Sign in

Emmanuel Levy's lab

@elevylab.bsky.social
146 followers 78 following 15 posts

Structural & Systems Biology Lab @ University of Geneva | Exploring protein & proteome assemblies | Structured thoughts, intrinsically disordered views

PostsRepliesMedia
Emmanuel Levy's lab @elevylab.bsky.social · 25/09/2026
It took a while, but here we are. Our micDROP paper is out in @natcomms.nature.com, led by @atargt.bsky.social. She asked whether the sequence of a disordered region can self-recognize specifically. She measured this for ten IDRs in living yeast cells. www.nature.com/articles/s41...
1199
Reposted by Emmanuel Levy's lab
Martin Pacesa @martinpacesa.bsky.social · 21/09/2026
ʙɪɴᴅᴄʀᴀꜰᴛ2 is out, and we're not waiting for the paper. The full code drops today, free for academic and industry use. We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition. github.com/PacesaLab/Bi...
4292140
Emmanuel Levy's lab @elevylab.bsky.social · 24/09/2026
Amazingly clever use of supramolecular protein self-assemblies as in vivo reporters and sensors
020
Reposted by Emmanuel Levy's lab
Sophie G Martin @sophiemartinlab.bsky.social · 03/03/2026
You are finishing your PhD and looking to continue in science? The Martin lab @biology-unige.bsky.social has an open postdoctoral position in cell biology to study cell-cell fusion. For more information, please consult mocel.unige.ch/research-gro.... Thanks for reposting!
mocel.unige.ch
Contact/Job - Department of Molecular and Cellular Biology - UNIGE
16576
Reposted by Emmanuel Levy's lab
European Conference on Computational Biology @eccb-europe.bsky.social · 04/03/2026
📣 #ECCB2026 proceedings deadline extended to 16 March 13:00 CET Submit to 1 of our 6️⃣ sessions: 🔹 Genomics 🔹 Transcriptomics & gene regulation 🔹 Proteins & structural biology 🔹 Systems biology 🔹 Environmental bioinformatics 🔹 ELIXIR Communities 👉 More info: eccb2026.org/call-proceedings
055
Emmanuel Levy's lab @elevylab.bsky.social · 09/02/2026
In 2017 we showed that homomers evolve on the edge of supramolecular self-assembly. Here we show how to exploit this vulnerability so that ALL homomers can become bona fide drug-🎯. Delighted that Aim 3 of our @erc.europa.eu finally polymerized! Manuscript: 👉 rdcu.be/e27bT
The image illustrates a principle by which homomers can be polymerized by mutations or by multivalent small molecules.
1216
Reposted by Emmanuel Levy's lab
Yamuna Krishnan @krishnanyamuna.bsky.social · 17/12/2025
Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
29546230
Reposted by Emmanuel Levy's lab
Paul & Virginie - Centriole Lab @centriolelab.bsky.social · 10/12/2025
We’re excited to announce the opening of the Geneva Expansion Microscopy Facility (GenExM)! GenExM is a full-service U-ExM platform (U-ExM, Cryo-ExM, iU-ExM), delivering nanoscale imaging. Led by Dr. Olivier Mercey, GenExM welcomes academic & industrial collaborations. 👉 www.unige.ch/genexm/
214235
Reposted by Emmanuel Levy's lab
Rosana Collepardo @rcollepardo.bsky.social · 05/12/2025
Our Science paper is out! Huge congratulations to @huabin-zhou.bsky.social, Mike Rosen, and the brilliant @janhuemar.bsky.social @juliamaristany.bsky.social and @kieran-russell.bsky.social from our group News: bit.ly/4avnkAr and bit.ly/3XBGVHS Great perspective by @vram142.bsky.social +K Zhang
28941
Reposted by Emmanuel Levy's lab
David Drubin @drubin.bsky.social · 02/12/2025
Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published: journals.biologists.com/jcs/article/... The result of a fantastic Iwasa-Drubin lab collaboration. @margotriggi.bsky.social @jiwasa.bsky.social movie.biologists.com/video/10.124...
413253
Reposted by Emmanuel Levy's lab
EMBL @embl.org · 27/11/2025
Anthony A. Hyman will become EMBL’s next Director General. He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999. www.embl.org/news/people-...
1125367
Reposted by Emmanuel Levy's lab
Miguel Correa @m-correa-m.bsky.social · 27/10/2025
Hot off the press! Our paper, “Global comparative structural analysis of responses to protein phosphorylation”, is now out in Nature Communications! www.nature.com/articles/s41...
nature.com
Global comparative structural analysis of responses to protein phosphorylation - Nature Communications
