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Biohub

@biohub.org
3.1K followers 108 following 80 posts

Combining frontier AI & frontier biology to help scientists cure or prevent disease

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Biohub @biohub.org · 24/09/2026
Biohub Investigator @jameszou.bsky.social built a “virtual biotech”—37K AI agents that analyzed 57K clinical trials and found clues to what makes drugs succeed. The New York Times traces its roots to a collaboration sparked by our scientist John Pak: bit.ly/4hLrpnm
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Loïc A. Royer 💻🔬🧪 @loicaroyer.bsky.social · 23/09/2026
What if any dataset, any size, any number of dimensions, opened in a browser tab from a link? 🔬🧪💻 Luxar is out today: write it in Python, share it as a link, explore it in any browser. Open source. 🧵 @biohub.org Preprint: doi.org/10.5281/zen... Code: github.com/royerlab/luxar
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Biohub @biohub.org · 21/09/2026
Three webinars on the science behind ESMC interpretability, ESMFold2, and binder design are now on YouTube. Hear from the researchers who built the models, and view live demos and tutorials that you can apply to your own research. Watch the playlist: bit.ly/4h1IObl
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Biohub Webinars: ESM Protein AI Models, Structure Prediction & Design - YouTube
Explore the ESM family of protein AI models with Biohub → https://biohub.ai/ This playlist collects Biohub's technical webinars on the ESM family of open pro...
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Loïc A. Royer 💻🔬🧪 @loicaroyer.bsky.social · 14/09/2026
AI has become such a powerful tool, enabling entire areas of science and biology. I got to talk about this as part of a new PBS special on how AI and biotech are transforming medicine. Overall, the documentary is quite interesting! It's worth a watch! www.pbs.org/video/data-c...
pbs.org
Data Cure: Stories of Healing and Hope | Episode 1
A race to stop superbugs before medicine enters an era where antibiotics no longer work.
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Biohub @biohub.org · 08/09/2026
Biohub scientist Dr. Angela Oliveira Pisco worked with a team of genomics and software experts to more than double the number of cells in the Tabula Sapiens dataset, and increase the number of cell types represented, to 700.
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Biohub @biohub.org · 02/09/2026
🔬New in @cellpress.bsky.social from Biohub Investigator Bo Huang: AI-designed proteins built from scratch (dubbed "Rhobins") work in living cells and now match or even surpass fluorescent tags refined over decades of natural protein engineering. Read the paper: www.cell.com/cell/fulltex...
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Biohub @biohub.org · 01/09/2026
Organoids can mimic human organs, but we study them mostly with static, endpoint assays. A new perspective argues for instrumented tissues, which are engineered human tissue woven with electrical, chemical, mechanical, and optical sensor arrays, to move faster from disease mechanism to therapy.
Diagram of instrumented 3D tissue receiving multimodal optical, electrical, and chemical stimuli, sending data to a laptop for AI reasoning.
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Biohub @biohub.org · 28/08/2026
This is the largest dataset contributed to the Billion Cells Project to date. It is an important step toward the scale and coordination needed to build the Virtual Biology Initiative.
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Biohub @biohub.org · 26/08/2026
Tumors aren't one disease—they're patchworks of coexisting cancer cell states. Two new Nature Genetics papers show these are AI-mappable (ARACNe+VIPER) and nearly identical across patients. We found drug combos hitting multiple states at once, doubling survival in a rare brain tumor. bit.ly/45TNIkb
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Why one drug isn't enough: AI reveals cancer's secret weapon
Tumors are patchworks of distinct malignant cell states, each with its own survival strategy. With AI, Biohub scientists are discovering drug combinations that defeat them all at once.
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Biohub @biohub.org · 06/08/2026
Proteins are the machinery of life. Scientists have cataloged billions of protein sequences—but their biology is still mostly unknown. ESM Atlas is a new way in. bit.ly/4dJcF6G
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Tatta Bio @tattabio.bsky.social · 06/08/2026
SeqHub protein searches now show which regions of a predicted structure are tied to specific biological functions or evolutionary patterns, powered by @biohub.org's SAE features. 🧵
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Biohub @biohub.org · 03/08/2026
🎉 Congrats to Scott Fraser, Biohub’s President of Dynamic Imaging, on receiving the Microscopy Society of America’s Distinguished Scientist Award - Biological Sciences, in recognition of his transformative contributions in bioimaging and molecular analysis!
