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Kaçar Lab at UW-Madison

@kacarlab.bsky.social
696 followers 185 following 122 posts

Past, Present and Future of Life Here and Elsewhere PI: Betül Kaçar Account managed by lab members. Latest paper: www.nature.com/articles/s41467-026-… ✨ kacarlab.org

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Reposted by Kaçar Lab at UW-Madison
Astrobiology @astrobiology.bsky.social · 25/09/2026
Meet the survivors of Earth’s worst days -These microbes endured the unlivable. The NASA astrobiologist who studies them reveals what that means for us today bigthink.com/the-well/ear... - Betül Kaçar #astrobiology
bigthink.com
Meet the survivors of Earth’s worst days
These microbes endured the unlivable. The NASA astrobiologist who studies them reveals what that means for us today
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Reposted by Kaçar Lab at UW-Madison
Cyanotrans @cyanotrans.bsky.social · 22/09/2026
We recently learned of the passing of Patricia Sánchez Baracaldo, who made many significant contributions in the field of phylogeny and cyanobacteria. www.bristol.ac.uk/news/2026/ju... Rest in peace.
bristol.ac.uk
June: Professor Patricia Sanchez-Baracaldo, 1970-2026 | News and features | University of Bristol
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Reposted by Kaçar Lab at UW-Madison
AbGradCon @abgradcon.bsky.social · 21/09/2026
That's a wrap on the 2026 Astrobiology Graduate Conference! We hope you all had a fantastic time learning and sharing your science with fellow early-career researchers in our field. Ad astra! ✨ #abgradcon #abgradcon26 #astrobiology #NASA
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Kaçar Lab at UW-Madison @kacarlab.bsky.social · 18/09/2026
Graduate student Allie Beyer crushing it at the #ICRP2026 (International Conference on Retinal Proteins) meeting in Sienna, Italy. Way to go, Allie & way to go ancient rhodopsins! 👏👏👏@uwmadgsed.bsky.social @uwbact.bsky.social
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Holly Rucker @hollyrucker.bsky.social · 16/07/2026
There truly is no feeling better than that spark of curiosity and excitement going into a new project. It’s my favorite part about being a scientist!
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Reposted by Kaçar Lab at UW-Madison
Rage Against the Miocene @organiccarbon.bsky.social · 23/04/2026
I am heartbroken to share that our wonderful colleague Patricia Sanchez-Baracaldo has passed away. She was a lovely person and a brilliant colleague and she will forever be an inspiration. royalsociety.org/about-us/who...
royalsociety.org
Dr Patricia Sanchez-Baracaldo - Parent Carer Scientist | Royal Society
This profile of Dr Patricia Sanchez-Baracaldo is part of Parent Carer Scientist, a project showcasing the diversity of approaches to combining scientific careers with caring responsibilities.
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Kaçar Lab at UW-Madison @kacarlab.bsky.social · 04/09/2026
Amazing! Latest spotlight in @cp-trendsbiochem.bsky.social highlights our lab's recent work on the origins of Mo/W!!! A first for the lab, congrats, Aya and everyone! 🎉 www.cell.com/trends/bioch... Link for the original paper: www.nature.com/articles/s41...
cell.com
A phylogenomic analysis of ancient transition metal biochemistry
Despite seemingly low levels of molybdenum (Mo)/tungsten (W) in the Earth’s ancient oceans, these metals play central roles in driving modern biogeochemical cycles. Klos et al. used phylogenomic appro...
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Reposted by Kaçar Lab at UW-Madison
Astrobiology @astrobiology.bsky.social · 06/09/2026
astrobiology.com/2026/09/06/t... #astrobiology #OriginOfLife #evolution
astrobiology.com
The Emergence Of Life In The Light Of Evolution
The origin of life is often framed primarily as a chemical problem, yet life s defining feature is evolution.
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Reposted by Kaçar Lab at UW-Madison
Astrobiology @astrobiology.bsky.social · 05/09/2026
astrobiology.com/2026/09/04/a... #Astrobiology #AbGradCon #AbGradCon26 #NASA @NASAScience_
astrobiology.com
Astrobiology Graduate Conference (AbGradCon26) Update
Astrobiology Graduate Conference (AbGradCon26) Update
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Kaçar Lab at UW-Madison @kacarlab.bsky.social · 04/09/2026
Amazing! Latest spotlight in @cp-trendsbiochem.bsky.social highlights our lab's recent work on the origins of Mo/W!!! A first for the lab, congrats, Aya and everyone! 🎉 www.cell.com/trends/bioch... Link for the original paper: www.nature.com/articles/s41...
cell.com
A phylogenomic analysis of ancient transition metal biochemistry
Despite seemingly low levels of molybdenum (Mo)/tungsten (W) in the Earth’s ancient oceans, these metals play central roles in driving modern biogeochemical cycles. Klos et al. used phylogenomic appro...
