Maslennikova et al. identify the ER membrane protein CLCC1 as an interaction partner of the dystonia-linked AAA+ ATPase Torsin1A. Torsin1A sustains the function of CLCC1, which is proposed to facilitate fusion of the nuclear envelope during NPC biogenesis by forming an oligomer that promotes lipid bilayer approach and remodeling.

Basement membranes are scaffolds of proteins, like collagen, that give organs shape. During development, basement membranes must adapt to the growing organ. We infer how fast the basement membrane adapts by measuring collagen turnover. We find that perlecan, another basement membrane protein, regulates collagen turnover to control organ shape.

In cells, ESCRT-III is unique in mediating fission of membrane necks from inside, a process called reverse-topology fission. Yet, in vitro, the complex primarily assembles outside membrane necks and m...

Molecules in the cytoplasm of an animal cell move by diffusion, motor activity, and/or fluid flow. A recent study demonstrates how directed, but often subtle, cytoplasmic drift currents carry cytoskel...

Almeida AC et al. uncover the physiological role of a long-elusive feedback pathway that regulates tubulin biosynthesis. By tuning microtubule dynamics, this mechanism preserves cell adhesion, surviva...

Sarkar et al. show that the CLASP protein Orbit stabilizes non-centrosomal microtubule plus ends in vivo, suppressing catastrophe and enabling persistent polymerization-based pushing forces. This stab...

Mani, Tardif, Rossier et al. show that mechanical stress triggers caveolin-1 release from caveolae, enabling its diffusion in the plasma membrane and interaction with signalling effectors to regulate ...

If the vaccine is effective in a late-stage trial, it would be “paradigm-shifting,” one expert said.

Septins are a family of GTP-binding proteins that assemble into heteromeric oligomers and polymers, associating with specific membrane domains and organelles according to their subunit composition. G...

The extraction of a phospholipid called phosphatidic acid from the mitochondrial outer membrane is regulated by the curvature of this membrane.

Growing misuse of, and unequal access to, AI tools requires universities to rethink how they evaluate learning

New webinar series on cell migration - News