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Dan Landau

@landau.bsky.social
3.5K followers 585 following 51 posts

Oncologist-scientist at Weill Cornell and New York genome center. Into somatic evolution, trees and words

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Reposted by Dan Landau
Carlos Caldas 🇵🇹🇮🇱🇪🇺🇬🇧 @carloscaldas1960.bsky.social · 25/08/2026
Amazing and well deserved! Congratulations @landau.bsky.social!
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The Mark Foundation for Cancer Research @themarkfdn.bsky.social · 27/08/2026
Safe to say he’s no longer just an “emerging” leader. 🚀 Huge congratulations to Dan Landau (@landau.bsky.social) on being named the inaugural Chair of the Department of Systems and Computational Biomedicine at @weillcornell.bsky.social! news.weill.cornell.edu/news/2026/08...
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New York Genome Center @nygenome.org · 24/08/2026
Congratulations to our Core Faculty Member @landau.bsky.social Full story: www.nygenome.org/news-events/... lnkd.in/p/g8UX_CfM
lnkd.in
Dr. Dan-Avi Landau, a world-renowned cancer researcher and pioneering geneticist, has been appointed inaugural chair of the newly created Department of Systems and Computational Biomedicine. The new…...
Dr. Dan-Avi Landau, a world-renowned cancer researcher and pioneering geneticist, has been appointed inaugural chair of the newly created Department of Systems and Computational Biomedicine. The new ...
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Nature Genetics @natgenet.nature.com · 16/07/2026
💫PUBLISHED @natgenet.nature.com 📰Longitudinal changes in DNA methylation in IDH-mutant glioma fuel disease progression through altered cell state differentiation. By @masashi-nomura.bsky.social, @landau.bsky.social, Mario L. Suvà and colleagues. ⬇️ www.nature.com/articles/s41...
nature.com
Longitudinal changes in DNA methylation in IDH-mutant glioma fuel disease progression through altered cell state differentiation - Nature Genetics
The authors use single-cell multi-omics to interrogate longitudinal samples of isocitrate dehydrogenase mutant gliomas. Their analyses couple progression and hypomethylation with changes in differenti...
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New York Genome Center @nygenome.org · 13/07/2026
A new study using laboratory technology reveals the inner workings of how a type of brain tumor progresses toward greater malignancy. NYGC Core Faculty @landau.bsky.social led this research with colleagues at Harvard Medical School and Mass General Brigham. Article: www.nygenome.org/news-events/...
nygenome.org
Cancer Evolution Study Reveals Biology of Glioma Progression - July 10, 2026
Read about Cancer Evolution Study Reveals Biology of Glioma Progression at the New York Genome Center on July 10, 2026
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Dan Landau @landau.bsky.social · 22/06/2026
New results with tree reconstruction of glioma progression. Phylodynamics applied to primary patient samples allow to define how progression is linked to changes in differentiation hierarchies. We ❤️ trees!
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New York Genome Center @nygenome.org · 16/06/2026
Congratulations to @landau.bsky.social, New York Genome Center Core Faculty Member, a 2026 Recipient of a Lotus Award from the Pershing Square Foundation www.nygenome.org/news-events/...
nygenome.org
New York Genome Center Core Faculty Member, Dr. Dan Landau, Receives Award for Research on New Ovarian Cancer Targets - June 16, 2026
Read about New York Genome Center Core Faculty Member, Dr. Dan Landau, Receives Award for Research on New Ovarian Cancer Targets at the New York Genome Center on June 16, 2026
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Caldas Lab 🇵🇹🇮🇱🇪🇺🇬🇧 @caldaslab.bsky.social · 05/06/2026
Beautiful work from @landau.bsky.social! I wonder if with some tweaks if it can be combined with single cell lentiviral barcoding. Single-cell mapping of regulatory DNA-protein interactions: Cell www.cell.com/cell/fulltex...
cell.com
Single-cell mapping of regulatory DNA-protein interactions
D&D-seq, a single-cell immune-tethering strategy, captures weak and transient DNA-protein interactions to enable integrated, genome-wide analysis of transcription factor binding across chromatin state...
