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Xavier Trepat

@xaviertrepat.bsky.social
3.1K followers 452 following 56 posts

Scientist of Living Matter. ICREA Professor at the Institute for Bioengineering of Catalonia, Barcelona. The need to know.

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Xavier Trepat @xaviertrepat.bsky.social · 06/08/2026
When tension increases, the nucleus escapes. New paper out in @natphys.nature.com. Check out Tom's thread for a summary 👇
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epithelial mechanics fan club @epimechfc.bsky.social · 26/07/2026
How do tissues safely remove cells? Join me, @marija-matejcic.bsky.social in this perspective on the past, present and future of epithelial cell extrusion 🧵 0/16
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Xavier Trepat @xaviertrepat.bsky.social · 17/04/2026
Our latest work on shape-programmable tissues is out in @science.org. By positioning topological defects in cellular nematics, we encode frustrated 2D force fields that relax into predictable 3D shapes. Collaboration with Marino Arroyo’s lab, led by @pauguillamat.bsky.social at @ibecbarcelona.eu.
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Raimon Sunyer @raimonsunyer.bsky.social · 27/03/2026
Since #durotaxis was described >25 years ago, most studies report cells migrating from soft → stiff New work from my team at @ub.edu (in collaboration with D. Odde's lab) suggests we may have been missing the point all along... 🔥 Check out our new preprint here 👇 www.biorxiv.org/content/10.6...
biorxiv.org
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Pietro Cicuta @pcicuta.bsky.social · 14/03/2026
International Congress in Biological Physics, Genova, Italy, 28 June to 3 July 2026. URGENT: submission deadline 25 March. Session topics, plenary and invited speakers: www.icbp2026.org IUPAP Physics of Life medal awarded at meeting. Spread the word - and act quickly to submit your work.
icbp2026.org
ICBP 2026
We proudly invite experts in biological physics worldwide to the International Conference on Biological Physics 2026 (ICBP 2026) in the magnificent Italian city of Genoa from June 28 to July 5, 2026
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Xavier Trepat @xaviertrepat.bsky.social · 27/02/2026
Less than a week to submit your abstract for #EESMechanobiology. Mechanobiology across the tree of life, from HeLa cells to weird animals and plants. The submission deadline is 3 March: s.embl.org/ees26-06-bl 🗓️ 9 – 12 June 2026
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Xavier Trepat @xaviertrepat.bsky.social · 18/02/2026
Best possible lab for a PhD / postdoc! Stay tuned for future openings and wonderful science.
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Theory of Living Matter Group @tlmcambridge.bsky.social · 12/01/2026
🚨Our first talk this new year would be a joint theory/experiment talk by Prof. Marino Arroyo and Prof. Xavier Trepat @xaviertrepat.bsky.social describing some of their recent work together on active morphogenesis🧫. Sign up to our mailing list for a zoom link to this talk and other upcoming talks🚨
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Xavier Trepat @xaviertrepat.bsky.social · 15/12/2025
📢 New extended abstract submission deadline: 6 January 2026! Outstanding speaker list, plus many slots for short talks by students, postdocs, and junior PIs. Join us in March in Barcelona! events.ibecbarcelona.eu/embl-ibec-co...
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Xavier Trepat @xaviertrepat.bsky.social · 22/10/2025
📣Announcing the 4th edition of the EMBL‑IBEC Conference on “Engineering Multicellular Systems”, taking place 11–13 March 2026 in Barcelona. Exploring organoids, mechanobiology, embryo models, organ-on-chip systems, multiomics and more. Abstracts open now! events.ibecbarcelona.eu/embl-ibec-co...
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Barriga Lab @eliasbarrigalab.bsky.social · 02/10/2025
New Review! #devbiol #bioelectricity #CellBiology #tissueregeneration In our new @annualreviews.bsky.social piece, we explore how bioelectricity is generated, sensed & translated into responses that sculpt tissues, guide growth & enable tissue regeneration. www.annualreviews.org/content/jour...
annualreviews.org
Bioelectricity in Morphogenesis
Bioelectricity is likely as old as life itself. From the moment the first proto-cell was enclosed in a lipid bilayer, a membrane potential arose. Thus, one can expect that bioelectrical activities inf...
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Buzz Baum @buzzbaum.bsky.social · 02/10/2025
LMB PhD studentship available in the Baum lab to use informatics to infer cell structure from genomic data in collaboration with the brilliant Tom Williams. If you write to me and I don’t reply - try again - the spam filter is hungry…
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Xavier Trepat @xaviertrepat.bsky.social · 02/10/2025
Active wetting at work 🤩
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David Brückner @davidbrueckner.bsky.social · 27/09/2025
How do cells navigate up gradients of adhesive proteins? 🤔 Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood We show that passive friction directs cells & explains complex trajectories on gradients 👉 www.nature.com/articles/s41...
