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Marco A. Maximo Prado

@maximoprado.bsky.social
2.5K followers 670 following 1.1K posts

Canada Research Chair. Misfolding proteins, chaperones and cholinergic function in neurodegeneration. Interested in reproducibility, translational research and open science. ORCID: 0000-0002-3028-5778 I also post pics of sunsets and bikes.

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Reposted by Marco A. Maximo Prado
Alicia Izquierdo @aliciaizquierdo.bsky.social · 5h
Newly-accepted paper from Sara Burke's lab: A 🐀 touchscreen task is sensitive to perceptual difficulty and captures performance declines with greater feature overlap, but does not detect age-related memory deficits 🤔@touchscreencog.bsky.social academic.oup.com/oons/article...
academic.oup.com
An Operant-based Touchscreen Morph Discrimination Task Does Not Detect Age-related Mnemonic Similarity Deficits in Rats
Abstract. The Mnemonic Similarity Task (MST) is sensitive to age-related cognitive decline in humans and has been adapted for rodents using 3D objects, whe
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Marco A. Maximo Prado @maximoprado.bsky.social · 15h
Government-led human trafficking
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Reposted by Marco A. Maximo Prado
Lula @lulaoficialbluesky.bsky.social · 03/10/2026
São Paulo, 3 de outubro de 2026. 📷 Ricardo Stuckert
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Marco A. Maximo Prado @maximoprado.bsky.social · 03/10/2026
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Marco A. Maximo Prado @maximoprado.bsky.social · 03/10/2026
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Marco A. Maximo Prado @maximoprado.bsky.social · 02/10/2026
#fluorescencefriday another test for the @mind-western.bsky.social and @shahrzadbahrampour.bsky.social labelling for MOG (Myelin Oligodendrocyte Glycoprotein) in a young 🐁 🧠 cleared and imaged By lightsheet 🔬
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Reposted by Marco A. Maximo Prado
Semafor @semafor.com · 30/09/2026
Visitors to the US are on track to drop by almost two million year-on-year. “We’re the only major country in the world losing visitation,” the head of the US Travel Association said. “It’s mind-boggling.” www.semafor.com/article/09/2...
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Reposted by Marco A. Maximo Prado
Science Magazine @science.org · 29/09/2026
Heart attacks and strokes triggered by electrical misfiring in the heart are among the biggest killers on the planet. In 2022, researchers created a “liquid wire” that, when injected into pig hearts, can guide the organs to a normal rhythm. Learn more on #WorldHeartDay: scim.ag/4iUYkai
Injectable electrodes could prevent deadly heart arrhythmias
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Reposted by Marco A. Maximo Prado
Timothy Caulfield @caulfieldtim.bsky.social · 28/09/2026
"Vaccines work" isn't a political statement. "Immigrants do not increase crime" isn't a political statement. "Climate change is real" isn't a political statement. "Genocide is bad" isn't a political statement. Stop neutralizing the power of facts by framing them as "politics." Reality matters.
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Marco A. Maximo Prado @maximoprado.bsky.social · 25/09/2026
our facility is testing few antibodies for one of our users and this is the stain for NF-H for axons using lightsheet microscopy in a cleared 🐁 🧠 #fluorescencefriday @shahrzadbahrampour.bsky.social @kesummers.bsky.social @mind-western.bsky.social
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Marco A. Maximo Prado @maximoprado.bsky.social · 25/09/2026
such good news for @westernu.ca which has one of the best facilities for these studies. And what an impressive person @margaretatwood.bsky.social is! www.theglobeandmail.com/canada/scien...
theglobeandmail.com
Margaret Atwood donates $1-million to establish research chair for bird science
Donation will allow Western University to add a new hire to its biology faculty with the goal of advancing scientific knowledge about birds and bird migration
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Reposted by Marco A. Maximo Prado
Ravi Menon @northernthrux.bsky.social · 23/09/2026
Phosphorylated α-synuclein pS129 is found in aggregates that are pathological hallmarks of PD and DLB. The toxicity of pS129 has been up for debate for years. Combining LSM, MRI, rsfMRI and task fMRI, we demonstrate a toxic role for pS129 in synucleinopathies. 1/2 www.biorxiv.org/content/10.6...
biorxiv.org
Phosphorylated ⍺-Synuclein shapes changes in brain structure, task-related activity and functional connectivity in M83 mice
Phosphorylated α-synuclein at S129 (pS129) is the predominant form of α-synuclein in the aggregates known as Lewy bodies (LB) and Lewy neurites (LN), the pathological hallmarks of Parkinson's disease ...
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Marco A. Maximo Prado @maximoprado.bsky.social · 20/09/2026
i guess things are so bad that now even podcast Jay is considered supportive of the NIH. It is really unbelievable what they are doing to destroy science in 🇺🇸
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Reposted by Marco A. Maximo Prado
Jarvis Googoo @jarvisgoogoo.com · 19/09/2026
Amazing editorial cartoon by @mackinnonart.bsky.social 😃
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Western Institute for Neuroscience (WIN) @westernuwin.bsky.social · 18/09/2026
For #OpenScienceWeek, we’re highlighting tools that make neurosci research more open + accessible. Check out MotorNet, an open-source Python toolbox developed by WIN researchers that combines neural network training with realistic biomechanical models of movement in a flexible framework.
