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Boris Sieber

@borissieber.bsky.social
1.5K followers 1.6K following 24 posts

Postdoc @SophieMartinLab.bsky.social studying #MAPK signalling in fission yeast and emerging multicellular model organisms. Alumnus of @mjafreeman.bsky.social and @jordanraff.bsky.social Latest paper: www.nature.com/articles/s41467-026-…

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Reposted by Boris Sieber
Michelle Frei @michellefrei17.bsky.social · 15h
This one is special! First lab preprint: From when the competent bacteria were not competent and all the mammalian cells died all the way to a superb biosensor for ERK activity that works in neurons, spheroids, and zebrafish! And all of it by FLIM. Congrats Elias, Rohan, Dennis! tinyurl.com/389xzbtc
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Matthew Freeman @mjafreeman.bsky.social · 10h
I wrote something (as did Mehul Malik) More importantly, @royalsociety.org has just launched a series: a practical guide to starting your PI career royalsociety.org/blog/2026/10...
royalsociety.org
The first member of your team: recruiting a postdoc | Royal Society
Matthew Freeman contributes to the 'Practical advice for an independent research career' essay series.
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Gabriel Flynn @gabrielflynn.bsky.social · 14/10/2026
AI researchers warn technology 'months away' from being able to connect to wifi using eduroam
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Dacks Lab (Evolutionary Cell Biology) @dackslabecb.bsky.social · 13/10/2026
We've been funded to start using Dictyostelium as a model system for early endomembrane evolution!! Now I'm hiring a Postdoc to join the lab in Edmonton and start playing with Dicty in the lab:) iaejup.fa.ocs.oraclecloud.com/hcmUI/Candid...
iaejup.fa.ocs.oraclecloud.com
Postdoctoral Scholar – Evolutionary Cell Biology
This position has an initial appointment of 2 years. Location - This role is hybrid with a mix of remote and in-person work at North Campus Edmonton. About the Role The Dacks Lab is seeking a highly m...
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Verena Kohler @verenakohler.bsky.social · 13/10/2026
Looking for a postdoc interested in ageing biology and proteostasis 📅 Deadline: Nov 15 More details in attached document #Postdoc #PostdocOpportunity #Proteostasis #LongevityResearch #AcademicJobs #ResearchJobs
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Jean Léon Maître @maitrejl.bsky.social · 12/10/2026
Bloop 🫧 bloop 🫧 bloop 🫧 Fluid-filled lumens are everywhere in our body How do they get soooo big? We find that osmotic pressure vastly dominates mechanical forces in controlling lumen swelling in mouse embryos biorxiv.org/content/10.6... @louise-dagher.bsky.social @matteo-bassanini.bsky.social
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Yanlan Mao @yanlanmao.bsky.social · 12/10/2026
Latest paper from our lab is now out in @embojournal.org! If you want to know how 3D cell shape changes promote #woundhealing, and see a 3D vertex model that allows #scutoids to form, read this article: link.springer.com/article/10.1... Many thanks and congrats to all co-authors!
link.springer.com
Three-dimensional mechanical cooperativity optimises epithelial wound healing - The EMBO Journal
Epithelial tissues serve as critical physical barriers that protect organs, making their efficient repair essential upon damage. To achieve this, tissues must quickly react, forcing cells to rearrange...
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Christophe 🔬 Leterrier @christlet.bsky.social · 12/10/2026
Our movie won at the @inp-marseille.bsky.social retreat! Behold NeuroCyto's latest blockbuster: "Neuronal culture is a piece of cake" 🍰
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Lillie Bell @lilliebell.bsky.social · 12/10/2026
Happy to share my PhD work on the regulatory mechanism of E3 ligase RNF213! RNF213 is not a monomer, but a dimer that switches between inhibited and activated states in an ATP-dependent manner. We tracked the activation mechanism and showed how disease mutations can destabilize the inhibited state.
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Christophe 🔬 Leterrier @christlet.bsky.social · 09/10/2026
Nikon Small World does the right thing
nikonsmallworld.com
Nikon Small World in Motion Video Statement | News | Nikon Small World
An update from Nikon Small World regarding the 2026 Small World in Motion first-place winning video: After thoroughly re-evaluating the video and supporting materials and consulting with members of…
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Paul & Virginie - Centriole Lab @centriolelab.bsky.social · 08/10/2026
We are updating our Expansion Microscopy (U-ExM) website with : - Protocols tips to help you get started - Examples of applications across different biological systems. - work in progress - an antibody database 👉 mocel.unige.ch/research-gro...