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Daniel J. Cohen (Princeton) @djcohen.bsky.social · 17/09/2025
SCHEPHERD--the bioelectric cell herding platform built for YOU. Single cells, monolayers, organoids--this herds them all + new tricks. Plz try it-- we will *give* you parts! Teaser here of a steering a single cell. GS Yubin Lin's lifeblood with J. Yodh on piano; Celeste R. and Paul K. Thread 1/N
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Benoit Ladoux @bladoux.bsky.social · 17/09/2025
Happy to share our new study @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social with C. Duclut and J. Prost. on forces generated by active fluid transport in epithelia and their role in tissue dynamics. Congrats to Huiqiong Wu, G. Arkowitz and R. Chilupuri! www.biorxiv.org/content/10.1...
biorxiv.org
Regulation of epithelial tissue homeostasis by active trans-epithelial transport
Epithelia are intricate tissues whose function is intimately linked to mechanics. While mechanobiology has primarily focused on factors such as cell-generated contractility and mechanical properties o...
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Daniel Alber @danielalber.bsky.social · 18/09/2025
A ring of cells deforms into a triangular keyhole in just 15 minutes. Meet the hindgut, a model for boundary-driven morphogenesis! Out now in @pnas.org at doi.org/10.1073/pnas... with @zhaoshh.bsky.social, Alex Jacinto, Eric Wieschaus, Stas Shvartsman, @lepuslapis.bsky.social (1/8)
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Barbara Marte @barbmarte.bsky.social · 06/09/2025
new out in Nature www.nature.com/articles/d41...
nature.com
Compression causes cancer cells to start spreading
The switch between proliferation and invasion is triggered by mechanical force.
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Xavier Trepat @xaviertrepat.bsky.social · 01/09/2025
New preprint! 🚨 We uncover a slow adaptation to stretch that links star-bundling of keratin filaments with nuclear escape from its keratin cage. Led by @tomgolde.bsky.social‬ 🙌 @IBECBarcelona www.biorxiv.org/content/10.1...
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Sylvain Gabriele @sgabriele.bsky.social · 25/08/2025
Excited to share our new publication in Nature Physics about the mechanical memory of morphology in confined migrating cells by @kyohalie.bsky.social 🥳 Super fun collab with @davidbrueckner.bsky.social and @gcharras.bsky.social 👏🏻 Enjoy the reading www.nature.com/articles/s41...
nature.com
The actin cortex acts as a mechanical memory of morphology in confined migrating cells - Nature Physics
Cells often navigate through confined spaces. Now it is shown that cells retain a mechanical memory of previous confinement events, which makes them more efficient at migrating through narrow microenv...
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Kate Miroshnikova @katemiro.bsky.social · 15/08/2025
Pathologists have used nuclear & tissue shapes to diagnose #cancer for decades, but what is the molecular basis for this? In our latest work, we develop a computational pipeline to figure this out in #colorectalcancer! Check out 🧵& preprint #mechanobiology #stemcells www.biorxiv.org/content/10.1...
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Jonas Neipel @neipel.bsky.social · 20/07/2025
(1/10) I am excited to finally share our work on avian left/right symmetry breaking with you. We reveal a tissue-scale active torque dipole generated at the Hensen’s node, thanks to crazy experiments by Julia @juliapfanzelter.bsky.social and some analysis by me. doi.org/10.1101/2025...
doi.org
An active torque dipole across tissue layers drives avian left-right symmetry breaking
Unlike in mice, frogs, and fish, left-right (L/R) body axis formation in avian embryos does not arise from the chiral beat of cilia. Instead, a counter-clockwise tissue rotation around Hensen′ node, t...
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Xavier Trepat @xaviertrepat.bsky.social · 08/07/2025
New paper from the lab led by @marija-matejcic.bsky.social ! Supracellular force patterns driving intestinal cell extrusion. 👇
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Nimesh Chahare @onenimesa.bsky.social · 03/07/2025
Have you ever thought about inflating tissues? Or maybe quickly deflating those inflated tissues? New #EpithelialMechanics pre-print: doi.org/10.1101/2025... 🧵 with pressure control, multiscale buckling, controlled wrinkling
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Xavier Trepat @xaviertrepat.bsky.social · 03/07/2025
🚨 Second preprint of the week! We uncover the multiscale dynamics of active viscoelastic buckling in epithelia. We harness these mechanical instabilities for synthetic morphogenesis. Led by @onenimesa.bsky.social 🙌. Theory by Marino Arroyo etal. @ibecbarcelona.eu www.biorxiv.org/content/10.1...