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Reposted by Marco A. Maximo Prado
Ryan Marino, MD @ryanmarino.bsky.social · 18/09/2026
If you want to protect your liver - a detoxing miracle that humans have yet to replicate - get your Hepatitis A and B vaccines! Bonus: they also prevent cancer!!
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Marco A. Maximo Prado @maximoprado.bsky.social · 18/09/2026
Looks like they are finally taking climate change seriously 🤷🏼‍♂️ emissão from airplanes means climate change, right?
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Reposted by Marco A. Maximo Prado
Elizabeth Jacobs, PhD @elizabethjacobs.bsky.social · 15/09/2026
The compound was likely contaminated with endotoxins. At least three people were hospitalized. It’s simple: don’t get recreational IVs or peptide injections. You don’t need them, there is no solid evidence of benefits, and they can make you very sick.
cdc.gov
Adverse Events Linked to Injectable Glutathione Compounded with Dietary Supplement Grade Ingredient: Current Situation
Adverse events linked to compounded injectable glutathione.
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Reposted by Marco A. Maximo Prado
Takuya Sasatani @takuyasasatani.bsky.social · 14/09/2026
Miniscope Zero, the first fully wireless Miniscope, is on @biorxivpreprint.bsky.social! Wireless power + data enable neural recordings in enclosed mazes, 3D environments & from two animals at once! @miniscope.bsky.social Paper: doi.org/10.64898/202... Wiki: miniscope.org/wiki/Minisco...
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Reposted by Marco A. Maximo Prado
PLOS Biology @plosbiology.org · 10/09/2026
#TrendingNow | The proportion of studies that successfully translate from animals to humans may be greater than we think. However, the low rate of final regulatory approval indicates potential design flaws of both animal studies and early clinical trials. #ICYMI #biomedical 🧪 buff.ly/XAysMWI
journals.plos.org
Analysis of animal-to-human translation shows that only 5% of animal-tested therapeutic interventions obtain regulatory approval for human applications
Based on the analysis of 376 therapies in 54 human diseases, this study shows that, contrary to widespread assertions, the proportion of successful animal-to-human translation may be higher than…
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Marco A. Maximo Prado @maximoprado.bsky.social · 07/09/2026
#carryshitolympics
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Marco A. Maximo Prado @maximoprado.bsky.social · 06/09/2026
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Marco A. Maximo Prado @maximoprado.bsky.social · 06/09/2026
#sunset
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Reposted by Marco A. Maximo Prado
Robert Zaichkowski @rzaichkowski.bsky.social · 04/09/2026
Mayor Olivia Chow and the City of Toronto had prepared design proposals for Bloor from Resurrection to Royal York which would have added a traffic lane while keeping the bike lanes, yet were rejected by the Ford government! #shame #BikeTO #TOpoli #ONpoli www.thestar.com/news/gta/dou...
thestar.com
Doug Ford’s government rejected Toronto’s proposals to restore traffic lanes and keep bike lanes: sources
Toronto Mayor Olivia Chow says the province walked away from compromises to restore traffic lanes while keeping bike lanes on major streets.
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Reposted by Marco A. Maximo Prado
TRIDENT Preclinical Trials @tridentpct.bsky.social · 04/09/2026
Happy #FluorescenceFriday! 🔬 Great to see TRIDENT collaborations in action! #TRIDENT #ParkinsonsResearch #Neurotherapeutics #Organoids
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Marco A. Maximo Prado @maximoprado.bsky.social · 04/09/2026
one of the advantages of working on @tridentpct.bsky.social is to interact with great collaborators like Tom Durcan at @theneuro.bsky.social to help stain and image with light sheet 🔬 their organoids (TH red and GFAP blue) used to test new drugs for Parkinson’s Disease
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Marco A. Maximo Prado @maximoprado.bsky.social · 02/09/2026
New paper alert. Work in collaboration with my late friend Rob Gros and Silvia Guatimosim STIP1 signaling drives protein synthesis in pathological cardiomyocyte hypertrophy | American Journal of Physiology-Cell Physiology | American Physiological Society journals.physiology.org/doi/abs/10.1...
journals.physiology.org
STIP1 signaling drives protein synthesis in pathological cardiomyocyte hypertrophy | American Journal of Physiology-Cell Physiology | American Physiological Society
Background: Stress-inducible phosphoprotein 1 (STIP1) is a co-chaperone involved in neuronal proteostasis and stress resilience. Although expressed in the heart, its role remains undefined. We assesse...