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Reposted by Kaçar Lab at UW-Madison
Sven T. Stripp @stripplab.bsky.social · 03/09/2026
Not to miss:
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Reposted by Kaçar Lab at UW-Madison
Protein Structure Evolution (ProSE) Seminar @proteinstructure.bsky.social · 01/09/2026
Join us next Tuesday, 5PM CET for our first ProSE after the summer! Betül Kaçar @kacarlab.bsky.social will talk about the origin and early evolution of ancient proteins! 📜🧬 tinyurl.com/prose-seminar2
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Reposted by Kaçar Lab at UW-Madison
Kaçar Lab at UW-Madison @kacarlab.bsky.social · 06/08/2026
🚨 Job alert! 🚨 Join the faculty at UW–Madison Bacteriology! We have two faculty searches: • Asst Prof (Microbial Communities & Bioeconomy) • Asst / Assoc / Full Prof (Systems & Synthetic Biology) Check out the open positions and apply👇 #FacultyJobs #SynBio #Microbiology #Astrobiology #Evolution
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Reposted by Kaçar Lab at UW-Madison
Karen Lloyd @karenlloyd.bsky.social · 17/08/2026
Check out this awesome New Yorker article James Dinneen wrote about our work with Emil Ruff's NASA ICAR work and Yasube Yabe's D-SEIS project in the South African Gold Mine! It was a pleasure to have James join us, he's an intrepid traveler! tinyurl.com/4k4fh33r
tinyurl.com
The Mystery of Dark Oxygen
Scientists once thought that life-sustaining oxygen existed only near Earth’s surface. Then they detected it deep underground.
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Reposted by Kaçar Lab at UW-Madison
Mel 📎🐟🌲⚓🌳🌊 @norska11.bsky.social · 18/08/2026
This is such an enjoyable episode of Star Talk. How life started, atoms, molecules, bacterium, enzymes, amino acids, possible life on other planets. youtu.be/72ugdkB7oQ4?...
youtu.be
An Astrobiologist Pieces Together How Life Started, with Betül Kaçar
YouTube video by StarTalk
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Reposted by Kaçar Lab at UW-Madison
Bruno Cuevas Zuviría @brunocuevaszuviria.bsky.social · 10/08/2026
I am looking for ideas on how to teach coding ensuring that students don't simply use the AI. Searching it online turns out to only give me courses on "No-code AI" when my search queries are actually different forms of "No AI coding"
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Kaçar Lab at UW-Madison @kacarlab.bsky.social · 06/08/2026
🚨 Job alert! 🚨 Join the faculty at UW–Madison Bacteriology! We have two faculty searches: • Asst Prof (Microbial Communities & Bioeconomy) • Asst / Assoc / Full Prof (Systems & Synthetic Biology) Check out the open positions and apply👇 #FacultyJobs #SynBio #Microbiology #Astrobiology #Evolution
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Kaçar Lab at UW-Madison @kacarlab.bsky.social · 04/08/2026
How can we study life’s deep evolutionary past? By bringing it into the lab! This @asm.org feature highlights our on-going efforts. Read how synthetic biology allows us to reconstruct ancient microbial systems, test hypotheses about early metabolism and explore how life and Earth co-evolved. 🌍
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ASM @asm.org · 31/07/2026
Synthetic biology is advancing how scientists study early microbial life. Their findings could revolutionize how we think about Earth’s earliest residents—and those that exist today. asm.org/articles/202...
asm.org
Synthetic Biology Sheds Light on Microbial Evolution | ASM.org
Synthetic biology is advancing how scientists study early microbial life. Their findings could revolutionize how we think about Earth’s earliest residents—and those that exist today.
