Dosage-sensitive transcription factors (TFs) underlie altered gene regulation in human developmental disorders, and cell type–specific gene regulation is linked to the reorganization of three-dimensio...

Scientists describe "amazing feeling" to look into the face of an animal that so few people knew existed.

Nature Communications - The 3D organisation of chromatin inside a human cell is still not fully resolved. Here the authors reveal that in situ cryo-ET resolves individual nucleosomes and predicts...

Cobb looks back at the complicated series events that led to the discovery of messenger RNA, highlighting the often difficult problem of attributing credit for scientific advances.

PTCHD1-AS, which encodes a long non-coding RNA, is associated with the aetiology of autism spectrum disorder in humans through striatal molecular and circuit-level dysregulation.

HIV-1 capsid nuclear import at the nuclear pore complex is a bottleneck to resting T cell infection, but HIV-1 overcomes this by triggering receptor-mediated signalling during cell–cell spread to drive nuclear import and licence infection.

Questions about the culprit virus and its route of spread remain as health officials make plans for stranded passengers

Nuclear speckles support the splicing of levelled exon–intron architecture transcripts, and their evolution shaped genome organization in amniotes.

HIV infections in Fiji are growing among the most vulnerable, including babies and young children

Herzog et al. discover that herpes simplex virus 1 protein ICP4 fluidizes the nucleus prior to chromatin marginalization. Nuclear fluidization enables viral condensate growth, increasing viral titer. This work reveals how viruses manipulate nuclear biophysics and provides a path to discover mechanisms that control nuclear physical properties.

Hepatitis D-like satellite viruses, known as deltaviruses, have been recently discovered in a wide range of animals. These viruses are thought to expr…

Abstract. Nuclear speckles are membraneless organelles implicated in multiple RNA processing steps. In this work, we systematically characterize the sequen

Scientists seek to understand the factors that have allowed people in Brazil to reach their 100th or even 110th birthdays despite facing adversities.

A trial was about to launch for a vaccine that would ward off the HIV virus. It would be an incredible breakthrough. Then it looked as if it would be over before it started.

My reflections on ERC-Plus, Europe’s newest ultra-competitive research grant and what it tells us about the academic culture we’re…

Accurate repair of DNA double-strand breaks (DSBs) is essential for genome stability, and defective repair underlies diseases such as cancer. Homologous recombination uses an intact homologous sequenc...

Following cell entry, HIV-1 capsids enter the nucleus by passage through nuclear pores and reach nuclear speckles with subsequent uncoating of the reverse-transcribed genome and its integration into s...

Jane Goodall, primatologist who transformed our understanding of the lives of apes, has died, according to an announcement from the Jane Goodall Institute.

Scientists used AI to write coherent viral genomes, using them to synthesize bacteriophages capable of killing resistant strains of bacteria.

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