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Biology-UNIGE @biology-unige.bsky.social · 08/10/2026
Check out this exciting #PhD opportunity in @helsenjana.bsky.social 's group @mocel.bsky.social @sciencesunige.bsky.social
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paveltomancak.bsky.social @paveltomancak.bsky.social · 08/10/2026
It appears that many big institutions are gearing up to do biology with #AI and #robots. I remain skeptical, since, for example, #smartmicroscopy is still more of a buzzword than reality. The price tag on the infrastructure required will be enormous - unreachable by 99% of the research community.
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Will Ratcliff @wcratcliff.bsky.social · 07/10/2026
Out today in @nature.com: our review on how single cells evolve into multicellular organisms. With Ozan Bozdag, @kaitong25.bsky.social, Peter Yunker, and @matthewherron.bsky.social. rdcu.be/9ZuiKow9twKa For an overview, check out the video below.
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Pawel Burkhardt @pawelburkhardt.bsky.social · 07/10/2026
From bioRxiv to PNAS! 🎉 Very happy to see our paper “Diversity and spatial segregation of TRP channels in the closest relatives of animals” now published in @pnas.org. Another piece in the puzzle of how animal cell signalling evolved. www.pnas.org/doi/10.1073/...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Rita Strack @ritastrack.bsky.social · 07/10/2026
Come work with me!! Nature Biomedical Engineering is hiring an interim editor for 2027. Diverse relevant backgrounds welcome to apply. Please feel free to contact me with questions. Please repost! springernature.wd3.myworkdayjobs.com/SpringerNatu...
springernature.wd3.myworkdayjobs.com
Interim Associate or Senior Editor, Nature Biomedical Engineering
Job Title: Interim Associate or Senior Editor, Nature Biomedical Engineering Locations: London or Pune – Hybrid working model Application deadline: 21st October About Springer Nature Springer Nature i...
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Sophie G Martin @sophiemartinlab.bsky.social · 06/10/2026
Happy to share our latest work showing that fungal cell fusion not only requires local cell wall digestion but also inhibition of cell wall repair! PAK-family kinases promote cell fusion irreversibility by preventing cell-wall repair doi.org/10.1016/j.cu... Led by @juliacoronasserna.bsky.social
Post-fusion pak2 mutant cells with narrow fusion pore blocked by a vacuole
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Jean Léon Maître @maitrejl.bsky.social · 06/10/2026
📣Our department is hiring a new group leader!📣 Want to start your team in a vibrant scientific environment in the center of Paris? I was very lucky to do that 10 years ago, reach out if you have any question. Apply by December 18th: jpi-recruitment-curie-umr3215-u934.curie.fr
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David Gaboriau @dgaboriau.bsky.social · 05/10/2026
Dream job @pasteur.fr with @jytinevez.bsky.social 😊
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Michael Way @drmichaelway.bsky.social · 02/10/2026
Looking for a PhD? @crick.ac.uk PhD applications for next year are open. 4 year program with lots of outstanding projects on offer. If you are interested in viral host interactions, cytoskeleton, cell bio, live cell imaging - see Way lab project + video. plz repost www.crick.ac.uk/careers-and-...
crick.ac.uk
PhD student positions
PhD projects for the 2027 Crick PhD programme.
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Igor Adameyko @adameykolab.bsky.social · 04/10/2026
From the tank in my office
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Snezhka Oliferenko @alebenoit.bsky.social · 02/10/2026
Guys! @jbahler.bsky.social and I are recruiting a PhD student in this round - if you know great undergrads or Masters students please tell them about us! And Crick in general, of course ;) Thank you!!
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Bryan Roth @zenbrainest.bsky.social · 01/10/2026
Cool!! Systematic identification of p11 as a signaling modulator across the GPCRome | Science Advances www.science.org/doi/10.1126/...
science.org
Systematic identification of p11 as a signaling modulator across the GPCRome
The microprotein p11 (S100A10) is a ubiquitously expressed molecular scaffold that is known to be required for behavioral responses to certain antidepressants, presumably through its effect on G prote...
