Sign in

Ali Maximilian Erturk

@erturklab.bsky.social
2.1K followers 643 following 179 posts

AI and tissue clearing-based technologies for health. Director at Helmholtz Munich, Full professor at LMU Munich, and CEO of Deep Piction (@deeppiction.bsky.social) We’re🇩🇪🇹🇷🇭🇷🇨🇳🇮🇹🇮🇳🇸🇮🇴🇲🇨🇱🇭🇺🇧🇬🇺🇦🇷🇴🇦🇹🇹🇼🏳‍🌈

PostsRepliesMedia
Reposted by Ali Maximilian Erturk
Danielle Beckman @daniellebeckman.bsky.social · 30/07/2026
What if acute COVID seems gone, but parts of the virus aren’t? Our lab is using advanced imaging to see what conventional methods miss, and turn those discoveries into urgently needed #LongCOVID treatments. 🔬 The evidence 👇🏻
49531
Reposted by Ali Maximilian Erturk
Markus Elsner @markuselsner.bsky.social · 30/07/2026
Check out what we have been up to recently, as we are now trying to make a real-world difference in Long COVID and other diseases
022
Ali Maximilian Erturk @erturklab.bsky.social · 30/07/2026
SARS-CoV-2 spike protein accumulates & persists in the body for years👇🏻. We develop advanced imaging/AI to cure Long COVID & beyond👇🏻. Join us 🤗 www.nature.com/articles/s41... www.cell.com/cell-host-mi... www.biorxiv.org/content/10.6... www.biorxiv.org/content/10.6... www.biorxiv.org/content/10.1...
0272
Ali Maximilian Erturk @erturklab.bsky.social · 28/07/2026
Brain vascular aging isn’t a single path. Our new work shows that the aging brain diverges into two states: 🧠 Hypovascular (expected) 🧠 Hypervascular (surprising), with BBB leakage, inflammation and cognitive decline. Our study👇🏻: www.biorxiv.org/content/10.6...
0175
Reposted by Ali Maximilian Erturk
Norma @looftsabine.bsky.social · 28/07/2026
www.biorxiv.org/content/10.64898/20…
biorxiv.org
Reversible hypervascularization drives cognitive decline and blood-brain barrier damage during aging
Cerebrovascular dysfunction emerges early in neurodegeneration, yet how vascular structure, blood–brain barrier (BBB) failure, and cognition are linked remains undefined. Using VesselPro, a whole-brai...
011
Ali Maximilian Erturk @erturklab.bsky.social · 13/06/2026
See our science at Deep Piction, how we use it to develop new precision medicine.
052
Reposted by Ali Maximilian Erturk
Hao Yin @haoyin.bsky.social · 05/06/2026
MouseMapper An imaging-omics workflow of whole-mouse analysis Up to single-cell resolution!👹 vDISCO WildDISCO whole-mouse optical clearing #SpatialProteomics Trigeminal ganglia VR annotation of major organs, peripheral nerve & Mφ @erturklab.bsky.social Nature 2026 www.nature.com/articles/s41...
0248
Reposted by Ali Maximilian Erturk
Markus Elsner @markuselsner.bsky.social · 28/05/2026
Ohhh, wow!
031
Ali Maximilian Erturk @erturklab.bsky.social · 28/05/2026
Our recent work in @Nature, MouseMapper uses foundation-model AI, mapping perturbations in mouse body cell-by-cell, revealed unexpected facial nerve damage. Proud to see >75K accesses & >60 news stories in the first week. Paper->> www.nature.com/articles/s41... Next www.biorxiv.org/content/10.6...