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Kaçar Lab at UW-Madison @kacarlab.bsky.social · 24/07/2026
Key point: Total trace-metal concentration is not enough to predict biological function. Metal speciation, microbial physiology & ecological context determine whether a scarce metal remains usable. Read more about our NASA funded work: museastrobiology.org PS: Join us. We are hiring postdocs!
museastrobiology.org
MUSE
Studying the natural selection of metals across eons. Muse is a NASA Interdisciplinary Consortium for Astrobiology Research, based at the University of Wisconsin-Madison
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Reposted by Kaçar Lab at UW-Madison
Kaçar Lab at UW-Madison @kacarlab.bsky.social · 24/07/2026
New publication! Together with the Dekas Lab at Stanford, we explored microbial N₂O reduction in sulfidic waters across varying copper and what this reveal about ancient oceans. Microbial N₂O Reduction in Sulfidic Waters: Implications for Proterozoic Oceans onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com
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Kaçar Lab at UW-Madison @kacarlab.bsky.social · 24/07/2026
New publication! Together with the Dekas Lab at Stanford, we explored microbial N₂O reduction in sulfidic waters across varying copper and what this reveal about ancient oceans. Microbial N₂O Reduction in Sulfidic Waters: Implications for Proterozoic Oceans onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com
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Reposted by Kaçar Lab at UW-Madison
Bruno Cuevas Zuviría @brunocuevaszuviria.bsky.social · 21/07/2026
La vida es lo que se te pasa tratando de navegar un documento de Word con 3 comentarios y 4 correcciones #word
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Reposted by Kaçar Lab at UW-Madison
Bruno Cuevas Zuviría @brunocuevaszuviria.bsky.social · 19/07/2026
España!!!! España!!! Me ha quedado un poco regulera pero bueno
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Reposted by Kaçar Lab at UW-Madison
Kaçar Lab at UW-Madison @kacarlab.bsky.social · 19/06/2026
New preprint! How do you engineer one of biology’s most complex enzymes without breaking it? We used evolution as a guide to map a protein interface in nitrogenase, screening >9,000 variants to reveal sequence-function rules for future nitrogen fixation engineering. www.biorxiv.org/content/10.6...
biorxiv.org
Evolution-guided engineering of an ancient nitrogenase interface enhances enzyme activity and stability
Nitrogenase is the only enzyme capable of biological nitrogen fixation and a major target for sustainable agricultural engineering, yet its functional and structural complexity has made it difficult t...
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STCmicrobeblog @stcmicrobeblog.bsky.social · 19/06/2026
#MicroSky
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Reposted by Kaçar Lab at UW-Madison
noam @prywes.bsky.social · 19/06/2026
Wow! Incredible work especially working in nitrogen fixing bacteria!
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Kaçar Lab at UW-Madison @kacarlab.bsky.social · 19/06/2026
New preprint! How do you engineer one of biology’s most complex enzymes without breaking it? We used evolution as a guide to map a protein interface in nitrogenase, screening >9,000 variants to reveal sequence-function rules for future nitrogen fixation engineering. www.biorxiv.org/content/10.6...
biorxiv.org
Evolution-guided engineering of an ancient nitrogenase interface enhances enzyme activity and stability
Nitrogenase is the only enzyme capable of biological nitrogen fixation and a major target for sustainable agricultural engineering, yet its functional and structural complexity has made it difficult t...
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Kaçar Lab at UW-Madison @kacarlab.bsky.social · 23/05/2026
Checkout our latest paper, tracing the history and evolution of rare metal utilization across billions of years. Focus: Molybdenum and Tungsten! www.nature.com/articles/s41...
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Reposted by Kaçar Lab at UW-Madison
Nature Portfolio @natureportfolio.nature.com · 10/05/2026
A study in Nature Communications shows that life began using molybdenum and tungsten enzymes as early as 3.7–3.1 billion years ago, It also reveals that key metabolic processes arose despite scarce metals, highlighting the early adaptability of microbial life. 🧪
go.nature.com
Biological use of molybdenum and tungsten stems back to 3.4 billion years ago - Nature Communications
The study shows that life began using molybdenum and tungsten enzymes as early as 3.7–3.1 billion years ago. Study reveals that key metabolic processes arose despite scarce metals and highlighting the early adaptability of microbial life.
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Morgan Sobol @msobol.bsky.social · 03/04/2026
🚨New pub is live! It was really fun to write this with my friend @carolinamicro.bsky.social. If you're curious about how phylogenomics has shaped our understanding of early life and want guidance on how to do this kind of work yourself, then this review is for you. Enjoy! 🚀 doi.org/10.1093/jamb...
doi.org
Tracing ancient life through the genomic record
Abstract. Since its origins, life has been profoundly interconnected with Earth’s history. The genomes that underpin the diversity of modern life forms hav
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AbGradCon @abgradcon.bsky.social · 17/04/2026
Abstract submissions for the Astrobiology Graduate Conference 2026 are open! Deadline is May 29th; see our website for more details! 🌵🪐🦠 #abgradcon #abgradcon2026 #astrobiology
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June Astford 🇨🇦 NASTY CANADIAN 🇨🇦 @june29.bsky.social · 14/05/2026
Maybe just me but this is spectacular. www.youtube.com/watch?v=72ug...
