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Rachael Ott

@rachaelott.bsky.social
2.6K followers 2.5K following 173 posts

Neurobiologist @UofSC 🔬 Super-resolution #microscopy, adipocytes, cytoskeleton, and #neurodegeneration 🦠

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Reposted by Rachael Ott
Zebrafish Rock! @zebrafishrock.bsky.social · 27/09/2026
Electrochemical response triggers organ growth, following tail injury in a #zebrafish embryo. Credit to @ritamateus.bsky.social, @nerlielisa.bsky.social, & @liujinghui.bsky.social. #ZebrafishZunday
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Mia Konjikusic, PhD @konjikusicmia.bsky.social · 25/09/2026
To add to all the lovely videos of non-AI processes multicilia beating: ctenophore multiciliated cells! They can reach up to 1mm long, causing a rainbow light refraction effect with the correct light positioning! Taken by myself at MBL in 2019 embryology. Realtime frame-rate!
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Venkat Rao @venkyrao.bsky.social · 26/09/2026
Jumping on the bandwagon with a 3D view of Xenopus multiciliated cells: cilia (magenta) sprouting above the apical actin network (cyan) 🐸. Not live, but no #AISLOP
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Loïc A. Royer 💻🔬🧪 @loicaroyer.bsky.social · 23/09/2026
What if any dataset, any size, any number of dimensions, opened in a browser tab from a link? 🔬🧪💻 Luxar is out today: write it in Python, share it as a link, explore it in any browser. Open source. 🧵 @biohub.org Preprint: doi.org/10.5281/zen... Code: github.com/royerlab/luxar
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Anna Bodzeta @annabodzeta.bsky.social · 11/09/2026
While waiting for the manuscript to be uploaded on bioRxiv, here some sneak peek #FluorescenceFriday
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Institut Necker Enfants Malades @inem-necker.bsky.social · 07/09/2026
🔬 New publication, now out in #ScienceImmunology led by Mathieu Deygas in Pablo Vargas team, shows that Adaptive motility enables neutrophils to rapidly navigate confined capillaries 📰 To read the article: tinyurl.com/52vxuhmp
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Anh Hoang Le, PhD 🏳️‍🌈🏴󠁧󠁢󠁳󠁣󠁴󠁿🇻🇳 @anhhle2702.bsky.social · 07/09/2026
Very happy to share my postdoc paper is out now in @natcellbio.nature.com titled "Tissue flow acts as a guidance cue for immune cell polarization and directional migration". If you love imaging and immune cells, this is for you! #microscopymonday www.nature.com/articles/s41... A 🧵: 1/n
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Anh Hoang Le, PhD 🏳️‍🌈🏴󠁧󠁢󠁳󠁣󠁴󠁿🇻🇳 @anhhle2702.bsky.social · 04/09/2026
Immune cells are fascinating 🤩 . Here, an embryonic myeloid cell (pre tissue-resident mac) ( 🔴 ) is seen in its (almost) natural tissue environment ( 🔵 ) of ectodermal cells. The cell is in a 2.5D-3D environment and looks it is being "swallowed up" by the surrounding cells 😁. #FluorescenceFriday.
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Dan Garisto @dangaristo.bsky.social · 25/08/2026
In May it was big news when 100+ suspicious images were found in Thermo Fisher's catalog. Now, that number has expanded dramatically to 18,000+, thanks to some arduous searching by @reeserichardson.bsky.social. My reporting on the massive trove and its implications for antibody reliability:
nature.com
More than 18,000 questionable images found in antibody catalogues of 15 companies
Science sleuth’s findings raise questions for researchers working to improve the reliability of commercial antibodies.
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 31/08/2026
Sad news. Yonath was/is a legend indeed. Now there are only 4 living female @nobelprize.org laureates in chemistry. There are 20 living Nobel Prize winners just at Stanford right now.
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voigtvision.bsky.social @voigtvision.bsky.social · 20/08/2026
🤩 It's time for some invertebrate eye candy! 🤩 Here's a ctenophore (or comb jelly) stained with phalloidin by John Alexander Salazar Hernandez & imaged on an exaSPIM built by Kaelin Wulf of the team of @adamkglaser.bsky.social as part of the FHL Functional Biodiversity course #microscopy
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The EMBO Journal @embojournal.org · 11/08/2026
What’s the function of embryonic ‘cytoplasmic lattices’? Using cryo-ET, @kashishsingh.bsky.social @carter-lab.bsky.social and coworkers reveal them as megadalton-size hubs of ubiquitination proteins/ubiquitin transfer link.springer.com/article/10.1...
link.springer.com
In-situ cryo-ET of mouse embryos reveals cytoplasmic lattices contain ubiquitin-charged E2-E3 ligase assemblies - The EMBO Journal
Cytoplasmic lattices (CPLs) are filamentous assemblies essential for mammalian embryonic development. They are known to regulate organelle organization, spindle assembly, and protein homeostasis, but ...