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Waggoner Lab @labwaggoner.bsky.social · 05/06/2026
D&D-seq, a single-cell immune-tethering strategy, captures weak and transient DNA-protein interactions to enable integrated, genome-wide analysis of transcription factor binding across chromatin states @cellcellpress.bsky.social @landau.bsky.social www.cell.com/cell/fulltex...
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MwahahahahahadScientist @mads100tist.bsky.social · 05/06/2026
This is superb. Congratulations!!
media.tenor.com
elmo from sesame street is standing in front of a fire
Alt: elmo from sesame street is standing in front of a fire
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Dan Landau @landau.bsky.social · 04/06/2026
Exciting breakthrough technology from the lab, now live in @cellcellpress.bsky.social ! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!
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Johanna Joyce @johannajoyce.bsky.social · 16/04/2026
What does it take to truly understand #cancer in all of its complexity? Delighted to share our Review in Cell "Cancer ecosystems: A dynamic interplay across scales" with Daniela Quail, where we propose a multi-scale framework connecting tumor ecology with physiology 🧪⚕️ www.cell.com/cell/fulltex...
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Dan Landau @landau.bsky.social · 07/04/2026
Woohoo! Excited to be the cover feature!
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Junyue Cao @junyuecao.bsky.social · 26/02/2026
New paper alert 🚀 Our organism-wide single-cell ATAC-seq atlas of mammalian aging is now out in @science.org, led by our fantastic graduate student Ziyu Lu from @rockefeller.edu! www.science.org/doi/10.1126/...
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Dan Landau @landau.bsky.social · 23/02/2026
NYC SN❄️❄️❄️❄️❄️❄️❄️❄️❄️W
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Michael Baym @baym.lol · 23/02/2026
"We're changing our approach to science philanthropy" -> they're funding AI, just like everyone else
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Tina's Wish @tinaswish.bsky.social · 20/02/2026
Proud to announce our 2026–2027 Research Grantees! Their innovative research is advancing ovarian cancer early detection and prevention—bringing us closer to a future where every woman has a fighting chance. tinaswish.org/grants-26-27/
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Eric Topol @erictopol.bsky.social · 18/02/2026
The unfounded move by HHSGov against mRNA vaccines will hurt our future potent immune therapy vs cancer. Another point of progress for triple-negative breast cancer with individualized neoantigen mRNA vaccines today Adds to pancreatic, renal cell, melanoma reports nature.com/articles/s41...
nature.com
Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC - Nature
In a phase 1 trial, personalized mRNA vaccines tailored to individual tumour mutations in triple-negative breast cancer induced robust, long-lasting T cell responses and improved prognosis.
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Irish Literary Times @irishlittimes.bsky.social · 14/02/2026
As Valentine’s Day #ValentinesDay arrives, here’s one of Ireland’s greatest love poems: Dark-Haired Miriam Ran Away by Patrick Kavanagh (1946), inspired by Hilda Moriarty, a 22-year-old med student he became infatuated with. Later set to music as Raglan Road and famously sung by Luke Kelly.
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The Mark Foundation for Cancer Research @themarkfdn.bsky.social · 03/02/2026
@landau.bsky.social @rdrapkin8-penn.bsky.social Paul Mischel, and Adam Widman are searching for pre-cancerous signals of ovarian cancer in the blood, laying the foundation for non-invasive screening test. 🩸@tinaswish.bsky.social @weillcornell.bsky.social @mskcancercenter.bsky.social
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Roychoudhuri Lab @roychoudhurilab.bsky.social · 03/02/2026
Absolutely remarkable: striking effects of infusion time-of-day on immunochemotherapy efficacy in nonsmall cell lung cancer in a randomized phase 3 trial www.nature.com/articles/s41...
nature.com
Time-of-day immunochemotherapy in nonsmall cell lung cancer: a randomized phase 3 trial - Nature Medicine
In this randomized phase 3 trial, patients with treatment-naive stage III–IV nonsmall cell lung cancer who received sintilimab or pembrolizumab in combination with chemotherapy early in the day (befor...
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Caleb Lareau @caleblareau.bsky.social · 28/01/2026
Today in @nature.com, we describe how discarded reads in biobank-scale WGS can help resolve the genetic predictors and consequences of Epstein-Barr Virus (EBV) infection. Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social www.nature.com/articles/s41...
nature.com
Population-scale sequencing resolves determinants of persistent EBV DNA - Nature
Population-scale WGS reveals genetic determinants of persistent EBV DNA, linking immune regulation—especially antigen processing and MHC class II variation—to EBV persistence and heterogeneous di...