youtube.com
An Astrobiologist Pieces Together How Life Started, with Betül Kaçar
YouTube video by StarTalk
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Dr. Or M. Bialik |📚|🔬|🌊|⚒️ @obialik.bsky.social · 06/05/2026
Molybdenum doesn't pop to mind when we think of elements biological system needs, nor does tungsten. But for some of the earliest forms of life on Earth, they might have been vital. 🧪⚒️ Link: www.nature.com/articles/s41467-026-…
Bacterial homologs that catalyze steps in the Moco synthesis pathway are shown in (a) with corresponding homologs in humans, plants, and fungi (Aspergillus nidulans and Neurospora crassa) detailed in (b). Chemical structures for the FeMo cofactor (FeMoco) and the unmodified form of the Mo cofactor (Moco or Mo-MPT for molybdopterin) incorporated by the SO family are also shown. The AOR, DMSOR, and XO families of enzymes require additional modification of Moco (or Wco for W-bound pterin) prior to enzyme incorporation. Chemical structures for these modified cofactors are depicted in (c) where asterisks refer to previous observations of the presence of either Mo or W in cofactors, as has been shown for certain enzymes of the DMSOR and AOR families. Unlike other Moco-using enzymes that contain a single metal center (mononuclear), aerobic carbon monoxide dehydrogenases (CODH) incorporate a binuclear [CuSMo] cluster. These enzymes are grouped into the XO family based on similarities in their coordination of the Mo atom.
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Kaçar Lab at UW-Madison @kacarlab.bsky.social · 06/05/2026
Latest paper out in Nature Communications! We find molecular dating evidence that life was using molybdenum and tungsten as far back as ~3.4 billion years ago, reshaping how we think about trace metals and early microbial evolution. Read here: www.nature.com/articles/s41...
nature.com
Biological use of molybdenum and tungsten stems back to 3.4 billion years ago - Nature Communications
The study shows that life began using molybdenum and tungsten enzymes as early as 3.7–3.1 billion years ago. Study reveals that key metabolic processes arose despite scarce metals and highlighting the...
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Thomas R. Holtz, Jr. @arctomet.bsky.social · 06/05/2026
Klos, A.S., Sobol, M.S., Boden, J.S. et al. Biological use of molybdenum and tungsten stems back to 3.4 billion years ago. Nat Commun 17, 3943 (2026). doi.org/10.1038/s414...
doi.org
Biological use of molybdenum and tungsten stems back to 3.4 billion years ago - Nature Communications
The study shows that life began using molybdenum and tungsten enzymes as early as 3.7–3.1 billion years ago. Study reveals that key metabolic processes arose despite scarce metals and highlighting the...
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Jérôme OLLIER @jeromeollier.bsky.social · 06/05/2026
NASA Research Shows Early Life Relied on Rare Metal - NASA Science
science.nasa.gov
NASA Research Shows Early Life Relied on Rare Metal - NASA Science
NASA-funded scientists have discovered that life on Earth over 3 billion years ago relied on the metal molybdenum, which was incredibly scarce in the environment at the time. The study, published in Nature Communications on Tuesday, is the first to show that molybdenum was used by ancient life this far back in our planet's history.
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Astrobiology @astrobiology.bsky.social · 06/05/2026
Early Life On Earth Relied On A Surprisingly Scarce Metal: Molybdenum astrobiology.com/2026/05/earl... #astrobiology #genomics #biochemistry
astrobiology.com
Early Life On Earth Relied On A Surprisingly Scarce Metal: Molybdenum - Astrobiology
life on Earth relied on a metal called molybdenum
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Kaçar Lab at UW-Madison @kacarlab.bsky.social · 06/05/2026
Thank you NASA for covering our new paper! Early life have used molybdenum and tungsten billions of years before oxygen-rich oceans made them more available --> an important clue for thinking about habitability and life detection beyond Earth! #astrobiology science.nasa.gov/science-rese...
science.nasa.gov
NASA Research Shows Early Life Relied on Rare Metal - NASA Science
NASA-funded scientists have discovered that life on Earth over 3 billion years ago relied on the metal molybdenum, which was incredibly scarce in the
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Kaçar Lab at UW-Madison @kacarlab.bsky.social · 06/05/2026
Thank you NASA for covering our new paper! Early life have used molybdenum and tungsten billions of years before oxygen-rich oceans made them more available --> an important clue for thinking about habitability and life detection beyond Earth! #astrobiology science.nasa.gov/science-rese...