Phosphorylation is central to protein regulation, yet its structural mechanisms remain poorly understood. Here, the authors conduct a global, systematic analysis of phosphorylated versus non-phosphory...
14512
Emmanuel Levy's lab @elevylab.bsky.social · 16/10/2025
Molecular Armor: Simple Rules to Keep Proteins (Re)Soluble💧 Check our preview of a cool study on how proteins stay soluble (or not) after desiccation—from the labs of S. Fried, @alexholehouse.bsky.social and @shaharsu.bsky.social in @cp-cellsystems.bsky.social www.sciencedirect.com/science/arti...
0153
Reposted by Emmanuel Levy's lab
Benjamin Towbin @betowbin.bsky.social · 30/09/2025
Tenure-track Assistant Professorship in #Quantitative #Cell #Biology at the ICB @unibern. Apply until 17 October. Combination of theory/computation and experiments particularly encouraged. Please repost! www.nature.com/naturecareer...
nature.com
Assistant Professor with tenure-track for Quantitative Cell Biology (80-100%) - Bern, Canton of Bern (CH) job with University of Bern, Institute of Cell Biology | 12844963
Assistant Professor with tenure-track for Quantitative Cell Biology (80-100%) at the University of Bern, Switzerland.
011
Reposted by Emmanuel Levy's lab
Paul & Virginie - Centriole Lab @centriolelab.bsky.social · 15/09/2025
Be our new colleague! 🎉 The Dept of Molecular and Cellular Biology at the University of Geneva is hiring an Assistant Professor or Associate Professor. 👉 More details here: lnkd.in/e8Z9eAm4 👉 Our department: mocel.unige.ch Please feel free to share this opportunity with your network.
04248
Reposted by Emmanuel Levy's lab
Molecular Systems Biology @molsystbiol.org · 07/10/2025
10/2025 Issue ➡️ www.embopress.org/toc/17444292... reduced genomes, adaptive mutations under stress, xenobiotics and gut microbiome, DMS analysis, TF effector metabolites Cover: proteins can agglomerate with limited impact on cell by @elevylab.bsky.social
152
Emmanuel Levy's lab @elevylab.bsky.social · 05/10/2025
@molsystbiol.org picked a neat cover for this month's issue 🙃 - Great work from Tal Levin, Hector Garcia-Seisdedos, many more colleagues (doi.org/10.1038/s443...) and great matching cover, too!
This month's cover highlights the article Mutation-induced filaments of folded proteins are inert and non-toxic in a cellular system by Emmanuel Levy, Hector Garcia-Seisdedos and colleagues. Yeast cells harboring mutation-induced filaments of folded proteins or “agglomerates”. The filaments appear large and disruptive, but surprisingly, Levin et al. reveal they are largely inert and non-toxic, unlike aggregates of misfolded proteins.
072
Emmanuel Levy's lab @elevylab.bsky.social · 03/10/2025
Nice to see Tal's work featured in biotech news ! www.genengnews.com/topics/biopr...
genengnews.com
Assay IDs Agglomerates for Intracellular Engineering
Protein agglomerates are reversible, so can serve as a regulatory mechanism for intracellular engineering.
020
Reposted by Emmanuel Levy's lab
Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 21/09/2025
MMseqs2-GPU sets new standards in single query search speed, allows near instant search of big databases, scales to multiple GPUs and is fast beyond VRAM. It enables ColabFold MSA generation in seconds and sub-second Foldseek search against AFDB50. 1/n 📄 www.nature.com/articles/s41... 💿 mmseqs.com
nature.com
GPU-accelerated homology search with MMseqs2 - Nature Methods
Graphics processing unit-accelerated MMseqs2 offers tremendous speedups for homology retrieval from metagenomic databases, query-centered multiple sequence alignment generation for structure predictio...
417463
Emmanuel Levy's lab @elevylab.bsky.social · 16/09/2025
Years ago we discovered that missense mutations in homomeric proteins often induces their supramolecular assembly, as in the 📽️👇 - Are such aberrant assemblies of *folded* proteins toxic? Surprisingly, NO. Cells are amazingly robust systems! Paper now online @molsystbiol.org doi.org/10.1038/s443...
1278
Reposted by Emmanuel Levy's lab
Biology-UNIGE @biology-unige.bsky.social · 22/08/2025
Congratulations @elevylab.bsky.social and collaborators for your latest publication in Cell 👏 and welcome to BlueSky 🦋@mocel.bsky.social‬ @sciencesunige.bsky.social
094