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Jay Shendure @jshendure.bsky.social · 31/07/2026
Preprint: biorxiv.org/content/10.6... This is the product of many years of effort, and particularly amazing summer teamwork by Qi Yu, Haedong Kim, @seidels.bsky.social @cxqiu.bsky.social and many others from Shendure Lab & SeaHub (a @alleninstitute.org @biohub.org @uwmedicine.bsky.social colab) 2/n
biorxiv.org
In vivo reconstruction of the cell lineage history of a developing mouse with DNA Typewriter, from zygote to late organogenesis
The complete cell lineage of C. elegans, mapped over four decades ago, was tractable because the animal is small, transparent, and lineage invariant. Most animals are none of these, having orders of m...
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Biohub @biohub.org · 24/07/2026
How hard was it to get the laser phase plate to work? Like “trying to hit a bullet with a bullet” hard, says Biohub scientist David Agard. Check out the latest episode of the Uncovered podcast from @cenmag.bsky.social.
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Biohub @biohub.org · 23/07/2026
Can science give you superpowers? Don’t miss Biohub Investigators @profhernandez.bsky.social and KC Huang at San Diego Comic-Con tonight! #SDCC
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Biohub @biohub.org · 16/07/2026
🚨 New preprint: We reprocessed 77k zebrafish RNA-seq datasets from across the global research community and found hidden viruses in 10% of them—including a fish virus whose proteins are 91% identical to human Influenza B—then built a generalizable pipeline. bit.ly/4vxFF72
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Biohub @biohub.org · 08/07/2026
7.5M people in the U.S. live with psoriasis. Many still struggle despite treatment. Our team combined AI + CRISPR to find overlooked biological pathways — then tested an existing asthma drug. It worked. This is frontier AI and frontier biology working together. 🧬 Learn more: bit.ly/44QSiyW
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A Genome-Wide CRISPR Screen Reveals New Psoriasis Targets
Biohub researchers combined a genome-wide CRISPR screen with AI to uncover an unexpected psoriasis drug target: the receptor for oxytocin.
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Biohub @biohub.org · 07/07/2026
Excited to be at #ICML 2026! We’ll share three papers on virtual cell modeling, single-cell data generation, and immune recognition. → Virtual Cells Need Context, Not Just Scale icml.cc/virtual/2026... → scLDM icml.cc/virtual/2026... → DecoderTCR icml.cc/virtual/2026...
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Biohub @biohub.org · 02/07/2026
🎉Congrats to the Remoscope team, 1st place winner of the Medical Device category of the Nebius AI Discovery Awards! Developed at Biohub, Remoscope is an AI-powered diagnostic platform that can rapidly image and analyze blood and other biological fluids to diagnose disease.
Three men sitting at a table hold a large prize check for $100,000 at the AI Discovery Awards 2026 event, with other attendees visible in the background.
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Biohub @biohub.org · 01/07/2026
The deadline for this funding opportunity is fast approaching: applications are due July 16!
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Biohub @biohub.org · 29/06/2026
How do you track thousands of cells in complex systems, in 3D & over time? We are launching a Kaggle challenge to push the frontier of AI-powered cell tracking, building on advances like Ultrack & the DaXi lightsheet microscope from the @loicaroyer.bsky.social lab. bit.ly/4bfdzWE
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Loïc A. Royer 💻🔬🧪 @loicaroyer.bsky.social · 29/06/2026
1/ 🧬🔬 How does one cell become an entire animal? We can now film it in 3D 🐟, but turning those movies into accurate cell tracks is brutally hard. Enter our new #Kaggle challenge: $60K prize pool, to help crack 3D+time cell tracking at scale! 🧵👇 www.kaggle.com/competitions... @biohub.org
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Biohub @biohub.org · 29/06/2026
What happens when physicists turn their tools on living systems? That's the question at the heart of the Physics of Life Symposium—and this year marks its fifth edition. Submit an abstract or register to attend by Aug. 14: bit.ly/4xJIPH7
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Biohub @biohub.org · 22/06/2026
The 2nd Chicago BioEngineering Conference (CBEC) is back — Sept. 17–18 in downtown Chicago! 🧬 Omics. Bioelectronics. AI × bio. A stellar speaker lineup. Two days of science that matters. Space is limited → register now: bit.ly/4vqlXLj
Promotional card for the 2nd Chicago BioEngineering Conference (CBEC), September 17–18, 2026, at the Sheraton Grand Chicago Riverwalk
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Biohub @biohub.org · 16/06/2026
Cryo-ET gives unparalleled views of cellular structures, but targeted sample preparation by cryo-FIB milling has been a constraint. No longer! A new workflow yields close to 100% targeting success for centrioles & other small structures. Read the preprint ⤵️ www.biorxiv.org/content/10.6...