science.nasa.gov
NASA Research Shows Early Life Relied on Rare Metal - NASA Science
NASA-funded scientists have discovered that life on Earth over 3 billion years ago relied on the metal molybdenum, which was incredibly scarce in the
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Kaçar Lab at UW-Madison @kacarlab.bsky.social · 06/05/2026
Latest paper out in Nature Communications! We find molecular dating evidence that life was using molybdenum and tungsten as far back as ~3.4 billion years ago, reshaping how we think about trace metals and early microbial evolution. Read here: www.nature.com/articles/s41...
nature.com
Biological use of molybdenum and tungsten stems back to 3.4 billion years ago - Nature Communications
The study shows that life began using molybdenum and tungsten enzymes as early as 3.7–3.1 billion years ago. Study reveals that key metabolic processes arose despite scarce metals and highlighting the...
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Cameron Thrash @jcamthrash.bsky.social · 05/05/2026
Biological use of molybdenum and tungsten stems back to 3.4 billion years ago www.nature.com/articles/s41... #jcampubs
nature.com
Biological use of molybdenum and tungsten stems back to 3.4 billion years ago - Nature Communications
The study shows that life began using molybdenum and tungsten enzymes as early as 3.7–3.1 billion years ago. Study reveals that key metabolic processes arose despite scarce metals and highlighting the...
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Kaçar Lab at UW-Madison @kacarlab.bsky.social · 30/01/2026
Our new paper, out today! We resurrected ancient nitrogenases first used by life on Earth 3 billion years ago. We combined synthetic biology and geology & validated their chemical #biosignature in rocks that helps reveal ancient life on Earth!(and beyond!) Link: www.nature.com/articles/s41...
nature.com
Resurrected nitrogenases recapitulate canonical N-isotope biosignatures over two billion years - Nature Communications
The study shows that nitrogenase enzymes have maintained stable isotope signatures over billions of years, revealing how ancient microbes shaped Earth’s nitrogen cycle and offering a new experimental ...
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Morgan Sobol @msobol.bsky.social · 28/02/2026
Looking for suggestions for concentrating multiple low concentration, replicate 50 uL DNA and RNA extractions ranging from 0-3 ng/uL. Column or mag bead preference? Or SpeedVac? TIA!! Please share.
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Kaçar Lab at UW-Madison @kacarlab.bsky.social · 11/02/2026
We show that losing the N-term slows growth under temp/pH stress, while adding archaeal C-term tails boosts fitness at high temp + anaerobiosis. Take home: Evolution of a conserved IF2 core with stress-tuning evolutionary add-ons. Study led by Evrim Fer @uwmadisonmdtp.bsky.social! #translation
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Kaçar Lab at UW-Madison @kacarlab.bsky.social · 11/02/2026
Latest work! 🧬 We uncover how evolution of translation initiation factor 2 (IF2) extensions links translation to bacterial stress response. We map 7 structural architectures & show how terminal extensions are enriched in intrinsic disorder & phase-separation features. Link: doi.org/10.64898/202...
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Jean-Michel Ané @jeanmichelane.bsky.social · 20/02/2026
@uwmadison.bsky.social is the #2 public university in the US! time.com/7358185/top-...
time.com
The World’s Top Universities of 2026
Explore the top universities of 2026 leading in innovation, academic performance, and global engagement.
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Bruno Cuevas Zuviría @brunocuevaszuviria.bsky.social · 18/02/2026
Does anybody know what happened with Ploomber? Why is the repo archived? Should I keep building ploomber pipelines? #datascience #python #jupyter github.com/ploomber/plo...
github.com
GitHub - ploomber/ploomber: The fastest ⚡️ way to build data pipelines. Develop iteratively, deploy anywhere. ☁️
The fastest ⚡️ way to build data pipelines. Develop iteratively, deploy anywhere. ☁️ - ploomber/ploomber
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Kaçar Lab at UW-Madison @kacarlab.bsky.social · 06/02/2026
New paper! Why are some Nitrogen fixing microbes more complex? @msobol.bsky.social et al. find that microbes with more N2-fixation genes have larger, more versatile genomes, showing how changing environments shaped this key metabolism! > academic.oup.com/ismecommun/a... @isme-microbes.bsky.social
academic.oup.com
Ecological constraints and evolutionary trade-offs shape nitrogen fixation across habitats
Abstract. From its earliest beginnings, life’s expansion into new habitats has been profoundly shaped by its reciprocal interactions with Earth’s changing
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