Office of University Interdisciplinary Programs

An accessible light-sheet microscope delivers subcellular-resolution, multicolor volumetric, and live-cell imaging, lowering barriers to state-of-the-art performance.

Despite advances in fluorescence microscopy, spectral overlap and limited resolution hinder the dense mapping of the cellular ultrastructure. To overcome these challenges, we developed Cy-ExM, a high-...

Limb loss remains a significant clinical challenge, but regenerative medicine approaches such as gene therapy offer a promising strategy to trigger endogenous regeneration programs. Optimal vector con...

The Center for Molecular Medicine in partnership with Departments of Biochemistry and Biophysics, Cell Biology and Physiology, Genetics, Microbiology and Immunology and Pediatrics at the University of...

This study reveals that cells of the zebrafish kidney can originate from the somites, structures traditionally held as precursors to the skeletal muscle, challenging a century-old paradigm and prompti...

NIH’s sudden move to multiyear grant funding is forcing shocking cuts in the number of grants funded. This is an effective budget cut. It's bad, folks.

For over a century it has been believed that the vertebrate kidney arises exclusively from the intermediate mesoderm. Here, we overturn this paradigm by demonstrating that some nephrons, the functiona...

Voigt et al. show that the 5′-inositol phosphatase gene inppl1a drives notochord expansion independent of vacuole fusion. Defects in notochord expansion are exacerbated by locomotion, causing more sev...

Drug-induced autoimmune diseases are increasingly recognized although mechanistic insight into disease causation is lacking. Hydralazine exposure has been linked to autoimmune diseases, including anti...

O’Brien will map the kidney nerve network from acute injury to chronic disease for the first time in a high-risk/high reward project. Sympathetic and sensory neurons innervate the kidney, with sympath...