Ubiquitin is a small protein that usually works by attaching itself to other proteins. But it can also exist freely, on its own or in chains, and this form has been hard to study. FMI researchers and ...

Across animal phyla, odor information is represented in the first olfactory processing center by combinatorial activation of discrete glomeruli. To examine how this organization of olfactory processin...

Researchers at the Biozentrum of the University of Basel and the FMI have created the most detailed map yet of the mouse motor cortex. The map reveals 16 distinct subregions and sheds new light on the...

Botond Roska, a former FMI group leader and now Director of Science at the Institute of Molecular and Clinical Ophthalmology Basel (IOB), has received the 2026 António Champalimaud Vision Award togeth...

Friedrich Miescher Institute, open position

The brain is constantly taking in sights, sounds and smells, and learning helps it decide which ones matter. Working in zebrafish, FMI neuroscientists have found that learning to tell smells apart cha...

Bulk transcriptome and proteome correlate only modestly, but this has not been investigated in the same cell or across cell-state changes. Here we introduce a scalable technology that quantifies thous...

The FMI has announced the winners of its 2026 internal science prizes, recognizing achievements in creative thinking, an outstanding PhD thesis, and an exceptional postdoc study. The prizes are being ...

For many postdoctoral researchers, the end of a fellowship brings a familiar question: academia or industry? Mario Iurlaro approached the decision differently. He wanted to continue doing research, an...

A molecular pathway known for controlling cell shape and movement also helps regulate the rhythm by which the vertebrate body is divided into repeated segments, FMI researchers report. The work links ...

The latent interactions of molecular glue degraders are identified proteome-wide.

Postdoctoral fellow Agata Misiaszek has received an Ambizione grant from the Swiss National Science Foundation (SNSF) to study how neurons control protein production and how faults in this process may...

Animal development depends on precise biological timing. FMI scientists have now uncovered a mechanism that helps keep this process on schedule. Their work in the tiny worm <em>C. elegans</em> shows t...

A forgotten memory is not always a vanished one. FMI neuroscientists investigating the fruit fly brain found that some memories become inaccessible while leaving a silent trace behind. The right remin...

Tünnermann et al. use live-cell imaging to study promoter activity under the control of an enhancer inserted at different genomic distances. RNA production from the promoter occurs in clusters of tran...

We show that, in a genomic locus with minimal complexity, the distance between promoter and enhancer modulates the frequency of clustered transcriptional bursts. Thus, besides the nucleotide sequence,...