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Elizabeth McKenna @elizsmckenna.bsky.social · 07/01/2026
Now online in Cancer Discovery @aacrjournals.bsky.social: Genotype-to-Phenotype Mapping of Somatic Clonal Mosaicism via Single-Cell Co-Capture of DNA Mutations & mRNA Transcripts by @dennisjyuan.bsky.social, @landau.bsky.social, et al. doi.org/10.1158/2159... @nygenome.org @weillcornell.bsky.social
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Dan Landau @landau.bsky.social · 07/01/2026
Happy new year/paper! A new tech (scG2P) maps genotype (DNA) to phenotype (RNA) in single cells, bringing together the worldviews of genetic & transcriptional heterogeneity. With scG2P we define how mosaicism drivers increase clonal fitness in the aging esophagus aacrjournals.org/cancerdiscov...
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Elizabeth McKenna @elizsmckenna.bsky.social · 06/01/2026
Now online in Cancer Discovery @aacrjournals.bsky.social: LINE-1 Locus Transcription Nucleates Oncogenic Chromatin Architecture - by Michael Lee, Yuannyu Zhang, Jian Xu, and colleagues doi.org/10.1158/2159... @stjuderesearch.bsky.social
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David A Knowles @davidaknowles.bsky.social · 06/01/2026
Excited to see this out www.nature.com/articles/s41...! Nonparametric kernel-based tests for spatially variable isoform usage in spatial transcriptomics. So many interesting examples in the CNS and cancer, we're only scratching the surface!
nature.com
Mapping isoforms and regulatory mechanisms from spatial transcriptomics data with SPLISOSM - Nature Biotechnology
Differential isoform usage is identified with high statistical power from spatial transcriptomics data.
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Caroline Bartman @cbartman.bsky.social · 06/01/2026
i hate elon musk for a lot of reasons but one of them is that now sometimes i first see interesting papers on linkedin LINKEDIN
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Dan Landau @landau.bsky.social · 05/01/2026
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Vijay G. Sankaran @bloodgenes.bsky.social · 02/01/2026
Delighted to have our work on 🧬 resilience to 🩸cancer led by @g-agarwal.bsky.social & amazing collaborators, including @kharaslab.bsky.social, published in @science.org: www.science.org/doi/10.1126/... 🧵
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Dan Landau @landau.bsky.social · 11/12/2025
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PortfolioCarmel @portfoliocarmel.bsky.social · 07/12/2025
His soul swooned slowly as he heard the snow falling faintly through the universe and faintly falling ~ James Joyce Fred Stein
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Raheleh Rahbari @r-rahbari.bsky.social · 05/12/2025
www.sanger.ac.uk/news_item/or...
sanger.ac.uk
Order of cancer-driving mutations affects the chance of tumour development
Scientists reveal that mutation order influences tumour growth in the intestine.
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Christina Daub @christinadaub.bsky.social · 01/12/2025
“…when grief weighs you down like your own flesh…” #smallpoemsunday @tomsnarsky.bsky.social #poetry
The Thing Is a poemby Ellen Bass. 
You can listen to it here: https://youtu.be/JONWgsZ6vm8?si=xtEqW09O-U4cTM57
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Eric Topol @erictopol.bsky.social · 21/11/2025
“I had hemophilia for nearly five decades. I went to Philadelphia and had a 45-minute infusion, and my hemophilia was gone.” Genes-> Medicine nature.com/articles/s41...
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Michael Baym @baym.lol · 20/11/2025
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/ www.science.org/doi/10.1126/...
science.org
Intracellular competition shapes plasmid population dynamics
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...
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Jeff Spence @jeffspence.github.io · 18/11/2025
Super cool paper from Sheel Chandra + Ziyue Gao. kmer context matters a lot for mutability of both methylated and unmethylated CpGs. But!! the effect of kmer context on unmethylated CpGs is basically independent of the effect of kmer context on methylated CpGs! www.biorxiv.org/content/10.1...
biorxiv.org
Sequence context and methylation interact to shape germline mutation rate variation at CpG sites
A prominent example of sequence context-dependent mutation rate variation is the elevated transition rate at CpG sites, which is largely attributed to cytosine methylation. CpGs with different flankin...