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Philipp Radler @radler92.bsky.social · 01/10/2026
The first paper of my PostDoc in Christa Schlepers group (@archaea-vienna.bsky.social) on the dynamics of Asgard archaea is now out in Nature! www.nature.com/articles/s41... This was a great team effort and I am looking forward to uncover the complex behavior of these cells further!
nature.com
Dynamic protrusions mediate crawling motility in Asgard archaea - Nature
Anoxic live-cell imaging shows actin-dependent crawling motility and dynamic protrusions in Asgard archaea, providing insights into cellular innovations that may have contributed to eukaryotic evoluti...
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Matthew Freeman @mjafreeman.bsky.social · 30/09/2026
Yet another opportunity @dunnschool.bsky.social! We are looking for an Associate Professor If you have exciting research plans, @dunnschool.bsky.social is a great place: excellent science (and lovely people, obvs) www.path.ox.ac.uk/vacancy/asso...
path.ox.ac.uk
Associate Professorship of Cancer Biology - Sir William Dunn School of Pathology in association with the Queen’s College. - Dunn School
We are seeking to appoint an Associate Professor working in the area of the cellular and/or molecular biology of cancer, to be based in Oxford University’s Sir William Dunn School of Pathology. The ro...
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Mathilda Lennartz @mathilda95.bsky.social · 30/09/2026
UPDATE!: I am absolutely stoked that the second paper of my PhD is now out in @natcellbio.nature.com :D. We combined lipid imaging, STED microscopy, and mathematical modelling in a super cool team effort to quantify lipid partitioning inside clathrin-coated pits. www.nature.com/articles/s41....
nature.com
Quantification of lipid sorting during clathrin-mediated endocytosis - Nature Cell Biology
Lennartz et al. evaluate lipid enrichment in clathrin-coated pits and observe that the differential lipid partitioning into clathrin-coated pits is largely driven by the lipid asymmetry of the plasma ...
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Michael Way @drmichaelway.bsky.social · 28/09/2026
very cool science as always!
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Iñaki Ruiz-Trillo @multicellgenome.bsky.social · 28/09/2026
We have a new branch in the family tree of animals: Atreyea- a previously unrecognized lineage among the closest unicell relatives of animals. Led by @konsmitsi.bsky.social & @freejakoba.bsky.social together with a fantastic team of collaborators. 🔗 papers.ssrn.com/sol3/papers.... #protistsOnSky
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Kinga Kamieniarz-Gdula @stoplab.bsky.social · 26/09/2026
A thoughtful essay on AI use in science. Found it a good read.
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Michael Way @drmichaelway.bsky.social · 26/09/2026
Arp2/3 iso-complexes strike again! Axonal actin ring assembly and maintenance involves different iso-complexes that change expression during neuronal maturation 🎉 Great collaboration with Ana Rita Costa & Monica Sousa @ i3S in Porto www.i3s.up.pt/research-gro... www.science.org/doi/10.1126/...
science.org
Distinct Arp2/3 isocomplexes drive axonal actin ring assembly and integrity
The actin-related protein 2/3 (Arp2/3) complex is a central nucleator of branched actin filaments, essential for numerous cellular processes. Using superresolution imaging, we demonstrate that Arp2/3 ...
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Emmanuel Levy's lab @elevylab.bsky.social · 25/09/2026
It took a while, but here we are. Our micDROP paper is out in @natcomms.nature.com, led by @atargt.bsky.social. She asked whether the sequence of a disordered region can self-recognize specifically. She measured this for ten IDRs in living yeast cells. www.nature.com/articles/s41...
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Kate Baker @ksbakes.bsky.social · 25/09/2026
We have an open Assistant/Associate Professor position in Pathogen Biology at the Department of Genetics - come and join us! 🦠 🧫 🧬https://www.cam.ac.uk/jobs/assistantassociate-professor-in-pathogen-genetics-pc51175
cam.ac.uk
Assistant/Associate Professor in Pathogen Genetics
Applications are invited for an Assistant or Associate Professorship in Pathogen Genetics to be held in the Department of Genetics. We are searching for a talented individual with a track record of fu...
