iiinova — where your digital self keeps evolving

A high-density micromass (50k cells/10 µL) #SmoothMuscleCell calcification assay Mimicking atherosclerotic chondromyocyte state (100-gene marker panel) Or mesenchymal condensation? 240/552 #CoronaryArteryDisease risk genes are differentially expressed bioRxiv 2026 www.biorxiv.org/content/10.6...

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Manuela Casasoli @manuelacasasoli.bsky.social · 02/10/2026

It is crucial to be aware that infectious agents are an important preventable cause of #cancer globally. A new study provides a comprehensive picture of cancer burden attributable to infections. 🧪 #Science #Health 1- www.scientificamerican.com/article/one-... 2- www.thelancet.com/journals/lan...

Image Source:
https://www.scientificamerican.com/article/one-in-eight-new-cancers-are-likely-caused-by-infections-theres-an-easy-way-to-protect-yourself/

Amanda Montañez; Source: “Global Burden of Cancer Attributable to Infections in 2024: A Worldwide Incidence Analysis,” by Harriet Rumgay et al., in Lancet Oncology, Vol. 27. Published online September 28, 2026 (data)

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Developmental Biology @devbiol.bsky.social · 01/10/2026

#DBfeature #ICYMI Ascidian Botryllus humilis is capable of whole-body regeneration, becoming a promising new model for aging and stem cell dynamics. By Arzu Karahan doi.org/10.1016/j.ydbio.2025.10.002

Whole body regeneration progression in a stage A colony (colony code: B4-3 (Ms1)) under the aquaculture conditions of 26 °C and 38 ppt salinity. A) Before ablation, B) right after the ablation, C, C′, C″) 25 h post-ablation, D, D′, D″) 48 h post-ablation, E, E′, E″) 64 h post-ablation, F) 90 h post-ablation, G) 112 h post-ablation, and H) formation of filter-feeding zooids, completing Whole body regeneration with two zooids approximately 138 h after ablation. Arrows indicate niches.

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Elisabeth Kugler @kuglerelisabeth.bsky.social · 01/10/2026

FREE GUIDE Develop Your Marketing Funnel Life Science & Biotech Edition (B2B) This is a short overview on how to develop a robust marketing funnel specifically for life science and biotech companies. Actionable. Useful. Practical. 👉️ www.zeeks-artforgeeks.com/develop-your...

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Anh Hoang Le, PhD 🏳️‍🌈🏴󠁧󠁢󠁳󠁣󠁴󠁿🇻🇳 @anhhle2702.bsky.social · 02/10/2026

Happy #FluorescenceFriday. Single immune cell migration is fascinating. But these cells can also behave like a coordinated collective, like 🐝 from a hive. I captured some embryonic myeloid cells (🔴) displaying swarming behaviour in a migrating ectoderm cell sheet (🔵), like neutrophils in our body!

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epithelial mechanics fan club @epimechfc.bsky.social · 02/10/2026

Choi, B. J., Chen, Y.-C., & Desplan, C. (2025). Retinal calcium waves coordinate uniform tissue patterning of the Drosophila eye. Science, 390(6775), eady5541. #EpithelialMechanics www.science.org/doi/10.1126/...

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Schallek Lab @schalleklab.bsky.social · 02/10/2026

#FluorescenceFriday Pericytes are tiny cells that surround microvessels. Here we show how single cells wrap their "tentacles" around retinal capillaries 👁️ Color: renders depth bit.ly/3TFifQe @flaumeye.bsky.social @cvsuor.bsky.social @urneuroscience.bsky.social @urochester.bsky.social

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Hao Yin @haoyin.bsky.social · 02/10/2026

Loss of Y chromosome is associated with ⬆️risk of #AAA #AbdominalAorticAneurysm but Not #TAA #ThoracicAorticAneurysm LOY was measured in blood cells #UKBiobank N=221k, 13.5 y f/up #MassGeneralBrighamBiobank N=14k #AortaEd @mariebillaud.bsky.social #JAMACardio 2026 jamanetwork.com/journals/jam...

