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TRIDENT Preclinical Trials

@tridentpct.bsky.social
1.4K followers 9.9K following 421 posts

Multi-site, transformative preclinical evaluation of novel neurotherapeutics through a Government of Canada $24M New Frontiers In Research grant. Check out our website tridentpreclinicaltrials.org for more info or email info@tridentpreclinicaltrial.org!

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TRIDENT Preclinical Trials @tridentpct.bsky.social · 25/09/2026
Happy Fluorescence Friday! NF-H staining highlights axons imaged with light-sheet microscopy in a cleared mouse brain. 🧠🐁 Great work by @mind-western.bsky.social ! 🔬 #FluorescenceFriday #LightSheetMicroscopy #Neuroscience
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 25/09/2026
New from the #TRIDENT team: Amr Eed et al. linked cellular-resolution whole-CNS light-sheet imaging with mesoscopic awake-mouse MRI in the same animals. More pS129 α-synuclein meant more atrophy, weaker connectivity, and sensorimotor hypoactivation, pointing to a toxic role in PD and DLB.🧠 #NFRF
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 21/09/2026
On World Alzheimer’s Day, we recognize those living with Alzheimer’s disease, along with their families and caregivers. At TRIDENT, we are advancing preclinical research to help move promising discoveries closer to new treatments. #WorldAlzheimersDay #TRIDENT #NFRF
A purple Alzheimer’s awareness ribbon wraps around a light purple globe, with the text “World Alzheimer’s Day, September 21” displayed in the centre.
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Reposted by TRIDENT Preclinical Trials
TRIDENT Preclinical Trials @tridentpct.bsky.social · 23/07/2026
🎥 Faculty Spotlight: Dr. Taylor Schmitz Dr. Taylor Schmitz, TRIDENT's Mouse Core Lead, discusses his current research, reflects on his journey as a researcher, and shares advice for aspiring research trainees. #NFRF #TRIDENT #FacultySpotlight #Neuroscience #Research #WesternU youtu.be/BLhvgMAcXts
youtu.be
Dr. Taylor Schmitz Faculty Spotlight
YouTube video by TRIDENT Preclinical Trials
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 09/09/2026
📣 TRIDENT’s Synaptozone e-newsletter is here! Catch up on the latest news, research updates, collaborations, events, and highlights from across the #TRIDENT community. #NFRF #kmb #neuroscience Check out the latest edition, linked here: createsend.com/t/y-CE4A3DF2...
Graphic announcing the release of TRIDENT’s Synaptozone e-newsletter, featuring the TRIDENT logo, a vintage camera, and the text “Catch up on what’s new across TRIDENT” and “Read the latest issue.”
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 04/09/2026
Happy #FluorescenceFriday! 🔬 Great to see TRIDENT collaborations in action! #TRIDENT #ParkinsonsResearch #Neurotherapeutics #Organoids
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 02/09/2026
September is World Alzheimer’s Month. At TRIDENT, we’re advancing neurotherapeutic research to help accelerate new treatment possibilities for Alzheimer’s disease and other neurodegenerative disorders. #WorldAlzheimersMonth #AlzheimersResearch #TRIDENT #NFRF
White graphic featuring a purple awareness ribbon and the words “World Alzheimer’s Month” in purple text.
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 25/08/2026
🎉 Congratulations to our TRIDENT Co-Principal Investigators @tedfon.bsky.social , @richardgold.bsky.social & @jonathankimmelman.bsky.social on being elected Fellows of the Canadian Academy of Health Sciences (CAHS) for 2026! A well-deserved recognition! 👏 #TRIDENT #CAHS #Neuroscience
cahs-acss.ca
Fifty-Nine New Fellows Elected to the Canadian Academy of Health Sciences | Cinquante-neuf nouveaux membres élus à l’Académie canadienne des sciences de la santé – Canadian Academy of Health Sciences ...
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 21/08/2026
These dancing neurons are lighting up our #FluorescenceFriday! 🧠✨ A closer look at how mapping neurons can help researchers better understand how neurons survive and what influences their fate in disease. Great work by @mind-western.bsky.social! 🔬
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 15/08/2026
Amazing view of microglia across the brain! 🧠🔬 So cool to see these essential immune cells in action. #FluorescenceFriday
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 07/08/2026
Amazing look at cholinergic neurons and nerve terminals in the mouse brain using light-sheet imaging 🔬🧠 Great work from the @mind-western.bsky.social team! #FluorescenceFriday
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 05/08/2026
Introducing the TRIDENT Data Hub! A centralized gateway to TRIDENT research datasets, metadata, and related resources, developed by the #TRIDENT Data Management & Sharing Team at the @douglasresearch.bsky.social CoBrA Lab. #NFRF #OpenScience TRIDENT Data Hub: data.tridentpreclinicaltrials.org
TRIDENT Data Hub announcement graphic featuring a digital database icon and TRIDENT branding.
