Hedgehog signaling in vertebrates is transduced by the transmembrane protein Smoothened (SMO) on the primary cilium, but the underlying mechanisms remain unclear. This study shows that SMO and ciliary...

The advent of modern transcriptomic approaches has revealed a breadth of neuromodulatory G protein-coupled receptor (GPCR) co-expression far exceeding what was previously thought. This raises a fundam...

Hedgehog signaling in vertebrates is transduced by the transmembrane protein Smoothened (SMO) on the primary cilium, but the underlying mechanisms remain unclear. This study shows that SMO and ciliary...

Garge et al. use experimentally matched mass spectrometry and RNA-sequencing to quantify proteins, phosphosites and transcripts across four key stages of human and mouse gastruloid development.

Primary cilia orchestrate several signaling pathways, and their disruption results in pleiotropic disorders called ciliopathies. Bardet-Beidl syndrome…

YouTube video by EarthWindandFireVEVO

Primary cilia orchestrate several signaling pathways, and their disruption results in pleiotropic disorders called ciliopathies. Bardet Beidl syndrome (BBS), one such ciliopathy, provides insights int...

The CPLANE complex is essential for ciliogenesis, and mutations to all but one subunit have been associated with ciliopathies. Here they identify three familial mutations in the final subunit, RSG1, t...

Voigt et al. show that the 5′-inositol phosphatase gene inppl1a drives notochord expansion independent of vacuole fusion. Defects in notochord expansion are exacerbated by locomotion, causing more sev...

Hedgehog (HH) signaling in vertebrates is dependent on the primary cilium, an organelle that scaffolds signal transduction. HH signals induce Smoothened (SMO) enrichment in the cilium and indirectly t...

Long Research Group - Univ. Kentucky