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Zebrafish Rock! @zebrafishrock.bsky.social · 01/10/2026

It's Spooky Season, y'all! 🐟🎸🎃 Credit carving to @zebraflow.bsky.social based on original artwork by @ethankocak.com. #sciart #Halloween #Spooktober #NewProfilePic

Pumpkin carved with Danny-O the zebrafish holding a guitar.

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Hao Yin @haoyin.bsky.social · 01/10/2026

Carbonic anhydrase 9, an intracellular pH regulator, is widely used to mark #Hypoxia in tumors (+some tissues) Here's new evidence for CA9 (+CA12) in human pulmonary arterial #SmoothMuscleCell & 🐭#PulmonaryHypertension (S4, CA9/CA12 dual inhibitor) 😎 #AJRCMB 2026 academic.oup.com/ajrcmb/advan...

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Mabruka Alfaidi @maalfaidi.bsky.social · 30/09/2026

🚨 Excited for #AHA26! ATVB's Women's Leadership Committee is hosting Speed Mentoring with Science Icons, a rotating roundtable mentoring & networking event. 📅 Sun, Nov 8, 2026 | 5–7 PM CST 📍 Chicago, IL #WomensLeadership #Mentorship #ATVB

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Rita Strack @ritastrack.bsky.social · 29/09/2026

We've had a wave of source data corrections lately across the Nature Portfolio. We wrote an editorial about the importance of bookkeeping and QC when preparing manuscripts. www.nature.com/articles/s41...

nature.com

Source data under scrutiny - Nature Biomedical Engineering

The source data underlying results and figures in our manuscripts can be critical for assessing the rigour of our studies and for reproducibility. Ensuring the quality and provenance of these data dur...

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Tessa Montague @tessamontague.bsky.social · 29/09/2026

My dream is to record neural activity in their brain while they camouflage so we can see how the visual world is represented in the brain & transformed into a recreation of the world on the skin. To do this, we need to generate new genetic lines: animals whose neurons fluoresce as they fire (GCaMP)

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Tessa Montague @tessamontague.bsky.social · 29/09/2026

I'm excited to share our new preprint: Generation of a transgenic cephalopod tinyurl.com/pc86jxz8 Cephalopods (cuttlefish, octopus & squid) are crazy critters that dynamically camouflage to their surroundings by changing the color, pattern, & texture of their skin, which they control w their brain.

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Anh Hoang Le, PhD 🏳️‍🌈🏴󠁧󠁢󠁳󠁣󠁴󠁿🇻🇳 @anhhle2702.bsky.social · 29/09/2026

Trying out #Filopodyan made by the Gallop lab for the first time and it's awesome! The export doesn't directly have the calculated speed, but good thing is you have all the information there to calculate it yourself. And the detection works well, especially for thicker filopodia. I like it! #fiji

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Manuela Casasoli @manuelacasasoli.bsky.social · 29/09/2026

"Photosynthesis sustains life on Earth by converting light to chemical energy through the coordinated action of photosystem I and photosystem II within thylakoid membranes." Here are the structures of plant photosystem supercomplexes. 🧪 #Science #Biology #Biochemistry www.nature.com/articles/s41...

Image Source:
https://www.nature.com/articles/s41586-026-10847-3

Fig. 1: In situ single-particle cryo-EM analysis of photosynthetic supercomplexes in thylakoid membranes from O. sativa chloroplasts.

