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Sjors Scheres

@sjorsscheres.bsky.social
3.6K followers 833 following 465 posts

Joint Head of Structural Studies at @mrclmb.bsky.social. We develop & use #cryoEM to study amyloids in neurodegeneration. #tau, #alphasynuclein, #opensoftware, #RELION. All opinions my own.

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Reposted by Sjors Scheres
Waggoner Lab @labwaggoner.bsky.social · 30/09/2026
Fibrillized tau protein, a feature of neurodegenerative disorders, acts as a prion-like template to induce misfolding in healthy tau @nature.com @sjorsscheres.bsky.social www.nature.com/articles/d41... www.nature.com/articles/s41...
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 30/09/2026
How does neurodegeneration spread across the brain? 🧠 @sjorsscheres.bsky.social, Michel Goedert & Masata Hasegawa’s groups have demonstrated that human misfolded tau filaments act as a molecular template for prion-like propagation in the mouse brain. mrclmb.ac.uk/news-events/... #LMBResearch 🧪
Alzheimer's and corticobasal degeneration tau filaments induce distinct pathologies in mouse brains, with corresponding cryo-EM images and structural models.
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Sjors Scheres @sjorsscheres.bsky.social · 30/09/2026
Our adventures into #proteinfolding: GuideFlip designs flexible molecular interactions by discrete flow matching to design sequence & structure together! Grateful for funding by Love Tito's (@titosvodka.bsky.social) and the @ukri.org. 🥳
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Sjors Scheres @sjorsscheres.bsky.social · 24/09/2026
Over the last week I have had separate discussions with three people being disillusioned by how bad their colleagues are at their job. Large organizations seem worse. I wonder whether having line managers work together with their people, instead of just leading from above, is a good solution.
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TW @twesq.bsky.social · 20/09/2026
this is fantastic and I learned something new
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Sjors Scheres @sjorsscheres.bsky.social · 15/09/2026
Michel Goedert and myself are looking for two postdocs to work on #cryoEM and #masspec of #alphasynuclein filaments from neurodegenerative disease. Come join our bubbly and friendly team at the @mrclmb.ac.uk in lovely Cambridge, UK. www.nature.com/naturecareer...
nature.com
Postdoctoral Scientist | Neurobiology | Dr Michel Goedert | LMB 2842 - Cambridgeshire job with MRC Laboratory of Molecular Biology | 12864505
Postdoctoral Scientist Salary £42,694 per annum Fixed term, 3 years MRC Laboratory of Molecular Biology, Cambridge, UK To work in the group of Dr M...
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Sami Chaaban @sami-c.bsky.social · 10/09/2026
Excited to share that the Chaaban Lab will be opening in January at the Crick!
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Sjors Scheres @sjorsscheres.bsky.social · 27/08/2026
🥳
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Sjors Scheres @sjorsscheres.bsky.social · 25/08/2026
This should be fun for the computer-minded among us who find joy in supporting science . 😍
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Bronwyn Lucas @bronwynalucas.bsky.social · 12/08/2026
Now on Arxiv: arxiv.org/abs/2608.10029 Led by grad student Matthew Giammar and collaborator Alex Strang, we provide a fast algorithm to calculate a low rank approximation to large (>100 million row) matrices with high fidelity that will accelerate template matching.
arxiv.org
A fast diagonalization algorithm to enable singular value decomposition of large matrices for efficient template matching
Many computational problems possess the following three features: (1) the problem could be solved efficiently if a linear operator could be diagonalized, (2) direct diagonalization is infeasible due t...
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Sjors Scheres @sjorsscheres.bsky.social · 01/08/2026
Good luck Morgan! We shall expect great things.
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 30/07/2026
Congratulations to Chris Russo, Group Leader in the LMB’s Structural Studies Division, who has been awarded the 2026 K. H. Kuo Award for Distinguished Scientist in Biological Electron Microscopy. www.bsc.org.cn/KuoSymposium... #LMBintheNews
Chris Russo
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Sjors Scheres @sjorsscheres.bsky.social · 27/07/2026
Where is all the money going? Every day we read about massive cuts by @ukri.org, but their budget wasn't cut.
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Sjors Scheres @sjorsscheres.bsky.social · 27/07/2026
I am quite happy taking medicines that I know were tested rigourously for efficacy and safety at the speed that takes... www.theguardian.com/business/202...
theguardian.com
AstraZeneca boss urges western drugmakers to move at ‘Chinese speed’
Europe and US risk being outpaced on innovation, as happened in the car industry, warns Pascal Soriot
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Bronwyn Lucas @bronwynalucas.bsky.social · 25/07/2026
New preprint from the lab! Led by graduate student @lainahall.bsky.social we show a new method to thin cells for cryo-EM imaging with minimal damage. www.biorxiv.org/content/10.6...
biorxiv.org
Optimized cryo-FIB milling strategy to generate thin, minimally damaged biological lamellae
Focused ion beam (FIB)-milling has been adapted to thin frozen cells for visualization of macromolecular structures in situ with cryogenic electron microscopy. However, only a few large and abundant c...