Diagram of FIB-SEM with integrated fluorescence microscope alongside cryo lamella micrograph and 3D segmentation highlighting targeted centrioles
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C&EN (Chemical & Engineering News) @cenmag.bsky.social · 13/06/2026
Phase contrast enables structures of smaller proteins, could drive in-cell proteomics: cen.acs.org/analytical-c... #chemsky 🧪
A new, ultrabright laser powers a cryo-EM advance 15 years in the making.
by Laurel Oldach.
A computer-assisted design schematic showing how an electron beam is routed within a microscope. After going through the sample, it crosses a bright cyan beam representing the laser beam.
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Biohub @biohub.org · 12/06/2026
“The laser phase plate has the highest continuous light intensity in the solar system, outside of the inner regions of the Sun,” says physicist Holger Müller. Learn more about this landmark achievement in microscopy in @cenmag.bsky.social: cen.acs.org/analytical-c...
cen.acs.org
15 years, flawless mirrors, and the brightest laser in the world: How physicists brought phase contrast to cryo-EM
Phase contrast enables structures of smaller proteins, could drive in-cell proteomics
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Biohub @biohub.org · 12/06/2026
Check out Alex Rives on Latent Space discussing the science behind ESMFold2, ESMC, and ESM Atlas, and what a world model of protein biology actually makes possible. 🎙️ bit.ly/4vwqLy3
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Biohub @biohub.org · 12/06/2026
The laser phase plate is leveling up cryoEM so we can see biology like never before. Learn more: bit.ly/4vK9LVn
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Jase Gehring @skyjase.bsky.social · 11/06/2026
met a grad student in Holger’s lab and asked him about his research. my jaw was on the floor about halfway through and he just kept piling on to the bonkers scope and challenge. This project is so insanely cool and ambitious.
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Biohub @biohub.org · 11/06/2026
In a series of 3 papers and preprints, we’re thrilled to share with you the working laser phase plate. In collaboration with research led by Holger Müller at UC Berkeley, this is a huge innovation in imaging to make small and faint objects inside cells visible. bit.ly/4vK9LVn
Waves of laser light coming from four different directions and meeting in the middle brightly inside the cavity of the laser phase plate
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Biohub @biohub.org · 05/06/2026
Dubbed a “Swiss army knife” for biological imaging, MOSAIC’s development was led by Biohub Investigator @supgokul.bsky.social of @ucberkeleyofficial.bsky.social . Learn more about the microscope, and the “AI mind” he’s creating to make sense of all the data ⤵️
news.berkeley.edu
Hi-res microscopes give biologists petabytes of data. Scientists are creating an AI assistant to make sense of it. - Berkeley News
At UC Berkeley, high-resolution microscopes are generating images of cells and embryos day and night, collecting massive amounts of data to train an AI model for living biological systems.
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Biohub @biohub.org · 04/06/2026
Better vitrification = better cryo-ET. We've opened an RFA for two-year grants to advance vitrification techniques for biological samples—welcoming applications from researchers in heat transfer, cryogenics, and materials science. Apply here: bit.ly/4uip6eJ
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Manu Leonetti @manu-leo.bsky.social · 03/06/2026
📣 new preprint multimodal atlas. Imaging + scRNA, 57M cells. 🧬🔬 Cells are complex dynamical systems — but most ways we measure them destroy them. We asked: how does live imaging compare to scRNA-seq, the field’s gold std? The answer surprised us 🧵 www.biorxiv.org/content/10.6...
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Biohub @biohub.org · 27/05/2026
👀🔥 @nature.com on why releasing ESMFold2, ESMC, and ESM Atlas openly changes what's possible for the research community
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Nature @nature.com · 27/05/2026
A newly released AI tool has generated an atlas of more than one billion predicted protein structures and billions more protein sequences. go.nature.com/4wS3Pen
go.nature.com
Move over, AlphaFold: open source model predicts shape of 1 billion proteins
The new open-source atlas, generated by an AI tool called ESMFold2, vastly increases the known protein universe.
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Biohub @biohub.org · 27/05/2026
Proteins are the machinery of life. Billions of their sequences have been cataloged—but the biology behind most is still unknown. Today we're releasing ESMFold2, ESMC and ESM Atlas to help change that. Open source, open to every scientist. biohub.ai/esm/protein
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Biohub @biohub.org · 19/05/2026
Inflammation drives nearly every major disease—cancer, heart disease, and autoimmune conditions. Yet we've never been able to watch it progress in living tissue. We're funding 15 projects to build real-time molecular tools to change that. Learn more ➡️ bit.ly/4wFDJej
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Biohub @biohub.org · 13/05/2026
New in @natbiotech.nature.com from Aly Khan: a platform combining yeast display with fine-tuned protein language models to identify antigens driving autoimmune disease. In collaboration with Chris Garcia at @stanfordpress.bsky.social / @hhmi-science.bsky.social 🧵
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Waggoner Lab @labwaggoner.bsky.social · 13/05/2026
Datasets of recognition profiles for individual TCRs vs millions of peptides offers a scalable approach to mapping TCR recognition, accelerating antigen discovery and guiding TCR engineering @stanforduniversity.bsky.social @biohub.org #Garcia @natbiotech.nature.com www.nature.com/articles/s41...