a,b, Cryo-EM grid preparation of chloroplasts isolated from O. sativa (a) and directly frozen onto cryo-EM grids (b). c, Representative cryo-EM micrograph of chloroplasts for single-particle analysis. Similar micrograph quality was observed across the entire dataset (n = 22,785 micrographs). Scale bar, 50 nm. d, Representative 2D class averages showing different types of photosynthetic supercomplex. e,f, Side (e) and lumenal (f) views of a representative high-resolution map of the C2S2M2L4-type PSII–LHCII supercomplex (Electron Microscopy Data Bank (EMDB) EMD-68060). g, Surface representation of the C2S2M2L4 complex (Protein Data Bank (PDB) 21WV), comprising the core (outlined by the red dashed box) and peripheral antenna proteins: CP29, CP24, CP26, S-LHCII, M-LHCII and L-LHCII. The L-LHCII regions were fitted with the LHCII models from the PSI–LHCI–LHCII complex according to their distinct triangular densities. h, High-resolution features of the C2S2M2L4 complex shown by representative density of amino acid residues and endogenous ligands. CLA, chlorophyll a; PHO, pheophytin a; CHL, chlorophyll b; BCR, β-carotene; NEX, neoxanthin; XAT, violaxanthin; HEM, heme; PL9, plastoquinone-9; LHG, 1,2-dipalmitoyl-phosphatidyl-glycerole; DGD, digalactosyl diacylglycerol. i,j, Side (i) and stromal (j) views of a representative high-resolution map of the PSI–LHCI–LHCII supercomplex (EMDB EMD-66932) in the native thylakoid membrane. k, Atomic model of PSI–LHCI–LHCII (PDB 9XJ9). l, High-resolution features of PSI–LHCI–LHCII shown by representative density of amino acid residues and endogenous ligands. PL0, chlorophyll a isomer; PQN, phylloquinone; SF4, iron/sulfur cluster.

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epithelial mechanics fan club @epimechfc.bsky.social · 29/09/2026

Bresteau, E., Suva, E. E., Revell, C., Hassan, O. A., Grata, A., Sheridan, J., Mitchell, J., ..., Jensen, O. E., & Mitchell, B. (2025). Apical size reduction by macropinocytosis alleviates tissue crowding. Nature Communications, 16(1), 5338. #EpithelialMechanics www.nature.com/articles/s41...

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Developmental Biology @devbiol.bsky.social · 22/09/2026

#DBfeature #ICYMI 🐠 Conserved genes play a role in facial soft tissue morphogenesis in humans and cichlids. By Ehsan Pashay Ahi, Christian Sturmbauer, R. Craig Albertson, Pooja Singh doi.org/10.1016/j.ydbio.2025.10.014

Examples of cichlid fish models for studying the heritable morphologies of human face. (A) Heritability map of human face. Red and blue areas indicate high and low levels of heritability, respectively (www.heritabilitymaps.info). White ovals were added arbitrarily to indicate specific regions of the forehead, upper lip, and nose that are reported to be highly heritable in humans. (B) African cichlids as models to study facial areas with high of levels of heritability in human (e.g. forehead, nose and upper lip). (C) Examples of predicted co-expression of facial morphogenic genes in human soft tissues (www.gtexportal.org) with potentially conserved role in cichlids.

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Developmental Biology @devbiol.bsky.social · 28/09/2026

#DBfeature #LatestResearch 🧠 A central role for Islr2 in direct pathway striatal projection neurons for the correct formation of the internal capsule and cerebral peduncle By S Ali, J Ehrman, P Merchan-Sala, M Kofron, R Waclaw, K Campbell doi.org/10.1016/j.ydbio.2026.07.003

Axonal defects in Isl1cre-vs Foxd1cre-driven Islr2 cKOs. A-L. E18.5 sagittal mouse brain sections of control (A,D,G,J,M Isl1cre;Islr2flx/+; Sox8-EGFP; Fezf2-TdTomato), Isl1cre-driven Islr2 cKO (B,E,H,K,N Isl1cre;Islr2flx/flx; Sox8-EGFP; Fezf2-TdTomato) and Foxd1cre-driven Islr2 cKO (C,F,I,L,O Foxd1cre; Islr2flx/flx; Sox8-EGFP; Fezf2-TdTomato). A-C. Sox8-EGFP labeling of dSPN projections. D-F. Fezf2-TdTomato labeling of corticofugal projections. G-I. Netrin-G1a labeling of TCAs (arrows in G,I show cortical innervation). J-O. Merged images show a severe disruption of dSPN axons, CFAs (arrowhead in B,E,K,N) and TCAs (open arrowhead showing normal telencephalic entry point in G-I, M-O and misrouted axons indicated by closed arrowhead in H) in Isl1cre-driven Islr2 cKO when compared to control (A,D,G,J). In contrast, Foxd1cre -driven Islr2 cKO (C,F,I,L,O) exhibit overtly normal axon trajectories. P-R. Schematics made using bioRender, with Islr2 expressing regions in yellow and recombined regions in white showing dSPN axon (green), CFA (red), and TCA (blue) trajectories in control (P) and Islr2 cKO - either Isl1cre-driven (mutant dSPNs shown with open green arrow; Q) or Foxd1cre-driven (R). cp, cerebral peduncle; Ctx, cortex; GP, globus pallidus; ic, internal capsule; TRN, thalamic reticular nucleus; SNr, substantia nigra pars reticulata; Stm, striatum; STN, subthalamic nucleus; Th, thalamus. Scale bar in A-L = 500 μm; M-O = 125 μm.

