In a new preprint we provide evidence that biophysical properties of protein condensates can explain the order of events in the endocytic pathway, and that these events are tuned by protein condensate phosphorylation. www.biorxiv.org/content/10.6...
biorxiv.org
Phosphoregulation of hierarchical protein condensate formation during clathrin-mediated endocytosis
The sequential assembly of over 50 proteins during clathrin-mediated endocytosis (CME) is well documented in yeast. However, the mechanisms governing this ordered recruitment remain poorly understood....