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Sjors Scheres @sjorsscheres.bsky.social · 25/07/2026
With half of Europe on fire, can our politicians finally get serious about the climate crisis? Burnham could look to the Spanish PM for inspiration.
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Joe Greener @jgreener64.bsky.social · 24/07/2026
I have often seen Microsoft software spread within organisations due to IT and procurement people being "captured" by effective lobbying and sales pitches. Microsoft software is not particularly good, safe or cheap, and researchers benefit from having choice over what they use. @ukri.org
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Sjors Scheres @sjorsscheres.bsky.social · 24/07/2026
Some inside the @ukri.org wish to push @microsoft.com software too far down into research. This is a risk that didn't work out well for the ICC! @ukri.org should focus on funding good science rather than homogenise for the sake of homogenisation. www.theguardian.com/commentisfre...
theguardian.com
The ICC is far from perfect – but it can hold the likes of Trump, Putin and Netanyahu to account | Steve Bloomfield
The US threat to shut down the international criminal court is chilling: actions must have consequences, says Steve Bloomfield, former international editor of the Observer
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Sjors Scheres @sjorsscheres.bsky.social · 08/07/2026
Sorry, I usually don't do politics on here, but this is so funny. You have to give it to the Brits: their sense of humour can be very powerful. share.google/oaD90DqioZAe...
share.google
Count Binface on Clacton byelection: ‘I didn’t know old Farage was going to self-detonate’
‘Perhaps it’s all a fever dream,’ suggests parody candidate, expected to be Reform leader’s only challenger for seat
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 03/07/2026
LMB spinout company @trimtechtx.bsky.social has now raised $47M in seed funding. Building on research by Leo James and @w-mcewan.bsky.social, TRIMTECH Therapeutics will utilise targeted protein degradation to develop novel neurodegeneration treatments. Read more here: shorturl.at/LeTaZ #LMBintheNews
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Sjors Scheres @sjorsscheres.bsky.social · 02/07/2026
With all this talk about decentralisation in UK politics this week, I wonder when @ukri.org will be up. Wouldn't it be great to devolve power to the research councils, whose expert staff care deeply about their area of science? 🤔
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Toula Drimonis @mtltoula.bsky.social · 15/06/2026
Ten years after Brexit. The front page of @theindependent.bsky.social
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Sjors Scheres @sjorsscheres.bsky.social · 06/06/2026
I wear a lot of orange! 🧡
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Sjors Scheres @sjorsscheres.bsky.social · 01/06/2026
This week the @ukri.org MRC will review the Structural Studies division at @mrclmb.ac.uk. I look forward to discussing our science with the panel. I left Spain 16 years ago and still remember how refreshing it felt that the quality of the science is what matters most in the UK. 😀
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Sjors Scheres @sjorsscheres.bsky.social · 26/05/2026
I was at the @royalsociety.org tonight for a @nobelprize.org dialogue about #AI with Hassabis & Nurse. An upcoming golden age for Science, or will benefits be limited for the go-getters? I will encourage my children to keep studying hard to better their chances of benefiting from it all.
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Sjors Scheres @sjorsscheres.bsky.social · 23/05/2026
I just came back from a lovely visit to the life science campus in Leiden, The Netherlands. >30,000 people working there, no traffic in sight, just cycle paths and a good train network nearby!
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Sjors Scheres @sjorsscheres.bsky.social · 22/05/2026
I hope @ukri.org will be able to find a scientist for this role.
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Sjors Scheres @sjorsscheres.bsky.social · 12/05/2026
Recommended for those who want to do a postdoc in neurodegeneration in the US. Mike is a great scientist and colleague. 🤗
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Sjors Scheres @sjorsscheres.bsky.social · 10/05/2026
It's great to see this important paper by Alexander Shtyrov out. If you hadn't read it yet on @biorxivpreprint.bsky.social, you can now do so in @pnas.org. 😀
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Hanjin Liu @liu-hanjin.bsky.social · 09/05/2026
Job navigation in table view, searchable tags, 3D mesh optimized for masks, and many more features! 👉👉👉 github.com/hanjinliu/hi... Let's make our RELION directory a better place.
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Hanjin Liu @liu-hanjin.bsky.social · 03/05/2026
A little Sunday fun - syntax highlighting for STAR files and MDOC files.
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Sjors Scheres @sjorsscheres.bsky.social · 04/05/2026
This looks really good! 🥳
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Sjors Scheres @sjorsscheres.bsky.social · 01/05/2026
Come and work with us on #cryoEM of alpha-synuclein amyloid filaments from #Parkinsons disease! 🥳 fa-evzn-saasfaukgovprod1.fa.ocs.oraclecloud.com/hcmUI/Candid...
fa-evzn-saasfaukgovprod1.fa.ocs.oraclecloud.com
Postdoctoral Scientist | Neurobiology | Dr Michel Goedert | LMB 2253
£42,694 per annum | Fixed-term for 3 years | Full-time | Closing date: 17 May 2026
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Sjors Scheres @sjorsscheres.bsky.social · 29/04/2026
Lori is a ⭐!
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Kiarash Jamali @kjamali.bsky.social · 28/04/2026
Thrilled with this result, tune in for more soon!