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 31/07/2026
Happy #FluorescenceFriday! Amazing work by the @mind-western.bsky.social. This striking visualization highlights GFP (yellow) and SynP129 (magenta), providing a glimpse of aggregated alpha-synuclein in a Slick-H Cre STIP1 mouse model. 🧠 🔬
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 24/07/2026
#FluorescenceFriday A glimpse into the microscopic world of blood vessels and plaques, courtesy of the @mind-western.bsky.social
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 23/07/2026
🎥 Faculty Spotlight: Dr. Taylor Schmitz Dr. Taylor Schmitz, TRIDENT's Mouse Core Lead, discusses his current research, reflects on his journey as a researcher, and shares advice for aspiring research trainees. #NFRF #TRIDENT #FacultySpotlight #Neuroscience #Research #WesternU youtu.be/BLhvgMAcXts
youtu.be
Dr. Taylor Schmitz Faculty Spotlight
YouTube video by TRIDENT Preclinical Trials
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 17/07/2026
🎉 Congratulations to our #TRIDENT imaging partner, @cfmm.bsky.social, on this investment from @braincanada.bsky.social and @westernu.ca. This expanded national MRI platform will strengthen access to world-leading neuroimaging infrastructure, accelerating collaboration and discovery across Canada. 👏🤩
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 17/07/2026
🚀 HQP Spotlight: David Roper, RA, #TRIDENT Data Management & Sharing Core, CoBrA Lab, @douglasresearch.bsky.social. David helps advance our collaboration and open science aims by supporting accessible, reproducible research data across TRIDENT. #NFRF🎥 Learn more: www.youtube.com/watch?v=L1x7...
youtube.com
HQP Spotlight: David Roper, RA, TRIDENT Data Management and Sharing Core, Douglas Research Centre
YouTube video by TRIDENT Preclinical Trials
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 15/07/2026
🔦 Spotlight on the #TRIDENT Data Mgmt & Sharing Core, CoBrA Lab at the @douglasresearch.bsky.social. Led by Dr. Mallar Chakravarty, the team combines computational neuroscience with animal and human studies to advance preclinical neurotherapeutics and open science. 🔗Learn more: www.cobralab.ca!
cobralab.ca
Accueil | CoBrALab
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 14/07/2026
Happy to see our partnering research institution @camhnews.bsky.social, lead Sex-Based Analysis+ researcher @liisagalea.bsky.social and expert team at #AAIC2026! Check out their talks below. 👇😍🐁🧠https://aaic.alz.org/program/schedule.asp
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 10/07/2026
🔬Great science doesn't happen in isolation.🧠🌎We are proud to see #TRIDENT leader Ravi Menon featured in @westernu.ca's #theimpactproject, speaking to the power of technology + team collaboration, also key elements of TRIDENT!👏 @northernthrux.bsky.social www.theimpactproject.ca/stories/ravi...?
theimpactproject.ca
How technology and teamwork power medical breakthroughs | The Impact Project
Join us as we uncover what it takes to make positive change in our world – featuring Ravi Menon, Neurophysicist, Professor, Schulich School of Medicine & Dentistry, Western University.
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 08/07/2026
One of the best parts of research is the people. Great to connect with our incredible colleagues yesterday at the @schulichmeddent.bsky.social Staff and Faculty Summer BBQ. Here's to continuing to build partnerships, support each other, + advance neuroscience together! 💜🧠 @cfmm.bsky.social #TRIDENT
Three smiling people stand together in front of a purple Western University Schulich School of Medicine & Dentistry backdrop. The person on the left wears a teal sleeveless dress, the person in the centre wears a black floral dress with a light beige cardigan, and the person on the right wears a burgundy short-sleeved dress. They have their arms around one another, smiling at the camera during a university event.