02210
Reposted by Ali Maximilian Erturk
Doris Kaltenecker @dorie00.bsky.social · 25/05/2026
Super happy to see our work published in @nature.com last week 🤩 By combining whole-body tissue clearing, light-sheet microscopy and AI, we mapped obesity-associated remodeling across the entire mouse body in 3D at cellular resolution. www.nature.com/articles/s41... @erturklab.bsky.social
2236
Reposted by Ali Maximilian Erturk
Nature @nature.com · 22/05/2026
Nature research paper: A deep-learning framework reveals whole-body perturbations at cell level go.nature.com/3Pjox61
go.nature.com
A deep-learning framework reveals whole-body perturbations at cell level - Nature
An analysis of diet-induced obesity using MouseMapper—a suite of foundation-model-based deep-learning algorithms—identifies structural alterations of the infraorbital branch of the trigeminal ganglia.
05218
Ali Maximilian Erturk @erturklab.bsky.social · 20/05/2026
Today in Nature, we report MouseMapper: foundation-model AI to map disease perturbations across the entire mouse body cell-by-cell. In obesity, it revealed body-wide inflammation & unexpected facial nerve damage. www.nature.com/articles/s41... More at: x.com/erturklab/st...
03013
Reposted by Ali Maximilian Erturk
Waggoner Lab @labwaggoner.bsky.social · 20/05/2026
A deep-learning framework reveals whole-body perturbations at cell level @nature.com @erturklab.bsky.social @dorie00.bsky.social www.nature.com/articles/s41...
0154
Reposted by Ali Maximilian Erturk
Helmholtz Munich @helmholtzmunich.bsky.social · 20/05/2026
#M1 Launches First Funding Period & Advances Translation in Munich🚀 Seven projects receive €7.45 million through the M1 – Munich Medicine Alliance. #HelmholtzMunich is involved in four funded projects. 👉 t1p.de/disle @tum.de @lmu.de @boyanbonev.bsky.social @erturklab.bsky.social #MunichMedicine
M1 Launches First Funding Period & Advances Translation in Munich
033
Reposted by Ali Maximilian Erturk
Helmholtz Munich @helmholtzmunich.bsky.social · 20/05/2026
AI Atlas Reveals Hidden Whole-Body-Damage Caused by Obesity Researchers around Prof. Ali Ertürk, #HelmholtzMunich, developed #MouseMapper – an #AI framework that maps disease-related changes throughout the entire mouse body at cellular resolution. 👉 t1p.de/svfv0 @erturklab.bsky.social
AI Atlas Reveals Hidden Whole-Body-Damage Caused by Obesity
1104
Reposted by Ali Maximilian Erturk
Markus Elsner @markuselsner.bsky.social · 18/05/2026
I was not very much involved in this project from our lab, but I can honestly say that I find this story really amazing!
042
Ali Maximilian Erturk @erturklab.bsky.social · 15/05/2026
🧠 Does brain aging always mean vessel loss? We found the opposite in some aged brains: maladaptive hypervascularization, linked to cognitive decline and blood-brain barrier damage. Check it out below! www.biorxiv.org/content/10.6...
0188
Ali Maximilian Erturk @erturklab.bsky.social · 13/05/2026
happy to share our new protocol paper on wildDISCO for whole-body immunolabeling, tissue clearing & 3D imaging of intact mice at cellular resolution using standard IgG antibodies, for mapping of neuronal, vascular, lymphatic and immune systems across the entire body. www.nature.com/articles/s41...
03812
Ali Maximilian Erturk @erturklab.bsky.social · 28/03/2026
One thing nobody teaches you in academia: 𝗵𝗼𝘄 𝘁𝗼 𝗻𝗲𝗴𝗼𝘁𝗶𝗮𝘁𝗲. We spend 10+ years learning how to do science, write grants, and present data. But when the job offer finally comes, most people just… accept it. Because we're relieved. Because we think the salary is fixed.
1100
Ali Maximilian Erturk @erturklab.bsky.social · 18/03/2026
Using vDISCO tissue clearing, and a new ultrabright chemical labeling strategy. This work introduces LINCS for rapid, scalable 3D connectivity mapping from single neurons to whole brains, advances for high-throughput circuit mapping. Great work by Rui Lin lab. www.sciencedirect.com/science/arti...
