Nature Reviews Cancer, Published online: 22 September 2026; doi:10.1038/s41568-026-00980-6This Editorial marks the 25th anniversary of Nature Reviews Cancer. On this milestone we contemplate how our view of cancer has changed over the past 25 years and speculate on what the future holds.

Clathrin plaques (magenta) form large, flat membrane-associated lattices embedded within the cortical actin cytoskeleton, and can be distinguished from individual clathrin-coated pits (yellow). These....

Transcription Factor EB (TFEB) regulates the biogenesis of lysosomes, which are acidic organelles of the endosomal network. While its role in cellular clearance is well established, the pleiotropic fu...

Published in Nucleus (Vol. 17, No. 1, 2026)

Cavanaugh et al. show that embryos from aged mice have increased contractility and tissue viscosity on embryonic day 4.5, which leads to poor spreading and attachment. Similar age-associated mechanica...

You can see AI everywhere except in the productivity statistics

Jha et al. show that the transmembrane protein CD44 restricts EGFR mobility to maintain an EGFR–PI3K–Rac gradient during bleb-based cell migration.

During regeneration, tissues must translate transient cellular variability into stable spatial organization. Tissue architecture generates a density-dependent window of heterogeneity in the mechanosen...

The geometry of confining boundaries is shown to control three-dimensional topological defect configurations that precede formation of the central lumen in the developing mouse embryo, a key process i...

Galvanin is an electric-field sensor that links electrical cues to directed migration in rapidly moving cells.

In contrast to prevailing dogma, we report that procollagen 1 assembles into a liquid condensate within cells, resolving the long-standing problem of how c

Lysosomal cargo sorting from the early endosomes should involve mechanisms that prevent their recycling to the plasma membrane. Here, Chouhan P and Phogat

Kozlova et al. report a functional role for NDRG1 in regulating R-loops and DNA repair, thereby linking cancer-associated fibroblast-derived extracellular matrix to chemotherapy responses in pancreati...

This Review synthesizes emerging insights into how microenvironmental cues, epigenetic programmes and immune interactions govern disseminated cancer cell dormancy and outlines how advances in dormancy...

A collection of antigen-stabilizable fluorescent nanobodies becomes fluorescent upon binding to their intracellular targets and enables background-free multicolor imaging and biosensing in living syst...

Endosomal GTPases, while often used as markers for specific endosomal organelles, functionalize the surface of endosomal compartments into biochemical…

Institute of Precision Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510275, China

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...