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adam grieve

@adamgrieve.bsky.social
1.1K followers 576 following 11 posts

Membrane protein signalling and turnover in neurons Sir Henry Dale Fellow at School of Biochemistry, University of Bristol grieve-lab.com

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Anna Bodzeta @annabodzeta.bsky.social · 17/09/2026
Here it is my 1st preprint about synapse and rhomboid intramembrane protease: www.biorxiv.org/content/10.6... Using imaging and biochemistry, together with @adamgrieve.bsky.social we identify RHBDL2 as a membrane-immersed regulator of synapses architecture. 1/2
biorxiv.org
The unhindered lateral mobility of a rhomboid intramembrane protease enables synapse remodelling
Synapses must maintain their stable molecular organisation while retaining the capacity to remodel in response to changing demands. In order to flexibly change synaptic strength, the abundance of tran...
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adam grieve @adamgrieve.bsky.social · 17/09/2026
What if a membrane protein’s movement is as important as what it does? Our latest work reveals the unrestricted lateral mobility of a rhomboid protease enables neuronal synapse remodelling tinyurl.com/yk6xfxzr All credit to @annabodzeta.bsky.social for this stunning work, who is on the job hunt!
A cartoon depicting the unhindered movement of the rhomboid protease RHBDL2, which is required for it to encounter available synaptic adhesion proteins. Without this process, excitatory synapses fail to remodel.
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Ian Collinson @ianofbristol.bsky.social · 02/06/2026
Apply here! meetings.embo.org/event/26-pro...
meetings.embo.org
Advances and new frontiers in protein translocation across membranes
The organization of cells into membrane-bound compartments is fundamental to life, requiring proteins to cross these barriers through highly specialized translocation systems. Understanding these pro…
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Journal of Cell Biology @jcb.org · 24/03/2026
The cell biology community mourns the loss of Catherine Rabouille, an exceptional scientist whose determination, innovation, and fearless engagement with ideas reshaped how we think about cellular organization. #InMemoriam from @adamgrieve.bsky.social and colleagues: rupress.org/jcb/article/...
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Proteostasis UK @proteostasisuk.bsky.social · 03/02/2026
📢 Next Proteostasis Consortium Seminar – Tomorrow, Wednesday 4 February 2026 at 4:00 pm GMT (10:00 am CT) Speaker: David Glass (Regeneron Pharmaceuticals) Title: Proteostatic Mechanisms Involved in Age‑Associated Disease 👉Link & Updates here: www.proteostasisconsortium.com/seminars/
proteostasisconsortium.com
Proteostasis Consortium Seminars | Proteostasis Consortium
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Proteostasis UK @proteostasisuk.bsky.social · 05/02/2026
📣 Proteostasis researchers - we want to hear from you! What techniques, protocols, or assays would you love to learn more about? 👉 Share your ideas in our quick survey (docs.google.com/forms/d/e/1F...)
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adam grieve @adamgrieve.bsky.social · 25/11/2025
Add our first pre-print to your reading list? Using AF2 and MD, we've characterised structures and conformational ensembles of human rhomboid proteases - and revealed some surprises along the way. Feel v.lucky to work alongside Bryony & @robincorey.bsky.social! Please share: tinyurl.com/3h8r7f5y
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Microsoft Research @msftresearch.bsky.social · 10/07/2025
Today in the journal Science: BioEmu from Microsoft Research AI for Science. This generative deep learning method emulates protein equilibrium ensembles – key for understanding protein function at scale. www.science.org/doi/10.1126/...
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Mathew Kiang @mathewkiang.com · 25/06/2025
Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages. ki.se/en/about-ki/...
ki.se
Call for 20 Assistant Professor positions
Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...
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adam grieve @adamgrieve.bsky.social · 24/06/2025
This sounds like a fun job!
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Britt Lundgren @brittlundgren.bsky.social · 29/05/2025
Are you a PI of a federal grant cancelled by the Trump administration? Please share your info with the Democratic Staff of the House Committee on Science, Space, and Technology, who launched this portal yesterday to track funding cancellations 🔭🧪 forms.office.com/pages/respon...
Grant Cancellation Web Form

WAS YOUR GRANT CANCELED BY PRESIDENT TRUMP?

