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Pau Guillamat

@pauguillamat.bsky.social
372 followers 308 following 22 posts

Active Nematics & Synthetic Morphogenesis @ub.edu Former @rouxlab.bsky.social @xaviertrepat.bsky.social

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Reposted by Pau Guillamat
Valeria Venturini @valeriaventurini.bsky.social · 22/09/2026
In @pcusachs.bsky.social’s lab at @ibecbarcelona.eu we have a fully founded open PhD position! It’s a very nice working environment & can promise cool mechanobiology🔬🧫 Here all the info ibecbarcelona.eu/predoctoral-...
ibecbarcelona.eu
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jared toettcher @toettch.bsky.social · 24/07/2026
OK, but how does this compare to a traveling wave of light, where cells have to respond to a macroscopic cue traveling across the tissue? Amazingly, we get migration in this case too but with some key differences.
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jared toettcher @toettch.bsky.social · 24/07/2026
New Toettchlab paper alert! Harrison Oatman just published his beautiful work combining software design for "smart" microscopy+optogenetics and some really beautiful work understanding EGFR-driven collective cell migration. www.cell.com/cell-systems...
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IBEC | Institute for Bioengineering of Catalonia @ibecbarcelona.eu · 23/04/2026
Per Sant Jordi, us deixem una rosa feta de ciència 🌹🔬 Controlant la posició dels defectes topològics en nemàtics cel·lulars, s'han programat camps de forces 2D frustrats que es relaxen en formes 3D predictibles.
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Xavier Trepat @xaviertrepat.bsky.social · 17/04/2026
Our latest work on shape-programmable tissues is out in @science.org. By positioning topological defects in cellular nematics, we encode frustrated 2D force fields that relax into predictable 3D shapes. Collaboration with Marino Arroyo’s lab, led by @pauguillamat.bsky.social at @ibecbarcelona.eu.
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Pau Guillamat @pauguillamat.bsky.social · 16/04/2026
Just published in @science.org 🚀 By controlling how cells align, we show that living nematic tissues can be programmed to generate forces and fold into predictable 3D shapes. A new platform for tissue engineering and the design of smart active materials! 🫆 www.science.org/doi/10.1126/...
science.org
Science | AAAS
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Raimon Sunyer @raimonsunyer.bsky.social · 27/03/2026
Since #durotaxis was described >25 years ago, most studies report cells migrating from soft → stiff New work from my team at @ub.edu (in collaboration with D. Odde's lab) suggests we may have been missing the point all along... 🔥 Check out our new preprint here 👇 www.biorxiv.org/content/10.6...
biorxiv.org
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Pau Guillamat @pauguillamat.bsky.social · 13/03/2026
From active chaos to crystallinity! We show that chaotic active turbulence in active nematics can self-organize into a spatiotemporal crystal: a lattice of density, orientation, and vorticity that breaks both spatial and temporal symmetry. arxiv.org/abs/2603.12079 #ActiveMatter
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epithelial mechanics fan club @epimechfc.bsky.social · 21/02/2026
How do epithelial cells organize uniform polar orientation during long-range collective migration? I'm @emmalaang.bsky.social , and my research focus on collective cell behaviors. In this thread, I will take you through the concept of topology-guided polar ordering of collective cell migration
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Alejandro Torres-Sánchez @torres-sanchez.bsky.social · 12/02/2026
Development builds... But it also breaks! Planarians split to reproduce. Hydra tears open a mouth. Embryos fracture to make cavities. Failure? No. Fracture is essential to development. Our new review on fracture physics and its uses in development: journals.biologists.com/dev/article/...
journals.biologists.com
Break to build: fracture as a unifying morphogenetic strategy
Summary: This Review presents mechanical fracture as a unifying morphogenetic strategy and describes how developmental systems actively exploit mechanical fracture to drive morphogenesis, reproduction...
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Brugues Lab @brugueslab.bsky.social · 28/01/2026
Really excited to share our new paper in @nature.com! We uncovered how a physical instability of the cytoplasm coupled with the cell cycle drives cytoplasmic partitioning in early embryos #zebrafish #drosophila. Read more in this🧵 www.nature.com/articles/s41... 🤩 @poldresden.bsky.social @mpi-cbg.de
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Manuel Thery @manuelthery.bsky.social · 05/12/2025
#LivingArchitectures We put cells and cytoskeleton filaments on the architecture of the musée d'Orsay. www.musee-orsay.fr/fr/agenda/ev... Scientists of the #CytoMorphoLab adapted their protocols to illustrate the questions that keep them awake at night. -> Two shows on the 24th and 25th of January.