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Sjors Scheres @sjorsscheres.bsky.social · 28/04/2026
The #ADFLIP approach by @kaiyi94.bsky.social and @kjamali.bsky.social, combined with their approach to backpropagation through #AlphaFold2, is really powerful. Keep tuned for more exciting results! 🥳
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 24/04/2026
Don’t miss the 20th Graduate Student Symposium at the LMB in July, organised by students from the LMB and École Polytechnique Fédérale de Lausanne (EPFL) School of Life Sciences. Registration is open now ➡️ www3.mrc-lmb.cam.ac.uk/sites/gsasym... Follow @lmbphdsymposium.bsky.social for updates!
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Sjors Scheres @sjorsscheres.bsky.social · 22/04/2026
Feeling somewhat frustrated this afternoon with the amount of work that is required for the final submission of an article that has passed review at one of the journal st @cellpress.bsky.social...
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 16/04/2026
The LMB Rising Talent Fellowship is open for new applicants! Aimed at Black heritage scientists, the Fellowship offers a 3-year postdoctoral position beginning Oct-Dec 2026. Visit our website for more info: mrclmb.ac.uk/careers-and-... Please circulate this post to anyone who might be interested!
Announcement for a three-year Rising Talent Fellowship for Black heritage postdoctoral scientists at MRC Laboratory of Molecular Biology.
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Reposted by Sjors Scheres
MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 15/04/2026
The LMB is proud to launch the Career Returner Fellowship, a three-year, fully funded postdoc placement for scientists who have had a career break of over 1 year. Applications are open now! More details: mrclmb.ac.uk/careers-and-... Please share this post with anyone who may be interested!
Three-year funded postdoctoral fellowship for scientists returning after a 12-month career break, deadline May 17, 2026.
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Sjors Scheres @sjorsscheres.bsky.social · 10/04/2026
Dimerisation and twist reversal of the Lewy fold in alpha-synuclein mutants with Parkinson's disease and dementia. Together with Yang Yang (now at @vai.org) and Michel Goedert. 🥳 www.biorxiv.org/content/10.6...
biorxiv.org
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Sjors Scheres @sjorsscheres.bsky.social · 03/04/2026
And we also have this targeted fellowship opening again soon. Do you identify as black? Then this opportunity is for you!
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Sjors Scheres @sjorsscheres.bsky.social · 03/04/2026
Did you take a career break of at least one year, perhaps to start a family, take care of a loved one, or for any other reason? Come and join the @mrclmb.ac.uk through this targeted fellowship, and discover the many more ways in which this is such a special place to work. 🤗
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Sjors Scheres @sjorsscheres.bsky.social · 02/04/2026
Our latest @biorxivpreprint.bsky.social: "Prion-like transmission of human tau strains in the mouse brain" 🥳 With Michel Goedert and Masato Hasegawa. www.biorxiv.org/content/10.6...
biorxiv.org
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Structural Biology @actacrystd.iucr.org · 28/03/2026
Vinith Kishore et al.: ICECREAM: high-fidelity equivariant cryo-electron tomography #CryogenicElectronTomography #SelfSupervisedLearning #MachineLearning @insadelyon...#IUCr journals.iucr.org/paper?S2059798326…
journals.iucr.org
ICECREAM: high-fidelity equivariant cryo-electron tomography
We present ICECREAM, a self-supervised approach that achieves substantially better denoising and more reliable missing-wedge recovery in cryo-ET, while reducing training and inference time relative to comparable baselines.
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Kelly Nguyen @kellythd-nguyen.bsky.social · 26/03/2026
Proud to share the yeast telomerase structure, led by the talented @hongmiaohu.bsky.social in collaboration with the Wellinger and Chartrand labs. Discovered 37 years ago and took us nearly 7 years but totally worth the wait 😍. www.science.org/doi/10.1126/... www.youtube.com/watch?v=gFE4...
youtube.com
Cryo-EM structure of yeast telomerase
YouTube video by MRC Laboratory of Molecular Biology
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Sjors Scheres @sjorsscheres.bsky.social · 25/03/2026
🤯
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Brent Toderian @brenttoderian.bsky.social · 23/03/2026
“Compared with non-active travelers, the cyclists had a 19% lower risk of all-cause dementia, a 22% lower risk of Alzheimer's, a 40% lower risk of young-onset dementia (before the age of 65), and a 17% lower risk of late-onset dementia.” Getting around a bike more often could reduce dementia risk.
sciencealert.com
Cycling Linked to Lower Risk of Dementia, Study of Half a Million Finds
Getting from A to B on a bicycle more often could reduce risk of dementia, possibly by protecting a part of the brain tied to memory functions, new research finds.
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Philippe Van der Stappen @phaips.vd.st · 20/03/2026
#TeamTomo if you want to use CTF-corrected 3D subtomos from AreTomo3 in RELION v.5.1 you can use this updated script: github.com/Phaips/aretomo3torelion5
github.com
GitHub - Phaips/aretomo3torelion5
Contribute to Phaips/aretomo3torelion5 development by creating an account on GitHub.
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Sjors Scheres @sjorsscheres.bsky.social · 18/03/2026
👇
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