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Xavier Trepat @xaviertrepat.bsky.social · 30/06/2025
How to turn a layer of fibroblasts into a tulip 🌷? Check out our new pre-print on shape-programmable living surfaces. Led by @pauguillamat.bsky.social‬ www.biorxiv.org/content/10.1...
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epithelial mechanics fan club @epimechfc.bsky.social · 20/04/2025
1/14 “Epithelial” & “Mesenchymal” aren’t binary categories—they form a spectrum, or better yet, a multidimensional space. This becomes especially clear in collective cell migration, which often depends on a finely tuned degree of “mesenchymal-ness”. #cellbio #devbio #cellmigration
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Denis Wirtz @deniswirtz.bsky.social · 05/04/2025
Be on the lookout for a new paper from the lab: "InterpolAI: Deep learning based optical flow interpolation and restoration of biomedical images for improved 3D tissue mapping" InterpolAI interpolates and restores defective images for enhanced 3D imaging (3D histology, MRI, confocal, ssTEM)
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Benoit Ladoux @bladoux.bsky.social · 14/03/2025
Happy to share our new publication in @naturematerials.bsky.social on mechanical cell competition! Great collaboration between our CAM team, Chavrier's and Doostmohammadi's. Special congrats @luanger.bsky.social, @andreasschoenit.bsky.social, Siavash Monfared! 🎉 www.nature.com/articles/s41...
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Irene Miguel-Aliaga @irenemiguel-aliaga.bsky.social · 19/03/2025
Lab’s latest: (mouse) mums grow their guts during pregnancy and lactation: www.cell.com/cell/fulltex...
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Carmelo Ferrai @carmeloferrai.bsky.social · 19/03/2025
I am Absolutely delighted to share the preprint of our last collaborative efforts where we investigated the impact of sonostimulation of Mesenchymal Stem Cells. Thread -1- www.biorxiv.org/content/10.1...
biorxiv.org
Sonoepigenetics: Spatiotemporal Calcium Dynamics and cAMP Signaling Driven by High Frequency Nanomechanostimulation Regulates Transient Epigenetic Modifications and Early Osteogenic Commitment in Mese...
Cells effectively balance and integrate numerous pathways to adapt to external signals in an attempt to regain homeostasis, although the complex nuclear mechanotransduction mechanism through which thi...
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Hallou Lab @halloulab.bsky.social · 17/03/2025
🚨 Paper Alert 🚨 Absolutely delighted to share our last paper on "spatial mechano-transcriptomics" @naturemethods👇!! www.nature.com/articles/s41...
nature.com
A computational pipeline for spatial mechano-transcriptomics - Nature Methods
The authors present a computational framework that leverages mechanical force inference and spatial transcriptomics to enable analyses of the interplay between the transcriptomic and mechanical state.
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Xavier Trepat @xaviertrepat.bsky.social · 03/03/2025
Great one-day meeting on #cancer #mechanobiology in Paris (March 14th).
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Alice Perucca @aliperri.bsky.social · 10/02/2025
1/7: New paper alert! Excited to share our co-first author paper on Micro Immune Response On-chip (MIRO) a model that recreates the tumour-stroma interface for immunotherapy testing! @oriolmb.bsky.social and I wrote this thread to break it down for you. 👇🧵 Read more: www.nature.com/articles/s41...
nature.com
Micro Immune Response On-chip (MIRO) models the tumour-stroma interface for immunotherapy testing - Nature Communications
Modelling the tumour immune microenvironment in vitro is a valuable tool to test immunotherapy efficiency but capturing its complexity is challenging. Here authors present a fully humanised in vitro p...
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Xavier Trepat @xaviertrepat.bsky.social · 07/02/2025
New paper from the lab🎈. Introducing Micro Immune Response On-chip (MIRO), a device that replicates tumors and their microenvironment to better understand responses to immunotherapies (cyan=immune cells, red=cancer, green=CAFs). www.nature.com/articles/s41... @ibecbarcelona.eu
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epithelial mechanics fan club @epimechfc.bsky.social · 01/02/2025
How do epithelial tissues develop their diverse, beautiful shapes? Some researchers have been controlling their forces with light to understand it. I’m Guillermo Martínez Ara and today I’ll tell you about how we can use optogenetics to study morphogenesis!