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 07/07/2026
🧠 Heading to #ISSCR2026? Be sure to catch #TRIDENT's valued collaborators Dr. Tom Durcan and Anna Franco Flores presenting a poster Wednesday, July 8 from 5:15–6:30 PM, entitled "From PDFs to Videos: Making iPSC Workflows Accessible Through Outreach." Great work folks! 🔬👇🤩 www.isscr2026.org
isscr2026.org
ISSCR 2026
An international gathering of the brightest minds in stem cell research and regenerative medicine across disciplines. Join us for the 2026 ISSCR Annual Meeting 8-11 July 2026 in Montréal, Canada.
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 01/07/2026
🍁 Happy Canada Day! 🇨🇦 Today we celebrate our incredible pan-Canadian team who make #TRIDENT possible. Proudly supported by the Government of Canada's New Frontiers in Research Fund, we're building a stronger future through worldclass research impact and innovation. #NFRF youtu.be/dfi8Fu29BQI?...
youtu.be
TRIDENT: Strengthening Canada's Path to Brain Health Innovation
YouTube video by TRIDENT Preclinical Trials
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 29/06/2026
👀 ICYMI Monday: Meet Kruti Joshi from our Imaging Team, one of the many talented HQP helping drive innovation across our collaborative research ecosystem at #TRIDENT. 🤝🔬🤩 🎥 #NFRF #Collaboration #HQP #Neuroscience
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 26/06/2026
Turning noisy data into clearer discoveries. This #FluorescenceFriday post shows how the @mind-western.bsky.social Platform is developing open science tools to remove imaging artifacts from light-sheet microscopy, helping researchers generate cleaner, more reliable 3D brain images. Great job team!🧠
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 26/06/2026
We're thrilled to share this video capsule produced in collaboration with @theneuro.bsky.social EDDU, showcasing #TRIDENT's overarching vision and goals, and highlights the key role the EDDU has played in bringing that vision to life. #neuroscience #collaboration #KMb #NFRF 📽️🧠🔬 youtu.be/3wKA2JhdXtg
youtu.be
TRIDENT x EDDU
YouTube video by TRIDENT Preclinical Trials
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 23/06/2026
🧠🔬 Shoutout to TRIDENT Imaging Team member Kruti Joshi, who presented a poster at the 2026 Robarts Research Retreat today! Proud to see our incredible students sharing discoveries and building new scientific connections. 👏 #TRIDENT #HQP #Neuroscience #fMRI #NFRF @schulichmeddent.bsky.social
Kruti Joshi, a trainee with the TRIDENT Imaging Team, stands smiling in front of her research poster at the 2026 Robarts Research Retreat. The poster presents findings from a study examining cognitive differences observed during awake and anesthetized mouse fMRI imaging and includes brain scans, figures, and data visualizations. The photo was taken in a conference poster session area, highlighting trainee-led neuroscience research and knowledge sharing.
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 22/06/2026
Congrats to @cfmm.bsky.social on 30 years of imaging discovery and innovation! 🎉🧠 #TRIDENT is proud to partner with this world-leading, made-in-Canada facility and thrilled to see CFMM receive its 3rd consecutive Platform Support Grant from @braincanada.bsky.social. news.westernu.ca/2026/06/west...
news.westernu.ca
Western CFMM imaging discovery hits 30 years - Western News
Western's Centre for Functional and Metabolic Mapping houses advanced suites of imaging technology, allowing researchers to study organs in detail.
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 19/06/2026
TGIFF! Happy #Fluorescencefriday everyone...tiny connections, big insights, below! 👇🧠🐁
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 19/06/2026
🧠Transformative, collaborative #NFRF research in action! Congrats to the #TRIDENT Marmoset Team at @westernu.ca and @mcgill.ca on this new preprint, demonstrating how team science and specialized models are advancing our understanding of Parkinson's disease. 🌎🗞️🎉 www.biorxiv.org/content/10.6...
biorxiv.org
α-synuclein pathology drives multi-scale reorganization of fronto-limbic networks and cognitive flexibility in the common marmoset
Understanding how α-synuclein misfolding and spreading affect brain systems is central to synucleinopathy research, yet evidence from primate models remains limited. Here, we combined histology, awake...
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 17/06/2026
From #TRIDENT to Bordeaux! ✈️🧠 Congrats to one of our valued @westernu.ca HQP Kruti Joshi (also spotlighted this week!) on presenting her work via @ohbmofficial.bsky.social. We love seeing our team connect, collaborate and showcase their research with the global neuro community! #OHBM2026 #HQP #NFRF
Kruti Joshi, a TRIDENT trainee from Western University, stands beside her research poster at OHBM 2026. The poster, titled "Investigating Cognitive Differences across Awake & Anesthetized Mice Imaging using fMRI," presents neuroimaging findings comparing cognitive performance under different imaging conditions. Kruti wears a black dress and conference badge and smiles in front of the poster during the international neuroscience conference.