The Committee on Science, Space, and Technology, Democratic Staff, is surveying the impact of the Trump Administration’s cancelation of federal research awards. If your award was terminated since January 20, 2025, please fill out this brief survey. If you had multiple awards terminated, please fill out a separate form for each award. While anonymous submissions will be helpful to the Committee’s efforts, we encourage you to leave your contact information if you are open to having a confidential conversation with Committee staff. Please find our confidentiality policies at the following link – any information you share will be treated with these protections, regardless of your current affiliation with any current or former funding agency: https://democrats-science.house.gov/contact/whistleblower
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Ben Langmead @benlangmead.bsky.social · 29/05/2025
Industry friends, now is the time for MUCH more speaking out on behalf of academic colleagues under duress. Here are core open source methods that many of your products doubtlessly depend on either directly or indirectly (see en.wikipedia.org/wiki/HMMER) being abruptly defunded. Make noise.
en.wikipedia.org
HMMER - Wikipedia
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Verena Kohler @verenakohler.bsky.social · 18/04/2025
🔬 Hiring: Postdoctoral Fellow Seeking a bioinformatician/screening expert to be part of our team running genome‑wide screens, building data‑integration pipelines & validating hits in higher organisms. 🌱 2‑yr fellowship with tailored mentorship, leadership & science‑communication training
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Anna Bodzeta @annabodzeta.bsky.social · 10/04/2025
Come and join us in solving mystery of plasma membrane proteostasis in beautiful neurons.
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adam grieve @adamgrieve.bsky.social · 09/04/2025
Pls re-skeet! There's a postdoc job available to join us in Bristol! We're looking for a molecular cell biologist to help us investigate plasma membrane proteostasis in neurons. Apply here by 23 April: www.jobs.ac.uk/job/DMO097/r.... If interested, do contact me and check out grieve-lab.com! Thanks!
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Michael Way @drmichaelway.bsky.social · 07/04/2025
A fitting announcement to an outstanding scientist and friend who is dearly missed by many. journals.biologists.com/jcs/article/...
journals.biologists.com
Announcing the JCS–David Stephens Prize and the 2024 winner Anja Konietzny
Over the past 25 years, Journal of Cell Science (JCS) has been awarding a prize of £1000 – ‘The JCS Prize’ – to the first author(s) of the paper that is judged by the Editors to be the best paper publ...
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Thom Sharp @thomsharp.bsky.social · 09/04/2025
Our new lab website is online! sharplab.uk Check it out and learn more about our research in Bristol!
Protein structure of C1 bound to IgM antibodies
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Camilla Godlee @camillagodlee.bsky.social · 31/03/2025
I am recruiting a research assistant. Please send to anyone you know who is interested in gaining more lab experience in host:pathogen interactions of bacterial infections. www.jobs.cam.ac.uk/job/50738/
jobs.cam.ac.uk
Research Assistant - Godlee Group (Fixed Term) - Job Opportunities - University of Cambridge
Research Assistant - Godlee Group (Fixed Term) in the Department of Biochemistry at the University of Cambridge.
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Aakriti Jain @aakritijain.bsky.social · 27/03/2025
SO excited to share that a major part of the postdoctoral work in @robzonculab.bsky.social lab is now published: “Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins” www.science.org/doi/10.1126/...
science.org
Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins
Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...
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Robin Corey @robincorey.bsky.social · 27/03/2025
Check out our new paper with Michael Landreh, @pstansfeld.bsky.social and others in @elife.bsky.social : Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization doi.org/10.7554/eLif...
doi.org
Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization
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Andrew Porter @retropz.bsky.social · 24/03/2025
Applications close today for this @uniofmanchester.bsky.social #DigitalNotebook #Metascience project, seasoned with #OpenResearch & served with helpings of #ResearchIntegrity and a side of #ResearchCulture Full details of everything on the menu below 👇 www.jobs.manchester.ac.uk/Job/JobDetai...
jobs.manchester.ac.uk
Research Associate_Metascience Project:Oxford Road
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adam grieve @adamgrieve.bsky.social · 23/03/2025
Thank you Ines! I had such a lovely time visiting sunny York this week, sharing our science and chatting cell bio, neuroscience and proteases. Thanks for the invite, special thanks to the one and only @yorkyeast.bsky.social for top-notch hosting!
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Iris @irismarchal.bsky.social · 18/03/2025
Nanopore technology might be able to sequence proteins soon! Read about the road ahead in this exciting Perspective rdcu.be/edWPi in @naturebiotech.bsky.social