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Stig Ove Bøe @stigoveboe.bsky.social · 29/12/2025
Our review article is now available in Annual Review of Condensed Matter Physics: “Full-Integer Topological Defects in Polar Active Matter.” @luizaangheluta.bsky.social @emmalaang.bsky.social doi.org/10.1146/annu...
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Juanma García-Arcos @juanmagararc.bsky.social · 27/11/2025
New paper from the @rouxlab.bsky.social on Nature Communications! We study how membrane tension is spatially organized in cells. Using the mechanosensitive probe Flipper-TR to visualize tension across the plasma membrane of adherent cells and to dissect the conditions needed for a gradient to happen
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IN²UB @in2ub.bsky.social · 24/11/2025
#ResearchIN2UB | Highlighted from #MaterialIN2UB Development of self-powered microfluidic systems for Lab-on-a-chip devices published at @pnas.org led by Prof. @jignes.bsky.social #RecercaUB #QuimicaUB #ActiveMatter #Microfluidics #SoftMatter #labonachip www.ub.edu/in2ub/develo...
ub.edu
Development of self-powered microfluidic systems for Lab-on-a-chip devices - IN²UB
Lab-on-a-chip systems enable the simultaneous analysis of multiple chemical samples and the execution of intricate in situ microfabrication within a single integrated platform, where fluids are driven...
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Benoit Ladoux @bladoux.bsky.social · 11/11/2025
Just out! Our work on active transport in epithelial tissues. Congrats to Huiqiong Wu, Greg Arkowitz and Ranjith Chilupuri in collaboration with C. Duclut and J. Prost! PNAS www.pnas.org/doi/10.1073/...
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Pau Guillamat @pauguillamat.bsky.social · 12/11/2025
Microfluidic pumping with active nematics! Self-organized and self-sustained. No external pumps. @pnas.org @ub.edu www.pnas.org/doi/10.1073/... #ActiveMatter #Microfluidics #SoftMatter
pnas.org
Active nematic pumps | PNAS
Microfluidics involves the manipulation of flows at the microscale, typically requiring external power sources to generate pressure gradients. Alte...
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Prakash Lab at Stanford @prakashlab.bsky.social · 24/10/2025
“Cellular Olympics” our catalog of freeky ultra fast cellular superhero’s is freely available “Ann Rev of microbiology” www.annualreviews.org/content/jour... This is a compilation of world’s fastest single cell organisms - enjoy this buffet of rare delightful protists with mind bending speeds. 🧪
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Max-Planck-Gesellschaft @maxplanck.de · 19/09/2025
Truly chuffed for our fearless food physicists @mpipks.bsky.social + collabs from AT @istaresearch.bsky.social, IT & ES who won this year’s Ig Nobel - the #NobelPrize of hearts❤️for cracking the science of perfect pasta !🍝Kudos to all for intrepidly consuming lots of cheese in the name of science!😋
the-scientist.com
The Secret to a Smooth Pasta Sauce Wins Ig Nobel Prize
Italian researchers studied how the ingredients of the traditional Roman dish cacio e pepe emulsify into a creamy sauce, winning the 2025 Physics Ig Nobel Prize.
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Raphaël Clément @raphclement.bsky.social · 27/08/2025
Mechanosensation and fast reorientation of ciliary structures: Marvin's work on the surprising locomotion capabilities of Trichoplax, an animal without neurons! www.biorxiv.org/content/10.1...
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Julia Eckert @juliaeckert.bsky.social · 15/08/2025
Now published in @natcomms.nature.com! 🥳 👉 rdcu.be/eATn3 We developed image analysis tools to capture the nematic orientation field of 3D tissue surfaces. Tested on epithelial aggregates, zebrafish hearts, myoblasts on spheres & micro-vessels, we combined soft matter physics with exp. biology.