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Zebrafish Rock! @zebrafishrock.bsky.social · 09/08/2026
Light sheet fluorescence microscopy (LSFM) movie of axon branching during #zebrafish development in a neurodegenerative disease gene (KLC4) mutant. Credit to @drlizhaynes.bsky.social. #ZebrafishZunday
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Anh Hoang Le, PhD 🏳️‍🌈🏴󠁧󠁢󠁳󠁣󠁴󠁿🇻🇳 @anhhle2702.bsky.social · 07/08/2026
Hot take but any reporter that makes the actin network visible will make any cell look awesome under the microscope! These Xenopus 🐸 ectoderm cells are expressing an actin tension sensor, and you can see the retrograde flow very nicely. Actin is better than microtubules 😁 #FluorescenceFriday
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Hao Yin @haoyin.bsky.social · 31/07/2026
Albumin-mScarlet-SpyTag transgenic mice for long-term visualization of blood & interstitial fluid dynamics Hirase lab bioRxiv 2025 www.biorxiv.org/content/10.1... Video GRIN lens imaging of prefrontal cortex in an Alb-mSc-ST (red)🐭 injected with AAV5/CamKII-GCaMP6f (green)
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Melanie D. White @melaniedwhite.bsky.social · 17/07/2026
Happy #FluorescenceFriday! 🔥🧪🔬 A blaze of neural crest cells migrates through a developing quail embryo on one of embryonic development's most epic journeys. Beautifully captured by @vanderspuy.bsky.social 👩‍🔬🐣 #Devbio
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Anh Hoang Le, PhD 🏳️‍🌈🏴󠁧󠁢󠁳󠁣󠁴󠁿🇻🇳 @anhhle2702.bsky.social · 10/07/2026
Another #FluorescenceFriday. When the world is going crazy, I find some peace watching at these myeloid cells (🔴) going about their day. They exist in tissue surrounded by other cells (🔵), and you can see them popping up and down, going in and out of plane as they explore their surrounding.
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Matyas Bubna-Litic @matyasbl.bsky.social · 03/07/2026
Happy #FluorescenceFriday! Eye of a zebrafish embryo🐟
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Jan Philipp Kreysing @jpkreysing.bsky.social · 11/04/2025
New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇
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Alexey Amunts @amunts.bsky.social · 04/07/2026
RNA can build. A short RNA self-assembles into a 60-subunit icosahedral cage like a viral capsid, but made entirely of RNA. The striking preprint also reveals a 57-nt RNA filament at ~2.7 Å. Congratulations, Lin Huang and colleagues! www.biorxiv.org/content/10.6...
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Ricardo Henriques @henriqueslab.bsky.social · 30/06/2026
Nuclei as constellations 🔭 #NucleiSky aligns microscopy images across modalities and scales by reading nuclei like stars to map between them. Joy to contribute, led by @ivanhcenalmor.bsky.social and @guijacquemet.bsky.social's team. #RxivMaker powered preprint. Check it out!
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Danielle Beckman @daniellebeckman.bsky.social · 22/06/2026
Biology was never meant to be studied in 2D. One of the coolest things about my new work is being able to visualize: 🧠 Neural circuits 🩸 Vascular networks 🎯 Drug biodistribution 🎗️ Disease progression Here's a small glimpse of what we're building at @deeppiction.bsky.social 🤩🔬 #3DImaging
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Zebrafish Rock! @zebrafishrock.bsky.social · 31/05/2026
Live imaging of immune cell response (🟢) to Salmonella infection (🔵) in the hindbrain of a transgenic #zebrafish larva. Credit to Drs. Jade Leiba & Mai Nguyen-Chi. #ZebrafishZunday 🧪
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Paulina Morlay @drpaulinamoreno.bsky.social · 29/05/2026
For this #FluorescenceFriday, some endosomes imaged with MI-SIM. Green: Rab21, Magenta: F-actin, Cyan: EPLINalpha.