rdcu.be
Toward single-molecule protein sequencing using nanopores
Nature Biotechnology - Maglia and colleagues discuss advances in nanopore technology en route to single-molecule protein sequencing
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Ali Twelvetrees @dozenoaks.bsky.social · 06/03/2025
Do you need some science joy in your life? Do you like neurons? Maybe glia? Molecules? Cell biology? Save the date for #NeuroBioUK25 - the venue is booked and we are excited to see you and your incredible science there on the 12th of September! neurobiouk.sites.sheffield.ac.uk
An image montage advertising NeuroBioUK - 12th of September 2025 in York. The image is York cathedral superimposed over a fluorescent cortex mouse section coloured to look a bit like a dawn sky.
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Ines Hahn @exdrososcientia.bsky.social · 06/03/2025
Save the date: We're excited that the third NeuroBioUK will take place on September. Block it in your calendar to join us in York for a fun day of neurons, glia, cool science and chats!
An image montage advertising NeuroBioUK - 12th of September 2025 in York. The image is York cathedral superimposed over a fluorescent cortex mouse section coloured to look a bit like a dawn sky.
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Joan Chang @tranejoan.bsky.social · 05/03/2025
Our lab's #1st manuscript from our #1st #PhD Katie is on #bioRxiv! Check it out 👇🏻 #macrophage regulation of fibroblast #collagen #circadian rhythm. #ImmunoECMatrix w/ @profandrewmac.bsky.social @tracyh9494.bsky.social @mcrcellmatrix.bsky.social @mcf-uom.bsky.social www.biorxiv.org/content/10.1...
biorxiv.org
Macrophages promote collagen deposition through circadian regulation of fibroblasts
Collagen deposition in fibroblasts, the primary collagen-producing cells, is regulated by both macrophages and the circadian rhythm, although how these regulatory processes interact with one another i...
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adam grieve @adamgrieve.bsky.social · 18/12/2024
Exciting opportunity in the newly minted McMillan lab in Liverpool. Kirsty is a great scientist and a top mentor for students - if you’re looking for a PhD and are interested in trafficking and neurodegeneration, do contact her!
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Jez Carlton @jezcarlton.bsky.social · 25/11/2024
UK Membrane Trafficking 2024 Who doesn’t like a deadline that gets brought forward? Please register by 3rd December - King’s need longer to make the sandwiches than I previously thought! estore.kcl.ac.uk/conferences-... Programme coming soon!
estore.kcl.ac.uk
UK Membrane Trafficking Meeting 2024 | King's College London eStore
Registration for the 2024 UK Membrane Trafficking Meeting, held at KCL.  Registration per person, to include sandwich lunch and coffee breaks and even
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adam grieve @adamgrieve.bsky.social · 27/11/2024
Amazing PhD opportunity to join an exciting new lab at Bristol Biochemistry - send your best students in Ferdos’ direction!
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Ferdos Abid Ali @abidalilab.bsky.social · 27/11/2024
If you’re interested in how molecular motors coordinate to power intracellular trafficking events (e.g. endocytosis), I’ve got a PhD position available to study this at vibrant Bristol uni. In this project, we will capture highly dynamic events by #cryoEM, single molecule imaging & cell biology. 🔬❄️🧪
This scheme shows the cargo adaptor FHF in the middle with arrows pointing to distinct microtubule and actin-based motors (dynein-dynactin, KIFC1, KIF1C and myosins V, IX and X as well as Tropomyosin 1). It also shows a link to Rab5 marked early endosomes. The hypothesis is that FHF coordinates multi motor binding at the early stages of endocytosis. The PhD project would address the hierarchy of motor binding and how these motors coordinate to allow the newly formed vesicle to transition from the actin to MT cytoskeletal network.
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adam grieve @adamgrieve.bsky.social · 15/11/2024
Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c
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Matthew Freeman @mjafreeman.bsky.social · 12/11/2024
Waves of new BlueSky arrivals in last few days! I’ve been tracking starter packs relevant to molecular/mechanistic/genetic/cellular…etc biology Hope it’s helpful but warning: now a v long thread! Probably the last time I can do this...
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adam grieve @adamgrieve.bsky.social · 08/11/2024
Interested in: - mitochondrial regulation and quality control related to Parkinson's Disease? - novel hemi-channels for mitochondrial protein import/degradation? - the structural basis of PINK1 recognition by PARL? Then read this cool paper from the Collinson and Corey labs! tinyurl.com/2hhp5h35
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Sebastian Kittelmann @sebkittelmann.bsky.social · 21/12/2023
Want to work on a 4-year BBSRC-funded project to tag all Drosophila transcription factors with an exchangeable epitope? This is a 0.5 FTE Research Technician post. Come join our collaborative team and help cloning constructs, injecting fly eggs, and screening for transgenics. tinyurl.com/44mprcev
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