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Developmental Biology @devbiol.bsky.social · 29/09/2026

#DBfeature #ICYMI Sfrp1a regulates hematopoietic stem and progenitor cell development and canonical Wnt signaling in a dose-dependent manner in zebrafish. By Amber Ide, Stephanie Grainger, et al doi.org/10.1016/j.ydbio.2025.09.019

Representative images of 7XTCF:GFP; kdrl:mCherryNLS fish injected with 500 pg control mRNA or 500 pg sfrp1a mRNA and the double positive cells were analyzed for GFP fluorescence at 16.5 hpf. Arrow heads point to double positive cells in the floor of the dorsal aorta.

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Hao Yin @haoyin.bsky.social · 29/09/2026

Real-time in vivo measurement of cGMP in cGi500 (FRET-based cGMP sensor- CFP/YFP ratio) 🐭 skeletal muscle Arterioles Acetylcholine-induced arteriolar dilations are Not attenuated in sGC−/−🐭 How flow modulates precapillary arteriolar cGMP?😁 #ActaPhysiol 2026 onlinelibrary.wiley.com/doi/10.1111/...

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Mark Peifer (He, him) @peiferlabunc.bsky.social · 28/09/2026

You can learn more about our lab at our website. If you are interested, email a CV and a cover letter and we can connect to tell you more about this opportunity peifer@unc.edu 5/n tarheels.live/peiferlab/

Cell Adhesion and the Cytoskeleton

Our challenge is to alter the current static model of cell adhesion to explain the remarkable cellular events of morphogenesis that shape the embryonic body plan. To do so, we must understand the dynamic regulation of cell adhesion and the interactions between adhesion and the cytoskeleton.

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Mark Peifer (He, him) @peiferlabunc.bsky.social · 28/09/2026

We combine genetic, cell biological & biochemical approaches to learn how cell-cell adhesion & the cytoskeleton are integrated, exploring this at multiple levels from whole animals to the structures of molecular machines. Here you can learn to mentor undergraduates & postbacs and build a team 3/n

Some of the recent postbacs in the last 10 years

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Mark Peifer (He, him) @peiferlabunc.bsky.social · 28/09/2026

Postdocs trained in our lab moved on to positions at places like Davidson, Bucknell, Franklin & Marshall, or Randolph Macon. At Carolina they gained teaching experience in our summer sessions, published first-author papers, & built a research program that was scaled for the college environment 2/n

Lab website
https://tarheels.live/peiferlab/

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Mark Peifer (He, him) @peiferlabunc.bsky.social · 28/09/2026

Are you looking for a postdoc exploring the cell biology of development, defining how cells change shape and move? Do you want to develop a research program & teaching skills preparing you for a position at a college or small University? Our new NIH grant will support those goals 1/n Please share

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@LaBonneLaB @labonnelab.bsky.social · 28/09/2026

great opportunity!

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Kirsty Wan @micromotility.bsky.social · 10/11/2024

ooh Bluesky can do videos now... here's an emergency #cilia movie

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Valentin Dunsing-Eichenauer @dunsingvalentin.bsky.social · 25/09/2026

#FluorescenceFriday: Given the recently grown interest in ciliary beating, here is a movie of beating cilia in a human airway model that I captured last week with lattice light-sheet microscopy. No AI „processing“, this is the raw data! Frame rate is ca. 170fps, displayed here at 25fps.