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 17/06/2026
At #TRIDENT, our greatest strength is our people. 🤝🔬🤩 We're excited to spotlight Kruti Joshi from our Imaging Team, one of the many talented HQP helping drive innovation across our collaborative research ecosystem. 🎥 #NFRF #Collaboration #HQP #Neuroscience www.youtube.com/watch?v=GSc_...
youtube.com
An Interview with Kruti Joshi, TRIDENT Imaging Core
YouTube video by TRIDENT Preclinical Trials
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 15/06/2026
ICYMI Monday...a fantastic video about our #TRIDENT partner @cfmm.bsky.social.📽️ 👇Curiosity built it. Innovation sustained it. Discovery continues to drive it. Congratulations to CFMM on 30 years of advancing imaging science and unlocking the secrets of the brain. 🎉🌎 www.youtube.com/watch?v=LzKK...
youtube.com
From Curiosity to Discovery: Western’s CFMM at 30
YouTube video by Schulich School of Medicine & Dentistry
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 12/06/2026
It's hard not to be amazed when an entire mouse brain can be visualized in such stunning detail. 🧠🔬Thanks to the world-class light-sheet microscopy infrastructure at @mind-western.bsky.social, we can explore brain architecture and reveal insights once impossible to see. 👀😍 👇#fluorescencefriday
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 09/06/2026
🌈 Diverse collaboration. Stronger discovery. At #TRIDENT, we know that innovation thrives when diverse perspectives come together. Happy Pride Month from the TRIDENT team. 🧠❤️ #PrideMonth #Neuroscience #TeamScience #Collaboration #NFRF
TRIDENT Pride Month graphic featuring the TRIDENT logo and wordmark in rainbow colours on a clean white background. Flowing rainbow ribbons frame the top left and bottom right corners. Centered text reads, “Diverse Collaboration. Stronger Discovery.” Above the slogan is a small rainbow heart icon. The graphic celebrates Pride Month and highlights TRIDENT’s commitment to inclusion, diversity, collaboration, and innovation in neuroscience research. A rainbow heart accompanies the text “Happy Pride Month” at the bottom.
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 05/06/2026
🧠 #FluorescenceFriday: Relationship status: Seeing plaques, but also talking to blood vessels. 💘🔬 We can't get enough of the incredible imaging from the MIND team, partnering platform of #TRIDENT 👇 🤩 . For more information check out their website 🔗 www.mind-western.ca.
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 04/06/2026
🧲🌎Congratulations to the incredible team at the Centre for Functional & Metabolic Mapping on 30 years of innovation and discovery. We're so proud to partner with a facility that's helping bring the future of brain research into focus! #TRIDENT #CFMM 🎉 www.schulich.uwo.ca/about/news-e...
schulich.uwo.ca
Western’s CFMM marks 30 years of imaging discovery - Schulich School of Medicine & Dentistry - Western University
Researchers have transformed understanding of the brain, healthy aging and disease.
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 02/06/2026
Mark your calendars to join and learn from a seriously cool world-renowned researcher @maximoprado.bsky.social! Thank you @stressmarq.bsky.social for hosting this event. 🎉 🙏 🔬 🌎
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 30/05/2026
Representing #TRIDENT at the Alzheimer Society Southwest Partners IG Wealth Management 2026 Walk for Alzheimer's! Great turnout for an incredible event to connect with community and help fund crucial programs and services for people with dementia, their caregivers and family!
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 30/05/2026
🔬🧠 Red meets white under the lights: proof that neuroscience has some of the brightest interactions around. #FluorescenceFriday ✨Great job to @arashsalah.bsky.social and the @mind-western.bsky.social team, incredible partnering platform of #TRIDENT.