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Torsten Wittmann @handle.invalid · 22/05/2026
A day in the life of a growing hiPSC spheroid expressing endogenously mStayGold-tagged histone 3.3 for #FluorescenceFriday and the #Snouty aficionados. 28 hours (and >50,000 exposures) later and they are still going! Home-brewed volume projection.
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Anh Hoang Le, PhD 🏳️‍🌈🏴󠁧󠁢󠁳󠁣󠁴󠁿🇻🇳 @anhhle2702.bsky.social · 22/05/2026
Happy #FluorescenceFriday! I captured this shot of a group of embryonic macrophages expressing LifeAct and H2B migrating inside tissue. These cells can use lamellipodia, filopodia, or blebs to migrate, and are frequently switching between these different modes or combining them. So fascinating.
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Joachim Goedhart @joachimgoedhart.bsky.social · 18/05/2026
RhoG, Rac1 and Cdc42 cooperation in cell protrusion revealed by multiplexed optogenetics and biosensor imaging by Klaus M. Hahn and team: www.biorxiv.org/content/10.6...
Validating the RhoG biosensor.
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Anh Hoang Le, PhD 🏳️‍🌈🏴󠁧󠁢󠁳󠁣󠁴󠁿🇻🇳 @anhhle2702.bsky.social · 15/05/2026
Happy #FluorescenceFriday. I feel so lucky to get to work with these weird and curious primary macrophages from 🐸. They exhibit myriad different morphologies and behaviours, including spinning endlessly and stationary, kinda like progenitor cells under compression from 🐟. Also actomyosin is strong!
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Ali Maximilian Erturk @erturklab.bsky.social · 13/05/2026
happy to share our new protocol paper on wildDISCO for whole-body immunolabeling, tissue clearing & 3D imaging of intact mice at cellular resolution using standard IgG antibodies, for mapping of neuronal, vascular, lymphatic and immune systems across the entire body. www.nature.com/articles/s41...
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Journal of Cell Science @jcellsci.bsky.social · 07/05/2026
In their Cell Science at a Glance article and poster, Kim Chi Thi Vu, Laura Bierau and Eva Herker evaherker.bsky.social unimarburg.bsky.social discuss the pro- and anti-viral functions of lipid droplets in infection. journals.biologists.com/jcs/article/...
JCS Cell Science at a Glance poster - Pro- and anti-viral functions of lipid droplets in infection at a glance by Kim Chi Thi Vu, Laura Bierau, Eva Herker
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Marco Enriquez @marcoenriquez18.bsky.social · 08/05/2026
#FluorescenceFriday From the archives: The Actin Cortex. Plasma membrane (Lck-mScarlet-I 🔴) Cortical actin (GFP-Utrophin 🔵) 1205Lus
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David Solecki @so-lets-kilab70.bsky.social · 05/05/2026
Hey y’all 👋 repost magic appreciated. The Solecki lab is recruiting multiple postdocs at St. Jude for a chromatin imaging project at the edge of live-cell imaging, neuronal cell biology, chromatin regulation, and quantitative image analysis. Ever dreamed of touring chromatin like this? We CAN 🔥
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Chad Hobson @cmhobson.bsky.social · 01/05/2026
Happy #FluorescenceFriday, here is a macrophage engulfing a deformable particle imaged on our LLSM. This project from Mira Krendel's lab and the @aicjanelia.bsky.social just came out as a preprint today! www.biorxiv.org/content/10.6...
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Marco A. Maximo Prado @maximoprado.bsky.social · 01/05/2026
happy #fluorescencefriday Compare with last week’s post on APOE3 mice now we have the AD APOE4 model with blood vessels in pink, amyloid in blue and microglia in green. Courtesy of the @mind-western.bsky.social @touchscreencog.bsky.social @tridentpct.bsky.social teams
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A/Prof Sam Stehbens PhD (She/Her) @samstehbens.bsky.social · 01/05/2026
#microtubules in orange hot, #F-actin greyscale, Fibroblast, spinning disc. @marcoenriquez18.bsky.social @aibnatuq.bsky.social #fluorescenceFriday
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Yuhui LI @yuhuili.bsky.social · 09/04/2026
🔬 First live-cell imaging experiments done in my lab at HKU! Human RPE1 cells expressing Lifeact-GFP (actin) and EB3-GFP (MT plus-ends), imaged in Fast Airyscan mode on a Zeiss LSM 900👇. Thanks to Denise Kuok Iok Teng for imaging setup, and to Manuel Théry & Louise Bonnemay for the cells 🙏🫶😆
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Viroscope @viroscope.bsky.social · 28/04/2026
The high-speed logistics of a lung cancer cell. Watch GFP-Rab25 (Gold) move cargo through the internal recycling pathway of A549 cells. Static maps are great, but time-lapse shows the real traffic. Want your science/tech to be highlighted? DM me at Viroscope!