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Ricard Solé @ricardsole.bsky.social · 09/01/2025
Can we construct mathematical models for psychology? Can phase transitions help understand critical changes in psycho-social systems? Check this fascinating @sfiscience.bsky.social talk by Han van der Maas, youtube.com/watch?v=eujJ...
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James Briscoe @jamesbriscoe.bsky.social · 19/12/2024
Our latest: how to generate the notochord "Timely TGFβ signalling inhibition induces notochord" A thread: www.nature.com/articles/s41...
nature.com
Timely TGFβ signalling inhibition induces notochord - Nature
Through analysis of developing chick embryos and in vitro differentiation of embryonic stem cells, a study develops a method to generate a model of the human trunk with a notochord.
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Xavier Trepat @xaviertrepat.bsky.social · 16/12/2024
Mechanics of cell extrusion unlike anything seen before in epithelia. If you are at ASCB #CellBio2024 don’t miss Marija’s talk on organoid mechanobiology.
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Xavier Trepat @xaviertrepat.bsky.social · 14/12/2024
After five decades of outstanding science and mentorship, Jeff Fredberg is retiring. Today, we gather in Boston to celebrate his career. A truly special day for all of us who had the privilege of growing under his leadership!
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CellMech2025 @cellmech2025.bsky.social · 10/12/2024
👋Hello #mechanobiology community in 🦋! This is the official account of the 10th Edition of the Cell Mech conference! 🔧We will soon announce the invited speaker list! Visit our website, subscribe to the mailing list, and follow us!: cellmech2025.org 😍Join us in Leuven 2025!
cellmech2025.org
The organizing committee, Sylvain Gabriele, Marine Luciano, Jorge Barrasa Fano, Yohalie Kalukula, Bart Smeets, Apeksha Shapeti, Hans Van Oosterwyck
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Xavier Trepat @xaviertrepat.bsky.social · 05/12/2024
A thread on our recent preprint👇👇👇
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Xavier Trepat @xaviertrepat.bsky.social · 04/12/2024
The IOP Mechanobiology meeting starts strong with @johannaivaska.bsky.social telling us that cells do not necessarily migrate towards stiff and that nuclear YAP does not necessarily correlate with cell spreading. 💪
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Xavier Trepat @xaviertrepat.bsky.social · 03/12/2024
🎈New preprint! We study how single cells move up, down and about fibronectin gradients. Experiments by @icfortunato.bsky.social, theory by David Bruckner. Collaboration with @raimonsunyer.bsky.social and @ehannezo.bsky.social 👇https://biorxiv.org/cgi/content/short/2024.12.02.626413v1
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epithelial mechanics fan club @epimechfc.bsky.social · 01/12/2024
Let’s understand collective cell migration by breaking it down to its essential elements! I'm Leone Rossetti, and this is a thread showcasing what we can learn from cells journeying along narrow paths, and from the forces they generate. 1/ #EpithelialMechanics
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Manuel Thery @manuelthery.bsky.social · 27/11/2024
Mix two motors of opposite polarity with microtubules and they will partition space ! Microtubules will get organized in polar and active barriers, sorting the two motors in separated domains, leading to the emergence of a new type of patterns. #morphogenesis doi.org/10.1073/pnas... (1/n)
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Xavier Trepat @xaviertrepat.bsky.social · 25/11/2024
Next week in London: Mechanobiology Shaping Life. The deadline for registration is tomorrow, 26/11. iop.eventsair.com/msl2025/
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Benoit Ladoux @bladoux.bsky.social · 24/11/2024
I am delighted to share our new preprint in which we reveal the crucial role for mechanical forces in myoblast fusion. Great work from Yoann, Sushil and Aleksandra and great collaboration with Christophe Marcelle and Amin Doostmohammadi! www.biorxiv.org/content/10.1...
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Xavier Trepat @xaviertrepat.bsky.social · 22/11/2024
And they should all be equipped with a blackboard like those at the Erwin Schrödinger Institute in Vienna (couldn’t help taking a picture 😅). #BringYourOwnChalk
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Xavier Trepat @xaviertrepat.bsky.social · 20/11/2024
Pre-announcing the EMBO/EMBL symposium "Mechanobiology Across the Tree of Life", Heidelberg, 9-12 June 2026. It is still very very far away, but save the date 🗓️. With Alba Diz-Munoz, @nicolettapetridou.bsky.social , Kirsty Wan @micromotility.bsky.social, Enrique Rojas. www.embl.org/about/info/c...
embl.org
Mechanobiology across the tree of life
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