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Human Cell Atlas @humancellatlas.org · 29/04/2026
Great to see Biohub's investment in the future of AI and cell biology with its 5-year Virtual Biology Initiative programme. Beautiful alignment with the roadmap for HCA 2.0, and lots of excitement about future synergies.
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Arc Institute @arcinstitute.org · 29/04/2026
By scaling high-quality foundational datasets to train virtual cell models, we can directly accelerate progress against complex diseases. We look forward to working with Biohub and other partner organizations on this effort.
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Open Source for Science Fund @os4science.org · 04/05/2026
Today we're launching the Open Source for Science Fund, a new multi-donor philanthropic fund by Renaissance Philanthropy, seeded by @biohub.org and @wellcometrust.bsky.social, with support from @kavlifoundation.org and @researchsoftware.bsky.social 🧵 os4science.org/news/open-so...
os4science.org
Open Source for Science Fund Launches to Power AI-Driven Discovery
A new multi-donor fund by Renaissance Philanthropy seeded by Biohub and Wellcome opens its first call for proposals.
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Biohub @biohub.org · 29/04/2026
Today we're announcing the Virtual Biology Initiative—a major new commitment to build the data foundation biology needs to power the next generation of AI models. Next-gen imaging. Molecular engineering tools. Open data infrastructure for the entire scientific community. Read more: bit.ly/3ONTkHO
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Biohub launches the Virtual Biology Initiative
A $500M commitment to galvanize a global, open-data effort to build predictive models of the human cell.
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Biohub @biohub.org · 24/04/2026
On the cover of @cp-cellbiomat.bsky.social! New study by Kangfu Chen, Danile Wang, Shana Kelly uses omics/engineering tools to better understand how tissues and cells behave in vivo, advancing both fundamental biology and better treatment options for cancer.
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Biohub @biohub.org · 23/04/2026
We're hosting the NY Symposium on Immune Cell Engineering and Reprogramming this July—bringing together researchers across immunology, synthetic biology, bioengineering, and AI to explore the next phase of programming immune systems. 📅 July 22–23. In-person + virtual registration: bit.ly/4ttMyGh
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Immune Cell Engineering and Reprogramming Symposium
Biohub convenes scientists across immunology, synthetic biology, and AI to explore the next phase of immune cell engineering. Register now.
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Utz Ermel @uermel.bsky.social · 20/04/2026
Excited to share our paper about copick, a dataset API and toolkit for collaborative annotation and analysis of #cryoET data! Whether you're picking particles or curating segmentations, copick reduces friction and brings #OME-Zarr to cryoET without breaking pipelines. 🧵👇 doi.org/10.1002/pro.70578
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SciLifeLab @scilifelab.se · 21/04/2026
How can modeling and #AI help build predictive, cell-scale theoretical frameworks? CB@S – a one-day symposium on AI-driven modeling & the future of #CellBiology. 📍 Stockholm, Sweden. 📅 June 3, 2026 🤝 Co-hosted by SciLifeLab and @biohub.org Info & registration ↓ www.scilifelab.se/event/cell-b...
Julia Fernandez Rodriguez, Platform Scientific Director, and Rafael Camacho, Head of Unit, at the SciLifeLab Integrated Microscopy Technologies unit in Gothenburg. The two scientists are in a dark room with several screens showing microscopy images. Rafael points to one of the screens, at which both are looking.
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Brandy A Freitas @brandy-syglass.bsky.social · 09/04/2026
#UMAP in VR for #3DThursday! In this zebrafish embryogenesis dataset, RNA-seq + ATAC-seq across 94k+ cells reveal changing regulatory programs over time. 🥼 Yang-Joon Kim, Loic Royer @loicaroyer.bsky.social , Matthias Haury 📝 www.biorxiv.org/content/10.1... 🏛️ Biohub @biohub.org 🎬 #syGlass v2.6.0
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Biohub @biohub.org · 06/04/2026
The 2nd Chicago BioEngineering Conference (CBEC) is coming! We have a stellar lineup of speakers and sessions on omics, bioelectronics & AI × bio. See you in downtown Chicago Sept. 17-18! Space is limited — register early. Learn more ➡️ biohub.org/event/chicag...
card with event title, dates, location (Sheraton Grand Chicago Riverwalk)
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