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Vermot Lab @vermotlab.bsky.social · 27/04/2026
🚨 How do mechanical forces shape a developing organ? Our new #ScienceAdvances @science.org study, led by the amazing @cvagenapantoula.bsky.social, reveals a Piezo1-driven hydraulic mechanism, where mechanical cues control cell volume to guide cardiac formation ❤️🐟 🔗 www.science.org/doi/10.1126/...
science.org
Piezo1-mediated mechanohydraulic control of cell volume drives cardiac morphogenesis
Mechanical forces shape the developing heart by controlling cell volume through a Piezo1-driven hydraulic mechanism.
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Justin Taraska @taraska.bsky.social · 26/04/2026
New perspective on caveolae www.nature.com/articles/s41...
nature.com
A lipid-centric view of endocytosis by caveolae - Nature Cell Biology
This Perspective discusses the mechanisms underlying both the formation and scission of caveolae, with a focus on highlighting the role of specific lipids in regulating and coupling these processes.
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Anna La Torre @latorrelab.bsky.social · 17/04/2026
It's #FluorescenceFriday and these retinal astrocytes understood the assignment: branching, glowing, and casually laying down the blueprint for the retinal vasculature #Retina #ConfocalMicroscopy
Confocal microscopy image of retinal astrocytes
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Lori O'Brien @llobrienlab.bsky.social · 24/04/2026
For #FluorescenceFriday, an E10 embryo showing Pax2 localization. #DevelopmentalBiology
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Chad Hobson @cmhobson.bsky.social · 24/04/2026
Happy #FluorescenceFriday! Just some random data I collected from a while back, actin and myosin in a U2OS cell imaged on our lattice light sheet microscope.
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Prof. Hao Wu @wulabharvard.bsky.social · 06/03/2026
I am excited to share with you an amazing video on the NLRP3 inflammasome pathway generated by talented Ann Liu from the Janet Iwasa lab @jiwasa.bsky.social @ann-hl.bsky.social. It shows the real structures of the pathway from #NLRP3, #ASC, #caspase-1, #GSDMD, #IL-1b, to #NINJ1. Enjoy!
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Evelyn Strickland @strickland-evelyn.bsky.social · 20/04/2026
What if you got to work with some of your best friends on a science project? I can't publish how fun this was, but I can show you the data (🧵)! Last week, we posted our second neutrophil swarming paper to bioRxiv and I wanted to post my favorite videos here~ www.biorxiv.org/content/10.6...
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Christopher Thomas @ovarylab.bsky.social · 20/04/2026
How does an ovarian follicle remodel in space and time to release an egg? 💥🥚 We have an exciting PhD project combining follicle culture, advanced imaging and quantitative analysis to understand the cellular dynamics of ovulation. 🔬 Co-supervised by me and @guignardlab.bsky.social. Please share! 🌱
An ovarian follicle poised for ovulation, with the oocyte at its centre. Cell membranes are shown in orange and DNA in blue.
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Panos Oikonomou @eigenp.bsky.social · 18/04/2026
1/ 🔬🧑‍💻 Tired of going back and forth between GUIs and code for your 3D image analysis needs? Would you like to keep your focus in one place (notebook), without sacrificing interactivity? Here’s a tool that can help!
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Xavier Trepat @xaviertrepat.bsky.social · 17/04/2026
Our latest work on shape-programmable tissues is out in @science.org. By positioning topological defects in cellular nematics, we encode frustrated 2D force fields that relax into predictable 3D shapes. Collaboration with Marino Arroyo’s lab, led by @pauguillamat.bsky.social at @ibecbarcelona.eu.
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Denis Wirtz @deniswirtz.bsky.social · 14/04/2026
Mapping nerves in a whole embryos. We find that across species and development stages, embryonic nerves display (beautiful) fractal geometry. More here: www.biorxiv.org/content/10.6...
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