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Anaïs Bailles @anaisbailles.bsky.social · 06/08/2025
Very happy that the first article from my postdoc work in the Tomancak lab is now published @PNAS! www.pnas.org/doi/10.1073/.... We studied the self-organization of actin in aggregates made from Hydra cells. Thread below (1/9)
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Ricard Alert Zenón @ricardalert.bsky.social · 02/08/2025
Dreaming of a swimming pool? Bacteria are surrounded by water! Water capillary forces organize bacterial colonies into gas, nematic streams, or droplet states. New paper @natphys.nature.com led by Matt Black and Chenyi Fei, with Ned Wingreen and Josh Shaevitz! www.nature.com/articles/s41...
nature.com
Capillary interactions drive the self-organization of bacterial colonies - Nature Physics
Bacteria tend to live in thin layers of water on surfaces. Now the capillary forces in these layers are shown to help organize the bacteria into dense packs.
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IBEC | Institute for Bioengineering of Catalonia @ibecbarcelona.eu · 26/07/2025
🔬#IBEC researchers create the world’s simplest artificial cell that can navigate using chemistry with just a membrane, an enzyme and a pore. A breakthrough on how life moves🧬 🧪 @science.org #ScienceAdvances 🤝 @ub.edu @liverpooluni.bsky.social 👉 Read the news: f.mtr.cool/tzjomevovt
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Claire Dessalles @clairedessalles.bsky.social · 17/07/2025
Our study on endothelial mechanics made the news! 🤩 Super nice and clear article on our findings and their implications. www.snexplores.org/article/how-...
snexplores.org
Here’s why your blood vessels don’t burst under pressure
Cells lining the blood vessels reorganize their inner structures to handle stressful boosts in pressure.
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Marija Matejčić (mateytch-itch) @marija-matejcic.bsky.social · 04/07/2025
On cell extrusion in the #intestine! After 80 years of observations, we finally took a deeper look thanks to 2D #organoids. We report: 3D #forces, #extrusion still only in the villus even without curvature, #lamellipodia generate 3D force.. and more. Have a look! www.biorxiv.org/content/10.1...
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Xavier Trepat @xaviertrepat.bsky.social · 03/07/2025
🚨 Second preprint of the week! We uncover the multiscale dynamics of active viscoelastic buckling in epithelia. We harness these mechanical instabilities for synthetic morphogenesis. Led by @onenimesa.bsky.social 🙌. Theory by Marino Arroyo etal. @ibecbarcelona.eu www.biorxiv.org/content/10.1...
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Xavier Trepat @xaviertrepat.bsky.social · 30/06/2025
How to turn a layer of fibroblasts into a tulip 🌷? Check out our new pre-print on shape-programmable living surfaces. Led by @pauguillamat.bsky.social‬ www.biorxiv.org/content/10.1...
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Pau Guillamat @pauguillamat.bsky.social · 30/06/2025
New preprint out! We show how cellular nematic order can be harnessed to program tissue-wide force fields and guide 3D shape transformations. The tissue morphogenesis logic, now engineered into living, programmable materials. www.biorxiv.org/content/10.1... #ActiveMatter #TissueEngineering
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Shashank Shekhar lab @sshekhr.bsky.social · 02/04/2025
📢Excited to share our new paper in Nature Physics @naturephysics.bsky.social: Cooperative hydrodynamics accompany multicellular-like colonial organization in the unicellular Stentor! How do single-celled organisms benefit from teamwork? Let’s dive in! #Multicellularity nature.com/articles/s41...?
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Erwin Frey @physicsoflifelmu.bsky.social · 31/03/2025
We may not have really squared the circle — but we came close! 😉 In our @NaturePhysics paper w/ @fakhrilab.bsky.social, light-triggered membrane excitability enables programmable shapes — a step toward engineering living matter. 🔗 www.nature.com/articles/s41... #biophysics #syntheticcell #softmatter
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Journal of Cell Science @jcellsci.bsky.social · 28/03/2025
In their Review, Laura Faure, Valeria Venturini @valeriaventurini.bsky.social and Pere Roca-Cusachs discuss the biological contexts of cell mechanical compression, the associated mechanisms and the experimental systems engineered to compress cells in vitro. journals.biologists.com/jcs/article/...