0127
Reposted by Ali Maximilian Erturk
Philip Ruthig @philipruthig.bsky.social · 09/03/2026
Be my colleague! :)
042
Reposted by Ali Maximilian Erturk
Markus Elsner @markuselsner.bsky.social · 09/03/2026
Come work with us!
022
Reposted by Ali Maximilian Erturk
Ruth Ann Crystal @drruth.bsky.social · 09/03/2026
Job available at the amazing Erturk lab in Munich
Photo of blood vessels in the brain in yellow with pink on the periphery and purple at the outer edges.
093
Ali Maximilian Erturk @erturklab.bsky.social · 09/03/2026
Hiring in Munich: Staff Scientist / Postdoc in Tissue Clearing and 3D Image Analysis. We’re looking for someone with strong hands-on expertise in tissue clearing, light-sheet microscopy, and quantitative 3D image analysis. Shares and recommendations are very welcome. www.linkedin.com/jobs/view/43...
linkedin.com
LMU Klinikum München hiring Staff Scientist / Postdoc – Tissue Clearing & 3D Image Analysis in Greater Munich Metropolitan Area | LinkedIn
Posted 8:17:54 AM. About us 🧠🔬The Institute for Stroke and Dementia Research (ISD) at LMU Klinikum is a highly…See this and similar jobs on LinkedIn.
01512
Ali Maximilian Erturk @erturklab.bsky.social · 13/02/2026
In this recent Nature Methods Perspective, I outline how tissue clearing, spatial-omics, and AI converge to create deep 3D histology, enabling unbiased, organism-scale biology and next-generation digital pathology. www.nature.com/articles/s41...
072
Ali Maximilian Erturk @erturklab.bsky.social · 08/02/2026
A new preprint introduces aDISCO, a DISCO-based clearing approach that makes whole archival FFPE human tissues transparent and antibody-compatible, enabling true 3D light-sheet histology across brain & multiple organs at cellular resolution. Aguzzi & Helmchen teams. www.biorxiv.org/content/10.1...
03813
Ali Maximilian Erturk @erturklab.bsky.social · 13/01/2026
We’re hiring – Computer Science PhD at iBIO (Helmholtz Munich / LMU). Build AI-driven, whole-body multi-omics atlases by combining scRNA-seq, spatial transcriptomics, proteomics & 3D imaging. Looking for strong omics data analysis skills with ML/DL. Apply or share: www.linkedin.com/jobs/view/43...
linkedin.com
Helmholtz Munich hiring PhD Position – Deep Learning for Multi-Omics Atlases of the Mammalian Body in Greater Munich Metropolitan Area | LinkedIn
Posted 8:43:27 PM. AI Scientist - PhD Position Institute for Intelligent Biotechnologies (iBIO), Helmholtz Munich /…See this and similar jobs on LinkedIn.
053
Reposted by Ali Maximilian Erturk
Markus Elsner @markuselsner.bsky.social · 29/12/2025
This is going to be fun! I promise!
021
Ali Maximilian Erturk @erturklab.bsky.social · 29/12/2025
My team at Deep Piction (Munich) is hiring a Senior Director, Drug Discovery (Long Covid) to build and lead our early discovery engine. If you have 10+ years in early-stage biotech/pharma, let’s talk. www.linkedin.com/jobs/view/43...
linkedin.com
Deep Piction hiring Senior Director Drug Discovery in Greater Munich Metropolitan Area | LinkedIn
Posted 10:31:52 AM. Senior Director, Drug Discovery (Long Covid)Location: Munich, Germany (Onsite)Type:…See this and similar jobs on LinkedIn.
087
Reposted by Ali Maximilian Erturk
Ali Maximilian Erturk @erturklab.bsky.social · 18/12/2025
Most transcriptomics studies sample ~0.001% of a mouse. Which region do we choose? Often: we guess. Meet DISCO-seq 🤗 flipping the order: RNA-preserving clearing → whole-organ/whole-body 3D imaging → pick ROIs in 3D → unbiased scRNA-seq. Preprint: www.biorxiv.org/content/10.6...
