great to see Cambridge South station now open. Located right next to the LMB, the new station makes it easier than ever for visitors, collaborators and colleagues to travel to our institute and the wider @cambridgebiocampus.bsky.social. #CambridgeSouth #SustainableTravel
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 30/06/2026
Congratulations to LMB Group Leaders Emmanuel Derivery, Kelly Nguyen and Julian Sale, who have all been elected members of @EMBO.org! Read more about their research at the LMB here: mrclmb.ac.uk/news-events/... #LMBNews @deriverylab.bsky.social @kellythd-nguyen.bsky.social @juliansalelab.bsky.social
Portrait photographs of Julian Sale, Emmanuel Derivery and Kelly Nguyen
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 26/06/2026
2026 marks the tenth edition of the Next Generation Biophysics Symposium! Registration for this year’s event, happening at the LMB on Wednesday 16th September, is open now ➡️ www3.mrc-lmb.cam.ac.uk/sites/nextge…
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 26/06/2026
Novel base editing technology has been used to test gene function in human embryos in a @loke-ctr.bsky.social study. LMB Investigator Scientist @kashishsingh.bsky.social purified the adenine-base editing enzyme which was used for the genome-editing experimental work. shorturl.at/i1WFt #LMBintheNews
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 26/06/2026
A new pathway to target intracellular pathogens - Listen to Tyler Rhinesmith and Leo James from the LMB’s PNAC Division discuss their new paper on the latest episode of The Naked Scientists podcast: www.thenakedscientists.com/podcasts/nak... #LMBintheNews
thenakedscientists.com
UK's under-16 social media ban, and the first trillionaire
Plus, scientists trace the origins of cotton to the Caribbean
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 25/06/2026
Congratulations to Jason Chin, former LMB Group Leader & Joint Head of the PNAC Division, on receiving the 2026 Heinrich Wieland Prize for his work on synthetic biology! Jason is now Executive Director of GBI at @eitoxford.bsky.social. boehringer-ingelheim-stiftung.de/en/scientifi... #LMBAlumni
Jason Chin stood in front of a grey backdrop
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 24/06/2026
Congrats to #LMBAlumni Girish Mali, @dyneinassembly.bsky.social, who has been awarded the Lister Prize from @thelisterinstitute.bsky.social! 🎉 Girish was a Career Development Fellow in the LMB’s Structural Studies Division from and now leads his own research group at the @dunnschool.bsky.social.
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 18/06/2026
Don’t miss tomorrow’s #LMBSeminar from Britt Glaunsinger: ‘Transcriptional trickery controls RNA abundance during viral stress’ Join us from 11am (BST). Visit our website for more details: mrclmb.ac.uk/news-events/seminars-e…
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 17/06/2026
The LMB was once again brightened by a colourful display of artistic talent for the 2026 Arts and Crafts Show! Check out some of the fantastic items on display here: mrclmb.ac.uk/news-events/... #LMBNews
mrclmb.ac.uk
Creative hobbies abound at the LMB Arts and Crafts Show | MRC Laboratory of Molecular Biology
A colourful display at the LMB with crafts ranging from sketching, painting and photography, to jewellery making, ceramics and crochet.
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 12/06/2026
Just one week to go until the next #LMBSeminar! Britt Glaunsinger from UC Berkeley will give her talk ‘Transcriptional trickery controls RNA abundance during viral stress’ at 11am (BST) on Friday 19th June. More details: mrclmb.ac.uk/news-events/seminars-e…
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Dr. Nicola Smyllie @nsmyllie.bsky.social · 11/06/2026
We had a great time representing @mrclmb.ac.uk and @bioclocksuk.bsky.social at #TheBigBangFair this week, bringing brains and body clocks to primary school students and teachers, with the aim of inspiring the next generation to pursue STEM careers.
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