Cartoon of techniques to apply one-dimensional, in-plane or volumetric cell compression in vitro.
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James Briscoe @jamesbriscoe.bsky.social · 25/03/2025
Peer review completed within 7 days! Paying peer reviewers! Yes, it's possible. Fast & Fair peer review by @biologyopen.bsky.social More innovation from @biologists.bsky.social Details here: www.biorxiv.org/content/10.1...
biorxiv.org
Fast & Fair peer review: a pilot study demonstrating feasibility of rapid, high-quality peer review in a biology journal
Traditional peer review is slow, often delayed by the time-consuming process of identifying reviewers and lengthy review turnaround times. This study tests the feasibility of the Fast & Fair peer revi...
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epithelial mechanics fan club @epimechfc.bsky.social · 01/03/2025
What do star fish, snowflakes, and even cells have in common? I am @juliaeckert.bsky.social and I would like to take you on a journey into the field of soft matter and give you a brief overview of experimental observations on symmetries in biological systems. #EpithelialMechanics
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Dagmar Iber & CoBi @iberd.bsky.social · 20/02/2025
What a beautiful cover for our #mechanobiology paper "Morphometry and mechanical instability at the onset of epithelial bladder cancer": doi.org/10.1038/s415... - thx @naturephysics.bsky.social !! News & Views "Tissue wrinkles foreshadow cancer" doi.org/10.1038/s415...
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epithelial mechanics fan club @epimechfc.bsky.social · 31/01/2025
Shim, G., Breinyn, I. B., Martínez-Calvo, A., Rao, S., & Cohen, D. J. (2024). Bioelectric stimulation controls tissue shape and size. Nature communications, 15(1), 2938. #EpithelialMechanics www.nature.com/articles/s41467-024-…
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Julia Eckert @juliaeckert.bsky.social · 29/01/2025
Thrilled to share our new preprint on detecting the nematic orientation field on surfaces of 3D multicellular systems! www.biorxiv.org/content/10.1... Huge thanks to all authors: @tobyandrews.bsky.social,Joe Pollard, @rashmi-priya.bsky.social, @yap-lab.bsky.social &Richard Morris Any 3D systems?👇
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Roux Lab, Geneva @rouxlab.bsky.social · 20/01/2025
Yamini @yamini-ravichan.bsky.social changed the topology of Hydra to show that actin orientational defects of Hydra induce the full program of head regeneration: www.science.org/doi/10.1126/... Mechanics controls development! Thanks to Dan Pearce, Karsten Kruse, Matthias Vogg & Brigitte Galliot.
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Xavier Trepat @xaviertrepat.bsky.social · 03/12/2024
🎈New preprint! We study how single cells move up, down and about fibronectin gradients. Experiments by @icfortunato.bsky.social, theory by David Bruckner. Collaboration with @raimonsunyer.bsky.social and @ehannezo.bsky.social 👇https://biorxiv.org/cgi/content/short/2024.12.02.626413v1
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Mike Norton @hapaxtaxon.bsky.social · 27/11/2024
abhorring an empty account, check out the recent work Piyush Grover and I published in PRE on bioinspired defect sensing in an active nematic. A big thanks to the community for all the discussions that inspired this work: journals.aps.org/pre/abstract... supported by DOE grant DE-SC0022280
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Manuel Thery @manuelthery.bsky.social · 27/11/2024
Mix two motors of opposite polarity with microtubules and they will partition space ! Microtubules will get organized in polar and active barriers, sorting the two motors in separated domains, leading to the emergence of a new type of patterns. #morphogenesis doi.org/10.1073/pnas... (1/n)
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epithelial mechanics fan club @epimechfc.bsky.social · 17/11/2024
Cells are strong & generate forces while interacting with their environment. Traction Force Microscopy has been instrumental in measuring these forces, revealing the underlying mechanics. Let's explore pioneering papers in this 🧵by @onenimesa.bsky.social & @juliaeckert.bsky.social
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Benoit Ladoux @bladoux.bsky.social · 24/11/2024
I am delighted to share our new preprint in which we reveal the crucial role for mechanical forces in myoblast fusion. Great work from Yoann, Sushil and Aleksandra and great collaboration with Christophe Marcelle and Amin Doostmohammadi! www.biorxiv.org/content/10.1...
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