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David Drubin @drubin.bsky.social · 22/09/2026
In a new preprint we provide evidence that biophysical properties of protein condensates can explain the order of events in the endocytic pathway, and that these events are tuned by protein condensate phosphorylation. www.biorxiv.org/content/10.6...
biorxiv.org
Phosphoregulation of hierarchical protein condensate formation during clathrin-mediated endocytosis
The sequential assembly of over 50 proteins during clathrin-mediated endocytosis (CME) is well documented in yeast. However, the mechanisms governing this ordered recruitment remain poorly understood....
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André Nadler @nadlerlab.bsky.social · 23/09/2026
This my friends, this is the big one. A long time coming. Lipid Cell Biology is coming of age and even for a hot field, this is a true game changer. This dataset will keep us all busy for years to come. Congrats to everybody on this amazing crew!!! Go party!!
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H. B. Beryl Rappaport @hbrappap.bsky.social · 22/09/2026
Our description of fire amoeba, 𝘐𝘯𝘤𝘦𝘯𝘥𝘪𝘢𝘮𝘰𝘦𝘣𝘢 𝘤𝘢𝘴𝘤𝘢𝘥𝘦𝘯𝘴𝘪𝘴, is now online at Cell! Thanks @oliverio.bsky.social and amazing team for questioning the limits of eukaryotes! 🔥 www.cell.com/cell/fulltex...
cell.com
A geothermal amoeba sets a new upper temperature limit for eukaryotes
The amoeba Incendiamoeba cascadensis demonstrates that eukaryotic life can withstand temperatures beyond what was thought possible and sheds light on molecular strategies for survival in extreme heat.
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The Company of Biologists @biologists.bsky.social · 21/09/2026
Applications are now open for early-career researchers to apply for a funded place at our Workshop on Membrane Function: Insights from Cellular Diversity and Evolution, organised by Snezhana Oliferenko @alebenoit.bsky.social & Cunqi Ye. Find out more and apply www.biologists.com/workshops/ju...
Membrane Function: Insights from Cellular Diversity and Evolution
Date: 13 – 16 June 2027

Location: Buxted Park, East Sussex, UK
Organisers: Snezhana Oliferenko and Cunqi Ye
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Buzz Baum @buzzbaum.bsky.social · 22/09/2026
We are looking for a research assistant! Come join the team: www.jobs.ac.uk/job/DSZ826/r...
jobs.ac.uk
Research Support Officer | Cell Biology | Dr Buzz Baum | LMB 2904 at MRC Laboratory of Molecular Biology
Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...
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Martin Pacesa @martinpacesa.bsky.social · 21/09/2026
ʙɪɴᴅᴄʀᴀꜰᴛ2 is out, and we're not waiting for the paper. The full code drops today, free for academic and industry use. We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition. github.com/PacesaLab/Bi...
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Thomas Arnesen @natmachinery.bsky.social · 21/09/2026
Coenzyme A biosynthesis is regulated by two distinct Ubiquitin E3 ligase complexes | UBR4-KCMF1 and MKLN1-CTLH independently converge on a common N-terminal MK Arg/N-degron to promote PANK degradation and restrict CoA biosynthesis | @ispt-proteinterm.bsky.social www.biorxiv.org/content/10.6...
biorxiv.org
Parallel Arg/N-degron recognition systems regulate coenzyme A biosynthesis
Coenzyme A (CoA) is an essential metabolic cofactor whose biosynthesis is controlled by pantothenate kinases (PANKs), the rate-limiting enzymes in CoA synthesis. Although CoA production is extensively...
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Akos Nyerges @akosnyerges.bsky.social · 19/09/2026
Proud and excited to share our first preprint 🚀 in which we • create a high-fitness firewalled organism, • that stably colonizes the mouse gut for >100 days, • resists all tested phages in the gut, • and blocks horizontal gene transfer. + A new method: Chimera genomes to tailor existing synthetic
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The EMBO Journal @embojournal.org · 18/09/2026
What defines limits & regulation of epigenetic inheritance? Florian Steiner et al show altered genomic distribution of histone modification H3K27me3 can be transmitted across C. elegans generations through successive SET-32 & MES-4 action that alters its deposition link.springer.com/article/10.1...
link.springer.com
Transgenerational inheritance of altered H3K27me3 in wild-type Caenorhabditis elegans - The EMBO Journal
Epigenetic inheritance provides mutation-free mechanisms for phenotypic adaptation, including modifications to DNA or DNA-associated proteins that create patterns of heritable gene regulation. However...