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Vijay G. Sankaran @bloodgenes.bsky.social · 17/11/2025
Honored to be recognized by @usnews.com as a 2025 #BestLeader alongside so many incredible colleagues and individuals I admire! www.usnews.com/news/best-le...
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Arjun Raj @arjunraj.bsky.social · 14/11/2025
So awesome to have this great paper from Sam Reffsin and Sara Cherry out! In it, we use retrospective clone tracing to show that there are particular single cell states that are more susceptible to viral infection (both SARS-CoV-2 and flu)! www.cell.com/cell/fulltex...
cell.com
Single-cell susceptibility to viral infection is driven by variable cell states
Not all cells that can be infected by a virus become infected with that virus. Single-cell clone tracing reveals intrinsic cell states with variable expression patterns that increase susceptibility to...
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Ryan Marino, MD @ryanmarino.bsky.social · 13/11/2025
You are infinitely closer to struggling than you ever will be to billionaires
eonline.com
James Van Der Beek Auctioning Off Dawson’s Creek Items Amid Cancer Journey
James Van Der Beek has put several Dawson’s Creek and Varsity Blues items up for auction as he continues to battle stage 3 colon cancer.
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Jay Shendure @jshendure.bsky.social · 14/10/2025
Super excited about first Shendure/Baker Lab collaboration & preprint on a multiplex sequencing-based strategy for screening de novo proteome editors in mammalian cells. Kudos to the brilliant Chase Suiter (not here) & @greenahn.bsky.social on the work! Preprint here: www.biorxiv.org/content/10.1...
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Oded Rechavi @odedrechavi.bsky.social · 14/10/2025
Trying to work from home with my kids around
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ivanraimondi.bsky.social @ivanraimondi.bsky.social · 14/10/2025
🚀 Excited to share SMART-PTA (miniaturized Primary Template Amplification) a high-throughput single-cell whole-genome amplification method that preserves clonal lineage information while enabling deep genomic and transcriptomic profiling.
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Dan Landau @landau.bsky.social · 14/10/2025
Big, beautiful trees!! SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life. www.biorxiv.org/content/10.1...
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ralucagordan.bsky.social @ralucagordan.bsky.social · 03/10/2025
I'm very pleased to announce the official publication of our lab's paper "DNA mutagenesis driven by transcription factor competition with mismatch repair" in today's issue of Cell! www.cell.com/cell/abstrac...
cell.com
DNA mutagenesis driven by transcription factor competition with mismatch repair
Competition between transcription factors and mismatch repair machinery drives localized hypermutation at regulatory elements, with implications for cancer and genome evolution.
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Wolfgang Huber @wkhuber.bsky.social · 29/09/2025
Do you like theoretical biology, mathematical&conceptual modelling and want to apply yourself to cutting-edge research at all levels of biology, from molecules to ecosystems? Come to EMBL! Scope includes physics-based models, emergence, statistics, ML/AI embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
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Thiago Carvalho @cyrilpedia.bsky.social · 27/09/2025
If you want to deep dive in to immunology you could do worse than Gabriel's evolutionary landscaping www.biorxiv.org/content/10.1...
biorxiv.org
Replaying germinal center evolution on a quantified affinity landscape
Darwinian evolution of immunoglobulin genes within germinal centers (GC) underlies the progressive increase in antibody affinity following antigen exposure. Whereas the mechanics of how competition be...
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Oded Rechavi @odedrechavi.bsky.social · 26/09/2025
It's probably the deterioration of social media (I hope) but i'm exposed to a lot less cool science. It used to feel like a new cool study is being preprinted/published every week, and lately it's rare (at least so it seems). Share a recent study that's worth knowing!
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Glen @vaguebiscuit.bsky.social · 27/09/2025
Well don't I feel stupid
A headline about the James Webb Telescope potentially finding a new stellar object dubbed a black hole star
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John Greally @greally.bsky.social · 25/09/2025
Seven years. Over 400 pages. About 750 references. Over 40 figures. Finally I get to hold the finished book. It’s a big day. #EpigeneticsBook @cshlpress.bsky.social
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