1279
Reposted by Ali Maximilian Erturk
Markus Elsner @markuselsner.bsky.social · 23/12/2025
Single cell transcriptomics from cleared tissue? Impossible you say? Check out our latest preprint!
082
Reposted by Ali Maximilian Erturk
Rita Strack @ritastrack.bsky.social · 23/12/2025
Very cool paper in NBT from the Dietz and Erturk labs @erturklab.bsky.social @markuselsner.bsky.social go.nature.com/4gNLjeC
go.nature.com
Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning - Nature Biotechnology
An integrated experimental and deep learning pipeline reveals cell-level targeting of nanocarriers in whole bodies.
0182
Ali Maximilian Erturk @erturklab.bsky.social · 18/12/2025
Most transcriptomics studies sample ~0.001% of a mouse. Which region do we choose? Often: we guess. Meet DISCO-seq 🤗 flipping the order: RNA-preserving clearing → whole-organ/whole-body 3D imaging → pick ROIs in 3D → unbiased scRNA-seq. Preprint: www.biorxiv.org/content/10.6...
1279
Ali Maximilian Erturk @erturklab.bsky.social · 08/12/2025
Congratulations to our scientist, Laurent Simons, for earning his PhD in quantum physics at just 15—an exceptional achievement. In our lab, Laurent’s work focuses on in silico biology to accelerate treatment of devastating diseases. We’re thrilled to have him on the team.
5162
Ali Maximilian Erturk @erturklab.bsky.social · 06/12/2025
Hiring: PostDoc in Tissue Clearing & 3D Histopathology 🧪🖥️ My lab at Helmholtz Munich is seeking a highly motivated PostDoc/Scientist to strengthen our efforts in advanced imaging of cancer tissues. More info: www.linkedin.com/posts/ali-ma...
linkedin.com
#histopathology #tissueclearing #lightsheetmicroscopy #postdoc #sciencecareers #munich | Ali Maximilian Ertürk
Hiring: PostDoc in Tissue Clearing & 3D Histopathology 🧪🖥️ My lab at Helmholtz Munich is seeking a highly motivated PostDoc/Scientist to strengthen our efforts in advanced imaging of cancer tissues. ...
0910
Ali Maximilian Erturk @erturklab.bsky.social · 04/11/2025
We are introducing LipiGo 🤗 A programmable DNA–lipid nanocarrier 🧬 with built-in targeting logic. It de-targets the liver and redirects mRNA delivery into lymphoid organs, enhancing therapies requiring the immune system. Precision delivery at the cell level isn't far! www.biorxiv.org/content/10.1...
11210
Reposted by Ali Maximilian Erturk
Markus Elsner @markuselsner.bsky.social · 19/09/2025
New pre-print from our lab (@erturklab.bsky.social) www.biorxiv.org/content/10.1... Skeetorial to follow, but check it out now if you are interested in targeted drug delivery
biorxiv.org
LipiGo: A Versatile DNA-Lipid Nanoparticle Hybrid for Precision Drug Delivery
Lipid nanoparticles (LNPs) are established carriers for nucleic acid delivery, however, achieving efficient delivery to non-hepatic tissues remains a major challenge. Here, we present LipiGo, a nanoca...
034
Ali Maximilian Erturk @erturklab.bsky.social · 17/09/2025
Your Brilliant Idea Won't Get You a PI Position As scientists, we are passionate about our research and great ideas. But this is a dream that rarely gets you hired. 1/9
1113
Ali Maximilian Erturk @erturklab.bsky.social · 13/08/2025
We discovered that the skull bone marrow has direct connections to the brain surface & mirrors brain inflammation, making it a new site for diagnosing & monitoring brain pathologies. Kolabas…Ertürk, Cell (2023): www.cell.com/cell/pdf/S00... Our Tech: www.biorxiv.org/content/10.1... bit.ly/3PQuymm
0141
Ali Maximilian Erturk @erturklab.bsky.social · 30/07/2025
We developed MouseMapper AI, a deep learning ensemble for the analysis of whole-body systems, including the nervous and immune systems, to map disease/drug perturbations tissue by tissue, organ by organ, at the cellular level in 3D. biorxiv.org/content/10.1...