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MwahahahahahadScientist @mads100tist.bsky.social · 17/09/2026
You know what's also interactive? Reading the paper. Talk to your colleagues about the paper you just read. Tell them why you loved it. Tell them why you hated it. And even better: invite the authors to talk about their paper 🧪
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Anna Bodzeta @annabodzeta.bsky.social · 17/09/2026
Here it is my 1st preprint about synapse and rhomboid intramembrane protease: www.biorxiv.org/content/10.6... Using imaging and biochemistry, together with @adamgrieve.bsky.social we identify RHBDL2 as a membrane-immersed regulator of synapses architecture. 1/2
biorxiv.org
The unhindered lateral mobility of a rhomboid intramembrane protease enables synapse remodelling
Synapses must maintain their stable molecular organisation while retaining the capacity to remodel in response to changing demands. In order to flexibly change synaptic strength, the abundance of tran...
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Felix Campelo @felixmendu.bsky.social · 16/09/2026
A great PhD opportunity with my former @icfo.eu colleague and friend Pamina Winkler, now starting her group at @cicbiomagune.bsky.social in beautiful San Sebastian! Biophysics, cell biology, protein interactions & advanced imaging 🔬, check it out: www.cicbiomagune.es/job-offer-de...
cicbiomagune.es
Job offer detail | CIC biomaGUNE
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Milot Mirdita @milot.bsky.social · 16/09/2026
ColabFold 1.6.3 is out! 2.5x faster, pip-installable, ipSAE+pDockQ2 scores. Thanks Choonghwan Lee, Marielle Russo, Gyuri Kim 🐍pip install colabfold[alphafold] CF2 Sneak Peak with AF3/Boltz/Protenix/ESMFold2… 🐍pip install "colabfold[alphafold3]@git+https://github.com/sokrypton/ColabFold@af3-preview"
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Sachin Kotak @spindlebehavior.bsky.social · 15/09/2026
Can light build centrosome-like activity? 💡🔬 Yes! We introduce LISA (Light-Induced Spindle Assembly), now in @emboreports.org. By clustering Aurora A with optogenetics, we build centrosome-like activity that nucleates microtubules and rescues spindle defects after centrosome loss. shorturl.at/9h3VQ
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Sjors Scheres @sjorsscheres.bsky.social · 15/09/2026
Michel Goedert and myself are looking for two postdocs to work on #cryoEM and #masspec of #alphasynuclein filaments from neurodegenerative disease. Come join our bubbly and friendly team at the @mrclmb.ac.uk in lovely Cambridge, UK. www.nature.com/naturecareer...
nature.com
Postdoctoral Scientist | Neurobiology | Dr Michel Goedert | LMB 2842 - Cambridgeshire job with MRC Laboratory of Molecular Biology | 12864505
Postdoctoral Scientist Salary £42,694 per annum Fixed term, 3 years MRC Laboratory of Molecular Biology, Cambridge, UK To work in the group of Dr M...
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Alex Ludwig @alexludwig.bsky.social · 14/09/2026
How do epithelial cells make a lumen as they polarize? We have some exciting new answers to this long standing question. Check out our new paper in which we show that lumen initiation is driven by large vacuoles that deliver a pre-assembled apical cortex to the AMIS: www.nature.com/articles/s41...
nature.com
Bulk delivery of a preassembled apical surface initiates epithelial lumen formation - Nature Communications
Epithelial lumen formation is fundamental to organ development, yet how apical surfaces first emerge remains unclear. Ghosh, Martin, and Chen et al., show that lumen initiation is driven via bulk deli...
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Ylva Ivarsson @ivarssonlab.bsky.social · 11/09/2026
Do you want to be my colleague? We are recruiting a tenured #Associate #Professor in #Biochemistry to the Department of Chemistry for Life Sciences at #Uppsala University. Deadline for application November 20. www.uu.se/en/about-uu/...
uu.se
Associate Professor in Biochemistry - Uppsala University
Associate Professor in Biochemistry, Department of Chemistry for life sciences, Uppsala University
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Andres Bendesky @bendeskylab.com · 11/09/2026
We have a tenure-track faculty position in Evolutionary Biology in Columbia's E3B Department. Application deadline is October 15. Come be our colleague. Please RT! apply.interfolio.com/193016
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
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