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Reposted by Marco A. Maximo Prado
NY Times Pitchbot @nytpitchbot.bsky.social · 02/09/2026
I'll put this in terms the Left can understand: Lake Ontario identified as Lake America, and it transitioned. Smile and hold for laughs to connect with audience and appear presidential. by J.D. Vance
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Mark Hamill @markhamillofficial.bsky.social · 01/09/2026
Bravo @mapquest.com…. for not bending the knee! #LakeOntario-Now&Forever🇨🇦
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Ravi Menon @northernthrux.bsky.social · 01/09/2026
Don’t buy 🇺🇸 beef. Reason 23,637.
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Reposted by Marco A. Maximo Prado
Bromptoning (Heather & Pier) @bromptoning.bsky.social · 29/08/2026
One for the record books! #BikeTO came out in force for Critical Mass! @cycletoronto.bsky.social @thebikinglawyer.bsky.social
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Western BrainsCAN @westernubrainscan.bsky.social · 31/08/2026
Ten years ago, BrainsCAN set out to transform brain research. Today is our final day. The funding ends. The impact doesn’t. People we supported. Discoveries we enabled. Technologies we developed. Infrastructure we built. Partnerships we created. To everyone who was part of it: thank you. ❤️
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Reposted by Marco A. Maximo Prado
bikebike @bikebikeyyc.bsky.social · 30/08/2026
Pump this energy straight into my veins #roadsafety
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Marco A. Maximo Prado @maximoprado.bsky.social · 29/08/2026
Bovine spongiform encephalopathy or mad cow disease for the win.
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Marco A. Maximo Prado @maximoprado.bsky.social · 29/08/2026
Santos, São Paulo 🇧🇷 winter 2022
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Marco A. Maximo Prado @maximoprado.bsky.social · 28/08/2026
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Reposted by Marco A. Maximo Prado
Nick Young @nickofnz.bsky.social · 26/08/2026
Adapting to climate change without ending the fossil fuel industry.
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Marco A. Maximo Prado @maximoprado.bsky.social · 27/08/2026
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Reposted by Marco A. Maximo Prado
Craig 🌎 🛩️ 💙🇨🇦 @bigdaddykreativ.bsky.social · 25/08/2026
Canada's largest ice cream company used to source its fruits and nuts from U.S. suppliers — some for over 30 YEARS. Then, Trump imposed a 25% tariff on Canadian products. So, what did Chapman's do? They called Italy. They called Spain. They signed multi-year contracts with European suppliers.
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Marco A. Maximo Prado @maximoprado.bsky.social · 25/08/2026
Ideal time to undermine vaccines 🤷🏼‍♂️
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Reposted by Marco A. Maximo Prado
Ann Telnaes @anntelnaes.bsky.social · 25/08/2026
We are all Canadians now anntelnaes.substack.com/p/we-are-all...
anntelnaes.substack.com
We are all Canadians now
Trump alienates one of our closest allies and neighbor
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Reposted by Marco A. Maximo Prado
Alex Usher @alexusherhesa.bsky.social · 25/08/2026
2025-26: the first year Canadian universities employed more tenured/TT professors over the age of 70 than under the age of 35.
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Jim Woodgett @jwoodgett.bsky.social · 24/08/2026
Just read the stories and then vote. Natalie is amazing. ❤️
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Governor Tim Walz @governorwalz.mn.gov · 24/08/2026
When a group of YMCA campers needed to be rescued during the wildfires on our northern border, it was Canada who immediately helped. Not a word from Trump.
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Matt Wall @mattwall.bsky.social · 23/08/2026
Small suggestion: If you're organising a conference, or academic meeting, or well, anything really in the US in the next couple of years, why not consider doing it in Canada instead? 🇨🇦🍁
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Shannon Proudfoot @sproudfoot.bsky.social · 23/08/2026
I hated the “do you know how bad you have to be to piss off the CANADIANS?!” memes because that wildly misunderstands us. But this one I know to be true in my bones.
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Andrew Weinstein @andrewjweinstein.com · 23/08/2026
The United States and Canada have been friends, partners, and allies for more than 150 years across 32 presidential administrations. And now, solely because of the arrogance, incompetence, and ego of the current occupant of the White House, that relationship is being driven straight toward a cliff.
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The Globe and Mail @theglobeandmail.com · 23/08/2026
theglobeandmail.com
No deal was better than this deal. Mark Carney was right to call Donald Trump’s bluff
Previous U.S. administrations believed in the possibility of mutual benefits, but that is not Trump’s vision
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Charlie Angus @charlieangus104.bsky.social · 23/08/2026
The war is on. This is the test of our nation and our generation. We call on allies from around the world to show solidarity and boycott the USA. Buy nothing from the tyrant regime. Canadians - push your grocery store to support the boycott. @laura-babcock.bsky.social youtu.be/yuzXL3VhoMY?...
youtu.be
CANADA VS USA - DROPPING THE GLOVES !!!
YouTube video by Charlie Angus
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Prof Peter Hotez MD PhD DSc(hon) @peterhotezmdphd.bsky.social · 22/08/2026
Ancient Rome
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