03417
Ali Maximilian Erturk @erturklab.bsky.social · 01/07/2025
Don’t Be Afraid to Use AI Tools: Learn How to Utilize Them to Drive Innovation Many people are concerned about using AI tools in science. They say it hallucinates or that using it is cheating. I disagree. I think these fears focus on the wrong thing and discourage many. 1/10
121
Ali Maximilian Erturk @erturklab.bsky.social · 12/06/2025
BIG NEWS: As the CEO, I am thrilled to announce the closure of our seed financing round for Deep Piction. 👉🏻https://bit.ly/3TnFpXq Our vision is to bring the fastest and most precise therapeutics to millions using our transparency and AI technology platform.
192
Ali Maximilian Erturk @erturklab.bsky.social · 11/06/2025
Failure is Inevitable: How to Build a Resilient Lab Culture In my last posts, I shared my experiences with building a team and focusing. When you look from the outside, you might see a story of quick, impactful papers and major grants. But that’s only half the story. 1/11
193
Ali Maximilian Erturk @erturklab.bsky.social · 09/06/2025
The importance of focusing on 1-2 projects as a starting PI. Something that might sound crazy: when I finished my postdoc, I didn't have a job lined up. No position, no safety net. As the academic job market is brutal, taking time off before securing my next position felt like career suicide. 1/10
191
Ali Maximilian Erturk @erturklab.bsky.social · 02/06/2025
Post 1: 𝐁𝐮𝐢𝐥𝐝𝐢𝐧𝐠 𝐮𝐩 𝐭𝐡𝐞 𝐭𝐞𝐚𝐦 𝐢𝐬 𝐰𝐡𝐞𝐫𝐞 𝐭𝐡𝐞 𝐦𝐨𝐬𝐭 𝐞𝐟𝐟𝐨𝐫𝐭 𝐬𝐡𝐨𝐮𝐥𝐝 𝐠𝐨. When I posted my first position, not surprisingly, I wasn't known as a young PI. Yet I received over 250 applications for that single position. How? 🧵
2112
Ali Maximilian Erturk @erturklab.bsky.social · 22/04/2025
Our Nature Biotech paper hit 225K+ accesses in 3 months! 🤩 7 first authors from computer science, biology & chemistry prove that great science is teamwork. We combined AI & imaging to visualize single cells across whole organisms. Team synergy > individual brilliance. www.nature.com/articles/s41...
0153
Ali Maximilian Erturk @erturklab.bsky.social · 18/03/2025
We build some of the most advanced AI for biomedical research, leveraging unique data and algorithms to drive precision medicine at scale. People ask if AI will replace humans. It isn’t about idea generation—it’s about selecting and implementing the right ideas with minimal effort & maximum impact.
011
Ali Maximilian Erturk @erturklab.bsky.social · 01/03/2025
Germany’s Science Minister @cem_oezdemir is spot on—we must welcome top scientific talent, especially as the US’s political attitude toward scientists shifts. Many exciting AI & biotech roles opening soon at our biotech @deeppiction.bsky.social. @danyalbayaz.bsky.social www.n-tv.de/politik/Grue...
n-tv.de
"Ziel der Trump-Regierung ist ein Regime Change - auch in Deutschland"
Die Trump-Regierung streicht Forschungsmittel, die Stimmung in den USA kippt. "Sollten die Amerikaner ihre besten Wissenschaftler verprellen, müssen wir das für uns nutzen", appelliert Cem Özdemir, Bu...
0122
Reposted by Ali Maximilian Erturk
Markus Elsner @markuselsner.bsky.social · 26/02/2025
Want to know what we do at our startup Deep Piction? Check out our paper with Denali Therapeutics. Using our proprietary clearing & imaging technologies, we mapped the full targeting profile of brain-penetrating transport vehicles (ATVs) in whole mouse bodies and monkey brains. go.nature.com/3Xifva2
0103