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Eric Chevet @ericchevet.bsky.social · 27/09/2026

Good morning! This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: Protein entanglement misfolding in proteasomal degradation or near-native misfolded states persistence www.nature.com/articles/s41...

biomed.news

bims-proteo 2026-09-27 papers

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Zebrafish Rock! @zebrafishrock.bsky.social · 27/09/2026

Electrochemical response triggers organ growth, following tail injury in a #zebrafish embryo. Credit to @ritamateus.bsky.social, @nerlielisa.bsky.social, & @liujinghui.bsky.social. #ZebrafishZunday

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epithelial mechanics fan club @epimechfc.bsky.social · 27/09/2026

Can mathematics explain how biological patterns are formed? Alan Turing thought so. Join me, @benswedlund.bsky.social , as we explore his reaction-diffusion theory and how it transformed our understanding of pattern formation and self-organisation.

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Kay Schink @kschink.bsky.social · 26/09/2026

According to the quoted email from Nikon spokesperson, AI was used for "postprocessing". However, I wonder how this lines up with this recent post on LinkedIn, which finds AI watermarks from Google AI generators. I checked this myself, and Gemini reports a watermark.

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Mark Peifer (He, him) @peiferlabunc.bsky.social · 26/09/2026

The AI cilia story deepens further

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Venkat Rao @venkyrao.bsky.social · 26/09/2026

Jumping on the bandwagon with a 3D view of Xenopus multiciliated cells: cilia (magenta) sprouting above the apical actin network (cyan) 🐸. Not live, but no #AISLOP

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Mia Konjikusic, PhD @konjikusicmia.bsky.social · 25/09/2026

To add to all the lovely videos of non-AI processes multicilia beating: ctenophore multiciliated cells! They can reach up to 1mm long, causing a rainbow light refraction effect with the correct light positioning! Taken by myself at MBL in 2019 embryology. Realtime frame-rate!

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Hao Yin @haoyin.bsky.social · 26/09/2026

Bulk transcriptomics Urolithin A vs Urolithin B on cultured human Myotubes FGF9 is downregulated by Urolithin A, not B But RNAseq data is not open accessible until Apr 2027...😶 #JCSM_cachexia 2026 onlinelibrary.wiley.com/doi/10.1002/...

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A/Prof Sam Stehbens PhD (She/Her) @samstehbens.bsky.social · 26/09/2026

#Nikon will address our concerns by next week. Hopefully the pre-processed movie & raw data will be part of that. #NikonSmallWorld

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A/Prof Sam Stehbens PhD (She/Her) @samstehbens.bsky.social · 26/09/2026

Thank-you to the community members who spoke up. In the age of AI it is increasingly important to maintain #biologicalreality. Hallucinating biological structures is not science. @melaniedwhite.bsky.social @christlet.bsky.social & Robert Hirst.

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Hao Yin @haoyin.bsky.social · 25/09/2026

True Cilia & True Winner👏

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🍁 Bryan Heit, PhD 🍁 @bryanheit.bsky.social · 25/09/2026

Happy #FluorescenceFriday. eSRRF reconstruction of actin dynamics in PMA-stimulated macrophages. Scale bar is 2 microns!

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Anh Hoang Le, PhD 🏳️‍🌈🏴󠁧󠁢󠁳󠁣󠁴󠁿🇻🇳 @anhhle2702.bsky.social · 25/09/2026

Happy #FluorescenceFriday. The first time I imaged a 🐸 embryo, I didn't realise they had these ciliated cells on the outer surface. So you can imagine how surprised and curious I was! These cilia are similar to those found in the human airway. And yes, this is just a good old confocal + 🔥LUT!

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Joachim Goedhart @joachimgoedhart.bsky.social · 25/09/2026

Don't you just love the natural panning?

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Christophe 🔬 Leterrier @christlet.bsky.social · 25/09/2026

Here's a balanced account of where the microscopy community stands on AI use by this year's Small World in Motion winner. My main issue is that no one seems to have seen the original data despite requests (no mention of it being reviewed by the organizers) www.the-scientist.com/allegations-...

the-scientist.com

Allegations of AI Use in Nikon Competition Spark Controversy | The Scientist

Microscopists raise concerns about inappropriate AI usage in Nikon's microscopy contest-winning video. Nikon stands their ground, citing no policy breach.

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