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 28/05/2026
Great work from our valued researchers @liisagalea.bsky.social and @bonniee-leee.bsky.social at #WOMHER2026! 👇👏🌎♀️
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 28/05/2026
Incredible news for brain research at @westernu.ca. Advancing therapies for complex brain diseases takes long-term infrastructure, collaboration, and translational research ecosystems. Proud for #TRIDENT to be part of the momentum. Thank you to the Lochan family for this transformational support! 🧠🌎
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 25/05/2026
A great day to highlight our iPSC & Organoid work via the @theneuro.bsky.social Early Drug Discovery Unit, partner of the #TRIDENT evaluation pipeline! A great example of collaborative science helping de-risk and accelerate neurotherapeutic development.🧠🔬 Learn more: www.mcgill.ca/neuro/resear...
mcgill.ca
The Early Drug Discovery Unit (EDDU)
The Early Drug Discovery Unit (EDDU)
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 22/05/2026
New article from #TRIDENT lead researcher @richardgold.bsky.social with @sciencepolicy.ca. 🍁📰🎉. From innovation to health preparedness, ensuring Canada can respond, adapt, and deliver at home matters more than ever in an increasingly fragile global landscape. 🌍🧠 sciencepolicy.ca/posts/defend...
sciencepolicy.ca
Defending Innovation Against Lock-Out - CSPC
Canada developed its Defence Industrial Strategy in light of an increasingly fragile international rules-based order. The Strategy outlines two responses to this reality: 1) engaging Canadian industry...
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 21/05/2026
Great to 👀 both #TRIDENT lead researcher Jackie Sullivan and Richard Vagnino with other great talks at the @rotmanphilosophy.bsky.social Research Retreat on Knowledge Translation today. Thanks to the organizers, speakers, and participants for such an engaging + collaborative event!👏 #KT@westernu.ca
A speaker presents at a podium in a modern conference room at Western University during a neuroscience-related event. A large presentation slide titled “Focus of my research: Translational Cognitive Neuroscience” is projected behind her, featuring text about cognition, disease, and translational research alongside illustrative graphics. Audience members are seated around the room listening attentively, with microphones and conference tables visible in the foreground.A presenter stands at a podium in a conference room at Western University delivering a talk titled “Analogical Inferences & Animal Models.” The presentation slide includes illustrations of various organisms and references knowledge translation between models and target systems. Audience members sit nearby at conference tables with notebooks, drinks, and microphones visible, while the speaker addresses the room from the front.
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 20/05/2026
🧠👏 Huge congrats to Dr. Fon on his appointment as the new Director of @theneuro.bsky.social + Head of the Neuroscience Mission at @cusm-muhc.bsky.social! #TRIDENT is so grateful for your continued expertise + leadership for our research! www.mcgill.ca/neuro/articl...
mcgill.ca
Edward Fon appointed Director of The Neuro
We are pleased to announce the appointment of Edward Fon, MD, as Director of The Neuro (Montreal Neurological Institute-Hospital), a joint position of the Faculty of Medicine and Health Sciences at Mc...
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 20/05/2026
🧠🔬 Lightsheet, MRI, and pizza🍕✨ Another packed @mind-western.bsky.social monthly lunch session bringing researchers together to connect, learn, and share some seriously cool imaging science. 🤩 #Neuroscience #LightSheet #MRI #Kmb @braincanada.bsky.social @westernu.ca @schulichmeddent.bsky.social
Wide-angle view of a seminar room filled with attendees seated and facing a projected presentation screen at the front of the room. A presenter stands near the podium while a “Thank you!” slide is displayed, featuring acknowledgements and logos from TRIDENT, Western BrainsCAN, and Schulich Medicine & Dentistry. The room has dimmed lighting, ceiling projectors, and an engaged audience listening to the neuroscience presentation.Audience seated in a darkened lecture room watching a scientific presentation slide titled “Stripe-artifacts in Light Sheet Data.” The slide shows grayscale brain imaging examples illustrating stripe-like imaging artefacts in light sheet microscopy data. A presenter stands near the screen while attendees face forward, listening to the technical discussion.Presentation slide displayed during a neuroscience imaging seminar showing colourful light sheet microscopy images of mouse brain tissue. The slide compares untreated and “PFF treated” brain samples with fluorescent labeling in green, blue, and yellow. Audience members are seated in the foreground while the presenter speaks from the side of the room.
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 16/05/2026
Check out this upcoming webinar from @stressmarq.bsky.social, featuring #TRIDENT lead researcher @maximoprado.bsky.social! 👇👏🔬😍
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TRIDENT Preclinical Trials @tridentpct.bsky.social · 16/05/2026
Incredible #FluorescenceFriday imaging from @maximoprado.bsky.social + @mind-western.bsky.social team, set to Coldplay.🤩🎶A cleared mouse brain shows amyloid (yellow) interacting with blood vessels (pink) and microglia (cyan) in a triple KI model with human Aβ, tau & ApoE4. @braincanada.bsky.social🧠🔬
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